	   SnapGene      (ôacgcgtgtagtcttatgcaatactcttgtagtcttgcaacatggtaacgatgagttagcaacatgccttacaaggagagaaaaagcaccgtgcatgccgattggtggaagtaaggtggtacgatcgtgccttattaggaaggcaacagacgggtctgacatggattggacgaaccactgaattgccgcattgcagagatattgtatttaagtgcctagctcgatacaataaacgggtctctctggttagaccagatctgagcctgggagctctctggctaactagggaacccactgcttaagcctcaataaagcttgccttgagtgcttcaagtagtgtgtgcccgtctgttgtgtgactctggtaactagagatccctcagacccttttagtcagtgtggaaaatctctagcagtggcgcccgaacagggacctgaaagcgaaagggaaaccagagctctctcgacgcaggactcggcttgctgaagcgcgcacggcaagaggcgaggggcggcgactggtgagtacgccaaaaattttgactagcggaggctagaaggagagagatgggtgcgagagcgtcagtattaagcgggggagaattagatcgcgatgggaaaaaattcggttaaggccagggggaaagaaaaaatataaattaaaacatatagtatgggcaagcagggagctagaacgattcgcagttaatcctggcctgttagaaacatcagaaggctgtagacaaatactgggacagctacaaccatcccttcagacaggatcagaagaacttagatcattatataatacagtagcaaccctctattgtgtgcatcaaaggatagagataaaagacaccaaggaagctttagacaagatagaggaagagcaaaacaaaagtaagaccaccgcacagcaagcggccactgatcttcagacctggaggaggagatatgagggacaattggagaagtgaattatataaatataaagtagtaaaaattgaaccattaggagtagcacccaccaaggcaaagagaagagtggtgcagagagaaaaaagagcagtgggaataggagctttgttccttgggttcttgggagcagcaggaagcactatgggcgcagcctcaatgacgctgacggtacaggccagacaattattgtctggtatagtgcagcagcagaacaatttgctgagggctattgaggcgcaacagcatctgttgcaactcacagtctggggcatcaagcagctccaggcaagaatcctggctgtggaaagatacctaaaggatcaacagctcctggggatttggggttgctctggaaaactcatttgcaccactgctgtgccttggaatgctagttggagtaataaatctctggaacagattggaatcacacgacctggatggagtgggacagagaaattaacaattacacaagcttaatacactccttaattgaagaatcgcaaaaccagcaagaaaagaatgaacaagaattattggaattagataaatgggcaagtttgtggaattggtttaacataacaaattggctgtggtatataaaattattcataatgatagtaggaggcttggtaggtttaagaatagtttttgctgtactttctatagtgaatagagttaggcagggatattcaccattatcgtttcagacccacctcccaaccccgaggggacccgacaggcccgaaggaatagaagaagaaggtggagagagagacagagacagatccattcgattagtgaacggatctcgacggtATCGGTtaacttttaaaagaaaaggggggattggggggtacagtgcaggggaaagaatagtagacataatagcaacagacatacaaactaaagaattacaaaaacaaattacaaaaattcaaaattttatcgatactagtattatgcccagtacatgaccttatgggactttcctacttggcagtacatctacgtattagtcatcgctattaccatggtgatgcggttttggcagtacatcaatgggcgtggatagcggtttgactcacggggatttccaagtctccaccccattgacgtcaatgggagtttgttttggcaccaaaatcaacgggactttccaaaatgtcgtaacaactccgccccattgacgcaaatgggcggtaggcgtgtacggtgggaggtTtatataagcagagctcgtttagtgaaccgtcagatcgcctggagacgccatccacgctgttttgacctccatagaagattctagagccaccatggaagacgccaaaaacataaagaaaggcccggcgccattctatcctcttgaggatggaaccgctggagagcaactgcataaggctatgaagagatacgccctggttcctggaacaattgcttttacagatgcacatatcgaggtgaacatcacgtacgcggaatacttcgaaatgtccgttcggttggcagaagctatgaaacgatatgggctgaatacaaatcacagaatcgtcgtatgcagtgaaaactctcttcaattctttatgccggtgttgggcgcgttatttatcggagttgcagttgcgcccgcgaacgacatttataatgaacgtgaattgctcaacagtatgaacatttcgcagcctaccgtagtgtttgtttccaaaaaggggttgcaaaaaattttgaacgtgcaaaaaaaattaccaataatccagaaaattattatcatggattctaaaacggattaccagggatttcagtcgatgtacacgttcgtcacatctcatctacctcccggttttaatgaatacgattttgtaccagagtcctttgatcgtgacaaaacaattgcactgataatgaactcctctggatctactgggttacctaagggtgtggcccttccgcatagaactgcctgcgtcagattctcgcatgccagagatcctatttttggcaatcaaatcattccggatactgcgattttaagtgttgttccattccatcacggttttggaatgtttactacactcggatatttgatatgtggatttcgagtcgtcttaatgtatagatttgaagaagagctgtttttacgatcccttcaggattacaaaattcaaagtgcgttgctagtaccaaccctattttcattcttcgccaaaagcactctgattgacaaatacgatttatctaatttacacgaaattgcttctgggggcgcacctctttcgaaagaagtcggggaagcggttgcaaaacgcttccatcttccagggatacgacaaggatatgggctcactgagactacatcagctattctgattacacccgagggggatgataaaccgggcgcggtcggtaaagttgttccattttttgaagcgaaggttgtggatctggataccgggaaaacgctgggcgttaatcagagaggcgaattatgtgtcagaggacctatgattatgtccggttatgtaaacaatccggaagcgaccaacgccttgattgacaaggatggatggctacattctggagacatagcttactgggacgaagacgaacacttcttcatagttgaccgcttgaagtctttaattaaatacaaaggataccaggtggcccccgctgaattggagtcgatattgttacaacaccccaacatcttcgacgcgggcgtggcaggtcttcccgacgatgacgccggtgaacttcccgccgccgttgttgttttggagcacggaaagacgatgacggaaaaagagatcgtggattacgtcgccagtcaagtaacaaccgcgaaaaagttgcgcggaggagttgtgtttgtggacgaagtaccgaaaggtcttaccggaaaactcgacgcaagaaaaatcagagagatcctcataaaggccaagaagggcggaaagtccaaattggaattcggtggaggcggatcaggaggcggtggatctatggcctctgccggaatgcagatcctgggagtcgtcctgacactgctgggctgggtgaatggcctggtctcctgtgccctgcccatgtggaaggtgaccgctttcatcggcaacagcatcgtggtggcccaggtggtgtgggagggcctgtggatgtcctgcgtggtgcagagcaccggccagatgcagtgcaaggtgtacgactcactgctggcgctgccacaggacctgcaggctgcacgtgccctctgtgtcatcgccctccttgtggccctgttcggcttgctggtctaccttgctggggccaagtgtaccacctgtgtggaggagaaggattccaaggcccgcctggtgctcacctctgggattgtctttgtcatctcaggggtcctgacgctaatccccgtgtgctggacggcgcatgccatcatccgggacttctataaccccctggtggctgaggcccaaaagcgggagctgggggcctccctctacttgggctgggcggcctcaggccttttgttgctgggtggggggttgctgtgctgcacttgcccctcgggggggtcccagggccccagccattacatggcccgctactcaacatctgcccctgccatctctcgggggccctctgagtaccctaccaagaattacgtctgagcggccgcGaaggatctgcgatcgctccggtgcccgtcagtgggcagagcgcacatcgcccacagtccccgagaagttggggggaggggtcggcaattgaacgggtgcctagagaaggtggcgcggggtaaactgggaaagtgatgtcgtgtactggctccgcctttttcccgagggtgggggagaaccgtatataagtgcagtagtcgccgtgaacgttctttttcgcaacgggtttgccgccagaacacagctgaagcttcgaggggctcgcatctctccttcacgcgcccgccgccctacctgaggccgccatccacgccggttgagtcgcgttctgccgcctcccgcctgtggtgcctcctgaactgcgtccgccgtctaggtaagtttaaagctcaggtcgagaccgggcctttgtccggcgctcccttggagcctacctagactcagccggctctccacgctttgcctgaccctgcttgctcaactctacgtctttgtttcgttttctgttctgcgccgttacagatccaagctgtgaccggcgcctacgctagacgccaccatggtgagcaagggcgaggaggataacatggccatcatcaaggagttcatgcgcttcaaggtgcacatggagggctccgtgaacggccacgagttcgagatcgagggcgagggcgagggccgcccctacgagggcacccagaccgccaagctgaaggtgaccaagggtggccccctgcccttcgcctgggacatcctgtcccctcagttcatgtacggctccaaggcctacgtgaagcaccccgccgacatccccgactacttgaagctgtccttccccgagggcttcaagtgggagcgcgtgatgaacttcgaggacggcggcgtggtgaccgtgacccaggactcctccctgcaggacggcgagttcatctacaaggtgaagctgcgcggcaccaacttcccctccgacggccccgtaatgcagaagaagaccatgggctgggaggcctcctccgagcggatgtaccccgaggacggcgccctgaagggcgagatcaagcagaggctgaagctgaaggacggcggccactacgacgctgaggtcaagaccacctacaaggccaagaagcccgtgcagctgcccggcgcctacaacgtcaacatcaagttggacatcacctcccacaacgaggactacaccatcgtggaacagtacgaacgcgccgagggccgccactccaccggcggcatggacgagctgtacaagggatctcgcgagggcagaggaagtcttctaacatgcggtgacgtggaggagaatcccggccctatgaccgagtacaagcccacggtgcgcctcgccacccgcgacgacgtccccagggccgtacgcaccctcgccgccgcgttcgccgactaccccgccacgcgccacaccgtcgatccggaccgccacatcgagcgggtcaccgagctgcaagaactcttcctcacgcgcgtcgggctcgacatcggcaaggtgtgggtcgcggacgacggcgccgcggtggcggtctggaccacgccggagagcgtcgaagcgggggcggtgttcgccgagatcggcccgcgcatggccgagttgagcggttcccggctggccgcgcagcaacagatggaaggcctcctggcgccgcaccggcccaaggagcccgcgtggttcctggccaccgtcggcgtctcgcccgaccaccagggcaagggtctgggcagcgccgtcgtgctccccggagtggaggcggccgagcgcgccggggtgcccgccttcctggagacctccgcgccccgcaacctccccttctacgagcggctcggcttcaccgtcaccgccgacgtcgaggtgcccgaaggaccgcgcacctggtgcatgacccgcaagcccggtgcctgaaatcaacctctggattacaaaatttgtgaaagattgactggtattcttaactatgttgctccttttacgctatgtggatacgctgctttaatgcctttgtatcatgctattgcttcccgtatggctttcattttctcctccttgtataaatcctggttgctgtctctttatgaggagttgtggcccgttgtcaggcaacgtggcgtggtgtgcactgtgtttgctgacgcaacccccactggttggggcattgccaccacctgtcagctcctttccgggactttcgctttccccctccctattgccacggcggaactcatcgccgcctgccttgcccgctgctggacaggggctcggctgttgggcactgacaattccgtggtgttgtcggggaagctgacgtcctttccatggctgctcgcctgtgttgccacctggattctgcgcgggacgtccttctgctacgtcccttcggccctcaatccagcggaccttccttcccgcggcctgctgccggctctgcggcctcttccgcgtctccgccttcgccctcagacgagtcggatctccctttggccgcctccccgcctggtacctttaagaccaatgacttacaaggcagctgtagatcttagccactttttaaaagaaaaggggggactggaagggctaattcactcccaacgaaaataagatctgctttttgcttgtactgggtctctctggttagaccagatctgagcctgggagctctctggctaactagggaacccactgcttaagcctcaataaagcttgccttgagtgcttcaagtagtgtgtgcccgtctgttgtgtgactctggtaactagagatccctcagacccttttagtcagtgtggaaaatctctagcagtagtagttcatgtcatcttattattcagtatttataacttgcaaagaaatgaatatcagagagtgagaggaacttgtttattgcagcttataatggttacaaataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgcattctagttgtggtttgtccaaactcatcaatgtatcttatcatgtctggctctagctatcccgcccctaactccgcccagttccgcccattctccgccccatggctgactaattttttttatttatgcagaggccgaggccgcctcggcctctgagctattccagaagtagtgaggaggcttttttggaggcctagacttttgcagagacggcccaaattcgtaatcatggtcatagctgtttcctgtgtgaaattgttatccgctcacaattccacacaacatacgagccggaagcataaagtgtaaagcctggggtgcctaatgagtgagctaactcacattaattgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgccagctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtattgggcgctcttccgcttcctcgctcactgactcgctgcgctcggtcgttcggctgcggcgagcggtatcagctcactcaaaggcggtaatacggttatccacagaatcaggggataacgcaggaaagaacatgtgagcaaaaggccagcaaaaggccaggaaccgtaaaaaggccgcgttgctggcgtttttccataggctccgcccccctgacgagcatcacaaaaatcgacgctcaagtcagaggtggcgaaacccgacaggactataaagataccaggcgtttccccctggaagctccctcgtgcgctctcctgttccgaccctgccgcttaccggatacctgtccgcctttctcccttcgggaagcgtggcgctttctcatagctcacgctgtaggtatctcagttcggtgtaggtcgttcgctccaagctgggctgtgtgcacgaaccccccgttcagcccgaccgctgcgccttatccggtaactatcgtcttgagtccaacccggtaagacacgacttatcgccactggcagcagccactggtaacaggattagcagagcgaggtatgtaggcggtgctacagagttcttgaagtggtggcctaactacggctacactagaaggacagtatttggtatctgcgctctgctgaagccagttaccttcggaaaaagagttggtagctcttgatccggcaaacaaaccaccgctggtagcggtggtttttttgtttgcaagcagcagattacgcgcagaaaaaaaggatctcaagaagatcctttgatcttttctacggggtctgacgctcagtggaacgaaaactcacgttaagggattttggtcatgagattatcaaaaaggatcttcacctagatccttttaaattaaaaatgaagttttaaatcaatctaaagtatatatgagtaaacttggtctgacagttaccaatgcttaatcagtgaggcacctatctcagcgatctgtctatttcgttcatccatagttgcctgactccccgtcgtgtagataactacgatacgggagggcttaccatctggccccagtgctgcaatgataccgcgagacccacgctcaccggctccagatttatcagcaataaaccagccagccggaagggccgagcgcagaagtggtcctgcaactttatccgcctccatccagtctattaattgttgccgggaagctagagtaagtagttcgccagttaatagtttgcgcaacgttgttgccattgctacaggcatcgtggtgtcacgctcgtcgtttggtatggcttcattcagctccggttcccaacgatcaaggcgagttacatgatcccccatgttgtgcaaaaaagcggttagctccttcggtcctccgatcgttgtcagaagtaagttggccgcagtgttatcactcatggttatggcagcactgcataattctcttactgtcatgccatccgtaagatgcttttctgtgactggtgagtactcaaccaagtcattctgagaatagtgtatgcggcgaccgagttgctcttgcccggcgtcaatacgggataataccgcgccacatagcagaactttaaaagtgctcatcattggaaaacgttcttcggggcgaaaactctcaaggatcttaccgctgttgagatccagttcgatgtaacccactcgtgcacccaactgatcttcagcatcttttactttcaccagcgtttctgggtgagcaaaaacaggaaggcaaaatgccgcaaaaaagggaataagggcgacacggaaatgttgaatactcatactcttcctttttcaatattattgaagcatttatcagggttattgtctcatgagcggatacatatttgaatgtatttagaaaaataaacaaataggggttccgcgcacatttccccgaaaagtgccacctgacgtctaagaaaccattattatcatgacattaacctataaaaataggcgtatcacgaggccctttcgtctcgcgcgtttcggtgatgacggtgaaaacctctgacacatgcagctcccggagacggtcacagcttgtctgtaagcggatgccgggagcagacaagcccgtcagggcgcgtcagcgggtgttggcgggtgtcggggctggcttaactatgcggcatcagagcagattgtactgagagtgcaccatatgcggtgtgaaataccgcacagatgcgtaaggagaaaataccgcatcaggcgccattcgccattcaggctgcgcaactgttgggaagggcgatcggtgcgggcctcttcgctattacgccagctggcgaaagggggatgtgctgcaaggcgattaagttgggtaacgccagggttttcccagtcacgacgttgtaaaacgacggccagtgccaagctg  Wé   >   ;   "   9   :   <   5   #   >      &      A   #   1   C   <   6   %   ,   E   7   %   (      "   $   0   0   #      '   =   (   )   1               4      '   !          $      7       !   7   8   5          F      *   4   1   7   <   =   7   6      5   7   >   -   &   +   %   (      "   0   3      D   5   (   2   ;   g   5   #      )   3         +   (      &                )          +   /   %   "      /   )   %   $   '      )   &   0   *      $         $   '   +   #       :   >   1   2   $   5      ,   3       *          1   0   6                  *                (      "   )      !   +   "   -   5      &   -   #   .   '   A   (   '   %   "   .   $         $   0   '   '   %   4      *   (   #   $   -   ,   %      .   8   .             #         &   ,   $   ,   Q   +   >   (   *   9   2      *   %      "   3             .   M   .   *   4            "   "      1   1      /   2   7   +   "      I   -   '   &   .   <      0   3   9   "   .   0        > ûQR}~Ú%§!"#0z
 ¡»´gh›œ�¸¹º»ùúmnot›ÑÒ(UV(¦7?@Aqó§"ã%õ&ã'œ(�(; ¬½Sf«î½-K�{¨1¥1M�Î
¼Ü`î¢ó9`p¥Ó{Æ8qB›¯Drôñ Ì"œ#;$¦%s&²'j(ž(" – é 8C&${
P[¼	—ž¼u…œÍûßô)|¨"M&»&ö&Ò'Ü'¸(Ã(9 ü¢`°Ûöõ{Ä	
¢î&kjQ·µiy~ÄûH)ºbž¿ÅËÚp?ó&ŽWîú§L‡9! #ü#ä%{&Æ'ä'o(|(: I 	#.T¬­°³Æõ4L[ˆ=Í2�¿4	
ÞC¦õømy£ËÎaqÔÑh€›|GJF¾9_œy…s�#�'³'7(< i ˆ �¾g€]r.Uÿ0Okuè»2ô+	a	“	×½a°­»Uc”à¦Þ- é9H°"vîEÿ$ ª ò '"¸"ø#<$Õ%\&t&„&k(5 ¡ 
G„|ôû'	¹
Å
Ï
G¬éø3ÝèSYËÏ)Ês‚Ôô*k#½ýfäõ× °!‡"Í"è"§%ô%Î&«'Ÿ(# ¦ ­Öï¾Ž©¦N�ïh$:‘¬»0]ºÏÎ"<ˆÇ	ršCŒ û!> f q 9ÊÙŒ�	
\1‰j½ä,JæL˜;†“Î‚Y’òü�Ð?n1[*~•©€.{ !!Ê!à!Z"�$]%N&j's'Ó'Ý'(w( * t jx‘ Eþ%0�ŸÙ ýÅÚ!j!„!©!¿!"3"T"”$¹(& ó rD'Iá“Z	ª	|
ü
QÑÃMŸŸbƒÉL¢†�Õ{â]"©$Þ$%¼&÷&Ä( — ê ,tÉ§
½v°uà7õ}°°'!©"Ô"0#$ë$–'A  öý aºö|ƒ		
£'l{kRp|\(–ÆAcÀÆ•˜¿4@a )4X¬Ú{æxˆ¾×= ~ � ú Ç!¹$…%›%å%|&G'Ç'Ù'I(p(•(¬(# Œ ï£Üí÷w´ç>®	›pôIzÛÝ'ïûs¨œ!B"O#y$#%`&ö'1 Ü&Ý±ù@E	Å	ïÓ¸qŸOzº*æŸ/qPŠ_d,NµM¦ú1|¸K :!î!¡#Ö#™$å'é'[(C xÈ™~³	a4HŠÄ9•¶ÝUj‚‰ÅÖü!R»t«Ìÿ7òd‡ôT�kvŽ¤·Ðg‹ª½ðNT]ˆ�f  1 ã!­#ý#%S'}(ã(< ôù$p®±»®¸>¥‘%		y‹önzÌSrË&Pfiœ½ÃÉØn�.NsÍñ$+H|]tLRwz†vy ½!M#ž#Q'6 J L Â r/13>UL´Ç“ÎÐÒÔÚÀ5	N	�÷wßÂ8:ÏeŽÕ´·CKGe:lr˜tÚ"Æ#v%&‘'(8(% 3 A
ö\‰q3
ÿDù¤f�±Â`z`ßÔny!Ó!."&#D$¼$`%Œ%(, 
Æ@­v&5M¡ê7	§2bMÒ\}ÛçI¿[•�déÁ \ ¹!$Q&Ê&´'ý'E j ‰ ä+Ú^sÉV¼¸ÁÄÇàõK	²	µ¾EJ±ó
NáÑ'g�ï@^Ó <TZ�.P¡…:Ioï« ó Û!ø!"�"	#ù#$=$þ$]&®&l(7 N �³¹¿h�…Ñ 1•Ñ3		�	º	è	ª
”±b®¼è /V§°Í:_#_ÅF  � (""½"Ö%è%…&å&'"'v'!(:(˜(% ² WÎ/òPv¿ÖàéPl¼7]”	É	×	B
Ø~>d•ÀMdaíx%u&�&Ú&( ª §³ì¢lÚð®,	b	„	,
<
S
Œ
=oùŒ�×ôŒ§ˆßèðê±w % F!¹"¾% 0 5c…Ü(	s	Ú
ÌÐ€µ >­…$�L%&m'¬'.( (" Ä Ý HNl¶ï6}„üP	¿	7­êñÞéZ*Ilþö– Ø Ž#—#¾#¨%Ï&$ b ¢ · qéãº
Æ
Ð
~µù4u‚•ÂËÕõ¾Ñg±!t"Î"Ü"Ý#(¯(0 y ý t] àõ· H�)TÄ<tƒœ+21¹EÉgå%g�="ˆ"“"›"é"õ"^#³$Å$ó$õ%&*&s(0 “ § Ðouû(rÂøðöe}ƒ²¸(%N’¼ï1^mB�„#&v“@sÜšY l ®"'p'“'Ó(à(# œ äðUg¿ƒ�¯ÖÜ?N0
&yãÆá®M»
#ˆ ‰!ü!5#&3'€'¹' d×§OùQ;ÝV­Ð®ÕÈD÷5Ž¢� Ž!~#Y%' ø }®‡¨“ª�ÖŽ¶çi¶ù=ãõ ¦{\Ï=æ<‰œ›‹Ç X!È#ˆ%= g r �ž+ý‹ Ëù�_öQ2nÈk€Þ *“ÉM™F”Ï€ýy›ÜE2Çûey~, Ó| ø Þ!á!["¶"$$( bÌjîÚ¬‚	æ	@
$Š¾å«ò;Z¥ó>ƒž¤Ñ@ËõpuÃ
 K#W%^%O&k't'()  OQ`‹;†
i
]½…þK‚¼Ç³\�Š/ZâäóÁù"!>!‰#‚$%}%Ô'Þ'(1 Y } Ò CS:=—H+�
DÑ-Dyç¦<‡äƒ“”o+–ªƒÖæP¶ @!Ë!´#Ò$É%&'(x(£(è(   Lá+àø:F<€f
é"ß14r!$!Ä!4"U"‹#J$ + m kƒã^_1¥Ýž øþ¨ûÛ* k!…!ª!(#F$%H%&¥'3(º(Ù( Ê Hž’!ÿ‹Âß	O
ÜÚ(AMê‚Æ!À! ""#•$%Þ&J' u y^&—¸ëˆ�	Ý
OM¾µ+'äb“wb%(4 ]É(X«	

!
}
¿HÄ6N›žîû‘ jc·|èMbl£1\ðÐ)7 0"w#5$g$j$Ï$÷$%Ž%&Š&Ö'g(µ(Ö( 5 ô s¿Ís
Ro O+‡‘Ëã"Ç"9#U$¾$ß$%%½&' ü	JU�â59”§Ñk
o
ý
ÒÜ!¡ 	¤Œ}Öº|@   ^"f"#\$�$G&e'Å(! <E[	¦	ã
Â9›øm!ƒ³%Ä§^„Ê7´Â !+!O!Õ!l#M$ª$Ü%&ø& \Ü	×
¸-FÑ¦w°ìh±ÆM×y4áAM±(!†#�$à'  ‡DÈ+³ç
z‡Ø„ÿBv¬ámo¸=±u Õ"„$ú$<%n%ž%—'Â'Ì'Î($ 	  ˜ ë Y�ÖuÊ¨ùš18ÝöSÉ~ìöt!ª"1#c#*$Ã&'\'¡' ¢	›Z©#¾_“Âd‡CvƒÚß {!$ì$7 þ!O—ß }‘	Á*hóSq}^€™–Û!b=Ý /5SY�]ço˜¨»oy¼ÃØÈ!X"Ü$ƒ%Ì&©'Ð'Ú'ô'(z(  ·÷<a*
³H|´æ%0dÁÇÀA"¿ »!\#Ä#º$†%æ%}&q(–(­(!  B÷„
xFml(k‘�™¥ KÅÛ|Ç'€5 > ž ö œ%E&H'c'Ê'1(7 ¡çéb»	

$
¤(ñ])O—>Ç&B‰Ù5¡ìq¼þ*p’­ÿ!#C�m,m‰ª¸ û _!"z"$`$±%ý&a'È'J(_(8 ¿ ›Ó¨¼(ORd™œŸäx-µèž¯	ã	
\
q™/AnJæ¸ýK–(”ü.„I•ü�! !¶!n"q"|"$%$%»%‡'¶'ÿ'5  # 9 � ð¤.x“½ÌîÄÍøHu9	€
’
œÇ+õF{^ì—ðJ¡t–Z�  C"j"¹#æ#$b$Ô$S&a&k&a(¨( [ º ?ÃÝ?	j…û+/r˜©£ºÈòY^ z$,%2&±&÷'C(  T ëŽûY=?v	2n¦©4u«Q•ÜCÞ—²�…B!P#'% &ÿ&()(F áÞr«úE[Î1	Æ	h;´¹Y_r¤±!Pd{”£¨8ìaÖQWp™é‹P�=O¯2·V§¹: !6!;!\!"Q"¶#þ%æ'\(’(¥(ï( '¯ô²TÎF	µ	KÔÛJö~N§fÍ!ï!@$s$†(* '8EÝa7¨Aj	šÎçë !ðÿ‹re!-ÏlsºËØ‡}9“Ð ý B#¢#š$O%�'ê'4 Ù Èç+£G
ðé6»+«Éç 0	`ë¼R¶ŸûÒ.‹›¬ÌL o ® º !/!"7"±"Ï#×#‰$¤$ã$‘%Ë%Š'1 _ · ÿ	†•˜‘"ïDS_r—ã(ÍJîõ�Ÿ¢«,Cbw�¯%só²ñOUë2 Í õ#þ#8$	%h&¯'7 yšÅìû	‰gÔI:b·/ÌïVQu¬çeˆøx·¾ÓÑ®á_,Rg   –!£!"ñ#Q$m$A%³%'L(S(Ž(¿(ä(ê(< @  Ô -<ÉgJ»_
t½‹ÅâkƒŠ‰Àu|…¼ÔõD8£s¥1¬öúV«¾Ïôü—ÀÏX^‰ 	ã a!ä!z#$~(= U£´’j	U	&
b5ÓØ{Š–ÞV±Æ×éý>X@GÐ ó7�œUhl¸Áâ-E�¥hÿŒÕè	*ž5Q T!®#—%T'¾'7 «¼ú|ª¼¯z¦/y
Í
ZÛPÃsÌ'a�¾ÄÊÙúo>ò%�íó>K®òË"Ÿ#û#r&z&º&ô&Å'n(›(Â(6 H ‡ Õ-	F\q¯²ô3T<º&	2çŒÊ(÷xgÍÓ)gj�«º/\Î,I½‡^uxþ# ‹ ¯!ú!†"ç"ó%[&6( p HÉ’€	L0sã
I’ž¯‘ñÏt}z !&!¾!5 ‹ õ%wÜ}¹ì?v²‚	D	zGo{pÜTˆQ6O†£rMS{‡wÖ  0 J œ Æ!N#x$¸$_&F'R'H(Z(«(7 K Á qÅó02?Kou%’pÏÑÓÙ é6	M	ŒvxŠÁ791L�M*HkmsK—ux ¸!Ò!-"C$ü'(> M *V„²ÐÙÈ¡ñ”¾ÐÕßOÀÃÆ6\ß	±	Ö	©
n´.MÐf�ÖÿŒLï9^nì ÷!~"�"$ý$w%½%ä&!'9(- Ã ü s4\Mkµpîß¶âO	r	}ŽÃ;›=0¸DfœÐ$f�• s"’"Û"ô"�#Ü#K%&(-(& ’ ÷ |ãTf†§‚’ÕÛ>MÁ÷øàõ±µÜMâz;Û
Š�™ˆ!Ç#’'¸'+ Ñ BNŠ�Ë*–Šií*«å	h
¼CC»EªãxÕáotøÝ!µ"J#³#
$%|%È%'(ç(% l KG�*‚ßâ÷]9;Š–·êN
NÜèãaÞ03Lqÿ!#'#E$I$ %a%( 4 ¾WûTr4
 
5íúi£‚²$Ã¶{a6Ï!Ô!"/"#8#v#L$T$[$½$%�%&´(   †ÕÇÖ
 ·E×Y¥^ëg0à@t z!)$m%Í(" ¶æ AN–ÿÀG³]N~ ÜJR€þ \—Âõ º!W"[#$Û$D&Ë&¨'Ï'0 8 S š§-w’ú'NQX›žÂãÌG�8	m¨ú3]BJ–-œ¢¹ñ  ] Ÿ!µ!m"p"å#&%º%1&R&°&µ'þ'3 Ø 7Ç®ó`6æ§¢´	æc ª7ë`ÕV˜è»<žÊ† e¶UË­ !5!6"?$£$â$‰'œ'‘(î( ,fë^
ËÓâ�gÀ¤+–¿êÿS!¢!"ð#ô#½'D G o Š »,vÛE[¹È	C	x
YæKÉ'FOâHÒÛ(‘`~�ðù5Î=[…¢¼ò†=JÕ  / ù!…"Ê"æ"ú#·$ò%^&q&y&5(m(š(ª(5 òƒSjt…
$ð½ÏÔÞNÂÅ5[áö	L	³ô°À-Ly‹îÏ	8e] ” ‡!,"Ž"‘"J% '( k Ð J�ÊÞú»B¶4ÛìXºh©â¢wµ/Ýp÷s Ü!
##	$H$ÿ$%l%Ç%'³(2 R +6µåM¦_•Wâ¦œ³	l¿F²\©6êA_ÔIUŽfQ£;¾É›¸ðþ¬ ô 4!"l">$Ú$¯&§'¼'í(; Q 5´º‚DR€Ý	#Ó4Z	
	w
Ak²3&¯¿ëEW[¨¨Î7<È\š·öýÔ   . “ +"„"å"#Ù$Æ%p&'™(g O P ‘ijk†‡ˆ”Qzåæ !"2ÆÒ'deqryDWþÿé	u
v
‚
ƒ
„
”
•
–
—
˜
«
À
):jÉc½¾éê!01ZÄ6;`$  , - e f )"*"€"�"‚"ƒ"¾"ã"ä"##Ö$×$Ø$Å%×%é%U&V&c&m&n&o&æ&ç&'@'A'w';(Û(5 ’l‰�ç×çc–ò(jszEXwž	Ï	…
™
¬
¢;|• 2^±ÅEa%`–ª³¢Æg þ"##d&†&è&ð&B'"(<(# å À•Ò{3ÇUf 	»	ê	Á
*Ê!d§" ÞG‚ E"I"¿"*#ë#Ø%ê%W&ì&#'x'Ü( lQ×ó3ò.YxŸ	9
:Ù	–Áúa�ç^#?#»#e&‡&Û&)  â 2Šè%Ø0`¬Qm½8D•	Ê	¡
}!bÅe—Ÿ´Ýè#X$y%¡%«%v&Ž&¥&é&ñ&C'#(=(3 ³ Xm�ÂÏè†¦—ž¸áê)^kt{f	õ	C
†
š
­
.<‹–?_e}Æ&Q«9£ÇØ#ÿ"1$0% “ÂódwÀFÐ	Ø	¤
ž£r«3N²F’&ªbîh ##F# - æ ´ñJ¼	-
=
�
Â
Ëeº‚õ¨©Êév\jùº"d$°$Ù%¼(Ý(+ % ; � ¨–Ó|£¿m›ÛJga	c	…	K
T
+¨úT\ß÷âo¯à8™â ¬!F"X&í&( mÎ4Vd;	ë	>p�#¡�‰ãñâëª Uxßm!è!À"+#‘#$¿%ë%&&î'c( « Áù0íÈŸ¯-	T"âDØL¶˜²H& ƒ G!!J"ì#h%&$'9'y'& ( Ÿ 6d ^†ô£×ó/yò)	Â	·
ìÍÑˆÂÔWr™
	tž*LŽ/®—$%!%  1 ¹mØ4›I	¸	:
Q
;“�¶†Zš[b_Ø"#$#¼#Ã$È&1'n' Z 	Û
Úô
ƒ™£Ü!®)%æù;èô Â!Í$&ˆ&Ü&¡(  > ] R�Ýt	á	ý	‡—?-‡û;G@#?%M%�%f&…'­'ò'(/( ›Im1”7Rgn¾9EýÝlä ´H !t#Y$z%¸%ò&D') ã 3�#OÕÛað%1Bš	A	7
¢
8CBàmCcÆS‹˜µô÷‘ �#é#.%©%w&ê&>' Å ‹™!·ÓÙ#~˜z	À	ëòêJÞf #"#¦&Ô&(   Þ é&­Q…Q	–	Ë	®~ß["+ÿåÞ— Ù ˜#¿#¢%¬%�&•&Ð&$(>(+ c £ ´ ¼ Ç 8ÃéŠµr¹å%og	D
/v—Ã@L`ö~Ò«Þ�È$„2$p$Ò%«&À&(/ „ JY‘Ðñ‡˜Ÿâë*‡ê_l�ÄÑ›
®
±
Ç
5€–ÌÏ¿E [²!u"Ý" #.$¨&('+'6'‰(°(% Ì §!9|
3
W
‡
Ñ
•¶íúZƒŒ>Ç3O¬¼:C"Ï"g#Þ#³&Ö&à&'" n¸-€åuä	ö	»
§Ç=`ÙfÖÜ'hRHÊ#i¤ÙŸ$1%q%O(V( z ^ÁŠ�Ë¸|	Ù	
!Åñý‡3UºÙØhðci q!“!|$ô$t(/ ÖAßxïGˆ	Ñ	´
Ÿ¤Ìÿs4u2x{F²¾³h¥äñ«Èï` à"#G#â#´$%Ï%·&.'L'ù'E() þ ”¡Åeö¼ì
ñ
I‡ÔU_„åò,1Èæ&h‘'@ì!	"‰"œ"ê"#V#_#©#ö%+&4&% uÃýôáÈ	¥
�*¬=�5Y2POÊG“Îæf!>"”"ö"p#$%$Æ$D%&$ ” ç ívòüKŠÃ
Ï«¹&ƒ©-“½ð2_l'ä›àì!¥"š#¤%‚&q'”'á(' . w ¨ µ}½	.
	'€’áñ÷~³O¯ÖkËæ‚$YÝ]çZ D!Œ!»"•#±$O'Ñ(Þ( À)‹	>
Ž
á
Ïwö<ªC…wwAt�Å"e$Ú%'Ô()   ÑpsÃÌùS	�	Ìf»f„)<]îHOnê•ºüAô”kúm !x"¯"Í#‡$Œ(½(& � ©ñ(�{ÀÓn�°×Ý(Kp	Ô	L
øe\.ášê‰ ­!Ð!ý!6#v$Y&š'+(0 E à å÷h}À„¤œ¤ÜSbhobd	Í	',8zä©Ç$RàÌƒ§ÈdÂ$”¨±Öàc G"î&º'* & < � —Ô@O™ºí	x	†	1
U
ê
ý×â]ÒãSp—N°¼9Öã Á$¶%Ò&'4'ƒ' V{¢¯ß
ã�ûU¯ÔÁÞŠ!ò!€&�'$ ¯ $ë�B<	4Mq°ôë±V¢·ŽÖ‡Ÿ Ey·Å2Ÿ™!¦!)%9%Z%'&(d( n[W‡àúWhÑ¯ã«6Ž n!é!ô!’#ï' `	¨°P˜	ýŽ<u­ZŠäÉ/Vy��!,#$À%;&$  eØÏ5±eì	?åp$RÞÞ®ûòìVøà£ÐÁ"#%d%ì%&‘&—&' V ‹°.	c
#]ãè6Ù·>ä¡ ]ÃÐä´ÔjpŠ' Ô Y!N"Á#Ó#‰%®%û%&(@(+ ¬ ù ÂúXˆî?É„ÔAïž
Ê
Q·-ÀTöà|Ö>çê±Œ™ K"<#¦#í#i%A&%'(# ¯©€˜ž×õ
U¨�j¬ÃíLØÁ=M‘·´bœIÛ !"ð"R#':'z'   ~1ý” « UWEúÞE§){™²�™³„ È H!€!É#&"&: 7e¡í,BJ_Ù$Œõ ¤ô0zŽÃ	
OŸíjí¡¶»³òfx}–šGl¤Ðzù¥{š†8!L&i(·(> h   ¥ Ž¬Åþ/NZjtƒ‡çÌú¾ó*	3	`	¸
FÖ÷RXÎÝB¥Ébl�ßÊ#Ðš¹Ý
F;Ÿ8¼üeG!„© ·"Ô%1 ) e s ò i�DØY	È+¦åK�XœÈ”ØK¡-ÿ…ü�Ô¯¨!ß!"2"S"\"Ó"/#$€$“$%\%2 ŸÇø³æ=­	`šÒ3o‰Ã[”NÕ•¹sþ3u�«Ï+fzMï¥ù0< } ù ›!â!¬#˜$%"%Ø'è'”($ 2 @	º­·$	öROe[r~\”Óqcv x!Ù"%#L#_%u%&P&É&
(5 ± ²ãÍë»Ùkï­J	ƒ	¹	È	ç	;
A
R
‹
<D=‹¿€ó‹¦î?]‡Ò;SY¯ÌcÄ`Ú!"#Œ&­&Ù&u' ( Ÿ5Û6ðt
”Á¬„<"š"½#Ä$)&l', › cntœ'qÕ%xÅ
‚·­æø<ôŸ¥A[›Ô’"?ö4¡X ­"4#}#X%'2'o''3 PR_aŒ:<üGÿ^õP„ýÐÝ�’ÆÈ¥:Êúd‚‰YãåòôÒÀÂ	 =!?!Ñ$V%(¢(    É à]‡Ü
¤L½´*&@!véú!#!Ã!Š#~%&Ý&¤'(Ø(* \Ì;È8Ð
j
n
¾ÁÛ 8N� ÿš� ]ç‹0[ï|¹ÊÁ e"4$i$Î$% &‰&Õ'f( Œ[¡	†š"ƒøþ¯ÁcRn·3<ÙõLÞ b#ƒ$ù$;%Â& 'ß'  ;Þ#
w²Eð'/�%ˆØ<plº&+©»· ^!"_$‚%ó'(0(^(y(1  " Z ¾ >˜Ë<,>	u	â	

‘
1Æ˜.@Emtªå”·ü•ë—„YƒÇH”XA!i"¸#$Ó$+%&†'(§(0 &Dàª*DSZi	F
J™³X£°è “¢§þê O�Q}®kr¹×9 Ì!"A#µ#r$N%�%Ê%¤(6 ? ^ ~ ¶ Ó ;TI‘þ	sˆ�Ò×az.°èî=ˆq„ô›,€«­àùþ^±Îç4QÌ y#7$l$@%–%g&'®'é( † ó2;Gu��­I !%!Å!ó&E' ö p)[±ÏâJenío¿=ÞèmŒÛL#‰Œö!ó"Œ#B$ã&   M…œá•V8Shì:‰Æªg
Mêà25Îsu#K$Z${% 7 × ™,ùFþå*,¡ÿµ!´!5"V"á$¹% n Ï *Lu„M›B	Xºá¡d½†!É"G$%I%x&'¦'4(²(* ä 4Ž“PÖÜä
bñ&Y	¿
 2¦DŸ§D5Ç™¶õü+ ’ ý"###)#ê#Ä%ë&?'Ú( Á$_«·2C8
£
9Šqù
PŒ8©"]ÜE#0$W$/%ª% , lš`ÞCn7á©ÿTøl!«!ç!�#&8'í'»(   Ÿ¸]�¢H	·	Á	à	ü	P
óë‚’˜¢‡Yåø)ZFÁ!##–$ %€%ñ'( Œš "ÒÔÚ“"$f—™6
AÝßBRŠ� #!#='( ƒ Æ Ë I7‰´ä,ŒÃÐ
°
”ìYKÛÝDGN€Bhƒ"f#-$§&ª&¿&Õ&ß&*'ˆ( ‰ €	{	
³
†gëðÍÇå!e!p!’!"ß"U#á#$%¶&-'K'" v ¿‰R	Ž	&àÎNGÕ,;jå”Xó €æßë!w"¤"”#™#£%‹() D ß ö'z¡®'Ran˜¹ìo	Ì	Þ
â7�üÖ#QÑ-Ë‚¦ÓcÁ“Ï!ñ!u$À$Ñ&  ê_†¯—	L¯ßêtÝ¶Yx8%c%:&�&–&(! Ób
�
É
ô
TP\,«¿K×(±˜ Ó Ú  ";#¥#À#­%ú%%(?(+ d ¤ ÄAI#MYsæC²å<¬	
™ÕA¤awkÏ¸¤îƒ…"1"Ò".#’$%Ó%×'h(¶(" ?ê¶º&pÔ#	Š
ïwCÀÄ	d\}ÓÒw!Ù!;"™"&‹&¬&Ø&-  È ^9:‹þ7m
À7OMœŸü‘÷ý�ÀÉ?cm2uñ{ÑØÉd"3$h$Ð$ø$Á&Ÿ'(×(5 ! µ ½ :ß©Ê);Yh	
"
E
~
0I˜Åï¢¯’¡¯óéNŽ¬ßý]qÍX‚“%*~8 h"x#6$^$k$q$�%•% 6 … õ „ZÎdòìtëÅ©)ˆ³!à$â&& Î )Kt’À™ª¶L ¹p¦à	4¼!\È"ü"##D#/$V$Ã%7'ì'±(-  ‚ Ñˆã+ˆŽ¡–û	

5
¯
²
…�—¡YCFQ‰ïAEÌäd!‘!Þ"à#$%%©&µ&¾&)','# C  `mÒn	œ
È
SÞ%6ŽéPÍÐ,Àò’Ò "v":#¤#¿$7%ù%9&Š(. 9¨":ýXä6;Ól
‰
˜ÔîB£üŽ
¿òÈ�íp×‚’}"c"g"˜"Ñ"]$‘$×&' Í ƒc
K~•¨m	ú	
4
ÿ
¸Ý$„�¥ñX3P~@Dû"#ß#$Â%8&´&á&A ‚VW}ã:Òl	ˆ
þ
–—·Ó"#[?@A¢�ÃÄüýð412no½¾¿À;<=>?€�‘A B _"`"a"b"Ÿ"Ð"ú"#Q%7&Ÿ& &Æ(( bŽªRX
p
Ò
û\­íÅþ/5ÁËÑG­Á»;C ¡ æ ÿ  "h#R%=&H&¡&'X'f'Ç(' o¹æš	§	Y
ä
üd®bgœÿ#´Œ¨_ÌˆÒ¥µî !,!$"i#N$è$à%&Y'g'P(ƒ(% G¤.��vò	Ó
/>]î9„�&tÅg0SÚ8I®ÂP!í"m#œ$ $.&>&¢&W(" Fcå	÷	¼
€aœÚÿ>ùn"4UÝ6izË$ç  !Ö!¡"2%S%r%Ý%I&. =«S\	q
f¨ÃÈÐ×:x�×Æhæö…Ë4#ÂÒ(HŸ£Ãj¼Ú<�•D ¢ Ã «$›&ù&'È($ Úp¨	
ç¹.hò�¶÷xiØb5‰â[Bd®¶ï !%"é$á%h'á'u( Û Îçù‚}	›	Ø
ý¯Gc&$²µ»�ÇÙ	Nzj & { ‹]¥Ú	Ý	å
"Æ§þ±Ú¦N²´ )!r!j#‡#}$‹$Ž$õ$&Z'$ _ºÂÌ¹Z
ƒeÒˆ4Ví -i v�©`àÍñTÓ™¥-!”!O$_'Q(„(0 zˆE×¥�´Ô
{0 tˆ5v†C­à"p¹ÙJiÉðv !Q!³"H#Y#ã#¡$û$/&¸&Ã'Í'ú'F(X(' 0HBjàwð,Hó	I
 ?Ùà|ŽuGw­³´�ÃÛåÒq Œ"á"#µ$f%Ÿ%ð%£&' 7/Éµ
ï
¥^Aï… 3y…'Æ1î9>âò¬²!Ö"n#�$%=%o%Í%Ð%“&Æ&/'% Ñy‚
‰	Ò	è
ÍòTë:¿âúhnT¦¯ÃÔ0�Îa 
!Ã"î"Ñ#…$%?&M'˜'Ï(4 ™ ð ÿ ZgŽÆ×-hDr�VÛŽðæ-o#9÷ºj{¸iƒ’£íú÷a
""«"2#`#ª#T%s%J&}'¢' —5d½æ	½
ò
Jˆ…©?r›
É5V*Ìý¢"#d#+$'* 
   ¢G!	ð	ø	b«Õ `vúú2ôÞVÁ'Aí�u!×!9"�"ë"5%“%Þ%÷%,&5&™&�(( ì î •ÊÌf÷î	í
�Ëóõ24éÞ7TÊç�¡(%¼ è !!Š"W#3%î%Ä&]'# g£	g©œ­68½”Ã¢ìË@Ã)ÄÌ'Ï�N Ä à g!?"$¦$ð$E%ú&$ éâTÉÚr
¦
ÄÉÑØ;[ØZë32ýI”ÛkÛ=çE 1!|!q#Ù#"$&$&- Ä>õ³¬	]	A‘>žªÍ$Ž6ˆe°÷¨Ì5í9<H¾Dw ½–¾ •"÷"$å$í$œ&, vþ›ø
+y‘n¿`ÇxËQi³çÄPˆ†P$ÓÙ„¤é÷X	£ ° ê �#¬$Ç$'Œ'É(% • è PLº%_i8_·ø„š¹ÞT'Å6pCpð ¦"›#:$¥%â%±'Ñ'Û'â'{( "ó’	
Ä
«è¯¬ºôTr“"Í!Eè™ãíÖ &"÷#ƒ&Í&�'ª'. qwýà~‹©	
û
ÐÂ+/žˆi~:a>m06Z‚¨z¯ÄÙá !i!ƒ!É!Y"¨$Ý$ê$i'r'•'(v(8 Ûîÿ˜	ó8ž'� yÅå@ª.”—¾Üñ3`cŸS(j‰¶Ù^cåŠ©´¼\œe·½í!A"Õ#„%š%õ'â(. ø=¤~	þdÊ%³e°¶¼ÂÈ×mŽÁ-BÌð#_ÚædyZ{ÞQèÀ[ ¼!Å# $»$‹%P' © ¦¸·œ	+
“°I}òøç	&çO„^€ E!¼"ç%
'—( / a x Ü b¶èƒ¾	Ù

´(�H´1È]#–#²$ò$&r(®(  Ï~®ú/
âµd|'PLUîl€ƒ­
%åuk ‡ Æ W!�!‡%~&Ò(ß(#  X | ø…?
�
#mÇÿ)x²ñ¤=‚š£“ÛDÆx}+Oµ ÷ ˆ#~$& Á^Œ	Þ	e
Û÷’'§�) G%I'2( Œ¦¥	
â
Gnš÷l*¦k(³6 ? Ÿ *!N!Æ"k#f$�$ö$Û%F&d'Õ(& XC*²Û	æ
yÐ¨A’™«†ÅLÖÜlxBu‚Èës!…#Œ$�%'['Á'Ë',  è`�	
)
)gåò$˜=j€Úë!~¤»ýÿ.o‘Ä"BŒn§Æln4 y"Ã#°%ü&`'b'É'$ ¹ Òê»�c¼Ãt[
i„¥**P.–q“±IŽ •û{"$a$%j&þ&((B(`(, qÍÍ0	Íg:ê^Ú5ÈïIŠoõÎÑ-8Š’š¦«n ¹ Ï ü !.![!"P"°"Î#ˆ$ý%…(Q ¢iºÄú	T	%
f¼…”—Ó‰áW¿î?CFU^t{–'CPÏæI6¢í÷rwž¡ª¶½Ò+Ba®á $0DròõUÎÔóû)WP â `!•!$P$²%K(R(�(¾(+ ªÔ{©S|ëy±.Ì
1Ú/rw	fo‡Â®ª¹Œìqñý" Š › ®!w$Z&¹&Ä'G(Y(Á(> ‘ À û {ÄØ¦� o‘‘ØÞLŸµq	°	Õ	¨
|‹u‰6š0<K/áþL)›ÚŽjJm–ëw ·!Ñ!r"}"Û#$ü$¼%·'û' (,(( ‰œF½))Ô)•¶éä	
M
Õ
ÖBD]ç#â/K?!þ!"´"7#I#²#($S$%
&Ì(æ(* ò‘Peš�ÁåË]
ùÊá—•ýº–…TÊ R!ž!¡!o"Z#ä#ï#ó#¢$%%0&C&ˆ'›'Î'�(9 F Iñ¥Zi”áï¥ÎÝùåÈÚ,KG¹Ú5_}�éø4vÍHx„Š´eí»ñ¢Ür 3!k"�"¶$k%ñ%»'©(ì(2 æCy~ÅTcipxCVvýÎ	t
�
“
(¡9@i{È%]YÃ[•©²Ý¡Ó  d D"H"â"Õ$T&b&l&ï&  á 1Ák…¥�ñ-e	ô	 
-�ª|%‘Äžæ×#>#º#ç# %¤&* $ : Ž ø/¾ÍžIIc:	J
S¹S[áöáâ¨®É˜Kµu—[ái~!$c$¯$g%%&b(% ' = \ ž šÖñ¶
†Û,ÓVq†˜(	:s™K:ó.­ ×"Â$Ì$%>%Ç&0'„' ˜0APÜ	@	y	kãB³äóG !s#-%·%”&Ó&(" » ð8†ä$n	2
V
¦Æ_=ØÎ2ª»É"Zo$ž$p%Ñ%²&'''5'N(U(3 Õü@ÄÞ»ÊîÇ‡	ë
ð
ËÓþ^ðü†14äñT0XwzOÇ±½Ø×ï?¤ã_ o#¨#$${$C%Î%3&ø'D( ì|ËŠ	à
Î‘ªv;\í®k¹û@ã!C!‹!Ä"Ì#†$�&N'Ð( �Òz£w	Ó	é
dR[–ÇÀÕ§°ÕÝßéb µ% '‚'™'*(  ® #œZA°3äoóü°U¬gú†ž.U¶Ä1žÏ˜!¥!ó!%(%&. U WŠü >ƒ—@î§V5ÂìSÝDß~ÀÕÿz˜Âã³Óéio�°³aM"ï"Q#Ò#!&@&'(M ñ hÆì«�Ø÷.i‚½2	X	_	ENžWiÜì µºÇZ¥²äñ"Je|•£¸:ŒªÎø7“»×J dþFz„™¤ûø; ¨ 7!š!§!R"«#[%K&ç'“(. š °  ±âžs¬Ç	5sõ	<¬QNŠ÷í:RXq®‘!>“3b W "¬"3#|#t%(&'~'	(* [ËßÇûF\ÏÏ€™Å¤~9bQˆ¶X î¸¿KÀ Ý !<!a#:%U%ÿ%£'e(4 %C=	rv±�²Ö&W`ls©çí.p�ý$¶×šêøPk|­°¹j¸Æ3W¨ºË ]!""·#$*%](¦( Ö o˜(°UˆçL‹œÚK¬+Íþ‹õ!ò"A$ 	X¾
W‰6O¨7æ!#' 6\³eÏ	G	¶	“X‘†@Xä÷Üg� o!T#e#,$<'ð'‡(" õ®¾a
ó
KáûÕªsÜJÖFÔ:XÊi�¥Ò°WÎ!ê!ð!£"“#t$"    9>Þ@HLB±"	¿�¡®v®Î [>ütÌÑWzv!Ø!:"-#”%ž'  B � (©µ èß(»BˆîÑ c!�!C#£#6%ø%ë'1 �b8a
©Qk	ù	¬ìûŒÂû¾ñï.WÀÊÐFì0m~�:å þ —"ž"ù"$P%Á%6&<&ž&W'1 F£™	ñ	e.c›ÏÖþaw�="8Œ
gs‹å3õ3Tf"y‡ž¢ÂÑÙŽ”í #"ì"›$ç$ß%-&š&‚( Ú ÍÙø¤‚æ%µö,uœßaSZ˜¤­³ Š$&^'/ /yiÐ6	H
î
ñ@Sê…ß¬ß!ùí�ØÂáÓ/œÍÑp !	!!‹"²"Â"X#Ð#%e%Ì%ï%’&Å&2  í ï f–ÉË4,g 	í	ï	Cqª�~ïqô 3è	ó¹U·À€‚ ¢ù)ü`Œ» "8"4%’%í%˜&|'€(7 è²šfÙ÷
@Ì�m7¼5w‡Êê¡1¯²ëÃü§
?Oì8;½ØËèöW&M ¯ ½ é 0!€#Ø#!$¥$ä$ï$‹'+ 	 
ú
ª$^�®‡’779`¸Ää?žRÌDˆµ&§Ä³ìÕ h!‚!@"Ô#ö#9$§$™%Ž'°'" ` ¥£­¶{cÉKTlí,ï^¬åcxätƒP† Å V!ÿ#ñ$Š%	' W W±¤	d
™@Úð˜)£¢ö’‘ÄÕk&j*ê( M!„#F%À'I ¸ Œh/	(
h9“–äéàÙ#¾BETsz•ÎåHö} £µÑ-n�°Ã/AHq‹Ÿô¦ÅÍòú(VÐ7‘3 O Î á Z!O"Â#$
%¯%ü%i&û&'(A(- ú Ãz€êÊ”§
Ë
ŠÙ.Õ;ÁÉà©‹ë•�l>S ! š "±#Ú#î#ò#'$R$	&B&�(À(Ë(å(' Y�BUüs
Ÿ
Rh¸ZJ\¸ÙX4è÷3á‰ºZÜ h2!}!=#®$j%$&ë(& ûï…ãÕ#mÆÛð	ÅÊÒ<Ú0ÍðWUv×J!-F r#§##$n$Ë$B%&'(M(T(. ­ "‰›ÿ@–ÊícÁZ[ìR­f}Æùþjy¸¿Ô?Òè�¯²â`-µÜè—!¤!L"Ë#´%&'< °ÅÊªö�¼W	^	uŸ«ÆÎÕ%k˜ÄãIìM}‰öüµ9©Í6’­Iµ÷Wc¬ý˜¾JV § ¿ Ê Ü {#$' Õ ­`
V’W�
ŠIÕÙEÓ9€¤WÛŠ
å!ñ"S#;'0 A € =€ ?K´Ÿd-¾�­‹Á7½Í	f2Sî=¿ûEx†�¡ÐëÐä ì b!""–"ø"æ$�&V'3 .x3h™Ø	ö
B©?Œ}Œîlp„´ÿv† ±êÂt›ø¦>N¸:×Ž¿×õÁY_—²  $î${'(9 V¤¢¬µ	'
ù
8z’ßØ?bÈAyGSkõ+‘�Q|´m‡Âã.G‚ž¦%i ¥ùé6… L!U!�!ƒ#˜%'�'¿'" !þ•œ“"lYÙWÀÈYß¨ÅiŠ¹œY´ ,Ÿ°#Ê#­$Ê$&#&Ê(. wÿ2V	c,VÔ|‹—Ho³ëþ	HÌûÒ´é8VšRÖÚ…�Öê
U ¦ ± É ë U'0 ¡!k67XFG²ÇêaÑFRjèô*‰³FQš›ÔÕø
+R S T ¤ ¥ I!J!K!‚#¯#È$É$'  8d  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                        6                                                                                                                                                                                                                                                                                                          9                                                                                                                                                  	                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
                                                                                                                             4                           3         	         
                  	         
                                           +                                           
                                         )                                         	                                          %   	   
   !   ,         	                        E   7               	   	                              	               %                      	         $                  ,   I   7      3   7      0   C   +   %   ¾   v      1   3   3   <   &   ˆ                     6                                                                                                                                        9                                                                  	                                                                                                                                                                                                              
                                               4         3   	   
      	   
               +               
               )               	              % 	 
 ! ,   	        E 7     	 	          	     %        	   $      , I 7  3 7  0 C + % ¾ v  1 3 3 < & ˆ   ž�   w   ¥  ¡'  §Ë  ¯{  ¹cml ¹'Í��` ¤ªö 
s
’?Œ­0FWXp²³´Íð?@ŠÈÉIy½ÑÒ	é+Æmµëj� E¡¬(h ( Î å!�'~#R\AÂSÕj»ÁšfL¡!šÁ�hÖ%ýt ç&‡%¦õüæX ,¯Uõ#S(&8RÆqä¼=
õ¾sW	Ã�(ª?ŠI<çŽY²ÃÄß÷Å´hYr¨Oæ>V|çÇ�ìh¢þ,Y‹¯¸�˜|öúV²¾ÏOU• ,€Ã5 q"õ#(C(J(S(q(Áñ[Á6_eÉùé+»
~#È#Àù÷+M~#ù+~#+++++AÖüÂSÕ{$%�&©W	Á©ý! Z	½Éð¹"&„	TÂi )õ¾ÂÊÙÉþÉ0ÍÁ‹]õ TtÉDµ9"Í]kµ…ÿV„M«Pp«P«p‹sQäò�àÍ-‘¬¨Œg	h¼ÃÄúûR'ª¼6èý �´âð$¨¼�" é"*&ÀŠ]	65ÃŒ']	5¬¨Œg	¼5
Q‰ˆ6£‡(„v@s'á<¨©­Ë_$^(jq a% >	;†‚AÛÝ4 )¬*~© O#I(ÐÛ[ÁÊ&õd$Ù%˜8 sªcu�Ïïe%â(lsz…
;dÅª¢âí:RX"£.-&v (Âø	ƒAN4 „)¬Úv@s›%'I((»  ß
 ‡B
Æ¡§2ç“ƒ�@!É%&(“ƒ@!&(¢µöbÈk+Äû [.$š	®SÑyÄû<“Ú+ƒæ@!&(sÏ
Æ¡îÄû)ž¿��®N'³ & 	A4 )¬I(õóu1[ …+¬ÝY)ý× Î&ëMë¢y“°#Ê(ßel¶ !Î!t$ 	\ÆA4 )¬þˆú I(ü $f� ¬¨©>	+	Z	4´	h¼½ÄÅúû;†º‚ÑAŸÛÿ/Ýò4 )ƒ¬¾É*~© °$ K O#­#Ö#©$÷&I(«½2	Ü7èØ#>"	Ñv!p ‹"ï%x 1ò$r(ê É}´:Æ#¿Š	v;zY?K£ÕðV	Ë
ÙŸÙH´ÀÁÉÍU÷3l¨,ïjŠ‹-ºë&â*J¦˜-PY¦ À(P•È©œ­8ËÔ g!¦$¹#» ªo$ÿ	†6_ã> ´²Ó#ç!®±öÌfH]w@¯8 Èh´¹±d{”6!—+-ä”s©x + 1¯W!ò$‡%r(Œ	’ÜÈ['À˜‘'ÕðUJ-_ 
SÆ¡î§Ñ2yçÄû<)“žÚ¿+ƒ�æ@!É%&(Ü
Ö"Æ&/' Y?KÕðÙÍU÷3ºJ-ï	óÀŒ˜&€(sK	[ 8Ýç¤“&
t…hYn Þ+×+@ãÿl‹Á!-¡öÿR«²Ë5R¿ : j"ñ#æ'z(Ž(’(ÕðUj-â*J¦-< [ …+9 ƒ'¿ü sßôGŽS;‚›*0ä$f�‡"’"è"ô"ô%&aÊ†Tï›(ã	A%#A°U¶Ä1(%-¦¥3û"#Â%Rpæg½”Ì'N à $
Æ¡�â«½2	Üí:RX7"£è.Ø#-&Pš�ž!o"C²W­"d(¬6_¦Éáî<†¬‚	Ý
Ü¥ŠK¨¼ž³ò“¥¬ƒ@!(#&(Ì_-h÷æ!	¦
"D©0V­ÛyvªÇˆ²µw Ë9ºkBï u!×!9"Œ"Ö"Ù#Æ&/'M'Ï(Áe	-|  ìÄ |!X·áã²/	9—-–¦TZ!O"ü%Î'�(îbwOþ#ÙaZl¶—T�((>"	»Ñp v!‹"ï%¥&¹Ç\ˆ%üÝ!&®é$7»–L&]–·êÜ
´ava%(*ò Ò…¥�%æ
ôGSs‚*ä‡"è"ô%tà�)<œ1É="“"õ"Å$&zÅªêö�¼W	^	Ë
Ù.ŸÆãIÁ©‹©Íë6’Icý˜! š § À(ë ÊÝSÉ~Ã&\'ÔÚÀ÷ß´:˜Æ#‘'Od™œä\
_r¨Ö–™é”üO¯„V§¹\!�! !n"¶#$%‡'\(¥(­©³	a�4h•µÝ
Ui½ÄÅÖûüºËÿòóTŽÎ<k·ˆg‹š�­#ü#$ë$S'|(	ù
$^7¸�Q‡&¦Ä�!9$˜%�'°'Ù�	‰½äYò�Ð?]%N&j's'‚ë¿âhnî"Ñ#?&­©�h
½Î<ˆš$ë$Od™œä\
–”ü„�! !n"$%‡'_r¨Ö™éO¯V§¹\!¶#\(¥(ûÆÊÒ0ðWv×§##$B%5c…(	ÌÐ�í&©-“½ð2_'ä›ì!á(˜ï—(�· þ—Od™œä\
•_r€¨"DSrÍ–ÖÛb–™õŸ¢é,�”¯ü]óO¨¯»ñ„UV§¹¼2 Í \!�! !n"¶#	%$%ƒ%h&‡'ô'\(¥(zÅªêö�¼	W	^	Ë
ù
Ù$^.ŸÆã7IÁ¸©�Q‹‡©Íë&6’¦IÄcý˜! š § �!9$˜%�'°'À(?ÃÝû/£^ z$2&÷'C(Üs	>L%¬'.(ëMë¢·ÖŸEy™!¦!Z%”Õ>"±#'$R$	&Ë(å(„'	ËÏ#«'Ÿ(üÇ4XOo#$$C%y…¬ß!Ø!²"X# ¬õQNq“bt%	(¬î½�¨¥Mî9ÆqB¾_‡ƒV (vÓü(Š°L
c
Ï\Ù¡álÃÔj‡à' ý!6#9%q'”'d( y¬WõQ…N¬ß!qØ(“b!²"X#t%'	(‰œ))ä	BD´"I#²#%æ(® #œA3ó°U†ž¶Ä1ž˜!¥!(%ÐorÂøeƒ(Nm“l ®"ò(Bx‘ KÛÇœ%Ê''
8’ßØAyG|´mÂ.Gž ¥ù6Oh^™ÝSooÐ'Ú'z(d×·òv¿ã×	º
~ÿD¤QÕfÝ­Mgß÷a¢íy!~#ÏúÛ	d|Ð'îl€ƒÅ%LÖuxk …#Œ$Ò(ß(™ ÿ z×¥�´
{çrtˆ5ìÙâ’iav Ä %"«"2#ð$û$s%}'ú' d-7	f2Sx†�¡Ðì ""æ$‰ +Ú¸ÇJNáÑ'�ï<Z¡…Iø!ù#]&l(+ bk_ç
$ROÝå+;óž¤@ámõþ‘k!ª!"9#„$¾$W%&—'º(Î(s¼ÁÄàõK	ó �"¢ð	bÕ `v2ôÁ�ë"Þ%,&™&�(ÿD¤fßy!d×QÝ­÷¢~#bç
$å;óž¤@ámõ„$W%—'Î(·òv¿ã×	º
~ÕMgaí· þ—•€"DSrÍ–ÛbõŸ¢,�¯]ó¨»ñU¼2 Í 	%ƒ%h&ô'® #‰œœ)A)ä	3ó°BUD†ž¶Ä1ž˜!¥!´"I#²#%(%æ(ØI	¸	:
Q
;†b_#.]î„&Å08m#œ$òÃ
«¹‚&£	¢)E% è`�	
)
)gåò$˜=j€Úë!~¤»ýÿ.o‘Ä"BŒn§Æln4 y"Ã#°%ü&`'b'É'¸ Œh/	(
h9“–äéàÙ#¾BETsz•ÎåHö} £µÑ-n�°Ã/AHq‹Ÿô¦ÅÍòú(VÐ7‘3 O Î á Z!O"Â#$
%¯%ü%i&û&'(A(þ!O—ß }‘	Á*hóSq}^€™–Û!b=Ý /5SY�]ço˜¨»oy¼ÃØÈ!X"Ü$ƒ%Ì&©'Ð'Ú'ô'(z(u y^&—¸ëˆ�	Ý
OM¾µ+'äb“wb%(Ø 7Ç®ó`6æ§¢´	æc ª7ë`ÕV˜è»<žÊ† e¶UË­ !5!6"?$£$â$‰'œ'‘(î(¡çéb»	

$
¤(ñ])O—>Ç&B‰Ù5¡ìq¼þ*p’­ÿ!#C�m,m‰ª¸ û _!"z"$`$±%ý&a'È'J(_(Ö o˜(°UˆçL‹œÚK¬+Íþ‹õ!ò"A$y ý t] àõ· H�)TÄ<tƒœ+21¹EÉgå%g�="ˆ"“"›"é"õ"^#³$Å$ó$õ%&*&s(xÈ™~³	a4HŠÄ9•¶ÝUj‚‰ÅÖü!R»t«Ìÿ7òd‡ôT�kvŽ¤·Ðg‹ª½ðNT]ˆ�f  1 ã!­#ý#%S'}(ã(	 
ú
ª$^�®‡’779`¸Ää?žRÌDˆµ&§Ä³ìÕ h!‚!@"Ô#ö#9$§$™%Ž'°'' = \ ž šÖñ¶
†Û,ÓVq†˜(	:s™K:ó.­ ×"Â$Ì$%>%Ç&0'„'Ø ,7ÇÜ&x®ÈÝó`™6f~±æù§@³¢ë	E	´	Å	^
aïÓæ4HŠ¸Ä9q•Ÿ¶ÝOUcjz‚‰ÅËÖü!º *Rª»Óâæ7tŸ«Ìëÿ/7`qÕòPVd‡�˜ôTg�èkvŠŽ¤·ÀÐ_d¤,g»<N‹ªµ½ð+M–ž¦¿Ê†ú 1NT]e|ˆ�¶êÿUf¸Ë  1 K ­ !5!:!S!¢!ã!î!"6"¡#­#Ö#ð#ô#ý#?$™$£$â$%S'‰'œ'½'å'é'[(}(‘(ã(î( ' = \ ž Œ˜šŸ "¸ÒÔÚ]“"$0fAP�š¢Ö—™Üñ	@	H	y	·	Á	à	ü	6
P
¶
k†óë‚’˜¢ãB‡Û,AÓÝßVq†˜(	:Ys™åø)BZK:RŠó.F­³äó G � !Á!×"#!###s#–$Â$Ì$% %-%>%€%·%”&Ç&Ó&0'='„'ñ'((À)‹	>
Ž
á
Ïwö<ªC…wwAt�Å"e$Ú%'Ô( " Z ¾ >˜Ë<,>	u	â	

‘
1Æ˜.@Emtªå”·ü•ë—„YƒÇH”XA!i"¸#$Ó$+%&†'(§(³ Xm�ÂÏè†¦—ž¸áê)^kt{f	õ	C
†
š
­
.<‹–?_e}Æ&Q«9£ÇØ#ÿ"1$0%.x3h™Ø	ö
B©?Œ}Œîlp„´ÿv† ±êÂt›ø¦>N¸:×Ž¿×õÁY_—²  $î${'(ôù$p®±»®¸>¥‘%		y‹önzÌSrË&Pfiœ½ÃÉØn�.NsÍñ$+H|]tLRwz†vy ½!M#ž#Q'Î )Kt’À™ª¶L ¹p¦à	4¼!\È"ü"##D#/$V$Ã%7'ì'±(p Ø 7¯Ç®ó`©6æ€§H˜ÉžÀ)’¢×€	‹	´	>
Ž
á
õ
U¨L�æ0sÏã
Ijw¬Ãíc’ö Lžª¯Ø7‘ëñ<`ÏÕVt˜ªÁC…è=Mw}‘·w´»<Abt�œžÊ† e¶IUËz ­ Û !!&!5!¾!!"6"Å"ð"R#?$e$£$â$Ú%'':'z'‰'œ'‘(Ô(î(Û Îçù‚}	›	Ø
ý¯Gc&$²µ»�ÇÙ	Nzj &  C0     
n  (ð        (ðs"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕZÕj›äšcô�‡é€z¾z'nri-³š}‚Â¨4�µ€È0¨{p¯RïÚµ€JŠ ßUµÀz½V,—^óý¡ÍX$2'*fSDì©!|´løÏosŠ¡ûÙk‘=öõWeECðÏk›î„ÎMxÙC˜QÏà¯�u£ªtcvlBmÉÌzÅbò° ÑNa\f…�[t[,˜Ò{ºÖº˜ðŠ2š›£J3ó©–!hít˜]«4ùòH¨«ÕP
5Uª#UU§Ö[ÑVšm�®UÁ§Ð´±‰Ü¬·nÛŸ¿
¥…œj‰ôKê!Õu£xe…ï¸žŸ”ƒúód^>2Ñ®Í�Doš¨5µm¯xÆ©H¢½¯mÂ¨*yÞÁš†b¬K.–&F¡EŠ©Æþ´uZÕ#(äŸ_æ«k¬õS{†‡Vq©¹jw£® 3~êÅE,L(Õs¯n½œu`;xG�´æ¸ißÄ a•ð3	RŠöª…1Bˆ�ŸW8¥´D1iˆ´Aù†˜¼)‰]o1õÏ¡¡Ô9ÚàGdéàQÅÞºÙ(|èRêZVuAŸBüáhÆh§]ÿ]ºÇ02¯ÇsÂ¯Ï<¢Š MÁQÆQ iË=-IuóRŒÁ¢* qIñPº|{ÔUmí•Q@ÁRõh°�A n`û��àËáÞ8‚ïˆþ?b|êÛtÛ ƒô ˆˆ¾2Ñ7ÃÑ�#P‰Ç·ŽãÝãC�Èþâ-³ûèƒø¬:8.~Ž õ"}øˆE½CóàŽß¸‹¨¶í ¾å¿ÈŽØöÛÀzæ_þ8CõS8 ûûž€à0ûCêŠ8 (â8Þ�û ýý=§`üçµÛ�øöîÀîŸQiË0óŒlïü´€Ñ3vÏÝ/ñ  @,5¡p#äE3 •à!‹"x;Ïª¿ É™HÒK<…Êê¬×£ÏEÝ8S¬@;6îúÜÏÏ?Ÿ„<ö÷<(K2¸óïÏˆ#ï…ã/<¹	J•;BÄ|¨¼3¿ OŸ‘í<;½Î£áþ:;^ç.¢¬ªâ¸Ï)Ñ½N!ðÏœäsß`„ÔA]ƒÛmA+c:Ô#vòq+±1ÏùÄý=N!õþ?¬øo‹þÒ¶'õœ…7üñÛüyèS‹ëü@ëR3!…ëpÃ ‡ÈAï¿�JÛ�Bã0ß^¿ï?ÉcE}€àûï'üAÃ?…µ4C…8PpÃÞqÎµ~uQOÈÓ�Ã>uË]µ(·ïÝq�öÈIÅÌñÏ{ß6‰ÔìÄRë—croÃù‡Ä�OÜ#>Ï1Ç/ô'7û<ó+<yÿ=Ì÷|±¼=Ûß�Eî¾ÜÌ°;°Ô"ÌpÏ0ƒ�÷<2Å0¬ñÌØ<J
ü8<Í5Ñ�Cïƒ<ßÔó ¯ƒß,2ìü}ô@¸3Ë#¿Á C3À#óëàGï3ü×ïúçÃ­òß<rÄ#ñAó7à�‡óSð�…m~àiÕj!Q¡àšéyŠ;êœæ g8êXú‰¶9£¯Éƒ«j»ï¢eo‚Ž.êa¢Ê-r‚#xŠŽ×ÿx(h÷ß‹Nú¼«:¿ûù£Ü0^Û<øú?8àt°â€ÞkÈ"‹ S‡/«Ø8ìøŠ=øã0¾¸ç/ëíoL¯¯Ì>8ðî0û¯2ï>³ûGÁ»úƒÏ¿Ï‚~¥Xzu8‘ºOz©TU �@å­ï×eŽª:'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒI+bÛ¦šÒjeèÕ…›DHD¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸;“›óþ^óô¯?k¼ÿ`áåªªjcD<CÏ°û„æ½’Cª Cäz£DpýZÉm‚Ù8«â!Z)¼íÖ½Ývq<ÙR%O€#å„„åíÚZ2Œíãó«ÒÀWâÈôãial=s0C
Œš;¯:û;x{8ÎÂÊÃŒ10›NÞÕ%œ)½Ñm eÍEØ„ÕCÓUA|•Pó(àÊ«ÙóÿáÄÛuVÇ;RÑ1_ÇAæTgÐÊ¿øïìŒîø¯ãÎŸ~/>®þ°È3«¶NÜâBnÒ°‰+;Ôà8ˆÜ_ÿ+OÇÎ3é¼%æË¡/_ÂQÜzl÷ƒM=à—A¤Ñ1	‰#�º‚—œ9ÞEI¨&ã;Žô§ëTJ	;¡¼5u}ó‚L ª¨¨ÔÓFœÍUíEêªç ¸s´�qW·)@j‚ØF›UAºß‘¾©ZUaJ¥mnT™˜I^‚áÒŸXém!ù»Ln.jÊÛÙ(ø{ü²$eçÀ@éöàÿHãXgÌG÷;|;Ñ©´ÖWÓÓÁ@ñ3E ¾5êo>öô¹¥¢�ND”’³Ò–JŒ×(£Ú9ÐÛ ‹s²Ê‚`ëkNð¯×PÄ§a¿ö(�UL);ëï(´RRƒÍ"›{`¦7�–»§‹cÛÉF:®!à„ž×Ô¶¸E’&0ÇÄ£º?µœYó=Ù4^¥R;m UÊë Å^íAº|â„oJÆ%ýì�ýxn´Ûªz·Ó*à!5WACU�5UeÁX¡g¶{¯ªµšhSjmš.ØLÙ¨Xš‘U•Õ�
ó7jÿH÷áË”WÚi¶¥ù•Y›qêË³2¬!‡Uû‡v4ïÁ-Ó¢âS<ÑÔü´ËL À‹ àéyŒ6Ñ4hž#}˜Â!Yótc%UŸ6ÐÏk=­3^(Àû¬æœôàÅ@#�CR€—=«ô·¢UÇHõ8           •  —  #  %  (ï  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  4�<?xml version="1.0"?><Features nextValidID="28"><Feature recentID="26" name="CLDN6" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="4780" maxFusedRunOn="4780"><Segment range="3977-4636" color="#ffcc00" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="27" name="2Ã—linker" directionality="1" translationMW="648.58" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="4780" maxFusedRunOn="4780"><Segment range="3947-3976" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="25" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2285-2294" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="24" name="luciferase" directionality="1" translationMW="60746.74" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="4780" maxFusedRunOn="4780"><Segment range="2291-3940" color="#ffcc00" type="standard" translated="1"/><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="experiment"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;luc&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;firefly luciferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="EC_number"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="23" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5199-5208" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="22" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="10455-10471" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="21" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7855-7871" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="mCherry" directionality="1" translationMW="26722.72" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="6575" maxFusedRunOn="6575"><Segment range="5205-5912" color="#ff0000" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric derivative of DsRed fluorescent protein (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot;&gt;Shaner et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="9807" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="9016-9807" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="9808-9876" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5976-6575" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="8257-8845" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="16" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6576-7163" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4902-5170" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7237-7470" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4678-4889" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2011-2214" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7682-7817" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7542-7663" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9877-9981" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="5972" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="6575" maxFusedRunOn="6575" detectionMode="exactProteinMatch"><Segment range="5922-5975" color="#cc99b2" type="standard" translated="1"/><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="7903-7909" color="#ffffff" type="standard"/><Segment range="7910-7927" color="#ffffff" type="standard"/><Segment name="-35" range="7928-7933" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7948-7969" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7879-7895" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7046" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="6663" maxFusedRunOn="6663" visible="0" detectionMode="exactProteinMatch"><Segment range="7047-7058" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>b4d3fdf4-6151-4e84-9df5-8633b4a70d9e</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="2:52:15">2025.10.27</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  <StrandColors><TopStrand><ColorRange range="3946..3975" colors="blue"/><ColorRange range="5204..5911" colors="black"/></TopStrand><BottomStrand><ColorRange range="3946..3975" colors="blue"/><ColorRange range="5204..5911" colors="black"/></BottomStrand></StrandColors>  E      €  16        16s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕZÕj›äšcô�‡é€z¾z'nri-³š}‚Â¨4�µ€È0¨{p¯RïÚµ€JŠ ßUµÀz½V,—^óý¡ÍX$2'*fSDì©!|´løÏosŠ¡ûÙk‘=öõWeECðÏk›î„ÎMxÙC˜QÏà¯�u£ªtcvlBmÉÌzÅbò° ÑNa\f…�[t[,˜Ò{ºÖº˜ðŠ2š›£J3ó©–!hít˜]«4ùòH¨«ÕP
5Uª#UU§Ö[ÑVšm�®UÁ§Ð´±‰Ü¬·nÛŸ¿
¥…œj‰ôKê!Õu£xe…ï¸žŸ”ƒúód^>2Ñ®Í�Doš¨5µm¯xÆ©H¢½¯mÂ¨*yÞÁš†b¬K.–&F¡EŠ©Æþ´uZÕ#(äŸ_æ«k¬õS{†‡Vq©¹jw£® 3~êÅE,L(Õs¯n½œu`;xG�´æ¸ißÄ a•ð3	RŠöª…1Bˆ�ŸW8¥´D1iˆ´Aù†˜¼)‰]o1õÏ¡¡Ô9ÚàGdéàQÅÞºÙ(|èRêZVuAŸBüáhÆh§]ÿ]ºÇ02¯ÇsÂ¯Ï<¢Š MÁQÆQ iË=-IuóRŒÁ¢* qIñPº|{ÔUmí•Q@ÁRõh°�A n`LÇ3 ó13¿À@ü0ÃÌlÍ=Î<C? 40ó/£ƒþ`r O8CÌüÞ=Aÿ]ù•'»8&‹IˆŠ]už‚‰š€¡_SˆõE)T£T,â¬D]¨âÎ!Ž>"„èãŠ‘§ÐG#d_EÙ˜�ukB „U
E>â>+F5P1ã�µçJâ"Ô!JEØ„M¥„÷Hý4
…sïŸîš® `k@Ñf§w ºø¦“W•UˆfyUØGÂfõÕ^¯õ·�6‹|&ô[¶–ÇYV&õXXëê·¥RTEj[á �PEõ¨tå&Ô>Ô¸7j®A´bipZ¯ÑÛ™V&X+Iö¡EAªN+­ çN¾TaQ÷z§{‰©_FºÐ¶¶`}-4…-µO£D
&
	Ž.…èÝø_¶újÑ¶�u(”Vvfáef ŠUf•)¹�øÓ±¡î¿FVy­©y…£ñ[«£À_WÓzÕú~Úº~S*7¨å„þ‡kš�þÒz6…¿´Tš R­ƒ¸u‰ªÕ˜Ôþê(9�øÔØ6„8wêv….eéb!©ájðï–\¶.—ß®T[â¦sÕ6ýQHßþ	Ò?ëuÿDeú;b_ë£Æ„­]Òµ¸xƒEFšSa^§ù�GäJïE]öâë«ôßJ˜HÓÔvécþ vùŸ tV*îpQë½x¸ŸAêE¯ºKâöV+j™U—}Rœ
û¿ßuåeVµ YšáN£§�Y’=b}«R™ƒ9êØwùã&8QQX"Ö,´‚øŠ‡¨i†(†¾‘áUEÛÉ}Ej†½{zêhŽ]N%Fvíú�â~G~“«j�·Aá—LDâ#`Ø{í€¡E¢–)ÝpmÑŠvÞ´ë›]QTOJ´v©R…]Ú�_©=E1A¸ÆÎð�ËH7lýÒÿJ ÃZ>DPƒ0	^R²'ƒ¼ú«ñ |™”�$³È\®ªÍp*<ô]Ó…:Ä³nï­ÌüóùøCÏosÂ„³+�>üø‚>ø^2óË�”©S´,GÀú‹Ã;úùùÓÃ»Üê>ã£µîrê*Ê®+Œò�ÔâùÎG=öM@ÄeØ=¶Ô¶3­B7`@ï!p÷±1<ÿœ@ßÑóÔáBP ÿãúÏ€vø¿í+bpïPùÈSÏ¿Çž…8¾¿Äµ 2^±2|‡ôûøÐpÄ­¹Ô!N3õëþñÃü–4QGØ¾ñ0bÄ3øP1SD8S…=çáQ÷çPõü�8ü3ç\µÛR�Û~ý×yßl�tœ\Ï<÷½ðÃ`q8�@nÌ@Ñ.¹v0‡ Aü?˜|IÔýÂ3ì÷órÿ@òs³Ï2³ÇŸóÜÏwËÁóÝ±0-ñ8Ô^ëíÌË±ÛB ,ÁÇó0¸sÁ,S 0ŠÏ°üÍƒÄ¡0¯ÃƒÌÓ]>ø3ÍðýA?2
ø=òÃ.ÏÇß@Ô€Ó<²;ü0ñ3<?>¾~ó?Í~ÿ®q0ì:ß-óÇ,B?3~Ø5?øV×î�V¢	®—˜£¾©ÎbsŽ¥�¨›cš:ü˜:¶«¾ú&Vø(âî¦J ü¢Ð× È"7ˆ¨áÍ÷‚€6�}ø´ï«Àz³«ÿ¿š=Ãí³Ï�£óŽ@;(áÖ¼‚(°8rú½ƒŽÏˆ£ß�®3ËëŽrþ°þÖôÁúúüÃã�ãºó.óë?´q,¿¨<ûüø'êQõ‡§PÓ‰¤÷ª•EP xZÞýqVQ¸ê£¢x»‚‘ônà»ƒ—�÷Ž”ûYS£èHëRHˆü¸¢!î	y¿´ªKH�VîM$’¶-ºi­&¦^�QXY´D„Az*hÓ¦X)Õ•5“mÕ«ueMª«xÚä¢
‹Õíµ‰ºm‹ƒ¹9¿?åï?Jóö»ÏöZª¦¦4CÄ<û¸NkÑI!:ª>Gª4GÕ¬–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äPtš‚n3¸áOJ~°UD “ºÃWWß8$Â
ªŠ�M4iÌÑUPnÔQ¾¡º®p‡;H{r”¨-„iµT­ùê•¥VªVÖåI™„•è.)õŽ–Òß›´Æâæ¬­½’�‡¿Ë"F^qœŸnôŽ5†|Äs·Ã½›Me}=<4Rã^¦óïoKšZ(ðäII+=)d¨ÍrŠ=£�²·;,¨&¶´ï
ýqµJvÿbˆÕTÂ“¾°¾ñ²‹E%(<Ò)·¶
`ÓxÙkºx¶=¼”cªâIí}Kk„Y"c|J;£ðËYÀeŸ3Ý“EêU#¶Ú\®°UîÔ§Î(Fô¬b_ÞÈß×†ëMº§«}2®Ut5XóUPP1ÜŠ{gºú«Y¦…6¦Ð)¢í„Á�š…‰©Y]Y ¯3v¯ñT�~¹E}¦›aÚ_™U�É·þ¬»3*Âp…_¸wcNüÂÝ:.%0cÀMOË@Ì´ÀŠ°—˜ÃmF‰á7ÙŒ"Ÿ7F2PEYómö³ÚÐã5â€P1°ŒºÎiÏNT b8Ô1¥(	sÐ*¿KqÊ%\pô�S           •  —  i  k  15  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  4Ÿ<?xml version="1.0"?><Features nextValidID="28"><Feature recentID="27" name="2Ã—linker" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="6754" maxFusedRunOn="6754"><Segment range="3947-3976" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="26" name="ENPP1" directionality="1" translationMW="104927.17" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3977-6754" color="#ffcc00" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="25" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2285-2294" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="24" name="luciferase" directionality="1" translationMW="60746.74" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="6754" maxFusedRunOn="6754"><Segment range="2291-3940" color="#ffcc00" type="standard" translated="1"/><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="experiment"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;luc&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;firefly luciferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="EC_number"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="23" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7317-7326" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="22" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="12573-12589" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="21" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9973-9989" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="mCherry" directionality="1" translationMW="26722.72" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="8693" maxFusedRunOn="8693"><Segment range="7323-8030" color="#ff0000" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric derivative of DsRed fluorescent protein (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot;&gt;Shaner et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="11925" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="11134-11925" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="11926-11994" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="8094-8693" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="10375-10963" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="16" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8694-9281" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7020-7288" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9355-9588" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6796-7007" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2011-2214" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9800-9935" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9660-9781" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="11995-12099" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="8090" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="8693" maxFusedRunOn="8693" detectionMode="exactProteinMatch"><Segment range="8040-8093" color="#cc99b2" type="standard" translated="1"/><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="10021-10027" color="#ffffff" type="standard"/><Segment range="10028-10045" color="#ffffff" type="standard"/><Segment name="-35" range="10046-10051" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="10066-10087" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="9997-10013" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="9164" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="8781" maxFusedRunOn="8781" visible="0" detectionMode="exactProteinMatch"><Segment range="9165-9176" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>b4d3fdf4-6151-4e84-9df5-8633b4a70d9e</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="2:51:54">2025.10.27</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  g<StrandColors><TopStrand><ColorRange range="3946..3975" colors="blue"/><ColorRange range="6751..6753" colors="blue"/><ColorRange range="7322..8029" colors="black"/></TopStrand><BottomStrand><ColorRange range="3946..3975" colors="blue"/><ColorRange range="6751..6753" colors="blue"/><ColorRange range="7322..8029" colors="black"/></BottomStrand></StrandColors>  Cw     x  1        1s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕZÕj›äšcô�‡é€z¾z'nri-³š}‚Â¨4�µ€È0¨{p¯RïÚµ€JŠ ßUµÀz½V,—^óý¡ÍX$2'*fSDì©!|´løÏosŠ¡ûÙk‘=öõWeECðÏk›î„ÎMxÙC˜QÏà¯�u£ªtcvlBmÉÌzÅbò° ÑNa\f…�[t[,˜Ò{ºÖº˜ðŠ2š›£J3ó©–!hít˜]«4ùòH¨«ÕP
5Uª#UU§Ö[ÑVšm�®UÁ§Ð´±‰Ü¬·nÛŸ¿
¥…œj‰ôKê!Õu£xe…ï¸žŸ”ƒúód^>2Ñ®Í�Doš¨5µm¯xÆ©H¢½¯mÂ¨*yÞÁš†b¬K.–&F¡EŠ©Æþ´uZÕ#(äŸ_æ«k¬õS{†‡Vq©¹jw£® 3~êÅE,L(Õs¯n½œu`;xG�´æ¸ißÄ a•ð3	RŠöª…1Bˆ�ŸW8¥´D1iˆ´Aù†˜¼)‰]o1õÏ¡¡Ô9ÚàGdéàQÅÞºÙ(|èRêZVuAŸBüáhÆh§]ÿ]ºÇ02¯ÇsÂ¯Ï<¢Š MÁQÆQ iË=-IuóRŒÁ¢* qIñPº|{ÔUmí•Q@ÁRõh¶Ìpã0 ÀO0Ã03;üÃ \<ÆÀ<ÓÜãÄ3ðóC2ú8?æ ó�0ÌÏÍãÔõß™R{³‚h´˜ˆ¥×Yè(™¨
õ8�TR•J5BÎ*ÄEÚ€^,âãâ(N�^8©}r6Eô]™�è×V´"EP¡ôSî#â´aãPu8Û^t®"-BT $Q}ˆDÚXOt�Ó@¨W>ùþéªê´jwz �ë¯Ši5yUX�vg•]„|&o]Uêÿ[yÓh·Á¢oE»`Ùlu•ba¿U…Ž¾«zU%DV¥¾	Õ_Z€·NRmCíKƒvªàôF V—ªý¹•be‚´ŸjT¤âºÒtëåFwªw¸š‘Eôk­kfÒÓHRÛTú4@¡‚` ˜á�‚áQ8^�Ñ�…ûo¦­`ØPÒ‰EgfnVj ¥ViR›˜�;þá‹ôegšÚ—˜PÚ?ºº<õ}7­_§á]«§å2£zŽQ!‘hOèv¹¨í ×£h[ûEAY¢ jØ;‡Xš­Y�Oî¢ƒ˜�­MƒhC‡~¡WhRæ^–"ž¡ßùeÁ{`Ré}úåE¾*g=SoÕ�ÿà�#þ·Q_ôF_ ã¶%þ±ª<hAªÕÝ+[‡ˆ4Qi¥6ê˜~D®ôPUßn.º¿Mô©„��=Gn–?êo™òEaÒ®ç»×‹‰ô¤Zû¤¾/eb¶©•YwÕ!)À¯»ý÷^VUkR™®ê:yÕ™#Ö'Ñ*µ)˜3ž­‡ž1Rc…‚-bËH/ˆ¨z†˜`rˆkénÕTQ-¼—ÔV¨k×·®¦ˆåÔâTgnÑÏ¨Þ!Wäwé:¶¨ûttÄN"6M‡¾Ø
Z)b�Ñ7Ý¡7mà{N¹µÕDô«Gj•(UÝ¨õú“ÔQá0óŒlïü´€Ñ3vÏÝ/ñ  @,5¡p#äE3 •à!‹"x;Ïª¿ É™HÒK<…Êê¬×£ÏEÝ8S¬@;6îúÜÏÏ?Ÿ„<ö÷<(K2¸óïÏˆ#ï…ã/<¹	J•;BÄ|¨¼3¿ OŸ‘í<;½Î£áþ:;^ç.¢¬ªâ¸Ï)Ñ½N!ðÏœäsß`„ÔA]ƒÛmA+c:Ô#vòq+±1ÏùÄý=N!õþ?¬øo‹þÒ¶'õœ…7üñÛüyèS‹ëü@ëR3!…ëpÃ ‡ÈAï¿�JÛ�Bã0ß^¿ï?ÉcE}€àûï'üAÃ?…µ4C…8PpÃÞqÎµ~uQOÈÓ�Ã>uË]µ(·ïÝq�öÈIÅÌñÏ{ß6‰ÔìÄRë—croÃù‡Ä�OÜ#>Ï1Ç/ô'7û<ó+<yÿ=Ì÷|±¼=Ûß�Eî¾ÜÌ°;°Ô"ÌpÏ0ƒ�÷<2Å0¬ñÌØ<J
ü8<Í5Ñ�Cïƒ<ßÔó ¯ƒß,2ìü}ô@¸3Ë#¿Á C3À#óëàGï3ü×ïúçÃ­òß<rÄ#ñAó7à�‡óSð�…m~àiÕj!Q¡àšéyŠ;êœæ g8êXú‰¶9£¯Éƒ«j»ï¢eo‚Ž.êa¢Ê-r‚#xŠŽ×ÿx(h÷ß‹Nú¼«:¿ûù£Ü0^Û<øú?8àt°â€ÞkÈ"‹ S‡/«Ø8ìøŠ=øã0¾¸ç/ëíoL¯¯Ì>8ðî0û¯2ï>³ûGÁ»úƒÏ¿Ï‚~¥Xzu8‘ºOz©TU �@å­ï×eŽª:'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒI+bÛ¦šÒjeèÕ…›DHD¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸;“›óþ^óô¯?k¼ÿ`áåªªjcD<CÏ°û„æ½’Cª Cäz£DpýZÉm‚Ù8«â!Z)¼íÖ½Ývq<ÙR%O€#å„„åíÚZ2Œíãó«ÒÀWâÈôãial=s0C
Œš;¯:û;x{8ÎÂÊÃŒ10›NÞÕ%œ)½Ñm eÍEØ„ÕCÓUA|•Pó(àÊ«ÙóÿáÄÛuVÇ;RÑ1_ÇAæTgÐÊ¿øïìŒîø¯ãÎŸ~/>®þ°È3«¶NÜâBnÒ°‰+;Ôà8ˆÜ_ÿ+OÇÎ3é¼%æË¡/_ÂQÜzl÷ƒM=à—A¤Ñ1	‰#�º‚—œ9ÞEI¨&ã;Žô§ëTJ	;¡¼5u}ó‚L ª¨¨ÔÓFœÍUíEêªç ¸s´�qW·)@j‚ØF›UAºß‘¾©ZUaJ¥mnT™˜I^‚áÒŸXém!ù»Ln.jÊÛÙ(ø{ü²$eçÀ@éöàÿHãXgÌG÷;|;Ñ©´ÖWÓÓÁ@ñ3E ¾5êo>öô¹¥¢�ND”’³Ò–JŒ×(£Ú9ÐÛ ‹s²Ê‚`ëkNð¯×PÄ§a¿ö(�UL);ëï(´RRƒÍ"›{`¦7�–»§‹cÛÉF:®!à„ž×Ô¶¸E’&0ÇÄ£º?µœYó=Ù4^¥R;m UÊë Å^íAº|â„oJÆ%ýì�ýxn´Ûªz·Ó*à!5WACU�5UeÁX¡g¶{¯ªµšhSjmš.ØLÙ¨Xš‘U•Õ�
ó7jÿH÷áË”WÚi¶¥ù•Y›qêË³2¬!‡Uû‡v4ïÁ-Ó¢âS<ÑÔü´ËL À‹ àéyŒ6Ñ4hž#}˜Â!Yótc%UŸ6ÐÏk=­3^(Àû¬æœôàÅ@#�CR€—=«ô·¢UÇHõ8           •  —  K  M  1  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  37<?xml version="1.0"?><Features nextValidID="27"><Feature recentID="26" name="ENPP1" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3947-6724" color="#ffcc00" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="25" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2285-2294" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="24" name="luciferase" directionality="1" translationMW="60746.74" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="6724" maxFusedRunOn="6724"><Segment range="2291-3940" color="#ffcc00" type="standard" translated="1"/><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="experiment"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;luc&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;firefly luciferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="EC_number"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="23" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7287-7296" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="22" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="12543-12559" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="21" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9943-9959" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="mCherry" directionality="1" translationMW="26722.72" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="8663" maxFusedRunOn="8663"><Segment range="7293-8000" color="#ff0000" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric derivative of DsRed fluorescent protein (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot;&gt;Shaner et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="11895" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="11104-11895" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="11896-11964" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="8064-8663" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="10345-10933" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="16" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8664-9251" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6990-7258" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9325-9558" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6766-6977" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2011-2214" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9770-9905" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9630-9751" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="11965-12069" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="8060" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="8663" maxFusedRunOn="8663" detectionMode="exactProteinMatch"><Segment range="8010-8063" color="#cc99b2" type="standard" translated="1"/><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="9991-9997" color="#ffffff" type="standard"/><Segment range="9998-10015" color="#ffffff" type="standard"/><Segment name="-35" range="10016-10021" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="10036-10057" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="9967-9983" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="9134" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="8751" maxFusedRunOn="8751" visible="0" detectionMode="exactProteinMatch"><Segment range="9135-9146" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>b4d3fdf4-6151-4e84-9df5-8633b4a70d9e</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="2:48:5">2025.10.27</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ¯<StrandColors><TopStrand><ColorRange range="7292..7999" colors="black"/></TopStrand><BottomStrand><ColorRange range="7292..7999" colors="black"/></BottomStrand></StrandColors>  A®     	á  &y        &ys"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕZÕj›äšcô�‡é€z¾z'nri-³š}‚Â¨4�µ€È0¨{p¯RïÚµ€JŠ ßUµÀz½V,—^óý¡ÍX$2'*fSDì©!|´løÏosŠ¡ûÙk‘=öõWeECðÏk›î„ÎMxÙC˜QÏà¯�u£ªtcvlBmÉÌzÅbò° ÑNa\f…�[t[,˜Ò{ºÖº˜ðŠ2š›£J3ó©–!hít˜]«4ùòH¨«ÕP
5Uª#UU§Ö[ÑVšm�®UÁ§Ð´±‰Ü¬·nÛŸ¿
¥…œj‰ôKê!Õu£xe…ï¸žŸ”ƒúód^>2Ñ®Í�Doš¨5µm¯xÆ©H¢½¯mÂ¨*yÞÁš†b¬K.–&F¡EŠ©Æþ´uZÕ#(äŸ_æ«k¬õS{†‡Vq©¹jw£® 3~êÅE,L(Õs¯n½œu`;xG�´æ¸ißÄ a•ð3	RŠöª…1Bˆ�ŸW8¥´D1iˆ´Aù†˜¼)‰]o1õÏ¡¡Ô9ÚàGdéàQÅÞºÙ(|èRêZVuAŸBüáhÆh§]ÿ]ºÇ02¯ÇsÂ¯Ï<¢Š MÁQÆQ iË=-IuóRŒÁ¢* qIñPº|{ÔUmí•Q@ÁRõh±4±ÆîÄ'Á¼yÔq‡RL<Åã;Â?- 4LÝ³÷KüE( h\ùBÀ%xHbÈžóê¯Ä EòfR4’Ï!rº«5À¨óÑwNëÍ»¾·3óÏçá=½Ï
Ì®<ûóâûáxËÏ.BR¥NÐ±ê/ïèçä{Oïs¨øŽŽ×¹Ë¨«*¸®3ÊtoSˆ|3ç9÷Ø!5A—`öÛPJØÎµÝ�¼…ÃÜJÄl@Ä@óþqGÏS…}@ƒÿ�ë>Ûâÿ´­‰Ã½Cç!Mÿ<vÿzâúÿ:Ô€LÈazÄ0È!òÐ{ïãAÃ¶çP…8Ì7×¯ûÇòXÑE`8>ûÄÁ‰ÿpÏá@ÄmMáN0÷œs„-Gß�CÔSò4ãðÏ�r×mJmû÷\Aç}²Òqs<@óÞ÷Ã�Äâu»1DºåØÂ�[ðþañ'S÷Ï³ßÌqËýÉÍþÏ<ÊÏÏs=ß,oÏvÄÀ·ÄãQ{¯·3,Çl5€³3Ì Âà}ÏL±L Â+<FÃó6„Â¿3Mt`PûàÏ7ÃõüÈ+à÷Ë»?}P.LòÈïðHÃÄÌðüúøûÌÿ5ûþ¹ÄÃ°ë|·Ï±üP|Íø#aüÔü#á[_¸uZˆThx&º^bŽú§9ˆÎ:–>¢mŽhëò`êÚ®ûè™[à£‹º˜A(ƒò‹C\ƒ ˆÞ"£‡5ÿÞ
 Ú=÷âÓ¾¯êÎ¯þþh÷¶Ï>>�Î8 ì8 7‡Zò¢ÀáËêö;>"�~¸Ì/®9ËúÃû[ÓëëóŽ<;Œ>ëÌ»Ï¬þÑÄ°nþ óïóàŸ©GÖ�CN$n“ÞªU@àP9k{õÅYFãªŽ‰à.î
GÑ¸O€Nî^@_Þ:SíeN�¡#­I"#òâˆ‡¸%äFþÑþ©-"[¹4’JØ¶é¦´š™z5EafÑè©£N™`§VTÖM·V­Õ•6ª­ãk’ˆ*/W¶Ö&é¶.äæüÿ—¼ý+ÏÚï?Ø8yjªš˜Ñóì>á9¯E$„ê¨ù¨Ñ?V²[`¶N*øˆVŠo;u¯w]œO6T‰Sàùa!9{v–Œ£;xüêô°ø²=8ÚX[\ÌÂ£&€ÎëÎ¾ÎÞÎ3°²°ãL&Ó·µC	g
ot[@sAQv!5PôÕCÐ_%T<Ê82ªöC¼ÿøq6ÝU±ÎÔ´BWñÐy•ô2¯þ;û#;¾+Çøó§ÁŸ‹Ï«¿¬2êí“·8�›´¬"BÊÎõ8"7ÿÊÓñóŒúo	y²èK×ð”w›=àÓOx%Ði4LBbCçD®… ƒåçw‘AÒj	¸Îã…=)úÁU‚Nèo]_|à“*ª*54Ñ§3EUA»QFú†ê¹À.í \UíÊP ¶¦ÕPn·äoªV•XR©[[•&fW ¸t§Ö:[HC~nÓ‹š²¶öJ>ÿ,‰yÆp:}¸?Ò8ÖóýÎßôjm5•ôôðP<LÑH/�z›Ï½½.ih£ÀS‘%$¬ô¥’£5Ê(öŽt6È"Üì² ˜:ÚÓ¼+õÆÔ1)ØoýŠ#US
NúÂûÆÊ-” óH¦ÞØ)ƒMãe®éâØöòQŽ«ˆx!'µõ-®d‰Œ1ñ(î�Ã-g–|ÏvM©TŽÛhrºÀ1W»PnŸ8¡Ò±‰{#^­6êž­ôÊ¸MUÐPÕcÍU@Y@ÇpV(Yížëê­fšÚ›@¦‹¶vj&¤Ueud¼ÍÚ¿ÅR=øråöšm‡i~eVC&ÜCú²ìÌ«aÂ~áÝ�;ðGtè¸”Á�4u?-2Ó(0"À8:^c´M'„Hßf0ˆV|ÝÉAgÍ´3ÚÏkCŒ×Š@ÆÂ0>ë9§=81PˆãPÆ” %Ï@ªý-Ç(•qÃÒ=N            •  —  n  …  Š  £  ¬  ®  &x  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  4<?xml version="1.0"?><Features nextValidID="27"><Feature recentID="26" name="FLAG" directionality="1" translationMW="1012.99" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="4006" maxFusedRunOn="4006" detectionMode="exactProteinMatch"><Segment range="3980-4003" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;FLAGÂ® epitope tag, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="25" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2285-2294" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="24" name="luciferase" directionality="1" translationMW="60746.74" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="4006" maxFusedRunOn="4006"><Segment range="2291-3940" color="#ffcc00" type="standard" translated="1"/><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="experiment"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;luc&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;firefly luciferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="EC_number"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="23" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4568-4577" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="22" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9824-9840" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="21" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7224-7240" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="mCherry" directionality="1" translationMW="26722.72" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="5944" maxFusedRunOn="5944"><Segment range="4574-5281" color="#ff0000" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric derivative of DsRed fluorescent protein (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot;&gt;Shaner et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="9176" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="8385-9176" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="9177-9245" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5345-5944" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="7626-8214" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="16" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5945-6532" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4271-4539" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6606-6839" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4047-4258" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2011-2214" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7051-7186" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6911-7032" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9246-9350" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="5341" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="5944" maxFusedRunOn="5944" detectionMode="exactProteinMatch"><Segment range="5291-5344" color="#cc99b2" type="standard" translated="1"/><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="7272-7278" color="#ffffff" type="standard"/><Segment range="7279-7296" color="#ffffff" type="standard"/><Segment name="-35" range="7297-7302" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7317-7338" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7248-7264" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6415" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="6032" maxFusedRunOn="6032" visible="0" detectionMode="exactProteinMatch"><Segment range="6416-6427" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>b4d3fdf4-6151-4e84-9df5-8633b4a70d9e</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="2:47:46">2025.10.27</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ¯<StrandColors><TopStrand><ColorRange range="4573..5280" colors="black"/></TopStrand><BottomStrand><ColorRange range="4573..5280" colors="black"/></BottomStrand></StrandColors>  A¾     	á  &{        &{s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕZÕj›äšcô�‡é€z¾z'nri-³š}‚Â¨4�µ€È0¨{p¯RïÚµ€JŠ ßUµÀz½V,—^óý¡ÍX$2'*fSDì©!|´løÏosŠ¡ûÙk‘=öõWeECðÏk›î„ÎMxÙC˜QÏà¯�u£ªtcvlBmÉÌzÅbò° ÑNa\f…�[t[,˜Ò{ºÖº˜ðŠ2š›£J3ó©–!hít˜]«4ùòH¨«ÕP
5Uª#UU§Ö[ÑVšm�®UÁ§Ð´±‰Ü¬·nÛŸ¿
¥…œj‰ôKê!Õu£xe…ï¸žŸ”ƒúód^>2Ñ®Í�Doš¨5µm¯xÆ©H¢½¯mÂ¨*yÞÁš†b¬K.–&F¡EŠ©Æþ´uZÕ#(äŸ_æ«k¬õS{†‡Vq©¹jw£® 3~êÅE,L(Õs¯n½œu`;xG�´æ¸ißÄ a•ð3	RŠöª…1Bˆ�ŸW8¥´D1iˆ´Aù†˜¼)‰]o1õÏ¡¡Ô9ÚàGdéàQÅÞºÙ(|èRêZVuAŸBüáhÆh§]ÿ]ºÇ02¯ÇsÂ¯Ï<¢Š MÁQÆQ iË=-IuóRŒÁ¢* qIñPº|{ÔUmí•Q@ÁRõh±4±ônìB|Ç�AÇu$ÃÌPn1³¼#òÒDÍÛ?t¿ÄR€ °Ö…À�‘ ÌW€T†,‰àï>ªü@€_&e#I,ò+ª³\
�=táN± ìÛ»ës?<þ~óÛÜð¡,ÊãÏ¿> �¾Œ¼òä%*Tíð>¢ðÎþ�>~G´ðî÷:�‡øèí{œºŠ²«Šã<§Fõ8‡Ã>s‘Ï}‚P1vmµ­ŒëP�Ø;È\=Ä¬FÄ@Ä?ç7ô|õ8P‡Ô?øþ³à¾/ûJØœ;Ô>rßóÇoñç¡N/¯ñ­HÌ†¬AÃ‚!ý¾þ41+nuSŒÃ}zÿ¼pÿ%�Qö€Cï¼LŸñþFÔÑáAÃyÇ8BÔ}ùÔ=E?#N?ù×-vÔ vß¿uÄwÛ ]'3Ä=ï|0ØN'P³4AK®]Œ!ÈE¿æu?pŒû=üÇ¿Ð<œßìóÌ¬ñçü÷3ÝòÆð|÷lL|N5ºûs2ÀìvÃPˆ0qÃ<Â.ÜðDËÀ"³Äl?3`ñ(L+ðàó4×F¾ó|?POÌ‚¾|°Ë³ñ÷Ð5à4Ï,Žÿ�<LÏ �Ï¯�¼Ïó_¿ëœL;·Ë|ñË�ÅÌß‚6ÍOÂ>µû�§U¨…F‡‚k¥æ(ïªs˜�œã©cê&ØæŽ¿&­ªï¾‰•¾
8»©„ˆ?(´5È2�â*8s_ýà £ß~-;êð¬êÿïæ�pÁ{lóãèüã�ÐÃŠxu¯ Š,N¾¯`ã³â(÷àkŒÀrúãœ¿¬?µ½0~¾¿0øãÃ¸Ãî¼Ë¼úÏíKïê>ÿ>	ú”}aéÔ4âFé=ê¥QT –·¿\U”n:¨èžîà¤}„øîàåäýã¥>ÖTèú:Ô’"?.(ˆ{‚^Doíê’Ò U»“I$­‹nškI©—£TVm!^Šš4é–
ueMdÛujÝYSjªÞ6¹(‚¢õ{mbn›bàîNoÏù{ÏÒ¼ý®óýƒ‡–ª©©�ñ>ÃîšôRHAª�‘ê�Ãõk%¶dâ¯ˆ…h¦ó·Z÷uÙÄðSeH•> �–—·ihÊ3·�Î¯K_‹#Ó�¥…°õÌÀ*2hî¼ëìíáìã;+0ÄÂm;{T0–p¦÷E´—4bUMT=òUCÌ£ƒ*¯d;Ïÿ‡mÕ[íKD Å™QŸC*ÿàS¿²3»â¼�:|ø¼ú»úÀS Î®Ù;s‰	»JÂ$,¬ïS€â#qü­?8Ï¦ð—›.„½	Gqé³Þ4÷‚]“DÄ&$0ŽtJèR>^pçy& ›Œî8SÒŸ¬Q($î†ðÕÕ÷Î	0‚ª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡.Q_i¦Øv—æUd2mÄ?«.ÌÊ°†!WîØÓ¿p·N‹‰LðGSòÐ3-0"ƒ,ƒ¥æ0ÛDÑ¢xD�öc…gÍÑŒ”V|ÛC=¬ö´8Íx l#î³šsÓƒ Ž5iJ\ô
¯ÒÜr‰W=#Ô8           •  —  n  ‡  Œ  ¥  ®  °  &z  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  4<?xml version="1.0"?><Features recycledIDs="27" nextValidID="28"><Feature recentID="26" name="FLAG" directionality="1" translationMW="1012.99" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="4008" maxFusedRunOn="4008" detectionMode="exactProteinMatch"><Segment range="3982-4005" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;FLAGÂ® epitope tag, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="25" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2285-2294" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="luciferase" directionality="1" translationMW="60746.74" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="4138" maxFusedRunOn="4138"><Segment range="2291-3940" color="#ffcc00" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;luc&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;firefly luciferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="experiment"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="EC_number"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="24" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4570-4579" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="23" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9826-9842" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="22" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7226-7242" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="21" name="mCherry" directionality="1" translationMW="26722.72" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="5946" maxFusedRunOn="5946"><Segment range="4576-5283" color="#ff0000" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric derivative of DsRed fluorescent protein (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot;&gt;Shaner et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="9178" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="8387-9178" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="9179-9247" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5347-5946" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="7628-8216" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5947-6534" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4273-4541" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6608-6841" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4049-4260" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2011-2214" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7053-7188" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6913-7034" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9248-9352" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="5343" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="5946" maxFusedRunOn="5946" detectionMode="exactProteinMatch"><Segment range="5293-5346" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="7274-7280" color="#ffffff" type="standard"/><Segment range="7281-7298" color="#ffffff" type="standard"/><Segment name="-35" range="7299-7304" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7319-7340" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7250-7266" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6417" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="6034" maxFusedRunOn="6034" visible="0" detectionMode="exactProteinMatch"><Segment range="6418-6429" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>703bb3a0-50d5-4f49-81f7-512b36e27f3a</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="2:18:55">2022.6.16</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ¯<StrandColors><TopStrand><ColorRange range="4575..5282" colors="black"/></TopStrand><BottomStrand><ColorRange range="4575..5282" colors="black"/></BottomStrand></StrandColors>  AÀ     	ã  &‚        &‚s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕZÕj›äšcô�‡é€z¾z'nri-³š}‚Â¨4�µ€È0¨{p¯RïÚµ€JŠ ßUµÀz½V,—^óý¡ÍX$2'*fSDì©!|´løÏosŠ¡ûÙk‘=öõWeECðÏk›î„ÎMxÙC˜QÏà¯�u£ªtcvlBmÉÌzÅbò° ÑNa\f…�[t[,˜Ò{ºÖº˜ðŠ2š›£J3ó©–!hít˜]«4ùòH¨«ÕP
5Uª#UU§Ö[ÑVšm�®UÁ§Ð´±‰Ü¬·nÛŸ¿
¥…œj‰ôKê!Õu£xe…ï¸žŸ”ƒúód^>2Ñ®Í�Doš¨5µm¯xÆ©H¢½¯mÂ¨*yÞÁš†b¬K.–&F¡EŠ©Æþ´uZÕ#(äŸ_æ«k¬õS{†‡Vq©¹jw£® 3~êÅE,L(Õs¯n½œu`;xG�´æ¸ißÄ a•ð3	RŠöª…1Bˆ�ŸW8¥´D1iˆ´Aù†˜¼)‰]o1õÏ¡¡Ô9ÚàGdéàQÅÞºÙ(|èRêZVuAŸBüáhÆh§]ÿ]ºÇ02¯ÇsÂ¯Ï<¢Š MÁQÆQ iË=-IuóRŒÁ¢* qIñPº|{ÔUmí•Q@ÁRõh±jVÒÇÑ»±	ðouaÔ“1A¸ÆÎð�ËH7lýÒÿJ ÃZ>DPƒ0	^R²'ƒ¼ú«ñ |™”�$³È\®ªÍp*<ô]Ó…:Ä³nï­ÌüóùøCÏosÂ„³+�>üø‚>ø^2óË�”©S´,GÀú‹Ã;úùùÓÃ»Üê>ã£µîrê*Ê®+Œò�ÔâùÎG=öM@ÄeØ=¶Ô¶3­B7`@ï!p÷±1<ÿœ@ßÑóÔáBP ÿãúÏ€vø¿í+bpïPùÈSÏ¿Çž…8¾¿Äµ 2^±2|‡ôûøÐpÄ­¹Ô!N3õëþñÃü–4QGØ¾ñ0bÄ3øP1SD8S…=çáQ÷çPõü�8ü3ç\µÛR�Û~ý×yßl�tœ\Ï<÷½ðÃ`q8�@nÌ@Ñ.¹v0‡ Aü?˜|IÔýÂ3ì÷órÿ@òs³Ï2³ÇŸóÜÏwËÁóÝ±0-ñ8Ô^ëíÌË±ÛB ,ÁÇó0¸sÁ,S 0ŠÏ°üÍƒÄ¡0¯ÃƒÌÓ]>ø3ÍðýA?2
ø=òÃ.ÏÇß@Ô€Ó<²;ü0ñ3<?>¾~ó?Í~ÿ®q0ì:ß-óÇ,B?3~Ø5?øV×î�V¢	®—˜£¾©ÎbsŽ¥�¨›cš:ü˜:¶«¾ú&Vø(âî¦J ü¢Ð× È"7ˆ¨áÍ÷‚€6�}ø´ï«Àz³«ÿ¿š=Ãí³Ï�£óŽ@;(áÖ¼‚(°8rú½ƒŽÏˆ£ß�®3ËëŽrþ°þÖôÁúúüÃã�ãºó.óë?´q,¿¨<ûüø'êQõ‡§PÓ‰¤÷ª•EP xZÞýqVQ¸ê£¢x»‚‘ônà»ƒ—�÷Ž”ûYS£èHëRHˆü¸¢!î	y¿´ªKH�VîM$’¶-ºi­&¦^�QXY´D„Az*hÓ¦X)Õ•5“mÕ«ueMª«xÚä¢
‹Õíµ‰ºm‹ƒ¹9¿?åï?Jóö»ÏöZª¦¦4CÄ<û¸NkÑI!:ª>Gª4GÕ¬–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äPtš‚n3¸áOJ~°UD “ºÃWWß8$Â
ªŠ�M4iÌÑUPnÔQ¾¡º®p‡;H{r”¨-„iµT­ùê•¥VªVÖåI™„•è.)õŽ–Òß›´Æâæ¬­½’�‡¿Ë"F^qœŸnôŽ5†|Äs·Ã½›Me}=<4Rã^¦óïoKšZ(ðäII+=)d¨ÍrŠ=£�²·;,¨&¶´ï
ýqµJvÿbˆÕTÂ“¾°¾ñ²‹E%(<Ò)·¶
`ÓxÙkºx¶=¼”cªâIí}Kk„Y"c|J;£ðËYÀeŸ3Ý“EêU#¶Ú\®°UîÔ§Î(Fô¬b_ÞÈß×†ëMº§«}2®Ut5XóUPP1ÜŠ{gºú«Y¦…6¦Ð)¢í„Á�š…‰©Y]Y ¯3v¯ñT�~¹E}¦›aÚ_™U�É·þ¬»3*Âp…_¸wcNüÂÝ:.%0cÀMOË@Ì´ÀŠ°—˜ÃmF‰á7ÙŒ"Ÿ7F2PEYómö³ÚÐã5â€P1°ŒºÎiÏNT b8Ô1¥(	sÐ*¿KqÊ%\pô�S           •  —  u  Ž  “  ¬  µ  ·  &�  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  4<?xml version="1.0"?><Features recycledIDs="27" nextValidID="28"><Feature recentID="26" name="FLAG" directionality="1" translationMW="1012.99" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="4015" maxFusedRunOn="4015" detectionMode="exactProteinMatch"><Segment range="3989-4012" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;FLAGÂ® epitope tag, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="25" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2285-2294" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="luciferase" directionality="1" translationMW="60746.74" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="4015" maxFusedRunOn="4015"><Segment range="2291-3940" color="#ffcc00" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;luc&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;firefly luciferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="experiment"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="EC_number"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="24" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4577-4586" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="23" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9833-9849" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="22" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7233-7249" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="21" name="mCherry" directionality="1" translationMW="26722.72" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="5953" maxFusedRunOn="5953"><Segment range="4583-5290" color="#ff0000" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric derivative of DsRed fluorescent protein (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot;&gt;Shaner et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="9185" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="8394-9185" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="9186-9254" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5354-5953" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="7635-8223" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5954-6541" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4280-4548" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6615-6848" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4056-4267" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2011-2214" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7060-7195" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6920-7041" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9255-9359" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="5350" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="5953" maxFusedRunOn="5953" detectionMode="exactProteinMatch"><Segment range="5300-5353" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="7281-7287" color="#ffffff" type="standard"/><Segment range="7288-7305" color="#ffffff" type="standard"/><Segment name="-35" range="7306-7311" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7326-7347" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7257-7273" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6424" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="6041" maxFusedRunOn="6041" visible="0" detectionMode="exactProteinMatch"><Segment range="6425-6436" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>703bb3a0-50d5-4f49-81f7-512b36e27f3a</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="2:18:35">2022.6.16</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ¯<StrandColors><TopStrand><ColorRange range="4582..5289" colors="black"/></TopStrand><BottomStrand><ColorRange range="4582..5289" colors="black"/></BottomStrand></StrandColors>  AÀ   
  	ä  &ˆ        &ˆs"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕZÕj›äšcô�‡é€z¾z'nri-³š}‚Â¨4�µ€È0¨{p¯RïÚµ€JŠ ßUµÀz½V,—^óý¡ÍX$2'*fSDì©!|´løÏosŠ¡ûÙk‘=öõWeECðÏk›î„ÎMxÙC˜QÏà¯�u£ªtcvlBmÉÌzÅbò° ÑNa\f…�[t[,˜Ò{ºÖº˜ðŠ2š›£J3ó©–!hít˜]«4ùòH¨«ÕP
5Uª#UU§Ö[ÑVšm�®UÁ§Ð´±‰Ü¬·nÛŸ¿
¥…œj‰ôKê!Õu£xe…ï¸žŸ”ƒúód^>2Ñ®Í�Doš¨5µm¯xÆ©H¢½¯mÂ¨*yÞÁš†b¬K.–&F¡EŠ©Æþ´uZÕ#(äŸ_æ«k¬õS{†‡Vq©¹jw£® 3~êÅE,L(Õs¯n½œu`;xG�´æ¸ißÄ a•ð3	RŠöª…1Bˆ�ŸW8¥´D1iˆ´Aù†˜¼)‰]o1õÏ¡¡Ô9ÚàGdéàQÅÞºÙ(|èRêZVuAŸBüáhÆh§]ÿ]ºÇ02¯ÇsÂ¯Ï<¢Š MÁQÆQ iË=-IuóRŒÁ¢* qIñPº|{ÔUmí•Q@ÁRõh91k¥m,}»ŸñçPqÆI0óŒlïü´€Ñ3vÏÝ/ñ  @,5¡p#äE3 •à!‹"x;Ïª¿ É™HÒK<…Êê¬×£ÏEÝ8S¬@;6îúÜÏÏ?Ÿ„<ö÷<(K2¸óïÏˆ#ï…ã/<¹	J•;BÄ|¨¼3¿ OŸ‘í<;½Î£áþ:;^ç.¢¬ªâ¸Ï)Ñ½N!ðÏœäsß`„ÔA]ƒÛmA+c:Ô#vòq+±1ÏùÄý=N!õþ?¬øo‹þÒ¶'õœ…7üñÛüyèS‹ëü@ëR3!…ëpÃ ‡ÈAï¿�JÛ�Bã0ß^¿ï?ÉcE}€àûï'üAÃ?…µ4C…8PpÃÞqÎµ~uQOÈÓ�Ã>uË]µ(·ïÝq�öÈIÅÌñÏ{ß6‰ÔìÄRë—croÃù‡Ä�OÜ#>Ï1Ç/ô'7û<ó+<yÿ=Ì÷|±¼=Ûß�Eî¾ÜÌ°;°Ô"ÌpÏ0ƒ�÷<2Å0¬ñÌØ<J
ü8<Í5Ñ�Cïƒ<ßÔó ¯ƒß,2ìü}ô@¸3Ë#¿Á C3À#óëàGï3ü×ïúçÃ­òß<rÄ#ñAó7à�‡óSð�…m~àiÕj!Q¡àšéyŠ;êœæ g8êXú‰¶9£¯Éƒ«j»ï¢eo‚Ž.êa¢Ê-r‚#xŠŽ×ÿx(h÷ß‹Nú¼«:¿ûù£Ü0^Û<øú?8àt°â€ÞkÈ"‹ S‡/«Ø8ìøŠ=øã0¾¸ç/ëíoL¯¯Ì>8ðî0û¯2ï>³ûGÁ»úƒÏ¿Ï‚~¥Xzu8‘ºOz©TU �@å­ï×eŽª:'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒI+bÛ¦šÒjeèÕ…›DHD¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸;“›óþ^óô¯?k¼ÿ`áåªªjcD<CÏ°û„æ½’Cª Cäz£DpýZÉm‚Ù8«â!Z)¼íÖ½Ývq<ÙR%O€#å„„åíÚZ2Œíãó«ÒÀWâÈôãial=s0C
Œš;¯:û;x{8ÎÂÊÃŒ10›NÞÕ%œ)½Ñm eÍEØ„ÕCÓUA|•Pó(àÊ«ÙóÿáÄÛuVÇ;RÑ1_ÇAæTgÐÊ¿øïìŒîø¯ãÎŸ~/>®þ°È3«¶NÜâBnÒ°‰+;Ôà8ˆÜ_ÿ+OÇÎ3é¼%æË¡/_ÂQÜzl÷ƒM=à—A¤Ñ1	‰#�º‚—œ9ÞEI¨&ã;Žô§ëTJ	;¡¼5u}ó‚L ª¨¨ÔÓFœÍUíEêªç ¸s´�qW·)@j‚ØF›UAºß‘¾©ZUaJ¥mnT™˜I^‚áÒŸXém!ù»Ln.jÊÛÙ(ø{ü²$eçÀ@éöàÿHãXgÌG÷;|;Ñ©´ÖWÓÓÁ@ñ3E ¾5êo>öô¹¥¢�ND”’³Ò–JŒ×(£Ú9ÐÛ ‹s²Ê‚`ëkNð¯×PÄ§a¿ö(�UL);ëï(´RRƒÍ"›{`¦7�–»§‹cÛÉF:®!à„ž×Ô¶¸E’&0ÇÄ£º?µœYó=Ù4^¥R;m UÊë Å^íAº|â„oJÆ%ýì�ýxn´Ûªz·Ó*à!5WACU�5UeÁX¡g¶{¯ªµšhSjmš.ØLÙ¨Xš‘U•Õ�
ó7jÿH÷áË”WÚi¶¥ù•Y›qêË³2¬!‡Uû‡v4ïÁ-Ó¢âS<ÑÔü´ËL À‹ àéyŒ6Ñ4hž#}˜Â!Yótc%UŸ6ÐÏk=­3^(Àû¬æœôàÅ@#�CR€—=«ô·¢UÇHõ8           •  —  {  ”  ™  ²  »  ½  &‡  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  4<?xml version="1.0"?><Features recycledIDs="27" nextValidID="28"><Feature recentID="26" name="FLAG" directionality="1" translationMW="1012.99" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="4021" maxFusedRunOn="4021" detectionMode="exactProteinMatch"><Segment range="3995-4018" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;FLAGÂ® epitope tag, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="25" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2285-2294" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="luciferase" directionality="1" translationMW="60746.74" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="4021" maxFusedRunOn="4021"><Segment range="2291-3940" color="#ffcc00" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;luc&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;firefly luciferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="experiment"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="EC_number"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="24" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4583-4592" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="23" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9839-9855" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="22" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7239-7255" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="21" name="mCherry" directionality="1" translationMW="26722.72" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="5959" maxFusedRunOn="5959"><Segment range="4589-5296" color="#ff0000" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric derivative of DsRed fluorescent protein (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot;&gt;Shaner et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="9191" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="8400-9191" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="9192-9260" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5360-5959" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="7641-8229" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5960-6547" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4286-4554" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6621-6854" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4062-4273" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2011-2214" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7066-7201" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6926-7047" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9261-9365" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="5356" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="5959" maxFusedRunOn="5959" detectionMode="exactProteinMatch"><Segment range="5306-5359" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="7287-7293" color="#ffffff" type="standard"/><Segment range="7294-7311" color="#ffffff" type="standard"/><Segment name="-35" range="7312-7317" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7332-7353" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7263-7279" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6430" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="6047" maxFusedRunOn="6047" visible="0" detectionMode="exactProteinMatch"><Segment range="6431-6442" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ><Notes>
<UUID>703bb3a0-50d5-4f49-81f7-512b36e27f3a</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="2:18:6">2022.6.16</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ¯<StrandColors><TopStrand><ColorRange range="4588..5295" colors="black"/></TopStrand><BottomStrand><ColorRange range="4588..5295" colors="black"/></BottomStrand></StrandColors>  AÂ   	  	å  &‰        &‰s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕZÕj›äšcô�‡é€z¾z'nri-³š}‚Â¨4�µ€È0¨{p¯RïÚµ€JŠ ßUµÀz½V,—^óý¡ÍX$2'*fSDì©!|´løÏosŠ¡ûÙk‘=öõWeECðÏk›î„ÎMxÙC˜QÏà¯�u£ªtcvlBmÉÌzÅbò° ÑNa\f…�[t[,˜Ò{ºÖº˜ðŠ2š›£J3ó©–!hít˜]«4ùòH¨«ÕP
5Uª#UU§Ö[ÑVšm�®UÁ§Ð´±‰Ü¬·nÛŸ¿
¥…œj‰ôKê!Õu£xe…ï¸žŸ”ƒúód^>2Ñ®Í�Doš¨5µm¯xÆ©H¢½¯mÂ¨*yÞÁš†b¬K.–&F¡EŠ©Æþ´uZÕ#(äŸ_æ«k¬õS{†‡Vq©¹jw£® 3~êÅE,L(Õs¯n½œu`;xG�´æ¸ißÄ a•ð3	RŠöª…1Bˆ�ŸW8¥´D1iˆ´Aù†˜¼)‰]o1õÏ¡¡Ô9ÚàGdéàQÅÞºÙ(|èRêZVuAŸBüáhÆh§]ÿ]ºÇ02¯ÇsÂ¯Ï<¢Š MÁQÆQ iË=-IuóRŒÁ¢* qIñPº|{ÔUmí•Q@ÁRõh91k¥m,|FîÄ'Á¼yÔq‡RL<Åã;Â?- 4LÝ³÷KüE( h\ùBÀ%xHbÈžóê¯Ä EòfR4’Ï!rº«5À¨óÑwNëÍ»¾·3óÏçá=½Ï
Ì®<ûóâûáxËÏ.BR¥NÐ±ê/ïèçä{Oïs¨øŽŽ×¹Ë¨«*¸®3ÊtoSˆ|3ç9÷Ø!5A—`öÛPJØÎµÝ�¼…ÃÜJÄl@Ä@óþqGÏS…}@ƒÿ�ë>Ûâÿ´­‰Ã½Cç!Mÿ<vÿzâúÿ:Ô€LÈazÄ0È!òÐ{ïãAÃ¶çP…8Ì7×¯ûÇòXÑE`8>ûÄÁ‰ÿpÏá@ÄmMáN0÷œs„-Gß�CÔSò4ãðÏ�r×mJmû÷\Aç}²Òqs<@óÞ÷Ã�Äâu»1DºåØÂ�[ðþañ'S÷Ï³ßÌqËýÉÍþÏ<ÊÏÏs=ß,oÏvÄÀ·ÄãQ{¯·3,Çl5€³3Ì Âà}ÏL±L Â+<FÃó6„Â¿3Mt`PûàÏ7ÃõüÈ+à÷Ë»?}P.LòÈïðHÃÄÌðüúøûÌÿ5ûþ¹ÄÃ°ë|·Ï±üP|Íø#aüÔü#á[_¸uZˆThx&º^bŽú§9ˆÎ:–>¢mŽhëò`êÚ®ûè™[à£‹º˜A(ƒò‹C\ƒ ˆÞ"£‡5ÿÞ
 Ú=÷âÓ¾¯êÎ¯þþh÷¶Ï>>�Î8 ì8 7‡Zò¢ÀáËêö;>"�~¸Ì/®9ËúÃû[ÓëëóŽ<;Œ>ëÌ»Ï¬þÑÄ°nþ óïóàŸ©GÖ�CN$n“ÞªU@àP9k{õÅYFãªŽ‰à.î
GÑ¸O€Nî^@_Þ:SíeN�¡#­I"#òâˆ‡¸%äFþÑþ©-"[¹4’JØ¶é¦´š™z5EafÑè©£N™`§VTÖM·V­Õ•6ª­ãk’ˆ*/W¶Ö&é¶.äæüÿ—¼ý+ÏÚï?Ø8yjªš˜Ñóì>á9¯E$„ê¨ù¨Ñ?V²[`¶N*øˆVŠo;u¯w]œO6T‰Sàùa!9{v–Œ£;xüêô°ø²=8ÚX[\ÌÂ£&€ÎëÎ¾ÎÞÎ3°²°ãL&Ó·µC	g
ot[@sAQv!5PôÕCÐ_%T<Ê82ªöC¼ÿøq6ÝU±ÎÔ´BWñÐy•ô2¯þ;û#;¾+Çøó§ÁŸ‹Ï«¿¬2êí“·8�›´¬"BÊÎõ8"7ÿÊÓñóŒúo	y²èK×ð”w›=àÓOx%Ði4LBbCçD®… ƒåçw‘AÒj	¸Îã…=)úÁU‚Nèo]_|à“*ª*54Ñ§3EUA»QFú†ê¹À.í \UíÊP ¶¦ÕPn·äoªV•XR©[[•&fW ¸t§Ö:[HC~nÓ‹š²¶öJ>ÿ,‰yÆp:}¸?Ò8ÖóýÎßôjm5•ôôðP<LÑH/�z›Ï½½.ih£ÀS‘%$¬ô¥’£5Ê(öŽt6È"Üì² ˜:ÚÓ¼+õÆÔ1)ØoýŠ#US
NúÂûÆÊ-” óH¦ÞØ)ƒMãe®éâØöòQŽ«ˆx!'µõ-®d‰Œ1ñ(î�Ã-g–|ÏvM©TŽÛhrºÀ1W»PnŸ8¡Ò±‰{#^­6êž­ôÊ¸MUÐPÕcÍU@Y@ÇpV(Yížëê­fšÚ›@¦‹¶vj&¤Ueud¼ÍÚ¿ÅR=øråöšm‡i~eVC&ÜCú²ìÌ«aÂ~áÝ�;ðGtè¸”Á�4u?-2Ó(0"À8:^c´M'„Hßf0ˆV|ÝÉAgÍ´3ÚÏkCŒ×Š@ÆÂ0>ë9§=81PˆãPÆ” %Ï@ªý-Ç(•qÃÒ=N            •  —  {  •  š  ³  ¼  ¾  &ˆ  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  4<?xml version="1.0"?><Features recycledIDs="27" nextValidID="28"><Feature recentID="26" name="FLAG" directionality="1" translationMW="1012.99" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="4022" maxFusedRunOn="4022" detectionMode="exactProteinMatch"><Segment range="3996-4019" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;FLAGÂ® epitope tag, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="25" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2285-2294" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="luciferase" directionality="1" translationMW="60746.74" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="4015" maxFusedRunOn="4015"><Segment range="2291-3940" color="#ffcc00" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;luc&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;firefly luciferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="experiment"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="EC_number"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="24" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4584-4593" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="23" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9840-9856" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="22" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7240-7256" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="21" name="mCherry" directionality="1" translationMW="26722.72" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="5960" maxFusedRunOn="5960"><Segment range="4590-5297" color="#ff0000" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric derivative of DsRed fluorescent protein (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot;&gt;Shaner et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="9192" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="8401-9192" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="9193-9261" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5361-5960" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="7642-8230" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5961-6548" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4287-4555" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6622-6855" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4063-4274" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2011-2214" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7067-7202" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6927-7048" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9262-9366" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="5357" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="5960" maxFusedRunOn="5960" detectionMode="exactProteinMatch"><Segment range="5307-5360" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="7288-7294" color="#ffffff" type="standard"/><Segment range="7295-7312" color="#ffffff" type="standard"/><Segment name="-35" range="7313-7318" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7333-7354" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7264-7280" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6431" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="6048" maxFusedRunOn="6048" visible="0" detectionMode="exactProteinMatch"><Segment range="6432-6443" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>703bb3a0-50d5-4f49-81f7-512b36e27f3a</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="2:17:54">2022.6.16</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ¯<StrandColors><TopStrand><ColorRange range="4589..5296" colors="black"/></TopStrand><BottomStrand><ColorRange range="4589..5296" colors="black"/></BottomStrand></StrandColors>  Bk     	æ  &�        &�s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕZÕj›äšcô�‡é€z¾z'nri-³š}‚Â¨4�µ€È0¨{p¯RïÚµ€JŠ ßUµÀz½V,—^óý¡ÍX$2'*fSDì©!|´løÏosŠ¡ûÙk‘=öõWeECðÏk›î„ÎMxÙC˜QÏà¯�u£ªtcvlBmÉÌzÅbò° ÑNa\f…�[t[,˜Ò{ºÖº˜ðŠ2š›£J3ó©–!hít˜]«4ùòH¨«ÕP
5Uª#UU§Ö[ÑVšm�®UÁ§Ð´±‰Ü¬·nÛŸ¿
¥…œj‰ôKê!Õu£xe…ï¸žŸ”ƒúód^>2Ñ®Í�Doš¨5µm¯xÆ©H¢½¯mÂ¨*yÞÁš†b¬K.–&F¡EŠ©Æþ´uZÕ#(äŸ_æ«k¬õS{†‡Vq©¹jw£® 3~êÅE,L(Õs¯n½œu`;xG�´æ¸ißÄ a•ð3	RŠöª…1Bˆ�ŸW8¥´D1iˆ´Aù†˜¼)‰]o1õÏ¡¡Ô9ÚàGdéàQÅÞºÙ(|èRêZVuAŸBüáhÆh§]ÿ]ºÇ02¯ÇsÂ¯Ï<¢Š MÁQÆQ iË=-IuóRŒÁ¢* qIñPº|{ÔUmí•Q@ÁRõh91k¥m°±ñ»ŸñçPqÆI0óŒlïü´€Ñ3vÏÝ/ñ  @,5¡p#äE3 •à!‹"x;Ïª¿ É™HÒK<…Êê¬×£ÏEÝ8S¬@;6îúÜÏÏ?Ÿ„<ö÷<(K2¸óïÏˆ#ï…ã/<¹	J•;BÄ|¨¼3¿ OŸ‘í<;½Î£áþ:;^ç.¢¬ªâ¸Ï)Ñ½N!ðÏœäsß`„ÔA]ƒÛmA+c:Ô#vòq+±1ÏùÄý=N!õþ?¬øo‹þÒ¶'õœ…7üñÛüyèS‹ëü@ëR3!…ëpÃ ‡ÈAï¿�JÛ�Bã0ß^¿ï?ÉcE}€àûï'üAÃ?…µ4C…8PpÃÞqÎµ~uQOÈÓ�Ã>uË]µ(·ïÝq�öÈIÅÌñÏ{ß6‰ÔìÄRë—croÃù‡Ä�OÜ#>Ï1Ç/ô'7û<ó+<yÿ=Ì÷|±¼=Ûß�Eî¾ÜÌ°;°Ô"ÌpÏ0ƒ�÷<2Å0¬ñÌØ<J
ü8<Í5Ñ�Cïƒ<ßÔó ¯ƒß,2ìü}ô@¸3Ë#¿Á C3À#óëàGï3ü×ïúçÃ­òß<rÄ#ñAó7à�‡óSð�…m~àiÕj!Q¡àšéyŠ;êœæ g8êXú‰¶9£¯Éƒ«j»ï¢eo‚Ž.êa¢Ê-r‚#xŠŽ×ÿx(h÷ß‹Nú¼«:¿ûù£Ü0^Û<øú?8àt°â€ÞkÈ"‹ S‡/«Ø8ìøŠ=øã0¾¸ç/ëíoL¯¯Ì>8ðî0û¯2ï>³ûGÁ»úƒÏ¿Ï‚~¥Xzu8‘ºOz©TU �@å­ï×eŽª:'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒI+bÛ¦šÒjeèÕ…›DHD¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸;“›óþ^óô¯?k¼ÿ`áåªªjcD<CÏ°û„æ½’Cª Cäz£DpýZÉm‚Ù8«â!Z)¼íÖ½Ývq<ÙR%O€#å„„åíÚZ2Œíãó«ÒÀWâÈôãial=s0C
Œš;¯:û;x{8ÎÂÊÃŒ10›NÞÕ%œ)½Ñm eÍEØ„ÕCÓUA|•Pó(àÊ«ÙóÿáÄÛuVÇ;RÑ1_ÇAæTgÐÊ¿øïìŒîø¯ãÎŸ~/>®þ°È3«¶NÜâBnÒ°‰+;Ôà8ˆÜ_ÿ+OÇÎ3é¼%æË¡/_ÂQÜzl÷ƒM=à—A¤Ñ1	‰#�º‚—œ9ÞEI¨&ã;Žô§ëTJ	;¡¼5u}ó‚L ª¨¨ÔÓFœÍUíEêªç ¸s´�qW·)@j‚ØF›UAºß‘¾©ZUaJ¥mnT™˜I^‚áÒŸXém!ù»Ln.jÊÛÙ(ø{ü²$eçÀ@éöàÿHãXgÌG÷;|;Ñ©´ÖWÓÓÁ@ñ3E ¾5êo>öô¹¥¢�ND”’³Ò–JŒ×(£Ú9ÐÛ ‹s²Ê‚`ëkNð¯×PÄ§a¿ö(�UL);ëï(´RRƒÍ"›{`¦7�–»§‹cÛÉF:®!à„ž×Ô¶¸E’&0ÇÄ£º?µœYó=Ù4^¥R;m UÊë Å^íAº|â„oJÆ%ýì�ýxn´Ûªz·Ó*à!5WACU�5UeÁX¡g¶{¯ªµšhSjmš.ØLÙ¨Xš‘U•Õ�
ó7jÿH÷áË”WÚi¶¥ù•Y›qêË³2¬!‡Uû‡v4ïÁ-Ó¢âS<ÑÔü´ËL À‹ àéyŒ6Ñ4hž#}˜Â!Yótc%UŸ6ÐÏk=­3^(Àû¬æœôàÅ@#�CR€—=«ô·¢UÇHõ8           •  —  {  œ  ¡  º  Ã  Å  &�  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  4½<?xml version="1.0"?><Features nextValidID="28"><Feature recentID="27" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3965-3996" color="#ffff99" type="standard"/></Feature><Feature recentID="26" name="FLAG" directionality="1" translationMW="1012.99" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="4029" maxFusedRunOn="4029" detectionMode="exactProteinMatch"><Segment range="4003-4026" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;FLAGÂ® epitope tag, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="25" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2285-2294" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="luciferase" directionality="1" translationMW="60746.74" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="4159" maxFusedRunOn="4159"><Segment range="2291-3940" color="#ffcc00" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;luc&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;firefly luciferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="experiment"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="EC_number"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="24" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4591-4600" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="23" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9847-9863" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="22" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7247-7263" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="21" name="mCherry" directionality="1" translationMW="26722.72" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="5967" maxFusedRunOn="5967"><Segment range="4597-5304" color="#ff0000" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric derivative of DsRed fluorescent protein (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot;&gt;Shaner et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="9199" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="8408-9199" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="9200-9268" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5368-5967" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="7649-8237" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5968-6555" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4294-4562" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6629-6862" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4070-4281" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2011-2214" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7074-7209" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6934-7055" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9269-9373" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="5364" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="5967" maxFusedRunOn="5967" detectionMode="exactProteinMatch"><Segment range="5314-5367" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="7295-7301" color="#ffffff" type="standard"/><Segment range="7302-7319" color="#ffffff" type="standard"/><Segment name="-35" range="7320-7325" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7340-7361" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7271-7287" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6438" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="6055" maxFusedRunOn="6055" visible="0" detectionMode="exactProteinMatch"><Segment range="6439-6450" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>703bb3a0-50d5-4f49-81f7-512b36e27f3a</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="2:17:33">2022.6.16</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ¯<StrandColors><TopStrand><ColorRange range="4596..5303" colors="black"/></TopStrand><BottomStrand><ColorRange range="4596..5303" colors="black"/></BottomStrand></StrandColors>  A¢     	Ö  &p        &ps"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕZÕj›äšcô�‡é€z¾z'nri-³š}‚Â¨4�µ€È0¨{p¯RïÚµ€JŠ ßUµÀz½V,—^óý¡ÍX$2'*fSDì©!|´løÏosŠ¡ûÙk‘=öõWeECðÏk›î„ÎMxÙC˜QÏà¯�u£ªtcvlBmÉÌzÅbò° ÑNa\f…�[t[,˜Ò{ºÖº˜ðŠ2š›£J3ó©–!hít˜]«4ùòH¨«ÕP
5Uª#UU§Ö[ÑVšm�®UÁ§Ð´±‰Ü¬·nÛŸ¿
¥…œj‰ôKê!Õu£xe…ï¸žŸ”ƒúód^>2Ñ®Í�Doš¨5µm¯xÆ©H¢½¯mÂ¨*yÞÁš†b¬K.–&F¡EŠ©Æþ´uZÕ#(äŸ_æ«k¬õS{†‡Vq©¹jw£® 3~êÅE,L(Õs¯n½œu`;xG�´æ¸ißÄ a•ð3	RŠöª…1Bˆ�ŸW8¥´D1iˆ´Aù†˜¼)‰]o1õÏ¡¡Ô9ÚàGdéàQÅÞºÙ(|èRêZVuAŸBüáhÆh§]ÿ]ºÇ02¯ÇsÂ¯Ï<¢Š MÁQÆQ iË=-IuóRŒÁ¢* qIñPº|{ÔUmí•Q@ÁRõh91k¥mñçPqÆI0óŒlïü´€Ñ3vÏÝ/ñ  @,5¡p#äE3 •à!‹"x;Ïª¿ É™HÒK<…Êê¬×£ÏEÝ8S¬@;6îúÜÏÏ?Ÿ„<ö÷<(K2¸óïÏˆ#ï…ã/<¹	J•;BÄ|¨¼3¿ OŸ‘í<;½Î£áþ:;^ç.¢¬ªâ¸Ï)Ñ½N!ðÏœäsß`„ÔA]ƒÛmA+c:Ô#vòq+±1ÏùÄý=N!õþ?¬øo‹þÒ¶'õœ…7üñÛüyèS‹ëü@ëR3!…ëpÃ ‡ÈAï¿�JÛ�Bã0ß^¿ï?ÉcE}€àûï'üAÃ?…µ4C…8PpÃÞqÎµ~uQOÈÓ�Ã>uË]µ(·ïÝq�öÈIÅÌñÏ{ß6‰ÔìÄRë—croÃù‡Ä�OÜ#>Ï1Ç/ô'7û<ó+<yÿ=Ì÷|±¼=Ûß�Eî¾ÜÌ°;°Ô"ÌpÏ0ƒ�÷<2Å0¬ñÌØ<J
ü8<Í5Ñ�Cïƒ<ßÔó ¯ƒß,2ìü}ô@¸3Ë#¿Á C3À#óëàGï3ü×ïúçÃ­òß<rÄ#ñAó7à�‡óSð�…m~àiÕj!Q¡àšéyŠ;êœæ g8êXú‰¶9£¯Éƒ«j»ï¢eo‚Ž.êa¢Ê-r‚#xŠŽ×ÿx(h÷ß‹Nú¼«:¿ûù£Ü0^Û<øú?8àt°â€ÞkÈ"‹ S‡/«Ø8ìøŠ=øã0¾¸ç/ëíoL¯¯Ì>8ðî0û¯2ï>³ûGÁ»úƒÏ¿Ï‚~¥Xzu8‘ºOz©TU �@å­ï×eŽª:'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒI+bÛ¦šÒjeèÕ…›DHD¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸;“›óþ^óô¯?k¼ÿ`áåªªjcD<CÏ°û„æ½’Cª Cäz£DpýZÉm‚Ù8«â!Z)¼íÖ½Ývq<ÙR%O€#å„„åíÚZ2Œíãó«ÒÀWâÈôãial=s0C
Œš;¯:û;x{8ÎÂÊÃŒ10›NÞÕ%œ)½Ñm eÍEØ„ÕCÓUA|•Pó(àÊ«ÙóÿáÄÛuVÇ;RÑ1_ÇAæTgÐÊ¿øïìŒîø¯ãÎŸ~/>®þ°È3«¶NÜâBnÒ°‰+;Ôà8ˆÜ_ÿ+OÇÎ3é¼%æË¡/_ÂQÜzl÷ƒM=à—A¤Ñ1	‰#�º‚—œ9ÞEI¨&ã;Žô§ëTJ	;¡¼5u}ó‚L ª¨¨ÔÓFœÍUíEêªç ¸s´�qW·)@j‚ØF›UAºß‘¾©ZUaJ¥mnT™˜I^‚áÒŸXém!ù»Ln.jÊÛÙ(ø{ü²$eçÀ@éöàÿHãXgÌG÷;|;Ñ©´ÖWÓÓÁ@ñ3E ¾5êo>öô¹¥¢�ND”’³Ò–JŒ×(£Ú9ÐÛ ‹s²Ê‚`ëkNð¯×PÄ§a¿ö(�UL);ëï(´RRƒÍ"›{`¦7�–»§‹cÛÉF:®!à„ž×Ô¶¸E’&0ÇÄ£º?µœYó=Ù4^¥R;m UÊë Å^íAº|â„oJÆ%ýì�ýxn´Ûªz·Ó*à!5WACU�5UeÁX¡g¶{¯ªµšhSjmš.ØLÙ¨Xš‘U•Õ�
ó7jÿH÷áË”WÚi¶¥ù•Y›qêË³2¬!‡Uû‡v4ïÁ-Ó¢âS<ÑÔü´ËL À‹ àéyŒ6Ñ4hž#}˜Â!Yótc%UŸ6ÐÏk=­3^(Àû¬æœôàÅ@#�CR€—=«ô·¢UÇHõ8           •  —  �  š  £  ¥  &o  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  4<?xml version="1.0"?><Features nextValidID="27"><Feature recentID="26" name="FLAG" directionality="1" translationMW="1012.99" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3997" maxFusedRunOn="3997" detectionMode="exactProteinMatch"><Segment range="3971-3994" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;FLAGÂ® epitope tag, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="25" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2285-2294" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="luciferase" directionality="1" translationMW="60746.74" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3997" maxFusedRunOn="3997"><Segment range="2291-3940" color="#ffcc00" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;luc&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;firefly luciferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="experiment"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="EC_number"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="24" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4559-4568" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="23" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9815-9831" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="22" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7215-7231" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="21" name="mCherry" directionality="1" translationMW="26722.72" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="5935" maxFusedRunOn="5935"><Segment range="4565-5272" color="#ff0000" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric derivative of DsRed fluorescent protein (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot;&gt;Shaner et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="9167" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="8376-9167" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="9168-9236" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5336-5935" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="7617-8205" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5936-6523" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4262-4530" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6597-6830" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4038-4249" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2011-2214" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7042-7177" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6902-7023" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9237-9341" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="5332" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="5935" maxFusedRunOn="5935" detectionMode="exactProteinMatch"><Segment range="5282-5335" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="7263-7269" color="#ffffff" type="standard"/><Segment range="7270-7287" color="#ffffff" type="standard"/><Segment name="-35" range="7288-7293" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7308-7329" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7239-7255" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6406" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="6023" maxFusedRunOn="6023" visible="0" detectionMode="exactProteinMatch"><Segment range="6407-6418" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>703bb3a0-50d5-4f49-81f7-512b36e27f3a</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="2:17:25">2022.6.16</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ¯<StrandColors><TopStrand><ColorRange range="4564..5271" colors="black"/></TopStrand><BottomStrand><ColorRange range="4564..5271" colors="black"/></BottomStrand></StrandColors>  A¢     	Ö  &o        &os"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕZÕj›äšcô�‡é€z¾z'nri-³š}‚Â¨4�µ€È0¨{p¯RïÚµ€JŠ ßUµÀz½V,—^óý¡ÍX$2'*fSDì©!|´løÏosŠ¡ûÙk‘=öõWeECðÏk›î„ÎMxÙC˜QÏà¯�u£ªtcvlBmÉÌzÅbò° ÑNa\f…�[t[,˜Ò{ºÖº˜ðŠ2š›£J3ó©–!hít˜]«4ùòH¨«ÕP
5Uª#UU§Ö[ÑVšm�®UÁ§Ð´±‰Ü¬·nÛŸ¿
¥…œj‰ôKê!Õu£xe…ï¸žŸ”ƒúód^>2Ñ®Í�Doš¨5µm¯xÆ©H¢½¯mÂ¨*yÞÁš†b¬K.–&F¡EŠ©Æþ´uZÕ#(äŸ_æ«k¬õS{†‡Vq©¹jw£® 3~êÅE,L(Õs¯n½œu`;xG�´æ¸ißÄ a•ð3	RŠöª…1Bˆ�ŸW8¥´D1iˆ´Aù†˜¼)‰]o1õÏ¡¡Ô9ÚàGdéàQÅÞºÙ(|èRêZVuAŸBüáhÆh§]ÿ]ºÇ02¯ÇsÂ¯Ï<¢Š MÁQÆQ iË=-IuóRŒÁ¢* qIñPº|{ÔUmí•Q@ÁRõh91k¥lÇ�AÇu$ÃÌPn1³¼#òÒDÍÛ?t¿ÄR€ °Ö…À�‘ ÌW€T†,‰àï>ªü@€_&e#I,ò+ª³\
�=táN± ìÛ»ës?<þ~óÛÜð¡,ÊãÏ¿> �¾Œ¼òä%*Tíð>¢ðÎþ�>~G´ðî÷:�‡øèí{œºŠ²«Šã<§Fõ8‡Ã>s‘Ï}‚P1vmµ­ŒëP�Ø;È\=Ä¬FÄ@Ä?ç7ô|õ8P‡Ô?øþ³à¾/ûJØœ;Ô>rßóÇoñç¡N/¯ñ­HÌ†¬AÃ‚!ý¾þ41+nuSŒÃ}zÿ¼pÿ%�Qö€Cï¼LŸñþFÔÑáAÃyÇ8BÔ}ùÔ=E?#N?ù×-vÔ vß¿uÄwÛ ]'3Ä=ï|0ØN'P³4AK®]Œ!ÈE¿æu?pŒû=üÇ¿Ð<œßìóÌ¬ñçü÷3ÝòÆð|÷lL|N5ºûs2ÀìvÃPˆ0qÃ<Â.ÜðDËÀ"³Äl?3`ñ(L+ðàó4×F¾ó|?POÌ‚¾|°Ë³ñ÷Ð5à4Ï,Žÿ�<LÏ �Ï¯�¼Ïó_¿ëœL;·Ë|ñË�ÅÌß‚6ÍOÂ>µû�§U¨…F‡‚k¥æ(ïªs˜�œã©cê&ØæŽ¿&­ªï¾‰•¾
8»©„ˆ?(´5È2�â*8s_ýà £ß~-;êð¬êÿïæ�pÁ{lóãèüã�ÐÃŠxu¯ Š,N¾¯`ã³â(÷àkŒÀrúãœ¿¬?µ½0~¾¿0øãÃ¸Ãî¼Ë¼úÏíKïê>ÿ>	ú”}aéÔ4âFé=ê¥QT –·¿\U”n:¨èžîà¤}„øîàåäýã¥>ÖTèú:Ô’"?.(ˆ{‚^Doíê’Ò U»“I$­‹nškI©—£TVm!^Šš4é–
ueMdÛujÝYSjªÞ6¹(‚¢õ{mbn›bàîNoÏù{ÏÒ¼ý®óýƒ‡–ª©©�ñ>ÃîšôRHAª�‘ê�Ãõk%¶dâ¯ˆ…h¦ó·Z÷uÙÄðSeH•> �–—·ihÊ3·�Î¯K_‹#Ó�¥…°õÌÀ*2hî¼ëìíáìã;+0ÄÂm;{T0–p¦÷E´—4bUMT=òUCÌ£ƒ*¯d;Ïÿ‡mÕ[íKD Å™QŸC*ÿàS¿²3»â¼�:|ø¼ú»úÀS Î®Ù;s‰	»JÂ$,¬ïS€â#qü­?8Ï¦ð—›.„½	Gqé³Þ4÷‚]“DÄ&$0ŽtJèR>^pçy& ›Œî8SÒŸ¬Q($î†ðÕÕ÷Î	0‚ª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡.Q_i¦Øv—æUd2mÄ?«.ÌÊ°†!WîØÓ¿p·N‹‰LðGSòÐ3-0"ƒ,ƒ¥æ0ÛDÑ¢xD�öc…gÍÑŒ”V|ÛC=¬ö´8Íx l#î³šsÓƒ Ž5iJ\ô
¯ÒÜr‰W=#Ô8           •  —  €  ™  ¢  ¤  &n  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  4<?xml version="1.0"?><Features nextValidID="27"><Feature recentID="26" name="FLAG" directionality="1" translationMW="1012.99" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3996" maxFusedRunOn="3996" detectionMode="exactProteinMatch"><Segment range="3970-3993" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;FLAGÂ® epitope tag, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="25" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2285-2294" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="luciferase" directionality="1" translationMW="60746.74" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="4126" maxFusedRunOn="4126"><Segment range="2291-3940" color="#ffcc00" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;luc&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;firefly luciferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="experiment"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="EC_number"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="24" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4558-4567" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="23" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9814-9830" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="22" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7214-7230" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="21" name="mCherry" directionality="1" translationMW="26722.72" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="5934" maxFusedRunOn="5934"><Segment range="4564-5271" color="#ff0000" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric derivative of DsRed fluorescent protein (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot;&gt;Shaner et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="9166" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="8375-9166" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="9167-9235" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5335-5934" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="7616-8204" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5935-6522" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4261-4529" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6596-6829" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4037-4248" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2011-2214" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7041-7176" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6901-7022" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9236-9340" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="5331" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="5934" maxFusedRunOn="5934" detectionMode="exactProteinMatch"><Segment range="5281-5334" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="7262-7268" color="#ffffff" type="standard"/><Segment range="7269-7286" color="#ffffff" type="standard"/><Segment name="-35" range="7287-7292" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7307-7328" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7238-7254" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6405" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="6022" maxFusedRunOn="6022" visible="0" detectionMode="exactProteinMatch"><Segment range="6406-6417" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>703bb3a0-50d5-4f49-81f7-512b36e27f3a</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="2:16:45">2022.6.16</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ¯<StrandColors><TopStrand><ColorRange range="4563..5270" colors="black"/></TopStrand><BottomStrand><ColorRange range="4563..5270" colors="black"/></BottomStrand></StrandColors>  ?„     	È  &U        &Us"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕZÕj›äšcô�‡é€z¾z'nri-³š}‚Â¨4�µ€È0¨{p¯RïÚµ€JŠ ßUµÀz½V,—^óý¡ÍX$2'*fSDì©!|´løÏosŠ¡ûÙk‘=öõWeECðÏk›î„ÎMxÙC˜QÏà¯�u£ªtcvlBmÉÌzÅbò° ÑNa\f…�[t[,˜Ò{ºÖº˜ðŠ2š›£J3ó©–!hít˜]«4ùòH¨«ÕP
5Uª#UU§Ö[ÑVšm�®UÁ§Ð´±‰Ü¬·nÛŸ¿
¥…œj‰ôKê!Õu£xe…ï¸žŸ”ƒúód^>2Ñ®Í�Doš¨5µm¯xÆ©H¢½¯mÂ¨*yÞÁš†b¬K.–&F¡EŠ©Æþ´uZÕ#(äŸ_æ«k¬õS{†‡Vq©¹jw£® 3~êÅE,L(Õs¯n½œu`;xG�´æ¸ißÄ a•ð3	RŠöª…1Bˆ�ŸW8¥´D1iˆ´Aù†˜¼)‰]o1õÏ¡¡Ô9ÚàGdéàQÅÞºÙ(|èRêZVuAŸBüáhÆh§]ÿ]ºÇ02¯ÇsÂ¯Ï<¢Š MÁQÆQ iË=-IuóRŒÁ¢* qIñPº|{ÔUmí•Q@ÁRõh91k¥lÌ<Åã;Â?- 4LÝ³÷KüE( h\ùBÀ%xHbÈžóê¯Ä EòfR4’Ï!rº«5À¨óÑwNëÍ»¾·3óÏçá=½Ï
Ì®<ûóâûáxËÏ.BR¥NÐ±ê/ïèçä{Oïs¨øŽŽ×¹Ë¨«*¸®3ÊtoSˆ|3ç9÷Ø!5A—`öÛPJØÎµÝ�¼…ÃÜJÄl@Ä@óþqGÏS…}@ƒÿ�ë>Ûâÿ´­‰Ã½Cç!Mÿ<vÿzâúÿ:Ô€LÈazÄ0È!òÐ{ïãAÃ¶çP…8Ì7×¯ûÇòXÑE`8>ûÄÁ‰ÿpÏá@ÄmMáN0÷œs„-Gß�CÔSò4ãðÏ�r×mJmû÷\Aç}²Òqs<@óÞ÷Ã�Äâu»1DºåØÂ�[ðþañ'S÷Ï³ßÌqËýÉÍþÏ<ÊÏÏs=ß,oÏvÄÀ·ÄãQ{¯·3,Çl5€³3Ì Âà}ÏL±L Â+<FÃó6„Â¿3Mt`PûàÏ7ÃõüÈ+à÷Ë»?}P.LòÈïðHÃÄÌðüúøûÌÿ5ûþ¹ÄÃ°ë|·Ï±üP|Íø#aüÔü#á[_¸uZˆThx&º^bŽú§9ˆÎ:–>¢mŽhëò`êÚ®ûè™[à£‹º˜A(ƒò‹C\ƒ ˆÞ"£‡5ÿÞ
 Ú=÷âÓ¾¯êÎ¯þþh÷¶Ï>>�Î8 ì8 7‡Zò¢ÀáËêö;>"�~¸Ì/®9ËúÃû[ÓëëóŽ<;Œ>ëÌ»Ï¬þÑÄ°nþ óïóàŸ©GÖ�CN$n“ÞªU@àP9k{õÅYFãªŽ‰à.î
GÑ¸O€Nî^@_Þ:SíeN�¡#­I"#òâˆ‡¸%äFþÑþ©-"[¹4’JØ¶é¦´š™z5EafÑè©£N™`§VTÖM·V­Õ•6ª­ãk’ˆ*/W¶Ö&é¶.äæüÿ—¼ý+ÏÚï?Ø8yjªš˜Ñóì>á9¯E$„ê¨ù¨Ñ?V²[`¶N*øˆVŠo;u¯w]œO6T‰Sàùa!9{v–Œ£;xüêô°ø²=8ÚX[\ÌÂ£&€ÎëÎ¾ÎÞÎ3°²°ãL&Ó·µC	g
ot[@sAQv!5PôÕCÐ_%T<Ê82ªöC¼ÿøq6ÝU±ÎÔ´BWñÐy•ô2¯þ;û#;¾+Çøó§ÁŸ‹Ï«¿¬2êí“·8�›´¬"BÊÎõ8"7ÿÊÓñóŒúo	y²èK×ð”w›=àÓOx%Ði4LBbCçD®… ƒåçw‘AÒj	¸Îã…=)úÁU‚Nèo]_|à“*ª*54Ñ§3EUA»QFú†ê¹À.í \UíÊP ¶¦ÕPn·äoªV•XR©[[•&fW ¸t§Ö:[HC~nÓ‹š²¶öJ>ÿ,‰yÆp:}¸?Ò8ÖóýÎßôjm5•ôôðP<LÑH/�z›Ï½½.ih£ÀS‘%$¬ô¥’£5Ê(öŽt6È"Üì² ˜:ÚÓ¼+õÆÔ1)ØoýŠ#US
NúÂûÆÊ-” óH¦ÞØ)ƒMãe®éâØöòQŽ«ˆx!'µõ-®d‰Œ1ñ(î�Ã-g–|ÏvM©TŽÛhrºÀ1W»PnŸ8¡Ò±‰{#^­6êž­ôÊ¸MUÐPÕcÍU@Y@ÇpV(Yížëê­fšÚ›@¦‹¶vj&¤Ueud¼ÍÚ¿ÅR=øråöšm‡i~eVC&ÜCú²ìÌ«aÂ~áÝ�;ðGtè¸”Á�4u?-2Ó(0"À8:^c´M'„Hßf0ˆV|ÝÉAgÍ´3ÚÏkCŒ×Š@ÆÂ0>ë9§=81PˆãPÆ” %Ï@ªý-Ç(•qÃÒ=N            •  —  ˆ  Š  &T  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  1ô<?xml version="1.0"?><Features nextValidID="26"><Feature recentID="25" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2285-2294" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="luciferase" directionality="1" translationMW="60746.74" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="4069" maxFusedRunOn="4069"><Segment range="2291-3940" color="#ffcc00" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;luc&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;firefly luciferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="experiment"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="EC_number"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="24" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4532-4541" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="23" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9788-9804" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="22" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7188-7204" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="21" name="mCherry" directionality="1" translationMW="26722.72" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="5908" maxFusedRunOn="5908"><Segment range="4538-5245" color="#ff0000" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric derivative of DsRed fluorescent protein (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot;&gt;Shaner et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="9140" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="8349-9140" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="9141-9209" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5309-5908" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="7590-8178" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5909-6496" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4235-4503" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6570-6803" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4011-4222" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2011-2214" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7015-7150" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6875-6996" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9210-9314" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="5305" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="5908" maxFusedRunOn="5908" detectionMode="exactProteinMatch"><Segment range="5255-5308" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="7236-7242" color="#ffffff" type="standard"/><Segment range="7243-7260" color="#ffffff" type="standard"/><Segment name="-35" range="7261-7266" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7281-7302" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7212-7228" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6379" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="5996" maxFusedRunOn="5996" visible="0" detectionMode="exactProteinMatch"><Segment range="6380-6391" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>703bb3a0-50d5-4f49-81f7-512b36e27f3a</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="2:16:12">2022.6.16</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ¯<StrandColors><TopStrand><ColorRange range="4537..5244" colors="black"/></TopStrand><BottomStrand><ColorRange range="4537..5244" colors="black"/></BottomStrand></StrandColors>  8�     *  Ý        Ýs"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕZÕj›äšcô�‡é€z¾z'nri-³š}‚Â¨4�µ€È0¨{p¯RïÚµ€JŠ ßUµÀz½V,—^óý¡ÍX$2'*fSDì©!|´løÏosŠ¡ûÙk‘91k¥lÌ<Åã;Â?- 4LÝ³÷KüE( h\ùBÀ%xHbÈžóê¯Ä EòfR4’Ï!rº«5À¨óÑwNëÍ»¾·3óÏçá=½Ï
Ì®<ûóâûáxËÏ.BR¥NÐ±ê/ïèçä{Oïs¨øŽŽ×¹Ë¨«*¸®3ÊtoSˆ|3ç9÷Ø!5A—`öÛPJØÎµÝ�¼…ÃÜJÄl@Ä@óþqGÏS…}@ƒÿ�ë>Ûâÿ´­‰Ã½Cç!Mÿ<vÿzâúÿ:Ô€LÈazÄ0È!òÐ{ïãAÃ¶çP…8Ì7×¯ûÇòXÑE`8>ûÄÁ‰ÿpÏá@ÄmMáN0÷œs„-Gß�CÔSò4ãðÏ�r×mJmû÷\Aç}²Òqs<@óÞ÷Ã�Äâu»1DºåØÂ�[ðþañ'S÷Ï³ßÌqËýÉÍþÏ<ÊÏÏs=ß,oÏvÄÀ·ÄãQ{¯·3,Çl5€³3Ì Âà}ÏL±L Â+<FÃó6„Â¿3Mt`PûàÏ7ÃõüÈ+à÷Ë»?}P.LòÈïðHÃÄÌðüúøûÌÿ5ûþ¹ÄÃ°ë|·Ï±üP|Íø#aüÔü#á[_¸uZˆThx&º^bŽú§9ˆÎ:–>¢mŽhëò`êÚ®ûè™[à£‹º˜A(ƒò‹C\ƒ ˆÞ"£‡5ÿÞ
 Ú=÷âÓ¾¯êÎ¯þþh÷¶Ï>>�Î8 ì8 7‡Zò¢ÀáËêö;>"�~¸Ì/®9ËúÃû[ÓëëóŽ<;Œ>ëÌ»Ï¬þÑÄ°nþ óïóàŸ©GÖ�CN$n“ÞªU@àP9k{õÅYFãªŽ‰à.î
GÑ¸O€Nî^@_Þ:SíeN�¡#­I"#òâˆ‡¸%äFþÑþ©-"[¹4’JØ¶é¦´š™z5EafÑè©£N™`§VTÖM·V­Õ•6ª­ãk’ˆ*/W¶Ö&é¶.äæüÿ—¼ý+ÏÚï?Ø8yjªš˜Ñóì>á9¯E$„ê¨ù¨Ñ?V²[`¶N*øˆVŠo;u¯w]œO6T‰Sàùa!9{v–Œ£;xüêô°ø²=8ÚX[\ÌÂ£&€ÎëÎ¾ÎÞÎ3°²°ãL&Ó·µC	g
ot[@sAQv!5PôÕCÐ_%T<Ê82ªöC¼ÿøq6ÝU±ÎÔ´BWñÐy•ô2¯þ;û#;¾+Çøó§ÁŸ‹Ï«¿¬2êí“·8�›´¬"BÊÎõ8"7ÿÊÓñóŒúo	y²èK×ð”w›=àÓOx%Ði4LBbCçD®… ƒåçw‘AÒj	¸Îã…=)úÁU‚Nèo]_|à“*ª*54Ñ§3EUA»QFú†ê¹À.í \UíÊP ¶¦ÕPn·äoªV•XR©[[•&fW ¸t§Ö:[HC~nÓ‹š²¶öJ>ÿ,‰yÆp:}¸?Ò8ÖóýÎßôjm5•ôôðP<LÑH/�z›Ï½½.ih£ÀS‘%$¬ô¥’£5Ê(öŽt6È"Üì² ˜:ÚÓ¼+õÆÔ1)ØoýŠ#US
NúÂûÆÊ-” óH¦ÞØ)ƒMãe®éâØöòQŽ«ˆx!'µõ-®d‰Œ1ñ(î�Ã-g–|ÏvM©TŽÛhrºÀ1W»PnŸ8¡Ò±‰{#^­6êž­ôÊ¸MUÐPÕcÍU@Y@ÇpV(Yížëê­fšÚ›@¦‹¶vj&¤Ueud¼ÍÚ¿ÅR=øråöšm‡i~eVC&ÜCú²ìÌ«aÂ~áÝ�;ðGtè¸”Á�4u?-2Ó(0"À8:^c´M'„Hßf0ˆV|ÝÉAgÍ´3ÚÏkCŒ×Š@ÆÂ0>ë9§=81PˆãPÆ” %Ï@ªý-Ç(•qÃÒ=N            •  —  	  	  Ü  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ,�<?xml version="1.0"?><Features recycledIDs="0" nextValidID="25"><Feature recentID="24" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2876-2885" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="23" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8132-8148" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="22" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5532-5548" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="21" name="mCherry" directionality="1" translationMW="26722.72" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="4252" maxFusedRunOn="4252"><Segment range="2882-3589" color="#ff0000" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric derivative of DsRed fluorescent protein (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot;&gt;Shaner et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7484" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="6693-7484" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="7485-7553" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3653-4252" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="5934-6522" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4253-4840" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2579-2847" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4914-5147" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2355-2566" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2011-2214" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5359-5494" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5219-5340" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7554-7658" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="3649" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="4252" maxFusedRunOn="4252" detectionMode="exactProteinMatch"><Segment range="3599-3652" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="5580-5586" color="#ffffff" type="standard"/><Segment range="5587-5604" color="#ffffff" type="standard"/><Segment name="-35" range="5605-5610" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="5625-5646" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="5556-5572" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="4723" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="4340" maxFusedRunOn="4340" visible="0" detectionMode="exactProteinMatch"><Segment range="4724-4735" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>703bb3a0-50d5-4f49-81f7-512b36e27f3a</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="2:14:48">2022.6.16</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ¯<StrandColors><TopStrand><ColorRange range="2881..3588" colors="black"/></TopStrand><BottomStrand><ColorRange range="2881..3588" colors="black"/></BottomStrand></StrandColors>  3^     3            s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕZÕj›äšcô�‡é€z¾z'nri-³š}‚Â¨4�µ€È0¨{p¯RïÚµ€JŠ ßUµÀz½V,—^óý¡ÍX$2'*fSDì©!|´løÏosŠ¡ûÙk‘91k¥lÌ<Åã;Â?- 4LÝ³÷KüE( h\ùBÀ%xHbÈžóê¯Ä EòfR4’Ï!rº«5À¨óÑwNëÍ»¾·3óÏçá=½Ï
Ì®<ûóâûáxËÏ.BR¥NÐ±ê/ïèçä{Oïs¨øŽŽ×¹Ë¨«*¸®3ÊtoSˆ|3ç9÷Ø1ÄL>?=�<Û|7ø\2¬N0DÿÔÐ<Ø}uQ7Õþ­?çã„÷!€ç¹÷¬7çý0çëãsÛ]pÃ�õßÍ±œAÃŽ7!:ÓŸ9Ä<<Èl1ëP‚|:ÿtÈn·ÇQ¶óMsß Møßör8 4ë?7ëOŒÇ9çN²=ØÞµ=½ÿM¾4\ ÿb³ëÏ2�Ó]ñ8²ŸMÏ­GÿlúÏFüÎÒËÖ¸òóÁü;ßìÄRë—croÃù‡Ä�OÜ#>Ï1Ç/ô'7û<ó+<yÿ=Ì÷|±¼=Ûß�Eî¾ÜÌ°;°Ô"ÌpÏ0ƒ�÷<2Å0¬ñÌØ<J
ü8<Í5Ñ�Cïƒ<ßÔó ¯ƒß,2ìü}ô@¸3Ë#¿Á C3À#óëàGï3ü×ïúçÃ­òß<rÄ#ñAó7à�‡óSð�…m~àiÕj!Q¡àšéyŠ;êœæ g8êXú‰¶9£¯Éƒ«j»ï¢eo‚Ž.êa¢Ê-r‚#xŠŽ×ÿx(h÷ß‹Nú¼«:¿ûù£Ü0^Û<øú?8àt°â€ÞkÈ"‹ S‡/«Ø8ìøŠ=øã0¾¸ç/ëíoL¯¯Ì>8ðî0û¯2ï>³ûGÁ»úƒÏ¿Ï‚~¥Xzu8‘ºOz©TU �@å­ï×eŽª:'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒI+bÛ¦šÒjeèÕ…›DHD¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸;“›óþ^óô¯?k¼ÿ`áåªªjcD<CÏ°û„æ½’Cª Cäz£DpýZÉm‚Ù8«â!Z)¼íÖ½Ývq<ÙR%O€#å„„åíÚZ2Œíãó«ÒÀWâÈôãial=s0C
Œš;¯:û;x{8ÎÂÊÃŒ10›NÞÕ%œ)½Ñm eÍEØ„ÕCÓUA|•Pó(àÊ«ÙóÿáÄÛuVÇ;RÑ1_ÇAæTgÐÊ¿øïìŒîø¯ãÎŸ~/>®þ°È3«¶NÜâBnÒ°‰+;Ôà8ˆÜ_ÿ+OÇÎ3é¼%æË¡/_ÂQÜzl÷ƒM=à—A¤Ñ1	‰#�º‚—œ9ÞEI¨&ã;Žô§ëTJ	;¡¼5u}ó‚L ª¨¨ÔÓFœÍUíEêªç ¸s´�qW·)@j‚ØF›UAºß‘¾©ZUaJ¥mnT™˜I^‚áÒŸXém!ù»Ln.jÊÛÙ(ø{ü²$eçÀ@éöàÿHãXgÌG÷;|;Ñ©´ÖWÓÓÁ@ñ3E ¾5êo>öô¹¥¢�ND”’³Ò–JŒ×(£Ú9ÐÛ ‹s²Ê‚`ëkNð¯×PÄ§a¿ö(�UL);ëï(´RRƒÍ"›{`¦7�–»§‹cÛÉF:®!à„ž×Ô¶¸E’&0ÇÄ£º?µœYó=Ù4^¥R;m UÊë Å^íAº|â„oJÆ%ýì�ýxn´Ûªz·Ó*à!5WACU�5UeÁX¡g¶{¯ªµšhSjmš.ØLÙ¨Xš‘U•Õ�
ó7jÿH÷áË”WÚi¶¥ù•Y›qêË³2¬!‡Uû‡v4ïÁ-Ó¢âS<ÑÔü´ËL À‹ àéyŒ6Ñ4hž#}˜Â!Yótc%UŸ6ÐÏk=­3^(Àû¬æœôàÅ@#�CR€—=«ô·¢UÇHõ8           •  —  	  	     !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  (<?xml version="1.0"?><Features nextValidID="22"><Feature recentID="21" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7523" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="6732-7523" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="7524-7592" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="20" name="CopGFP" directionality="1" translationMW="24523.27" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" maxRunOn="4291" maxFusedRunOn="4291"><Segment range="2906-3568" color="#05fd14" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;green fluorescent protein 2 from Pontellina plumata, also known as ppluGFP2 (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot;&gt;Shagin et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="19" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3692-4291" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="18" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="5973-6561" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4292-4879" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2579-2847" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4953-5186" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2355-2566" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2011-2214" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5398-5533" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5258-5379" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7593-7697" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="3688" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="4291" maxFusedRunOn="4291" detectionMode="exactProteinMatch"><Segment range="3638-3691" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="4" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="5619-5625" color="#ffffff" type="standard"/><Segment range="5626-5643" color="#ffffff" type="standard"/><Segment name="-35" range="5644-5649" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="5664-5685" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="5595-5611" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="4762" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="4379" maxFusedRunOn="4379" visible="0" detectionMode="exactProteinMatch"><Segment range="4763-4774" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="0" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2279-2321" color="#ffff99" type="standard"/></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>8984b589-cf3a-4b62-9fd7-cbb814bc6791</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="2:15:43">2021.12.28</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  ÅX     +            s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕZÕj›äšcô�‡é€z¾z'nri-³š}‚Â¨4�µ€È0¨{p¯RïÚµ€JŠ ßUµÀz½V,—^óý¡ÍX$2'.fSDì©!|´løÏosŠ¡ûÙk‘91k¥lÌ<Åã;Â?- 4LÝ³÷KüE( h\ùBÀ%xHbÈžóê¯Ä EòfR4’Ï!rº«5À¨óÑwNëÍ»¾·3óÏçá=½Ï
Ì®<ûóâûáxËÏ.BR¥NÐ±ê/ïèçä{Oïs¨øŽŽ×¹Ë¨«*¸®3ÊtoSˆ|3ç9÷Ø1ÄL>?=�<Û|7ø\2¬N0DÿÔÐ<Ø}uQ7Õþ­?çã„÷!€ç¹÷¬7çý0çëãsÛ]pÃ�õßÍ±œAÃŽ7!:ÓŸ9Ä<<Èl1ëP‚|:ÿtÈn·ÇQ¶óMsß Møßör8 4ë?7ëOŒÇ9çN²=ØÞµ=½ÿM¾4\ ÿb³ëÏ2�Ó]ñ8²ŸMÏ­GÿlúÏFüÎÒËÖ¸òóÁü;ßìÄRë—croÃù‡Ä�OÜ#>Ï1Ç/ô'7û<ó+<yÿ=Ì÷|±¼=Ûß�Eî¾ÜÌ°;°Ô"ÌpÏ0ƒ�÷<2Å0¬ñÌØ<J
ü8<Í5Ñ�Cïƒ<ßÔó ¯ƒß,2ìü}ô@¸3Ë#¿Á C3À#óëàGï3ü×ïúçÃ­òß<rÄ#ñAó7à�‡óSð�…m~àiÕj!Q¡àšéyŠ;êœæ g8êXú‰¶9£¯Éƒ«j»ï¢eo‚Ž.êa¢Ê-r‚#xŠŽ×ÿx(h÷ß‹Nú¼«:¿ûù£Ü0^Û<øú?8àt°â€ÞkÈ"‹ S‡/«Ø8ìøŠ=øã0¾¸ç/ëíoL¯¯Ì>8ðî0û¯2ï>³ûGÁ»úƒÏ¿Ï‚~¥Xzu8‘ºOz©TU �@å­ï×eŽª:'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒI+bÛ¦šÒjeèÕ…›DHD¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸;“›óþ^óô¯?k¼ÿ`áåªªjcD<CÏ°û„æ½’Cª Cäz£DpýZÉm‚Ù8«â!Z)¼íÖ½Ývq<ÙR%O€#å„„åíÚZ2Œíãó«ÒÀWâÈôãial=s0C
Œš;¯:û;x{8ÎÂÊÃŒ10›NÞÕ%œ)½Ñm eÍEØ„ÕCÓUA|•Pó(àÊ«ÙóÿáÄÛuVÇ;RÑ1_ÇAæTgÐÊ¿øïìŒîø¯ãÎŸ~/>®þ°È3«¶NÜâBnÒ°‰+;Ôà8ˆÜ_ÿ+OÇÎ3é¼%æË¡/_ÂQÜzl÷ƒM=à—A¤Ñ1	‰#�º‚—œ9ÞEI¨&ã;Žô§ëTJ	;¡¼5u}ó‚L ª¨¨ÔÓFœÍUíEêªç ¸s´�qW·)@j‚ØF›UAºß‘¾©ZUaJ¥mnT™˜I^‚áÒŸXém!ù»Ln.jÊÛÙ(ø{ü²$eçÀ@éöàÿHãXgÌG÷;|;Ñ©´ÖWÓÓÁ@ñ3E ¾5êo>öô¹¥¢�ND”’³Ò–JŒ×(£Ú9ÐÛ ‹s²Ê‚`ëkNð¯×PÄ§a¿ö(�UL);ëï(´RRƒÍ"›{`¦7�–»§‹cÛÉF:®!à„ž×Ô¶¸E’&0ÇÄ£º?µœYó=Ù4^¥R;m UÊë Å^íAº|â„oJÆ%ýì�ýxn´Ûªz·Ó*à!5WACU�5UeÁX¡g¶{¯ªµšhSjmš.ØLÙ¨Xš‘U•Õ�
ó7jÿH÷áË”WÚi¶¥ù•Y›qêË³2¬!‡Uû‡v4ïÁ-Ó¢âS<ÑÔü´ËL À‹ àéyŒ6Ñ4hž#}˜Â!Yótc%UŸ6ÐÏk=­3^(Àû¬æœôàÅ@#�CR€—=«ô·¢UÇHõ8           	  	     IÕ      IÌ®ZTR

SMP4      D¦ao  xÁÉË·ëšäó¼îæi~Ýû~ÍZkï]IÕ^{oS	•T¥
ƒIQDÑTÊh 		$’Ì"Á�QA0ˆEÉ@ð8ã_!Ž:Ñˆ¨$U©Ú«ùš·ùuOsß÷uzüûÿ0ý¤è!…œB?äã~<îŽûqß¾{÷£÷_<¼ýÁ/}ý£_üÁ/¼ÿúg¿üÇåWåí/ÿìË_þ¥ŸþË_ìO	øøSÂÃôSüMÿÆÔCÓoãÿùÿþñÿûÏþÏßý=ü“ßý½ßüÃÿûŸ¼üÞ7ÿô»ßü³—ñéÛ?üðóoÏß¿|zýþûóë<Ï÷ÛR¶Òš†ßÆÿŽø¿ÿþ' :(!)€r@A
€ ˆà!€¦A‘20Â@eI.ˆt¡u ™²9ärBÔin‚À–)¹à�  )ƒ”‰.§"[‚D2Â2@WU	jNŠƒHQ ‚àÁÖ	ˆ„¤ Né¤ : IpH¤A¨îMNH7@'5��à³à4@9¼A�Š$‚@'H‰tÒ§œt8Íh€)©&¹ ºÜ]S²ÔÊ¶Â\0§¿Á›7YNÀ Òœîµ!…¡ÈW(2�Ó/@î[KCf,Kl!äÆé-¶(Ë%¬�R Áé?‚à­ÕÈÔ[¨µT–`AÓ¯@ðæM!3ÃË¢P;X$¯¡¦”™7ÝÕ-D‚€ÜËæJ]ÚZ«0æŽ¨eÖØ#H´ª§‡Ð®¯—.tâôcˆ@�ò¾bY7ô]@¶¸UÅq,óóµ™ô(Ÿ¾„ùÖBwæÛ<3¤.6ý"¤¥Y<¤Îî—euîÆ4Þ×r­Jyl]ãô3ˆ€×j­ë‡ëVÏ]‡¾p=7	9Fqú
"P@Ë9±¬ë-zêåRoån›õò¥œ9„H›þ8À·Rb|È­ÞžŸi§Mÿ5Ðk)Ûîm¶§×—Çî!´öz^.ˆ}òàœöÐ±•[¿ÿÁnùørNñ!J§ß‚dVê½ôïß¶öñókOƒmAÒô@ZµÖ�·Û¦Üg¦ÊéÏC ·Õe�ÁÖò¼¡O]8ƒÏ÷5ñKßÿáwxüÑc¨r*Ûôc@i…»Üoåò:ç~GjŠh,ä¾³¶\–và^4úô[è[ÛúáÔ•Ûùå†´34båú¡Óz»ÊwÖ‰œþ-HÆ6ß½{÷î°¼~óùòöñ*ä"Pïk9¾;�¯×o¯ñq|t|xº4{8”4ýH¤_×u|ûðo~þÞÞÄRƒ‹Ó¿�î[EwÌiÛnKû}-÷—;ãs4}Ð²–îá„út¾¶zˆ»Q[¹Í‹ï†š8ým`Ã¥ÅÝ›Ü>|¾ÞíÍÐmA)Ôõ¾ÆÃW'¾|úØìá!‡Ü¤un|ÿö ùÓÇó}ì¿ò<ß>TŒ}J-¸8ýC€Ú~xËóù¼ tûa©óëm¶>¾¡éürû!­-Ûô« •KÁÃã»Ûüôé–ÆáxÝm~>W¥ã1ÅÛåóYèÀMï¡)¢”-î÷º�¯K|ØÇ°šþ*°áµ…ÃÛ¸>ŸŸ·Ç¼%Hš~éó½ôoN¹{þæ#ºÓy£‹Óß‚ ¢œïøâ‡?ðá÷^ò»‡ã\¡S9¯ñþè{üþÏ¼ýêáMÆýõÛ-æÜ7„9ýÐÚºïâVŸ?oèãP!C›ÃûŸ—çË6v�¢B+P7în×ùu)Aù°;¼Ü?ÝË8ŒÑ�Òôl¬æûÔß·ó¹ïE£O;H¡¶ûÆÝÃÁ_Ÿž–a’É éoC
�uKáíÎçËÇéa¿k×ë§—Á†}1‡¦ÿ"ØP‚�zmåu‘¥á”ŸçÚÆMFŸþ!º/ã0ÜÖõ\ÉNÃv_Ã›_ü!Î?ÿý+v��yl—çkë£¦ˆ¦¦îMO¿_–¶·A2 j[ñíºÜ�S
0úô3"–y�ï¾—×o¿½ø¸?eÀ·ëÖÇÔÈé7!@,Ë–_�ëüÍ‡+ŽÙ* M"Pçö»=çù¼aLÙš8ý=ˆ,uŽa7l¸•ÙœôéA ë¼Î»·‡þv}þt{8ŒÎhúØ¼,ýá‘Ûíùi;í´�ôé/@êÒb?Œ×õ~®!åH£O_@…»i8Îœ/Wïó¨@úô·á&Õë½ß=>¶ÏŸžýqÜÑ*é€‚æS:DJ)Ð	ND¤@'8�©iúÔƒ‘š O?€HA¤ :@ RSú´ƒHÑ§¯!R è D:)ÐAŸ:ˆÔ”ADJ¤@}úÓA
 súË¡ÐÂìc;/—ËuM»Ã¨u[–‚Ñz}z‘šzÐ§‘DŠ>u O¿ ‘‚H‰„ ôéÏ@±¬·îðå1==ø”w§ÁJ�4½‡@×¬–OÜ®/×Íb~8…íõåvÇhcpÒ§CÅ­„Ó¡kçÛë«ÙnÈñ¾µõ^<¦‡}\Êm™5¦D7úô5DºÖVÓ¡ë¶ûõ|7‘éÓ¯B —Û¥í¿újÀ§�ÿÃ»} c­7ç—_íqùþçkÿåéÔ*$MÂô¯@¤×23�¾z×}xúü™]p'}úEˆ ÊRÑ±;`þðay†âôUæ¹ö_ÄõÃËË§´èaˆ(—™Ãûß|÷ŸŽyìª,øôTq�8æ¬õ:cŠ	�>ý§éµ¹â®G]æ�ìcT Oÿ	Dªø:ïo±]o¯ŸjêPÁ§ÿ
Ri°<t­´ë6Gë–k»®0ËŒÁ§ŸBdÕæ8<˜žo—û<Æ@Ÿ„éïCÚ‹‡Au}i
}ì= ðM›ò.4-¥”ÌÎ,9éµ®[:<¼·ùéå[bŸw�Ó mæ}ÚYkuÛŒv)¡¶Bêb_Ì¦ß‚HÕíºª;0_^.iûhh O^Ûº¦Ã±×:{.Ùzv"§Ÿ@d[UOÛú|»(f&€ü^î<>¾Çýéå[»]t7
š¾†¼,D¿KŽu.	]
2›�o@MÝ`¾ÕY°>#Õé‡Yµ­6>tv[_ž‹âØç!J÷m=¼8Ÿ?~û1ÖS?0púò¥®
Ç‡q]/óó.u §D”yÞòþÝÀ‡§oÓx
Ü²Ãk)K÷uyý|^Á~°Ôb˜þ'¸
ã.*Ìó-®f6´0ý ‚6/b?<nóíu½l)öÜ¨Vëê»Sðù|½ÆúÐ�´éäm­�ùqu¾>¿”>�)oœ~"[[\8…®.ëÍe9fNÈËVbÎÙ½Þ¶£õ§ß€¼ºÅ0ô´²®–Sö0ýÜ­ìSŸ4_–£õ‡–W^µ 9$ƒÙô×àÖ:÷¹-¾?>2~¾}¯ýnc“HpúZ¬kõ´w[¹ßÚ†„‰œ6ý¯\ZZ©ñx¶åååºîs?2(@Õke<�óëëÝã°‹dFjú£\Õ9tÉ°µË!€Ó¯BòÖÖÎrgIõ¾aË¡Bë­Éi„à* Ù˜zmeöf)Zïäô—àª%4ërë…KnHHà4@p©l‹ÒØ�õ²¬·BcŠ
 §rÖÀ¾W×´ÝWù.IµÜ‹”™•DH­)ÅÈæe&ÆÜE´¶úÐÅ`�®ºn
ùØÅ¥œ·Û‚!Ç „Ù!´Ô¬lU]ÞUÛæyÒž!.¸×51Z•êÜZØïvázÿXoÀ.D·@3N=Ü+ŠqŸ:¬e½%³i„CÍ[MÖ‡ÌÖjñj‚…&\ÔóÈ\Û6»bH¦¿Á½••H»`¥Ü—ÕCŒ!�múã˜¢€šGh¾¶¢Í-1:mú3pHj¾°v».…e›å9YFAÒ¦r*{‘‡¸ë:”eáÊ��‚ƒ0â4B€ o¾E¦˜‰º®M�‰Qæ O?€ ‘rÔº©†~Œ¬å¾®2v#@púu�ÃÕ¬Tö}D«]»6„h1@´é/A€WÑJl¸•ùÞ*-´‚ $8 &o6 /”Éé_‡Ò½Uš¥œL>—*!X¨é ‰Õ´ÁÅCË­�×Ñ²YAÓpk]K@³J‹¹§|Ùª#‡d¤ôé× 8œ
„nì»6ûën	
tR.ÁÛ¶)Žã¾âör]ÆÜõ�0s
³Ê¸Œ÷Û|QwÚ§íR®]Ù$zpÚô/A$|úW!´“¼¸‡Þ"›7©ä	múäµâŠ]€0·Æ`É¢"E	uó9†°h]œ1^ã†F‚ÑŒ”W+•]b«mm—û e[¶ž	Imú‹D@.§Â¦û>Ú²^Úª”2-ÐÕB3ÍW¯tÆ`Nrä•Pê9Å•¡O€šWSrKN¥ê%3'R[k²jú�S�{5w)­¨1008œà‡±¢À†>¢.bM]Tji�¾Ëq¹-3cº/uEA€\‚ ‚Z«ÆÜuuÖD&7ƒd€{qÅ�àë&v=´]—bbLA€œ"äÑÊ�Öõc½ÝæóÖ’å`0:Ü$ãôßBr�`A;vMmŽk""@9A›¾€ATØÀ>�lX¶ªÖu)ÔV
,púª)¸àkª9¤n¶¥®M»fÙ¸î§äh™ò¶!…±«VÚ½}ˆ„\FÚôcHp¸haË¡Á›×¢æ1PÜ[í˜-´µÖ6Œýp»×§6–bm­™‚3øôŸC‚à ¬…ªú�Õ¶²5¦dÉ 9	púe-;=À¬¹µœ»�Ò}ÙB`�Ô¼5� Ý\ ¦‚D'©1
ÉRlln-z‘ªVMˆ‚ÀéobŠ¢`$áœH3£{krÒœþ.$Š„{kÎC@s®f±‡±%Š�Š$(sI-Ç�hô5”æ`€EŠ 4š7ÌŒ %M_Â­u-+šAPC° Òš7ÈÝ%#Á)ŠÓ[H(Àá H$‡€Ã"hS†[ËtN	"ˆ`ÁXÃ,Ä¨PU@ÈR6ßTbŒÁP±Òe6%°˜B�W[ƒ*Å@PîT"5l�Bh	p`Ê§¯  „KMD‰– šAÞjl‰´I6or( òRÝ-X¦yõšäPÒÛŸ€—×ôæ0 æ°i€9°º+‚TØanÑ�àtD‡ÁCEtØ”`n. æˆÌÍå¡Z…M<T`hÁ@·jf–�^å­ tDƒA±"B€9€o¡ªVa–Í`îÕ·ÎÝén†¬^9Â[Ù–T«b53BE„ s«ˆuWZ¨VÍenÑ­¦ë N	"RtN	�è C¤“ ƒ t®­ßv-d„|í7©G¹!lZ‡9yëòÖ¡u-ØzÌ»ë®…œ€æUÕºm—??nèA:	§9 N	ª]�÷Û1„Ìe«ë†ýöåïýäÞš˜ƒõV)JM¾�4Ë4N‚ZñÒ…>7àÞš%Ä@5Ô`]è\Û¶1Ö¹¨%%%§‚ûÆ.÷âz½¯UêºNÐZš,…@c+.ëbrÍÜ,©Yeîº`^ïÅ<K4ýˆJ�ä`c·Z�CÝ˜{`k÷êèƒeºµØDÇÎºâóº!y×gØº¬kLÁ‚Mÿ>DÀW´ØÖ´Üî[H;K›~"T·Íó +K©Ì!‘6ý"T‹B©:oÕ02Ð¦_‡ Uo‘{j~š[ßFN"àen!ö(óeÑ:MTÝ-zøu½FîÓ¡¶å¥µ‘9# ¨­ŽüÐ“—r©c<	šNÁÊ•ù�šßÊL¶x|ŒËÓçKÃnìªCØ´–|:ä—åÓÝC7š~›Ï}ÿ8Î÷ËSòqˆ¬¤Oôr÷p<¡Î·ç™c×µäœ~ lÞj<�Pn¯7¤n‚¨lðuc~xè¯÷Ï—{; QV—¥òô¥×ç—O¥õù°{èï¯ß}öaèhúÀgÇðØÛz=ßÍBÞŸ¢>^¿¿/»1¿ÏÝ|ýü|ÓãÞªšöÀ¦µ¤Ã£×óë•qèb‰-rú-@©%ïÆt™_/mÔ EúôS@�‹åc[×k½i—³\T6h)­{sŒ—ûómélçŠê\~Qy<îÂåöáw�
Ð4B¹ms¿Ü‡×ï~îãñd�n”º…qì—Ûå<¯]é¾z�ó·Ÿ7ìÃ°Ø/çOç[7ì­P.óíÌô°^Ïg�c¶lÓ Í[í±<}º½Æ.ç‡ òòz]†ñí8Øóë‡–R<>æîååé<Ú)™ hú’Ñçu9¼Ù÷ÏŸ¿yf|Ãf€¦D ›×¸ïB™ŸÖ6Z¯Ô¤é·¡)b+…‡Ãy~¾Õô.4@Ó¯A ´Vïû¶Þn—¥&;¾éU>÷‚wC/§‹Ó	�Þæ€~è°\Wï»Qé"PçM»7}üt»œÃ0*@Òô×à&ÕÛw�Ã:¿|Ä°S¨€¦ÿš"¶¶Æî½•Oçv»]h”4ý)HÆrk8Ãr½¾–t¢‚¤é+t­^ûa÷ùº))¸  ­,ëøå|ùù'`·?<îçåéyÃnèšLPZa÷�}¹–yƒÇ7§]»}þàãî�\ÁÅéW )¢”Mû7Ÿ®ß\çî´?>†ör>/©?<¼]—ï>�·Ã›1«šþÀïÕ‡ãØ-·×'Ôa8�âýÓËçÙN{V4ýÇ Ÿáã~Ï²\`àFŸþÜä~i¾ÚÛíÓÓ<ÚÄ;!¾VtÇ#Úõv›“ãøîíîúñå’¾Œ{ÁÙ²MPêŠýÃ°®÷×VQš¾€¦ˆÅ—qÿ&òòòéÆãIÓŸ„ ¨\¶±?Ü.—o/ù8�rˆ¾®­{<ùz;ÏKî i€ nØ°ÛwµÜ®‹s7úô! ­x9��ë}~9Ë<=žúøtý®µ±Ïh‘.rãã)Ïíå~N–ððð6¾~¾^N»cJÍ éÇè~÷šÞË.óëmCg- ðrV8œŽËüôëã¾Q”¦z›a»Ã€už›íòØ’|ú5ô¶–Ú=¾^®çÐ�ãš«4�Àf×Žo:Ìç§ŠÝ~p š~ÐªÇôPçí:ß5Ž4±åàZ†/Þ>|ÿóµ{ØEwQ9ÔíZÒc7ÖùÓ©ƒ M#°µ{‰ïjûîÃG½¡:ä&_gôo¿ðéÃ‡‚áÑLpóíF¼}7^ï>—:v»Ó~W^¾}Å›ã!ºšFHf.èÞîÃíûçïÒ¾;YÔuÝÆý›r_ž.—0dé"ü^–Ý›æ×ÏŸ–¡ ‹l\�‡Ým=¿,4å7opþþãwÃîôö8ž/°1F¢};#žÞÚrùô¢@¾èðòùÃùv…r´U·ÓÈ×õùzÙh‡·ïüõúá¬lÃûcß=?ýü¥�JÓ �^æ…»‡];_Ÿ>£YÚ½�íõòrÏi×m±JÓ¯A`ceàüzÛ<âñôe¼=�§ñHNu^«[·Ëh¯ËÍZß¿8^îß¾v½šAÓ ¬÷Ròã›‡Ûw¾ãòî8Úõþü¹åÓÎ@ ª¥Ôá1¯åõósŽû.º@¾�;,Ëý¦šR¿?äu=?•´éÓ_ƒ 6-%¼{“.——�>¾Ù‡\,(ñ8¢ÜŸ–9#iôéK`Ó-âñýŸžg;è”4�À:ou8=z¹¼ÜÖ�ºþËë|¸mïÞ�©Á¨ÍÍ‡Ã›åõr¾”œÒãcæçg÷]XÍD¶òºôoG¼~~~FÚ=»\^ž®C7<¼ßÛýÓË‹íöè2ø]Þöéå~žï-ö‡7#ÎO_v½PIŸþDP®’‡Ün¯÷³0îÞöñþüùœÇýl›"Tn+oŽ¸Þž>�=§1q}}~A8¤ £O_C Úês¿?r]¯×šSaÎinântÍ—×8Xh¤O#D:Öºâø×r{ÙìÞìÀõrÝòq´¼d¬\-íŽ¡,ç{›ãÛ±O¯/6v`�ôi„ 6/KÞ?ÿðòŒÝØ�%TNÿDºoâ~d8ß·-Æ.×há÷²å‡7¸]¯OÛ±“9éÓ×émÝÐ?<¸¿œkÎƒ…Júô5jóµå·Šçù|™úÃÃi­ç×g ïRÎééÕ�}Ÿm)gÕæÝé}?¬—oîØFPàô«ÙêVÛáÑôúúr«!uïìØž/Ÿ_Ðõc1Ñ§=D¶²JýÚz¿SCÈà¡67¥Ç.Î×û½ä¾ï8E°±nÞe,××çëÖŸöï»öúúÝ‡¥ÛÞw¡»Ü¿Y¶¸ß	 §ß„Hok%�Cz]/çë½Þ>,·—Oß…tÚÓk OD¶ZšÅáey½‹ùø˜à/Ÿžñ˜NnpN?�@¯¥Ôîm€¿¼\·]·�B¤ m›ÃñíÑ¯ÏŸÎ:=ìÇf’O#DzmUáâ­~Þæ’l||ìîŸ??Ïq‘>í RµÔˆCìªŸ�ÜuF3‘¾l÷pxónðOOßÀŽ{SM|Ùžö§TÏOß#†ñíízùˆ°÷ŒÍæÚº7'Ãýåìë¡$è@ã¶ZÿÒív=‡|² Ò§Ÿ@¤·¥0Çz^Î×iýãˆxy½}ŽýØ¢O_@¤W/âiçëv~¾^[>¾íÃýüúòâÇÝ›Ü>½~j}„[å´‡ÈVæbÝ®«~»^kGÑ§/!›jH‡£ã|«s¯>¸ 6…ýCÀõéù©�Ã�7„i„lX1c{™o·%ô;ÒHÊ·uæáÍ›ÝíòáyÝƒG‘>émÖƒÅû|¾#]2ç´‡HowÕá¸ãu½¼^ë>Å\Ì¦ß�ÈMåý®›çËùEqÌÝœ@Ÿþ$Dzm†ãqœ·ËË+ûqPhœ~aÃæñ°(óËeÎÃÀèœŽP[Ò>g¬ÛõÞÚ0(ÀèÂ†ã>um[–ºänwê½]ŸÖs¶êôˆô2uÇ}·.·ó­ô!åfÁ§Ÿ¡ÙLÆ]ßÊk)9‡e½¾×Ô‡^äôC¨:Ê¸Ïæ÷ùµ`cj�>ý:TUÌw}¯m¹/wãaDx�Ÿæ…ØY Ùt€ÈR× ¾7ßÖ¹6ã!-6[>¢+õi^·N©Ý__Ï^º]bPði€@¯î-�‡Ní~.5²‡f-–VB:Œõ¼�ëŒÜçÔÒôÇàm†ºÃ!Îëv)ž¬‡!ˆ¨¸“Ý°Û–m~=#ç‡C.·óürõ°³¾%ÀËÚlØÅa«óe©ÈùpÀ\ÖsÝº�2NÿTYCúl[]71¤ÄéUÜÑõÇ¸Ôr�Å!ö §ß€T»=±-×f1§hÍ|:¢…!Æ¡†º,e­Š‡cg×òt½YÎ}£Ùt€Ú…>ŒPÙnÍ¢íÒn[Ëõ¾®¡÷žÛýv¿7äœ=
®º°Ån0n÷[Ýr8„û|©Åú>É9ýu¨•µZ;b»nB—SÓ¯Cò�[Jc&ë2¯Ž˜Ž!]çùÖ°9":Ù|5¦¾�ÐR®°’Yà´‡ûZ¹å}¶vžÏ³lèèm°‹#´ÔËf–Ž=„ûåZ[bH£8í¡V
ó“·­Õ- ‹t°ï,,xE£º~oP™Ï¾Æ0J~­·­‘1jú)ÄgÆ®¼”rs�aœ�WT¥Ôµ¶UÐB°0ýuHp®1vCT-WŒÉ¢:mzÁ½Õ†”ÝË²%O)$§r4+R�I­46X&Áé Wm5w!›ä^=0"pú�Øb“!w1´R÷ÀD™ê¶yÓ€R.[aßí»Nu^nc:¤NÛr•»®sl*KöœÆY¶eÝ‚u1»pú®º•À]Š­Ôë½ªYA´égp5+RN_,äa„õvs´3, ª¨-ä,[]åÆƒhÓ/A‚¼ÚÙu!5¿Ý!…nó¹ÞÃÖ!$d�Ó¹oJ}Š®{)-0æ ³é?ƒ¤ŠZ,�`Õ¶´@vH"¼­¡öcg®y]—ˆ}Þ-¬å¾nf!†\iÓŸF‹EÎ®KD½–3ËDhÑ[Y#‡˜­¶y�™úcê–mY£Â;Ûj»³EKÁ ƒ8=Bèe[¢wQÛºµº}Tê¬�}K€  ‚ÓÀ†Ù1v{Ðï÷+�s@®‚ )B £Ö²)t=¡²^‰Ü�)´:Ïîì÷C¿�BwÊ}[¶ekÌŒIÆ©ƒ¨Ô¬³4ÃºÞgä~ûâ[½[‰b°Èi¹·Re;vTmµ:C°8ýNÅ†æ–»ßÊÅÙïÇÁZ½X¢õ$¨VQÑÇ÷9ÕÈ-M‚¬%ßl‹¡Ï°º¶bÊ!ZH„Fl-t£µæ—Õª…¬¾Š.pJA–Zr6¨”!Y2
š"$ºZ
Ðí{WYî÷Æ.F0  šVn!ö9»¶uñ÷±³µÜ7·cr£T
Zê:¶y¾!Y—IIS„d0÷êÍ¼;b|öë¼‚©OaŠÔ4@­ÂmÈæZj±ªµÕ¢Bôõ>ûq¬—m9KÈ¶óä„É@¨¡@±ïàmž«a—¯m¾«Y>05´V¶´·ê}½ß-¢Cv£CS‚@y•vÉZ™—¥“%‹tN;ˆî37SJó²lÖºÝ|ZA9 Ho^=zêrj~_¯)ÇÁ!qú§MZCÊ#Mër‰eØ¥¶vŸ�.¦“ç¢Ûk5œúž¾ž+r�h‚S‚S‰ÍÊJq_l»µì‡­Ünq³”Ì¢‰N	©Y5¤ÜyÃ½¬°”�A©É<åDmóì){$„†ZSN1”¶n±�cìï~¿¯Ír‡ÎÍÀ)B¤ä­l[MyHòyYˆ”Øµ0í!µÆÆ#RÑ²n°.1ô©ƒH5bq—¨­.Á™@Ÿ�—*,º$eKäô/K`~`*÷õ’·\²l RjÕ£‡Só¹m†c°Ho+ˆ®ë¼¶¹`´qŒ^Öeë•c†Yhyê!okj;î«®l–“%
ªa“ÇÜÇe.Áº±3a½­%[N£©¬eATÉI‡×PSèbj¬U*1  Æ©ƒäl¡nÆ¬uÙœ�ºÆàÓï@rÉÖº™ÁØÊVk¨9EZ˜~Sé^Jˆ]Ì­.ë¢¨,š�6%È9¼æ”Btßä´œœzä^SHÖ5ÕEÐŒtÚô	.ShÍB(Ìî�]` DN	N@Pi²Ü#ÔÚª–H#½Õ¨ÙµâµR–haŠÐô5�\U9tÙËZÖ-‚Ù¢ B.ÐQlKÝÀ€¹Õµ¥`‰SA@½Õû@j)n›1‚tT±5™÷â�YÛZ7"Dt"]^ÍÙ‡H¶V‰�FÈA9a´6SNµm‘b�\tÚô �NJò)ÒÕBcìC�´n¬}ÌÎR‹<z Í ã” Hò¶YoÙ5·1õYáÞ÷l9! ª¡°¡±4®° hú1ä^B0‘Æ�ºÖ´61Y4N=$(À‚cÅÝD:)Nò)Á]s$en
r—Ddr¯hì:£×»‹
"dÆé?€ÜÄ„Ü÷RÑ‚CòÊà!¦³)ÂPŠ\•i‘‚ P%ÂÕ"2½’¡fŠ„ >EZõRÍsîÀz[¶ƒõ°º¶–='o­n@Ÿ³%GÛšËÉ@�Ó�!d2 îr‘‚¹Ãá‚]dˆ¢Ë«•ÖHFãô�(ðæî4‘"à¥nÁE0œEZŽØU–hT³-zBH/wA!&vÍ¼VÀé¤“ Õ(…h½«•­¶F#-ˆ”tÚô ‰¢òšÜƒà54 °Y©0n’Ja@JÉ€â%n™I@±Ò` AH.Õil­¹$ ºà�`f0ª1¸Óh ¢ �‚0E9‘´ Zÿà»ÿ’¦
ºŒD€�è" 4EP€ M” *t DA$ 8ä šD@2 D@)‚œp Œ0r8¦(ˆÊAd)B¢³. $,€Äå’AƒN�èbË”Y i€7Wœe :Ø:Ÿ"è$9 $ÂœÁ!—C.@Ž–@‹)X4x+µ5e€™H8é D
” A.9 F2Š
Õ¼ 2"HM¯?ýf9µüúþ¾ü><~ÿ¾„öÕ?}ÿ¬õô1íf}ùòé'/Ó{hM~Ù‡aÏpÛ.Á®~�¾€ R°F;ZDÝ¶�­³‘òÍšd¢Aî­&Ë)·ÐTÝ‚¦‚ZµÚÙž]ñµº¢rúË¼UEÏ]ŠÞê7¦ä§µ²BÝ0tä|wÅl]jš~Þ*™ûœXZÝ€ˆ„DMÿ.TcÙŒå}ñgûþ4÷<Äëé:!ùÂš‰XÚ[¶§?Ýóë¾¾!oë§—¶ËyûÁ M›sÜqm——yÉ¹7Fçô%D¨Õ¦t8Z¸^_*;�Ñ§ù¦%C²u¾µÒ…Ì N¿mñ†í;>žKÙS=Ü¦ÿ"Ð°z×÷¹µÛFmèa[_ÂØ%9ý"„M-vGG½>/m´   áê8½ûøê¯ü÷è:Ó¸è××—{ÝÜÀiMë:ÇÓcïç×ó�û½bÜœ(‹§qÌëÝÑwL•Ó½¶…ÝÛ¼Ý__^¥RýÝùþíßýÝ3oŽp§‹Ó×�Bc][ÿUßß?}º­‡a'6"´6u�ƒùý23Ú(}ú¤Ðp¯íðfèŸoÏë~ìS3IÓO! ­nÈïòýõóuÝE+vx5~y:îÆ¤j‚›Êù²ìñ—ðÍïÿóo2Þ¿Õ¹BàôÜäu»¦Ý»wÛùéÛ‹å!©�-Ûô‚ÈºÜæîëQÿù÷§w8«ºdŽ[]wo¾jë§ŸŸñpH	§£…×ó­†ÎØßÒ_ÏWÇ.$�-Û4@ Z-ØŸNõåþñÓ!£¥
Úªòi×^o÷kêw15ƒD@ó&{“úùõõcßvB4ýYt¬Åóî”—óe½…<˜ M"d*·y|óÅßý›ßüü[ètÚ/V2ÄéOA |YËxzS—ëÓ+†a A¬ÃYxÿ0ìîOOßƒäøÌé 7©Þn¾ûÑvë÷ß~ùaŒEtqê!@¬å¢Ã�öxýøÝ:çœB¤ßç§3:Ö|<u»~^-šç·‡ÃíãÓ‡šÆ–oÇyþôr^ö
»Çnyyú|Ùu§èpsù¼åñm
×ùS5:ö?|³ûî_üáàÔï»‡wÑ_ž¾Û1÷Ç4àÓÓÓšNG„Ð´ƒ¼Ü[ènç—›ÿÿÁ[«¥kzàûyÞÍ·cÌ9«jV­ÎŽÕ»´ é$D0ÝIh‘l<IGsAB”  ¢ˆ‡9É¹¼x�€�3ñŸˆ“¶ÛµjUÕÜ�1¾Ý»yn¯«³êOwþšÎÕßô±:’éÀä±Ù6î†§åÃÓ†é(’é-Bòžík¯o¯ŸÞuwãèûis×Ëš]/AV¶Ý/ÑØ Òìºòí·ßâ‹¿ú¿ƒŸ»k{Áô@©;‡Ie»>ƒÝr MM(UüxÚ,¯L]çLÅÒ‚‚}›û»ÏNöñáÃÒA‡7¯ï€ŸüÍrûúõ±ÔFêsÍwŸ¿]?üÕ�¿ÂíñüQô2Ÿgvƒ“*€)ÛZtxuÌûå1»þ®))bmÍu¼¿ÃüüéKœ¼‡	m[.×ÖÆ»!ÏÏŸ>­ƒ›†7Ìóõ¡Èí0U(˜¾R¥Í³÷÷7ùáýZoÆ(qc[žö#âplkY_v‰=b¡¤w  u«5¾š†ry|¡ž¼š‚
î3¦7?ÕÏç�ïqº=¹Æ˜Fb¶ÕÚnŸ—kuªêÅÒ„4ÝÌM1Ú~.5Š7˜šÔµno~æî÷þú�Û×îyob”ô9H•²l¾¿U¯_,ìG×õ7ÊõzÇÎKS±ôMP€½å~:	æóÓUâàh”ô/A Å¶p<2çëeÅíè¤ {‹Gë¾m¹ú6ýôÑðøåÇõUcpíúá\ý Í‘TÛ®³¾þÆ;\~üöîþ.ô“`[ž¯´AÆñ(û2o‹¨„ã^×Oçu@ìûi”úòt©ÇÒ  ìÍ‡fÛyã{G‘ôMÔŒU†×ÞêåéQºah&FI¿	BÌ6£ÞvnÛÖ,!v¢ LYk–éöÕ¶¼|Ê~�b”4€!ýaŒyy^¼£3€ib¥µqØ–ÙZÐ¡F“t!V6óÃl×YÐ‡ØDÒÐlwýÛúø¢áÐFEÙj½ysèÖ‡¯>µé.
`º©bëfúî]ÀOž~‚ñÕ©ZÔô‡ ¤a§ô‡,kÎžÎ9ÓôunÛ®Ÿ¿;áG?ùñ�qw‡Þ·—óù*]¼³n{¾^à§NDÅÒ;�®I^íðÙÔòÃW/¸}ÕÁÀ4‚ ZÛk|#X—ÇgÇ _Éô Áé”Û|]Jº®©XúU /ûyxóù=Îó¿ÿç»ýìfc£¤¤kXŠŒoúxý°p8Ä
€i“GÎY_ßßÞ><|Qq¼>ÀôMPêpV¼ë^éöñaN·ûq—ÖÑPj•þæyyÞ7`zs{lO¿Zønz}´——/æ&{p²\?P§C¤62½àÞDOc)Ëã\»n ½Xú/ ÄjÍn¼ë�/üa¨®’ XÉðÇI8/›}ð¦bé Õ"Ýë€íÓãSôÇà0M ÄÊ¶©¾íöËóËº±'T,ý.(âÜžâöéå:óØÒ‰¨ÅtêFÚ¾_¹×z¸?ÝÉ‡/ñöæLÄÒ B¬¶�îîåi=‡nì„^,ý#P Ø[qÇ×ÁÏ�Î†Î»êÅÒB¬¶UÆûƒÙÃóc‹Î…áÖºõå)k#šK#1.ûu:¼õËã§‡OSw`š<š”ÆCËçë¼47õ%TIPÄl‡¸ƒ—Ziê�¨r/rw£îr]¶ã©"&é› @ØêÖŽnY/Ÿj8^LÅÒB¬í¥¯†¸^¯—'ŠŠ¥ïƒ"­]Áã�×íéYc?ÀT,½)õ\»›Ÿió‡O?j77¯ch5y”²¶ÓÛ›0¿|ø£LÝtö¶>_sè‡&PöMççÜ¿ûü¾üÑÿ[æÛWÎ²
™~¹V¼ºëíåÓÓuêÆh”ôbµdö÷'l—/Öí'ŸáËkë§Ñmõygì;Kï@³­”þöüÓ2—.ŒŒYÅÒB¬–býíqŸ®Oê»1˜:KßYwZƒå¼ê:œÞøöôøðÜã)„¤· H«¥`zÓ×ÇËËeë§Ž´ô=PÄÚ¶·xsƒ:??ÃnFu€Xú:(ìVÓ~è÷yß3Ý›¯�‡§§/>M‡7'�L(R¥ÁO�çZæÚù�) ðâÂ«£Ôåù™ºH1Iï@�TÛ8Þñòòéi�Î»Ó+-ûåÓ§%Äã0ÖR–Ë5{�±±ô‹ „eÉ{<}-–Ç�ï·ýxš|�£¥· HÅ\¥»ëÛÓõ|ntñæíñ/O_6jM X¹fL·§íåüüàÂ86 ’~aá³çñ®¶ó§e�Çnƒb-sÖ.&¯€4—›†Sðœ÷k�-xzgéŸÀªÀü‘.·�ÙI§"éW@ÛÕº)ôÈåÊâ5*\º‘›±{5¢Í�s�Äþ0�íq9Ÿá‡1˜ƒXú!h9›ÆÛø²?\úÁÁ™Xú(b,û&Ó©Ï_j<ÁW'–îA@÷‹ßþqyÿñ¹?ö=H±ô]PÐ–=ÇÛ·G>}xÁq8‘*é(�ÖöÜOwÓvùø¸´p;¨5/dúw 3›ï¦ioÛ97�½(œ¥_E¬–�îæUØÎ—¯æ<ÅU˜¾«‚æv›7²‹^½¦ïƒ€˜-»¹›Ûn»<|ºRoúž5Xú6Øò^e8Ž%/ÏÛêú\U­6¸.©e­EB§±¦�»Uú!çy»6tA½¦_‚17§ý0°n3spn(±¦À¬lNÇn+{ŒLÒ	”†¼Åx°�ŸÏ-�½wªfeÉoÅ]×—kÖÎ‡@‘ôˆíu‹îöÆ°^ç³–.ÞP»^Ö•.NPƒJ«fè�±Ïûz�¨Ó¾ºô+`Å,6ê²åê|çœIúi4ÍP7v²c_›R\ K7`Û‘cwR·ïÏuóœÓ–~¤ 5_³Ž§q\×—åŠC8"Z½ÖìtpLÍÏ>Ç.y©®«ÇYa`Å&ì‡rÞ7��ÒU¥‰”|µpêººÏsïºXDØDSŠX+›à$¡•e±ÎùN  ,[Öî0:¾®KÁýÚõUL¤ä½únèÌÖmÏ½(Øƒ¦i/íœ‹C?Þ»µ¾ä2¹¨
K¯@@Ãš-ÜLc¸¾<Ï¶|ïÍ'OI÷ 3ªõSïmYÎµv¾gG‘ôs  d­«)O‡^÷åáœÝÑ�ºN$ÛÖŠª‹¦
À¬ìN† mygsŒ’~lŒ}yo@Ñ(fÅÔz7šÛÖfè\'4–Â¦ƒã|}z®èã ^ ’`Ó0øÑtÍ»ip.VMÿ †‚ê[×÷`¾n[uÂØõ›­wç;¡¤ï�@ó™Rý†–óš«�>ªªHz
ˆR÷ªS¯ýR/;áÆaÌ¶×—\ááDÄ,3×ØûPm[-¨�ðª`Ûö¬ýk�íãü°¶~;ïªÙV«9qª€ÙÅ=ëV6Å44K_wÝõ®Ü[^ËƒÔÃ¸½Þ"Övi2Ðu�}‰:@4M EÌ¶&ÖÑj^·*µ÷£­{ÍÍ#x¯ÞÑöVÐMwÇœ¯ÏOÓ0/›e˜sc§�m_ÀÞ%@AÅŠnÔ­Ûaˆ¡ßëj�F/ V3úA-—=+|ì¢k(¹” à †jºþ(Óžónîöùí*ÉÃ˜¡ìºìy[µŒÃ8æ¼ÍO¹h×O]h,Ûî]u`úC�Ò\u&}„Z]Xµ©„&šz� ÀZiÅÉ$Š|ÙwuÓÍ¨îº>_®õ0LãV°lÕ[�N ’ š–VÔ¨RçZ1j€HzÍ²µ w½Äu[Vºè:	M™þ1¬•ÍÑ\(º­Å·A;¦ˆæÚîá&·¯ÅŠ�*$M U·;êabØ÷½±u~º‹š¨!„b[�9Og¢é·`B_kõ>ôÎår½šsãM7äëþ¼oˆÚyFf¥x×E¯¬Õ6oê‚‰Jú:hhš¹õáÐëe+¾ô�sæ@HúM$Ïj%êœÉ†ÂÔAÒ?�4,ÚüéÖuyœ³ß9TDSÁfe‡Ct­¬«4xïBG²´æBT×JaÓ ê½ˆ¤Ÿ°dC×E©6¯]Uçœ
ÀV6WÇ)v(ë•Dˆâ��
Q 4�l-#†q€æy6´aˆjlµî{±‹êj±5l^¼wHúÐ ¢ùçü$Š|½¢uaÁÚ¾5(4š Õôç YZ3íœ×V–µ®sÁ,ïN½z3kjŽ”ô' �°Ö
\¼!×ì÷à;SAµ nRä¶f±M¶Ü´Y¨Î@$ýX;À�‡r,jgî-x‹ËÓÜ×ÎÔ÷.ìmECçÕ«š´¾¥?E
¶"r;!¬ëË6ƒ=@@T!i„	 ÂÊ*Œ“÷¥í;}4Oš8Húc˜ &€R+Åõ1¢•ki^ãÔ«åªæ½F´ª†Îu¦µlÀ£¶\ŠsÒÁ‘ ÓŸƒ Ä Q4Gß÷Ml)"Î‹* ìŒ’Þ�QC	Å!Ê(ÔÜ 0É}î{»åìÔG£ä©A( ùæjpA; ag3 bâ é’'”àÕ{+æk€ƒ
4µ&¾WoÜk3&×›ßònêàb1!d
 Ùî½ëÑä¼£ŸB´º—ðÎ{ ¹R¾—@î­V‹½¹±EzzlÍLµW(vÐÔ*´\Ý©Wäm-æ�v•¦¦hBWE%ŒAÝ¾Ô]Lz
›ŠŠj:€$L[(Ž.úÐˆ«µ çB«¨ÒÇ`R/¬pÞ;Q:Vk!ª8Û›îžN!„é› °VZcð.T–-À98�„‰¦Ÿa¨Àª–\Ùu1d.;Š3çáT ¤’îA BÐŒ&>ˆÀªE…"k­™è«íÅóÀ¥^l¯^œsQ¡$ÀêÍjGï5h­¥U2ôN­îµyƒƒªŠH£•fœ¹6sâ5Í
AœcÔGg„Y–ßG‡Z¯K3ÇP¡NTÌ(¤ 0QŠfU«Jç;%¶Ñ×\±¦hPïV=�‹pÖv8ƒ#AªAÓß)„@F 5WºÐ‹³’|ª/{FóðNE�¨s"žÚt÷�†ÆÝškêÄ‘¬âÍ¹è“WYd5gªÁ;§Ž4š8Q±ŠÚHG8 i ‰ä	�-:Z++$HU+…N}!³kM)*’þLŒõª€AÅZ)pUÐ¬Äyç„e7S>�-[sTU€  ¨-Jõï£ˆÒµVšÎA` Q@`0š°#àD½µš‰s06Å©4‚„²#%ý}� @mÁ&Ñi€6­Ú`¢& „¢¤¤­3ˆ(„ž5ˆ¨zÌ¬� (© ¤¿‚¦Éƒ†Öµ
¼¨—Æ¢Ö Þ© …æ…t‚fL^ ÖÐ¢ˆ
A� Á@„´Úµžá¯û¿ß+„K!„ S€˜!1�Hˆ‰PLÔD`"aÚ¢ $RL”¢G Ò  ¡	#HˆªTšÐÃ` „¢€ÂÎÒ 1QµäA@€ 1@L1PØ(€¦--2BD4€4«ÎŒŠˆR b 	U1›T�Š€Í5BU½*PÙ‚ªQA1À PU€ÖŒ$¨&1
	±äA@L„Dõ¥‰*¨`ê o€Ë¨z¯ªËhâáÌU­Zµ**<š«æ�ÖÁ˜<¬ ÷¦ÑÅ•vPT»íX$}¤Yiæzéªl,"â¼¨¤‚­em>F%¶bÍ1 R-}†F©±7»V˜×èE ±8S×«²´R4£‹]JÞŒÜ(`É[¦ú8z¶\w@½h¦¯ƒ°VEúƒYnÙ	½ú ¦{¬.+;7©K­-hpê˜~º]¡SÐ²ÏWipqê:–y!CŒð€¨…ˆ‡Qü¼ÏNcPM¿
ÈUÌúb—óuGßyq”ô ÀÚfÆ®­e¹Hî0á.óy_û0ŠkÐô-P€F«qêÆ—}~,ƒžŽN×ËåEBC?ÀÖíJzß<-Ýƒ4¬µëO¹nçZâP%}ÐXªnã¶¼<?‡nÒ®ª2ýPØ×’·pzÚ‡—Ë~8Ž±	ijB)E£b}¾žÇnh"–¾à¶ÒÝÜ»ýüü¼LÃÁÐ ¦Ï@ Ìkó·¯ýöøôü<LG­0ý<±ÜàÆƒXÞ6ô£¦bé—A u+.ÞÖm¾.‹s½#Àô( wC7(ûrŒNœIú äRìî3¿üø¡ÅþèY�QÒ�´V5ÇsY¯Õ!@ÅÒŸ‚ JÍa¸ñ×õ9Ï¾;PÖ—«¹¡s£¤ÿ
À�ì��Ôu.Úû ¦bé×@ª”¹âpÒøáúRà¦7·ùéáâ³Ó6Ñô; €V�Ã8­Û<gßÅh Óg Uj©íxs[žÏ/�~:E£‚é‡  ÜÀ¡›¤îË^CçéÅÒ?`n'K}¹
ƒ1I_°æ§{-×Ëû3ú	¨ Ó? !Mg¶á–:Ï¹DL„K#HÍ×ÒßÞö×õã‚þœ� eÏ~8ººœ—ÍÇ¢bé BÌrqÝM÷öRØgÂÎ„Òà.Ô}Ý�>Š£¥	¤kXJìîâRŸçãÄ�E,}S²•­÷opýôÕKpÓˆêAI¿ `Ýš;¾e¹~¸pÄpûJËöøðÒÇC¸ïýãËW+ú8ÞÜÝçåÃÇ‡ÐºÓ›)žÏ_>a¼™|V€éwAHÃnÝ8ªÍ9» Sq´ôg  Y–a¢•Ë^Gé*i¸nýá¶b~¼xt£@…-­õo0”óå¬ÝA:˜Þ� Z+êOQ¶ýak7½øFIßE¬Ò4NÑÊ:û#B•t ànäMìç2ç]pFI¿B¬åÜmççýRe
A(é—@ˆ•µr»v½^×Ú	îÆãöéù±ÄÓ�ØsöÓ–óóC‰Ö‡7oyýêá‹vàÔ¿¹òW¾¨^†ÃM‡åòþÃÞ‡átû¦<.ïŽý	MAIÿ„X[µ†¤,—]šö¯Ž¸^/ç"ƒ?Œ/ë‡—>:G€é/AªÔ²†ñõ®Ï¦0€é» ]“º·áÍ”—Ç÷íÅõþp§u:?êƒ3€é‡`òØ·†{¿ÎOO‹R©`ú:HÝ¶ÜÝÞù—÷¾Âp<ºf ({Æøö¸==Íûx¼�
”œõæ®çryÜBìš‚i©ûJ¹¹×õéüp®*ãÍ+Ù¿üð^n�'WA2ý%À–Ý›WírþôA†î$æH¦{be]d¼úòtyDC€éO@ˆÙ¶”x{{˜ß|¸êÝA‹’L
Å†vÌµfßN‡a(Ë§çAú�j`z
¤¢Ú4÷}..Œ±y“ô-PÄZ.Þ�ýÕ®Û…ðþæ8–OëÇ¬]ïµ9 äÚš»Ü2?=¶¾?Å$} õºjÿjì×ç�†^…�ô}bmme8¼&ž_ž€8	jò w£Cä¶.¥½§O'P¤"g™‚Ûì²;í:±ô¤.­¸»™ç��ë0ž¨UÄÒ’¹1¾	þúòði=ô·BÒ7@ ­®ê_½~õòþË3ú»ƒ3S±ô±jÍãh[½”zt½y±ôë kièŽ!”œ±®o1˜]‡ñf¯óyË½„N,½Eª4tÃèKÙvzôÎD,½E¬¶ÊØö²^–t¯š;×ëežmè�Ç}Ÿ/Ï‚›®£7Iß!fK6sï——OOÛá0ùj*–¾	Š´¶Ñ†.´6—­ï]G'–þr.6¾î¹ÍOOªîÞ(êåùã"‘¯ÁíççG;ž&_é@‘Šý±óOå¥´¾ï"–~¤´UÜÛ×¯ñåãW6ö“Â’îAZÍŽ¯Ž­=?}\4ø›×ÓM]ÞÙp8A«Š¥ïƒ«¥¶éÎ¡ÌÏ�¾S—!–îA�TÛK|£Çëüx‘xìãL,}±œ3w�›—÷5ÞÍK?‚¼_9Þ6êû?Yµ»U·EÈ,y<¾jÛütyŽc¾¨¦ï�"´r±:¼º®�Om‹ýÝí­¬ËËyÏS¼¡ž/Öõ†€³ô±ZjëßŒîº�/�ÝèÇ*"–¾B¬–Ìþî¶/ŸŸJŒƒ%M ˆqÏ{÷±äùù!S†Û;ßð2?áïªK(Â&»Õãí©ž—÷¨wƒKŸƒ"l8×v|=Ùy~ÿ•ÝM§$E›ß÷Š»c_?Íç3»!º¦*–îA³­(Ž‡Ý_¶-»‚Jò`ÛŠÇ±­û²,,Ótç±=¿Ì[ã›SÀ~ù°Ú'_¨XöŠiŒ¡msÝ8Ó[Ý/óRå0¥äõÓ¼8ß;˜
™FPP±éÁ�b9o™ÚGøçíòR1‡#ò’Ï—µx×Ûüt½x¸¾ÛCh{i~¸ÓvÙžæ­¢7
 +{Õ>vë\šÈ8žL×y½zL£:sDs9›��^·ëœuDMÓ@ÛÕ†nòµå…‹è8Âž÷Ëµ¸Ø‹£K¿¶­Tíïz^Öç¶~ŒM$ý ¬ÜÇ»®ÎO——¾��(“G-�2ôÑ°¬[GJÕôo@d¹"ž†º¬ëK®±ïÅ5I?³ÕÄbWsž¯EÆÞ©BÒ ¹·‚xw’/ç‹táà	—>€,V[7b^×yÞD}„¯é÷ÁRróýx’ú²<_�1(ÔYúEÖÊÊÖÇÎ¸^–ªÖ{‰MÒwÐÜîêÐgm+èÑ›jú5�h&s§!^×ëœ­�=UÒ¿a–¹D?M«_×kC¢s¦ÎÒïÃZ«Šèû&¶¶*�NÒÏƒÖvoˆC¥åµBnòÖj®0u^»&š¾‹ä™ÁmŽ{W×¹ÄEÇ H: Úæ‹ö] \Ú\ÇÊqÔD¤¿ 	’e7ŒqìÜ’—®çL4ý[XÕ¬2vj­íWG­kêÒO@	+;&¬Í™JÑD!égAÂ­bw]ìœÕ¹\Z§ãJÎëL¨×ÎÔÀô�`«dé‡¾ÏÜöÍ™×à „¤[Ð ‰€]7Ar™iÂ N=DS	’-Ka78—KÙ¶à[4¯É‹¦’€µêàºà+òÞèàÄƒ"©	¢ùì›ŒQãÚ.ÆÖ!¨ˆ*Óç ÁXëîÐ÷Î·¼ÕÍ‚:¨&š¾Ff ±nËÛ¥š;Ç‚º–æ}o�Ú2ÔÇ¾æºBšs
(DÓ·`0RPrnnœœÌÛ\ª‹Ó¶V®›QÔ©D%ý’'hmƒ÷‡à˜çÙ„]ˆUBÒ¿hZ)6„Ñ—¼,‡ êEÓ¿I´¾yf1éz¯,e_ã0ìaÍs6• A ŠP… HiB8?j°²]Í›÷AD¡ @Òß�J“ÝË0zÁ–KFPß›¨"–þ¤	Œ»éFÕ­å%8ïœ´@Òƒ˜¤oƒ0�¢îÒtŒž9o90h'¢JP$ý:H1‘êj@pÆÍš3¨ƒ˜$ýW�}SHç=X Ñ9GBL„ ScÝa„«u½:£jUˆ@LŸƒFS:š•
×9WÛn,AÄ $}¢˜R,±ïBk—ën2�XÖœ£óÚÓ»"KGP„ š•†ÝIßÃçúì>¨S13QSRÒÏÂÐ‚Á«WÛ¸û®WßJ.Ye@$Ð‚KÿRÔµ62 ¬„UD¨bÐ �³Òrô]§d-Ê Á©‚TI$R V±;í±VÏ¼�ÇÎ·Ü®Eô^ÄTS!ÓÏ€4B4`U¼ªsB4×H%„ )’¤8†&
I Â(4#Ì¬™Ä®‹¨yµÚ…ãÐlm«‰H/±IòF„ ¦ÿ‚0ÐQçÔÍk�(@6Õ{«d3� Ñ¤é,h×”ÉW	:6°µZœ/NH!!L¿’°‰Qà4h@EH8kU¢.B¤ÈêÍù.4_QDÍ‹Si�F…’bÚ¢¦?ÀÿW~bÆBASE      O[  xÁA  ƒ°Yãx` þµ,¹ª¨ÆH"gÛh�6‰™®S¦˜kÛB§Œ 6GäÈ`3ØÌbš¥s3§µÔ&­’ÈDf*ÒT#h«*ªf	[`µtDP+³j€«€k¶†+§é¶M�jUhcZÒh¦-°Ím›	VÛÒ”@$äfT9“9§›˜©iêÐEiÊÓÚ¢™m.M§¦kµtºÀeÓ´9jÐ6 '5#´ÒmMËœºéÐNÒrN1·¥u¹åç°¹­m¶m®ÍeÚ†Är-´L‡9ÂeEd‘¥KMY3ZšL´D]`ÙŠ6#W«,‹¨DUH*M
B,ˆD�2u¡›¤:t¹H±Å*‡åæPÜ,Ñ¡J–ÃT7]bÊÁ²¢ j2#h…eÙr‰-r“šC(-Í³7¡V«DËM5
ÉsSCˆ1Ulš5HBPOS      8a  xÁÁ‘A ±ãsìt){"À#>¸…éHÿýùñõõužóôÞÏÏÓ=¿úÖØîõYõ½Óíœ÷±á¾OÏæ,ÏÜÜ¸;–‡îôqç&«rÜ˜6º·“r#w»=¹jI¨Q™V¶©rL1ww¶*Z,™©@˜im¦dÆ‰–�b 3–	�#6C[†Ë ¬#˜fpL-Ë `  6´Ã,d Xc±` 0Ú`& AÖÈÂ²À0aD°!  ØÀÄˆih[0	-!&´(M ‚ V€ ‚"DZ2 E4di¤%0ZFˆXÀ`fm ƒNŒ¦9mÃ´ÌÌ�e46óÒvgYf¶ÆÌfkæžÖZã4[�{z63�ín�õü~æã¨ç>®ÔÉó~z×¹·;ý!õ5 CNF4      y   xÁÁnQ€áæÞ3C[Z2ImpaâÚ…õÎ“ø¾ÆÄ4Ý4!2B�™Ã�ã÷e?î@¿gˆgN†<ËÂâ�Þ}³òŸ“·.þ¸:¼:ŽwåZjl[³­ã²£>Mµd=§+×Ô‚I×,ÁD+Ös­XÏµ Hít_þ…¹Ö¤ ·¤ CRÐ‚}%û©~#ýB
º ]a¢Ž~Æò &ú�‚‰
›YsOD#¿>ê) )¤ÃÊ %¢)è˜Á@À˜!†`B"hÄ@LTx„‰ O1{²ëÃ'ìùáTB»…yeˆ‰Ò5usz³Í[n^ê}Å]·¹úvö;ŽÎ#Œsz�Ÿi—M»|&”ä/PÐ÷�×dÒ@‘Ÿ[ ‹ù@GúséBVV'òrávWŠu=×´WÐru‰G&ÿÆpÈˆÉU(zùPùaÜMú|Ô‡ž‡á¬Ž:ê¨£Ž:ê¨£Ž:ê¨£Ž.ø’V½-TEXT       Ëò   xÁËn‚@àÿQÎÀä\d($,f`b	¢IWD—Æ.jß¾ß‡)Œ	Â”ð�Óa?!4%YÛˆgûÆ3gkS±Çi-Ä;6BÖ„õu'¯ob©Yë¢"eú}Òúº“�×7±Ö¦µyRVÁrž:(«p!âXX‹ŠrRVáBÄ±ššG÷•fôq³Òx›�s¹Åný3÷xÞ0†ö!ò¹Í…Õc<v¬4FlÃ€>ºÛ÷.iìã’EIœÿÎw4vCLIP       	           GI     G@®ZTR

SMP4      B!ÿi  xÁK¬¯Yzäßû®ËwûßöÞçÔ9Uít—»Ëm[Ø]� Hn»ã H¬�Rn)²Ã'$$&$ e!KÆ `ˆ„„@BH™b…‹bÓI§»ªÎeïÿý»­µÞÏ#¿ö@úK Tºè¶¾šÍ0|kßíöo÷‡ï|òêÕ§oÞ~û;Ÿþé_üâW¿ú+_üêíËÿöóï}¿”"þ—ßþpÉãï¥âï§Àô+øAzÂ#€ïâþ øgÿøÃòÿþÉýŸô‡_½ÿÉÿóOòÇ?ýÉ¿zyùÙé«Ÿ�Þ_¿y÷ÕW/åt<ßÇÛeÎy-µš(~ÿ+ð .$AŠ	 Õ�Kb" @ €’0yP„€¤�BBH!@Š¥ Jò @€ S€XjA@L„€Xò LÄR€@ 
À*’ AQˆ�"°ä!–Ä@‚"Lb€Ä$m –(T€UÍQEÄ�4«4:*`òK€	¡¨¨
V#i"1% Š˜ˆAL B b€˜ˆ¥T¡Iz ÍŒ&^ÍÍ¾÷¸É±&Ó[ú–šÍ¹¦S'ÚàDÒ ä’¥ó‡‹|œ.£‹Û&ç£»îõ›áã§§ô� •B¢élY§F:¦ßØºÎê?¼~ùPú~ë½˜ˆ¥ÿ°�¥iË·jl„*é3P€"(nÛ„2Ý®µx �ô§A�ÕÙ»0x½­óìµHú>1[×Ìð‰l.—ÓÕvƒóÕ�éP ®ejý«Fqùp^›Ð·:Xú.(”\!í V¦¥bÓ €RÎ»þÓGà§ï>ûX ¦ÿ	Lud	oàýWýÓ@¿ŠXúE,·Ùo¿³Ç¿úÙWÀnïk®¦×  ‹Å¡Ÿ¦ë|O¾¡ær»Õìší&Œóõ˜uhÅeK_€€Ô²d÷°óåùùŠÎÚPëøq\ºØ¢zƒ¤ßp®u»ð|ººmÓ)(dú¤–²;ln—çsØ·Íº‚ ]å�útØùŸ?�úa³y,õòîZö±+¦FI¿	S°NwôŸ>ÊõÝû#ú}_¤LoA œÖysxrþgßŒssè1dú.±µ.¾ßhXÏ÷Ö¹vç]×1gô°×q<ÝQãfÏÛxº/a?xuYBìÛ¼Œ¶>ÆèéÄÒ¿Â\Y§Óúø­oãýWïÞýƒ·¹Á%ýP€:›�–ë¸šj+±ô}˜R¬\>}‹Û»�/^õ2Àô=�¢7ÑíŽ/ó‡‹íàª€é·@ˆåŠúüåt¾Î6"¦„fæf³p:Wt2´Þåå~Ÿ‘;·SÊ|¥†ÖÓ‰¥LAÞköŸpüêë–O_É\Uªjú=�*ežóðºÛçïß¿�CTÌµÚp@¾\Ïw7ô�BPhSvÝ¡ÜÆó|všM#·—ûµh‡¶æu¼ßá70ý¤Ê:×?q}>?g7`úH•:­¥yõ]}>_¥šÂJPªUçwÎ–ù:qb°ôCÔëŠíë�½¼|¸µ�;) QÒ�@@ªÝ½t�˜¦ãM]Û8V©ªé¯‚pÉæ†]ÐÛz´q£×ëZƒ¤Š¥$T¦ùâ¿sÀ»¯~‚í·¾i`ú�º.9ìw»]îkú4Jê@²NKÙ}þ„wÇoÎÿÇ÷Ž7O
,#Û®Öi¼ï]¯¾RÒoÃ´ñ†ðz°å_¾û®Û†·¶äÓ}Ìâû~——ÛMÚ]tf`ú[ El.w÷ôiÀÇùÓ	Ÿú²`ú}PÄ¸º-qÏ·B¸¦·×ÉDû�bœO>ªÅ><N×ñrƒïÅ6;kzï§½ó;¿«Çé4j�°m1^Nw	‡Á±‚éKb˜1»m_Žóù†×nkb`z
„vË¶X¯×;ÚÝàJú(b¥ÐúVê:^ë´ºy¼�·A;S±ô7@ªØ4ß_=îæéëŸØð°�¹VÇë¿ó9¾ùãQðé£ï‹˜~ Rµ.víö�ûöýñ›¥u»ýS˜—ãå¼²õÛÝP.·‘ÚÅ¨UÅÒ_©bsYÞîÞçûûo€ýÎÃL¯AlY$ÚÍr]Æˆû8¯ëižú€~³Í·ãËíC€Ñ(éK@]Šï_+ËûÓÉµ»®.dzB¬.3â¦«Ëý2•!D%ý„TWnl©ãˆvÛ-*–Þ€€T^iûƒwþø.®Û&˜2}ÈkÆîå:~1´±h%Ó— ÄÖº6Ýy¹Þ»­ÇÐ¶s™NÑ`1îCžn75ët?”õ”o3»µªXú(€-‹Ä¾½×Û±íÔWK©6V×lY¯Ë&ô}–´\Á.úãr¾”§Á…êÄÒ  E²Æýv#×Óåü0lj½MG§!6Ð
€u®u÷°ÝÞïï–‡ÖO ™Þ€Éc½Ï~óép-ïß=ÇþÕàV™:�
,ËjoßlóÏ¾ù÷ÍÓ“º›L-H­×ŠÇOžjþðrf?t›Xy»�›µ÷QL Ðf››ÃÎsz>/ûí6ÌZÉô	(bX'ÅîÁ‡——çûàúàM¥ªÂîµt¯^uñë÷GÌ‡m\5›¤× @°¬àCKŒ·†¦¨*–¾E¬ä5ø­.¸Ì±ÁïZŒ·û³ËM«”"i RëˆæÐ8\ÏçûClÍ‰¥ ë|Ëý'‡â_¾zÏvxÜõ¡¹./÷»½ê÷ÛP/ã‡Òî7-P$ý ×<í7O¹¿ž§%øÁÔÄ¨(KÅö	rÿp;×…vãËóz¼âáÑ’¾ŠX]çA:Þ–‹­ÍàE³¤·  %iž¬>Ÿ�7øÇ pbéÇ ÄêŒêŸb~žŽKéB+ð XF¿v‡OÉ×Ë²}3;iÆë„½öÞ™ÃUðêõ>~ü¸Î²Ù"›7Hê@ ¥ŽêŸ¾©ßœÊnØ J!Ó (ß´˜Þ½;¡í`Q±ô	H©‹5¯ŸšòòòõØìvÃ
À2WëöOEnÇcÉ!ì»×Ó­Üô}“Ëñv½ÑI·{Ó¯Ï·Spû&ZU±ô�\îëð8<èñôaÌÍþá­¶§ÛÑè¥PÒo‚"V§ZÝc‹Ûýt+ÛOâfËqœÎ#°�pYÒŠ…‹¯Êî²|6þQýu½Òuƒ�ô› ¹®‹ƒÜ®_Ÿ§f»§AiéG ­Þ]×?Ï÷Ûup~#$ý§`�›ÍFÂý|*›®�Ž&–zP¤”uáðq»]rqû¦™ÄÄÒ¯ƒaYg<üöörùÆd·uRT,u ˆ•yaØ½~˜N¿¹#¼êu%ý— r±ÜGÑ©.“5±zMßëºÖÐïó=_s0¿mp–~r]=›­vy:O£µÍÎëz[.Ë6h'æÄÒÿ«³Ë~4Öqœf?lT«wÔ¢MëTnÓ²5¿Ûj3ß_fvÚx5Ÿ>mÍÚ6]Wê=_oêC4ÈtŸ,ºèÄ$}

r™ÇfxÕV|=}XÛ¶oªU²•2l·ùºœokmº¨Õ9K?®³±Ún®§ÓÏnõÐl¬ ª2—i�»í'Äó×î¾yjuuÅ$ýPÄê²HÓö²ÌcîáC¨ÁÄÒ ÚºfÛãñx¿ ~ëýf]ç•ôA}úælŒ»Óx9N1lvCµÓz½”]lƒÐ9KoAäróq»	åòÍò±¸MÓ.R%�ÀRDÙ¶bµN7 '&éïÃ¬3²nC˜§ëå^\ë[$é¿	æZg×>¶Äñãe„n;QT‘ôû X—•�;ì¤{¾~+6ÝÌe&khÛÁ{[¦u¡ú 
—ZÐä²T›Ý°žïÏ–%¶
ˆ°–Z:ÙUÏ|WéCç
§õÎ¬ÎE5Õô˜H©k.aØˆÕñØ.¡ú@Yæ:J#â(¨D·�•y\7ÂFb’þ&ˆ*E`!tç2]Gä¦oC©o¤6-Û*éAT©k¶Úví6Ç¹–èC¤¹ôDÑUØ£-X1:¸Ð˜“Ô"yš•ÕÊ¦é¤œç©k0©(šƒßD©eZX'f¢ëãjãZ³†0D
l*V‚oƒ[d)b¦.(¼‚)€ ¤èâàÛ¡Çz¯Á‹€¬Yœö¡YÊR$hÓˆVI=ÀêBCœ[ò’k«�R°NÎõ:´àœG3J§ƒ�u­KÞoWWæyÊh$ª8Q¦‚•Å|õÃÆOó|½Á¦u"˜~*–X}ì<9å›«‡ÐÆJ·®êLÚ ÞJ¶\¡>Àkz­f�†¶«2O÷%4ôI4JÈª±	®VË¥×I,¶®"%˜¨¦DUsëª¡Û†užOóÜß8hŠ �¨\‹¹aëú2�§±‘V�VUH
0Y¬Xð�«u^mà%PR£R¹ZÓÅÍšqÂõ�9*E“‡�´ºÖâÚÞ{Ÿ¯ój±Ù¬v_Jõô5«ku¾é\-ÓuFt‘ó�w‚ Lß!Ö²fÈy-™çàV³ËƒàÊZÄª†"€�­³¼¬UèuUÄ’µ :ßd²…ÅÁ;1€u¥¸!´K™¬6ôNÓkÐ+FzFŽs\oRòl3¼º†>0ýYf–­­¡m¼-s¥Q/U%}d‰€§dÌ½÷}a�¦¢Cô‹YYKt�w†%‹â¼JŠHžµZÕÐ	°ÔQúÐúše®K8ïE éÛ ÁJ¥íÔ™�-=bsDeª“úÁ·«­“¬�öÜZÆ<5E¼"($ýy°ÚªÐÆ©šeÍJ#‹˜8QM;˜P¥Úb¦}£K©·2;'­©ˆ@5ma¤�ZÅ­1úe\ÇìBÛyYJ™$;Í	$}’•V]0 ç¶ˆ† ‡â­Š0[X|h­–qÉUü~­³eªxx$ýu°Z1“Ø8›é-8U1PTÒƒT¡Xei´T¢‰ÍXÏ×Ké|„‚jMßITD
‹©ïR²jh‚k+** !S„eŸƒö.².˜
}ÛÉuB†h0	@¢
ˆºÕmG×i† @…ª– *³¯Nzñ9×ÊàƒRfo*Î‹ˆQ)EKã{ï$OMcè(f_Y"!¦¿ ‚FVT… óVG?ÃïMs]šìMU(éO�0°Êì} \Üä!�‹Î¬ÎXc…¯ŽP ’~¤‘¥:õ�iÎ`Ð†^²**éh0q�jfÒ¨™E½S%¦YÅ$8Çš]�É\�I4uaú·A
Í
Mƒ×Šu®Ð>„ÂÙªWª@ U˜@h0DÈj¹Ñ�‰-øÐ_W]¬ÀÄ*ÅDE40ý9�¨*QG¢
� ©âÔA`5‹+£¢bºlÕë f[„¬1y')ÂhÕ¨Ñ#˜-ÙÌ‰Õ²Öä!¦è±š„œÔ¼dgâc­ E5½YÍà½ˆåši\)ëêÅÔ;g0 Åà(²¢HÔ“•VèEU… +ÍÐ1!èÅ)²TTÓ'0«F	ôÊbPBaQ+âTX­@ÔIz€	U …(ÔXÈªª>8AÖjJqbB¤'@3# ‘ô¯ƒ1%ÌT”€èÕ—:çêch\A™×éá�BŒR•ª¢^+ç®úœqA�£ïÄ(„0}
ª€¥Âœø\ïÐ¡AežXiœ·ÊµºZõª^É
u‘Þ³ …*NÄ*Ì­­H%@Q
…4€¨Rºê-˜T«Åª¨¯.Ã¬R 1T…BÓò{øå•4Ä 1Qb ÄDM45˜@ )€ ¤ ” &J
)$  @BHS€  ``¥Áˆˆz§Ra–}…Q¾ŠW@H‚•–< "Ua,Ñ¤Š„�  4 ŽÉ«™c‰R õN}‘*Å×"F!*)B @ BˆAL ª˜	ÕQE½ˆTV«f„xj X­š)Ä;c¥5¨`5;²*DE1bšˆ¥­¢ªwê´qVV3s".}„Y-"Á‹[ëª°i+ŠÜ#;çàƒ2µ �–}uQË”§ ß±Ø<±†nk~²r©5†f[YÆ:¡FZÍ€5Ác±k.ü&HYÆû
lš¶ØœW4¥ä)/½Î¡®+Þy¥dVWÅ9�¤
Q«U¤É:•ê<¼Ó´�j%C†­¬y’�!T°ÖEC­e2í‚6B•ôC´ì
]ô�6%$xç4ýy,ÌA‚�Rê˜MC„óé·A¡¬Uš>êÓXrt�9@rrËf«:/—¼¼FT�€«Siâf/÷ãz:'ÅÁÒ 
Pa}te¬·�¹&n›|Ê—ÅobÍ·i¾õ1´ŽNY²!ìÕÝ—¹Î­�j¾Zú˜-hÓÆ…·1× �0ÀÒ·@)2ÕºßÓqºKpmnW°f®Ã¦o›é¾Ö�qã®·Û­¸&TK¿
Ps­nƒvÊ·k5Bµô æ’u£a^.3œF_ ™³×]°<Ýï[×†@Ó÷@ 6£¯b>]ošK”fp{;2ô]ÍdÚÀ¬ÓèúW/—÷Gnû 4òV¤{B½\Ž¹é©dÚ‚Ë¦M·uíù2ïw÷Íñ|‹»MÈ�b°î!O·Ó¸ ¶UÅÒ  Ké¢�nóe×îúØÞ¾þx·®jj”ô·A@jÉ"‡m+øhcØmÚÕ ¦/A \gë»·�žOýNÛAH]—²;4¸ÌN¥Ù4Jo�ô�×êúÃºžÏ§¨±WS”y^÷O½–ÓÏ¯ºÙl¨+Àô#�
™eŒ��Ÿâãñçþöû8š3JêÁä±Nâ»×=ÆÀ6d˜þ}0yäeòÍ'!¼¾Þb³Y]˜>!†EÙoÅíx-¾ÙH Ó 
€¼ä¦{X×—ùý¦&`ú÷@ˆ•53î�—{Þbè”^,m@P«,o¯Æë7§k³ÙÊ
©"@©³µ¯Ûáåò¡ºCïÝcy¹žfmÚf-Î(é©6Va›_¦›…èœ2½…)XÊÒöÚœ¦÷£6ƒ  Ó[�®ºqvÍƒb>ÞÖv×y)"–¾&�¼ærxpõåø|óŸõâ*©È5cûÆëå:bÛ- Ó÷@:«ëÝmv}ÏçI‡¦½‡J¦·  X—ê†]¹Oã*Ý 0‚T”kqÃÛOp?ýtóÉŸ ¥US&�EÊ°Ý÷ÓõE×ÐFO%ýM0yÌEuóàq|.Èn¿=Ä�ëeÛïèªT€å–ñê±Ï—¯»Ø›öå4fö�;ôî/§Å÷Cq«‚Še)Ûí€é|½®@+¯?i��€¡š	 Ó�*ÙÃ##Îãõ±ï<@€XÔd·Ár=?/Ã&8Ph¢bk6ßlºžî
tºytúr>­®ÙWLH•œúF›>Œ¥m]ß‚/kÛ8SaJ pÖ¸ß•ëe}õþ°mÇoV´MÓ÷Ûu|¾Ìq78]D,}	¨S‰qïóxºzß:ó”´!fëRv];Í÷cdÛGºB¦¿
¤Ö‚0Ä5Ï£©oMT,ý ×eÒÃþA�ÇãÚ·Ûêf€i AábhŸÚr™®KýV´Lÿ L‹dö;9�Žy´Ù¶ý|=úfoËýøò,qÓxšTÕô�@�Ðî±í–f:_:t�]»¾;�ìÓ°�)Àô9L¥Ú¸ôÝÝåzY¤ÔeK¯Áä‘—™ÛƒV¼œGÙÍ(0
P—Õù×ÍnýøJè]³{òy~žV	ì‡O±œOkŸš˜L_‚ lkÿÐát›ÜN�	˜�š—Ùï·˜Î÷£„8xTJú/@ uÎÞ®ÇóhëÐDWLPG�»ÏÚÞ=?Cßtíë(çû»¼†¦Ùwp|>^+£‡€åù|*]×
(dú-@±*þüùvÌêÚ†ZÈô„˜MD³Ý5ÓýèŠtûAêùý¹nº.K€['„}zÉ®Œ±QóbéHgu)~óÆÑN/·ŒÎ÷­æÛåãµkw�'0×,íöíÄé¾°‹íL%(°uÝÌëÇ‹²·ëwr¹¾\·�‹õz™´ï²Š¥ßb˜½Ûï¶÷ùyœ‡~£æ- @L'ó›Ã�óuš-ÐíZ·^®§Nbç!EÒwAˆå²¢ÛÇåz¹Ü‹wØÊûñC¨]P 
ë\eðñ:ÞnKØ…UÓ„X¶¬ñq[ít:×íS«0 ¬ËˆæU\ÇÛÑ‹FWÇ—ç�›N@Hú» @˜W`ÓºãršÇ¦ë´:±ô%(–ì¥?ˆÎ§ëã°(-ý:(®óªÃ°‘é|[¤o›¢EÒß!fã:‡Ã~àõÃs~ØÄf¢£¥‹i;8m�ã2
B×[»žO96[ïŠK„§¼¶»C�—Óibÿ¹_�7ËÜoƒÍ—+‚ï7
PÒï€Áº,ÍpÐõÃuÌþu=«¤€"†÷Ø=Ð_/ÇE|«®¨Xú%P¤Ú6�×iÂÜèàDÔÒ�@³uÊnÛ3œ./‹­‡fI?E,×·�]{½¾<s»ße©"–ˆôß�A™ÖÜ6ùþr5bBÑ"é¿E¬Ì†¸mù<ßnNšÞ±ŠXú±ll›}[¦ùãmÚ·½7/bé¯€"V›Ûýá€ûËåÛ}—¦©ë²´Ýƒ´—ÛÄö}ÕÄÒwAã\àŸ^½6~ü8.›í®JõbéP Ù�Ua×ÜÎïKm‡‡6�çÛ8ì7¾_®u\žúOüC·Þ?íq·-.«XêA�pÍÓ¾ßùë|=Ý$öEUX0‡fÓa½\¯'†6* –¾B¬Ž¹ö;æÓýãÐ÷�Ûízš¬~Ö½nWïnêÂ6n6óí:‹¾î�^ŽGÚ›Ã¦kËíºœJl“ô)XgºfÛúööü|¾K{8ìC3ÝÏ/·¨ý~hÛñþrræ7Û6¬§õtÏ¢ñ!úfº�N9º~ˆëýz¹Ì1Í3}Š”u^šÍNËåþá½ë‚RÓ?ëš�McS¾Œ5û]¿�ÇËiƒ]¡fé—@¬y‘8t³Ýîë„]Ûõ[›îÓËRÂ¾WÐ¥=X×9ú�ïK>^oØ„]VMV×UÛ~pyÍó:ª¶Ã¾]0?_ëcì”PKo@‘º®ÔÇnËóx>¶!ÀUaÍ¹sÝïë¸ÌõÕÐµôK°² 7»e¼Î·›.@L,ý˜Í·óñrŸÊMèDª¤oÁ2&‘}û8žçó×OÀlV»CëÇ—t³@ÄÒk�\g/CÃöå|<‹]t"Õîš›Í“ŽãóI¡ÛM« Ìe=léO·—tÛ©Všr�u}xøl¿:¾Ü¤o{LF�³•¾y°z}9Ê-h¿6Ïã±k›Øx]²[²…ÞÖéºtÝþçÓu‘º&U55 Y—œÝþ°]ïçoÊ›¦™¥’”aJÁ2ÏôOC±¯ïï¯àCë}Q!SŠX�ÖoÃ:�×1çÆG­ž’¾ŠX]òŒ¶íuY¯««ÎÚåî:Ýš\_D,`)\|º]½�Ë}�¾‰L,½kEç£”<#«…m³ìe¹Ï%ôÁ‡â$}
«kn¬íš•ã}¶â]qš¾ KáÚ¸Á»\n6/Œ®‹Žu½�3B¢ä2Ý§åaÛöÍ”O÷ºJ×ŠEJ]œÉ&ÊfÇ’¡Þ‡â$ýo •Å¿Ù*îóy†øàœTÑôÐ².­ô�“µÜgSñ*¢éƒ¤•"Nº5ÛµXlú`Ëz›suí!Š-ušªÔ^U(iãÊB×øvrë:Q¥ëc-õ>Ï^4ˆBEÒkÐlE¡‰~ª£ƒ�ˆŒdY³i?Àò2O9'-(�ô9H®\kï7@™J£—ÆVWŠn=gÌ²:	¾�Jú�AT­ÈÒô¾7æû„âÕ7¦*iƒŠ,ÅÅÆ	óÊfí<‚sé‡ ³ÁºØ‰]ëµ£“ ¢’>a("µñ›¨ë<]goðNàTÒ¿µÖâ�ï-ä|_+ºvÃ0–;W5¥©¢’�0+5ûÐv4æRèû¸¥X™Ö}pÁ{jzÂP-+½�ÍTçõ~¨›m”në}§¢�šÚZ«¸®…\§Ë4½–�º\×[4¢‰
$+µ–fˆ‘˜Æ	µE„�¤G�`-Yªo=×<­¼�
ï%ýßHž0+YÐºŽ—µÖ]3„:å»ÔÄ7tRQWcã[­s«	‚B�AŒµD	AYëH+›¾y\3°nÕ7PjúÇ -ûïƒVÉË¼¶Ò5³ŒÀ:¨@DTÒg0€V3¬mšN—õR²õ~Ç:Ïë\q>P!æ"vVW['À9‰UUÒH¢V[5ºAÌ¦EÌ‚©¢�ô Â@fÍê}ðšó:Q‡užƒ4±GÆmUxxGUI?I˜ÙR]�/u^Š xUª
Ó YHÌÈ¬:DÈ\šM3¡r�‰zïU˜~&°fq24�µÜÌœ´E=(`úf…U]_š\j.„R×jAœº´i‚ºzµtL IŸÂ ’%S|o™y¼¯¬…Ð�ö 	šƒ÷A³,b"Ôà é/‚&t¨(ŽÚzo–³¨±Š€�ô	ˆŠl�>8•œM£ˆ«ÙêÄÅª©FDˆÔ¢kÑêœ: é	Â,Gj¨u]5($Q’þ&”âs”=Èi	@PU¢–bíê›‚Îi®)¢U$y¤atê¤ {mú€:]Öî)½ëí>›ATGG³ì�Þ{�Ë«9SÔlÒ„Î;Y×ek�CžVË.°3¯R@�B+…Ð¶C¶r›$îšVËºB¼ŠŠ¤'˜PÌu"„†(Z2Ë«:ç*”ôc�„Á¬Vß8çÍ×ŒlÑõ
ê$RÄW@@Ò¤	DÅJ­âi�s¨Q#<h„Šh:€ 	QIÞi-!ªËy­&tN¡°B3(š~¤Ð B (ÕÌkCÍ‹˜zÊl®ß”ºæ»¡kZ›kžÛ"â¼S@«…p�SãZ«_Å¡ª€€¤«š:À©–AQ…€ )ÉÓDà+«­âµ%ê29Ï¦‰êevÅ‹S—HÚƒ L  ^„‘
	ŠWÂ*B� &‚äÕQˆj$ „éÏÂ@ÂQ`fôˆ’ui €K¤AgU|g^×
õ®”UjµBªŠ�ˆ¦G�B�„©Š«™	D…fÕŒ"¼ýï�Ok&Í"»ìóšs�i¤*Œb"	�¤$HA(ªN f(( …à†ûðñŸãXh4�€˜@@Hj 
 Š˜@  –ZP„ˆ˜¤ b©PÒB0P¨B€Eá’€Æš<MÍgG%(aòƒX
ƒ˜ˆ	$PÔ’‡ÄK-(B±A� bšS„˜@ „P!*X«@E£9Œ%TLAU Š˜ˆ‰P,P„ Ä * ÂS£9±jÙçh *’þH–â*;m³a\œwtâ�JêATO´p~­«ƒw�ô�bM…1xOÉ›Y�jºXž|�ÚWWkY'zôÑ¹UG¿4@0ç$½Vêú>ú:O¹­O!8ÕªÂš�t]›æëÒ{ïCB”je*ÕùÐ9‡µÞ,kÔ¹VkÃ¦)Ëuœµi£ÓÔƒ©˜ªÄMï—ûóýÚIëO+e-²ku=žžW i=è�…¹t­×ù~»÷®m‚A$}B*gz·é•ï¦ëXûØxP$ý(Ó¼8¿ÆûºÀ÷Îƒš¶  u]Í·{Øm<g¶­C÷”ÇùåâCïšf‹ŒûTá½G,’¾
P$7èwu¹]/3cp]×r™ÏkuMëà	€ÌV£;D\Êí¾éÐ¸ê Â–œ¥ÛøËõ~iC·µ¸:XzÌ,}ÓÔqÎ@ïÔ,õ ˆÕå.zØæûËé¶6í.£ˆXúË €¹Ô®JÉ×¢ƒ6"P …cöûGÌçS-:´‡‡ò<_F†Ø(LHÍÓ¢‡¦¹Ü?ï��Š�‚lÀÐÇûíz½F‹Y»ý×i^sèT«Š¥/@ y­6a¾_NÎBçQ)é?EnvÙlvíåþÕ%Ç_øÉ¯�œ¥?
ª�.ù›OÝ²¥· Eì^ÇîéÛ-~öÓ�·?|»k^�L_‚+sµ~Ó¯Óù2ºMl‹V2ý]�ªÅæÒ~khðî«¯uûº©~×ëòñt¹mö±[‹pQvýº>ß/ÅÁ×ÍëìëãÇí°ku%Àôï€ QOãm÷í_ÄÇÿï�¾>û¬›N*"–ë*ýÁ‡çÓG?tm@QÂÄÙršÊÛÏ^ÇëO_nøå7Ñ—l¹ñj.8%m@�°Ž*ÛNïÇÛÇª¼n<¾ûèÚa#0°¹¢{z›§ãõŠö=Mªjú�*uºÎÃë_ÞÿñO~þæ³7»&FJžoE]#1ŠÖ9»á¡»�§¶ûÝì*˜~	PÒñ~¿-Ñù^éai )À|Ÿõ³o‚þõžðº�áAÝýåÝeìÚÎ± L¤Èºn÷e:Ÿ_Úí+ï	¡)¥r‰~ù¾Ì“l|(–¾ A‘u^,þâƒ]úóÓ†m›%ýS�šÇ†Ç�³çc‰í–X¦_©õ’¹»É^¾>÷Od) Óo�T)óZo^nÇ£;m®"U5ýE¬wºÇÇÿó—c{hºšgX`Ór½Þ.cðEÁôë UÊ²ZûI§—é›�í&¢ß„rO^Üp°1_^V‹ÝcßÞ¯ïoY·-XAŠTÞ
_m:¹^^&�M±¬çu+n }ò Í�mÓ×i�kn‚§§¤Lav‡^my{þêâÞ:J˜>A‘¼Þ¹ÿÖøé7ÇaØu‹fÓï€ 8ëvoœûêÝ¾k%¸Þ—õv¯�v€Ko@ˆ­ÙÙ°�Êù:gçz¡Kß©6ŽÍþàÖëé|‹C'©d@@
'lŸ¶ƒ]ß-uØö`úHÕÂ³õO‡î’þqÜõzîù>Ž\k^«*8-swøV¾ùxÂîÛÛv¡LÿP§¢‡m1]Ðt1B*™ Çu‡}?ŸŸÏu3Ä¸�é×Àä‘grx³ÁíÃ»Líbhúv¹ÝOkyÕ3ôC�óiº—¶4ÛM‹÷çÉÚØTÍ ¤æËŠÃëÿäýìôAÊ}ºf?tð90ëÒuj¹Ï«ßD¥Kß!fË\†Ã.7—ó•mëÔw”©Œ+£sZ5ýu Çœã«ÖåëñŠØGÇ" €Ë}j‡ÏB=¾ûºÊ›�«UIæõ¦¯¾½�/_ÿdíÞîC_LŒ’þ-P ¬ËšGçp¼ÞbÛŒZÉôW@@J×öÕ'¢_½ûžöq]«húH.S·û/—Ké›ÖàÄÒ BŒCØî7¸=Ïµñ}Ìž’¾b3níþmÓ,Ço¼üŠB¦¿
BÌf”þ1–ÓýèÌ5A«K¿
Ä¤¬aß6¥ï‹8ï»ð´ÜÇóÂv«RU,}	ŠX]–ÿ¿ 8ÙÕu»ÎüŽ1‹¯ø«µ×.�±Û‰HQ*·H,Ñ€„&Ž„(š@\ÂÇ­pÐ ‡hÐCBIìã½÷*þê+æœc¼<�Žã0ÏsY«öÉC
l1	§¸a¾Å±;†*ÓÀ;<ìÞÍŸu½§ý)˜)8ý]P ØÖ�ïÞöçó/—¶shN™ö HóÍÃ0�¥z!«ét ØºÉñÝþtÿú«¥äÝŽÎ@Ÿ~‚j¼moß|‡ö—¿|ÞobÃ&âÓA÷Å!=_ÊSp>fB¦=(â¶5Mƒ4«W´Ò1?Ê`Ësåá]J dúŠ¸-hÝ~àm»4t9‹ñéç [()ŽÉC±^û7´½þß?¿þï7ïCkkhäôë  Vï&û�½m_¿ÞÃ7ûÈ9�œ~‚j¸yÿý^ÿâÿ]ía?äv¶ù>ú]�î~9Û»±�MƒO¶ê2Ž"‹•«ôYƒÐ§oA¡¯ÙûN¬ÎzKLŠ|úg ˆ{ÙJßØ¼¾lk¿Ï	ââÓ€AÙîšß%œ___lØ�-ˆO uu=}xkñOŸßàíCgpñéw@@¬ÜK|÷áÍø|~¹¶C¿C(">ýsÐ+¼{Yp[K�ˆÓ7 Äm-ÛËëç{ü^w\…*>½!låfzøØµË/ñÚ†îMCñé(â>×m¿ß�Ê—×ÛÙ÷ŸFP X}	‡GàWO_1Núô·@/µ…ñq8Ì/O¾‡>‹«øô?Aª6\!»�c½~þü9åãÀ*âÓ¯ƒ dgä·§‡òòù|‰ÃÛÎ°‰øDLÿDµæáÑÚm-osèÕeúhesOäe›½ä£˜L?½´-äÝpê–ëu–0f¦:=ÀœOÝ{”ö‹úuä£ÈÃ¢ èU"ºµ•%ybfÓ_}[ê÷z˜×ûêìSTF�þ¾ñ¾K»±ø×¥îØuëû³LŸ@ Y�õð8ñõå©„ÜïzµUhbŠ&Ó·p_ÅSzxlçùrä”Ä§ßYê9uCº­O×j]!Ð‰˜þ5Üjha¹†ŠYRÖCÌë6·`©ïQ–uE¯Q§O ¬ ¶œ——%v¹— R¦=è­)rè¢c©[b€‚m½¢¥®Ï°m^¯Aû¬:ý˜Û&¡ëƒaóMrêw¡w¶{€Cêk.²Zõ¶†\¸ÍÜ:Bði²Z+»î$¨Ïå¼!ÈÐ!ÂlÕ{n]Ê5–Ù4d�M« YÜÊºBãpzÀVîmÕrPiÒVÇñ´èùukiè;�KA±’ìc“¶bmA’g“é°5¶�wÙK¹-tšLÃô 7[Ç> ­7ÛTB@®¢Óo� ÛŠÂñá“e¿ž¡ã~¯êUgmÌm-ìºñÞæËZ¸K’[TÈô�@‡gýNOi½]*{ö ÊÀéÁ¬T"q½¯áË#¢ïo:}²iK’{øÝ`*šB èôk f-zNƒ¡Îº‘!‹™ˆé.03²oÑJ]�ªÉE¦ÿ’h¡&É]Åï±j–‚�é€ÍcîMëj­ŠG$“Àég €Wm5¯¶ÌÆ€Ìà€h 8}]¨Æ-uÝ¾|^%ë… §ÿ16ALûDlK�"]‹NÄô$\Ä½4ùà¡¬ËÝ%+¢@P¦ÿº€æ› ½¹µµtŒ–€ ÒE\ÐÌ<¦Îµ.ëÖvAáÍ,É™>‚p6m‘}ÌÊºl!e	10Ð€Œ¬fV¼e‘)A¦ÂE ÒÍ1¶(óz÷à²ms{*s		�»­)™¨84¥ênØ¶íZkˆšB€@,púmhjÉíÐÆhZx‚Ç’ iƒË´ƒÓ)¢Ê�¦CLZÖëBPÖXh.}—Åe)+É !ˆ«‡éû H73FMpŸÝ‡8Tçêµf†à±‰‚Ó? A‡ˆ",Öb×G[ÊŠ �ƒ.*Ó 	Š"tó†Û—NSiBK„ …„¸U	w*B7§ˆ[É1'ÐKv¦YBã*1-5ßfKQCR€ E¦¿�"!ÄPÍÈØÅàµ,9ŠÆA'"Ó'¤8(U�tÒ	€„©†�RÑHÑs8E§ÿ
ˆ@©TEqº�T§?	�n&ªc]TØZ(bR²y	¦*™z$ p¸»„£‚æÍaâJQ ¤@BCÜZ0"«ÄÖ–ªÚÅ˜ÜËzÑAo-šÁMâ ©¢™" D%Nq‘é )�Á=U·VÇ–³ªW5#BLR¥‘T�pú	¤!š‚Ò[‹.YBToÆ&ª*JÁé_Áò–!.È!ˆ ˆ‹¸@8õ @P@@
)H
„ "„B”¢ @Òà‡O	(D¦!!$ÄEH@@�ˆ‹pÊ œ(Bˆ‹8§8U¡1ˆ(œæ^3DCD€{�ft* �‚j@p%›˜Ãá"hŒDèlÉi@PÄ"„ÐE\ 
D@  ˆâ2u |Š Ä§âˆÀEH'è‘¢‚ÖÞ%uA¬‚‰
™PH³ÚÅQÕk]!}èz¤ÖÖºÈ�¢dW™þ>÷‚Æœú&KÙ´u’U œ~
Ü*(q¯¬k¹U�cß%,­JÞ'•¨$ØÌ=iO´•9ˆ„§?…ôB„1f³µÅ"R¬XÒc,¡Í‹Q�-¶ég ÀlÍzõºÜ»<U DÅ:ê!Ë¼È¨YÕdúÀÊÆ~—Þ•óí¼öcŠÑDA¥µÆþ4¢¬¯kë‡ž�"Ó€·R<õÖ|]—ô=9˜:eúï  V‹…þÁËýuyAŸ²J§Ÿ‚ |^Zzûk˜¿þê¥½=Œ˜	pÚ� lkßÇýåå|ez÷éyýúçËn·Û5§ÿNËºäÇ7å»¯_‘ßŽ08ý€KËÃã0\¾,U�‡CÞ>?]†x‡‡¼}~}¹ÇqH"FNï@ ¶Œb=Ÿo5·>>|ïqö§×ËÃp’ââ”éG  ÖªäÝ>ßÎÏHþ®óã›a{yúî:a­	U§  ÖÊ8~8Ø—ëó»¡9Àé#ªánrüÐÕí—O%>�&¦X¹åôîƒœ//f»CT
8ý`Óî´ËO·¯yHP3ˆÕ5�¸¿žÏÛ€”Ž±|ý®åý!°	HjiûþM]žn_ª�}F¢Çé-j»^—·ý˜( §Ÿ€³Mû}Ò°]g‰§]Áé_€¯Üºa/[y­-Ç^Å§O ÄQ–è‡‡ŒÛåÕ°ß7 äôcâ,w§aK·2#÷ššP·mì·—ë=�púS�ªµÝ=~ˆƒ|y~Õ‡·±»
Hó[û·½^f9îºY@N¿B¼¢aØÑ×Kóæ-<p]ŸžLÆC£€œÞÃl¶Å‡Ç8”ów›ìN]iÁ)ÓŸ‚Tñußÿ nñÝã~Ôæb"@³Êá­Øçë—ÙÇQ©FN; ËÊx8�>_fè˜÷Ç‡rÿz¾¥a×BQØ¶D=íâüòtERjÍ
÷ï£•Ë%àÐw«šS¦ß�+ØÚ"ù}ÂËõ‚îSßµœ2ý1(@C“¾OµÞ¡OAšLàŠ’;¿,¯ë¶ë«88ýÄÚfýÃ#¶¿|ùjvû±ž_¿[ü£ŽÝðüåÙ•.¦:} âa	²…ó­¨ L@|Aywór;÷ØÅÎ“‘Ó?!ÎÖ,îN¾Ý®7‡»C°×Ë\ä˜ûÍƒ© ¾H}Ó�6¯ó]cú/·óòªcŸ( §?€+Ü®­Þ¿K—ç—G¦ñøàéëË–ún8ä¼^nO·ønÔc�°Î/sË}"œ~
BÜjC7ä6_oU=âÓ�AˆùVvû1Ôz©¨-õ§‡d÷gt]? pA V–´?uþõ~ymAe7C¹=­Û©�ÇÝ`õõ¼VÍc÷xª¯¯Ÿïy?öÍN{â¶&9Œ”õ¶:ÇÅ§ÿ`»U¼}»[^¾¾\ßŒ©ÁéG  Ö6§#Î//›~`Ø}êÆ§×¿\åÍ>»Ó)Ó�@°iãÃ�óí†Üiª*>} X™™ã.Û9Œ©ƒ9ýˆëå0¶e¹.ÚC(Ó� lsÛ½ÿÔ^–¯÷§ååz_úc/„�Óï€ |®–>d±Ûíßr°è�é÷@ˆÙÓ8¦yÛfésm2}B¼Xíûã¾–ë}LaP¨øôsâ(ëÖïßk»¼>ßv}(¨¶¥þmöóëçÒngppú'pë6ÇÇÇ!]^¾¬-‡´ïGÞÏŸY‡·�k8�  �kÉ'œ¯Ïgëƒ´@€BÛÇã±½žo®]
0™v „VVÅãæóëKãaŸ” §ÿâµÍáøØùýËùU†!7:eúmâØ°úaß¼~^s¿7º‚ÓT·.Ÿö·ky½kÚ]÷·é B¼š¡?¦zY^æ4ô�Òdú=P (•ûþ¡Ý—û½h$€2}!´6‡q|Ôì·ó]ö]i2í@ˆ·2K:ue¾´‹è(ªU¦O @\È>b�ç—`‡Lñé#q[Zß»×ûÓ}Óa›"(àÊúx_ï«§”ŸFP leÓáÝiûåý—Õ»S¦Gñé§ ˆsKˆ‡ÞÛ}¹zî0TŸþ |ØÅá¾¼ÚCÊQL§ß Âº†ñ°‹z½�W|ÓG•*Óo‚"î[cînm¾…‚ ø4‚"Ž[8¥õúz]öÇØ‹E ×©?Ð×ë*Ø„ŠO;PÄì®Þèö|y½C×E2ý.¡•eóÓé±~Y~±ÈîØ7™v ˆÙRRz“Zz=¯!ƒÅ§¶­¤üNùõöeµþ8uñiŠxE³SŸo^�"
E|[Wß½í–üôº¦´ëÕƒøôˆ{XŽ£Í¯Ëõ°0Ÿ~ Š86¬<œbþrûr/þö¸{D>ÿòâ§~õå¼>“»áðpòùËeEØf L@� ”Êá1Ô§Ëý^Ô»‡ãÇç§ËŸ_×¡Û?žÖûõóµ¡÷§öôzyNÃØm¡@qñ4ƒÕõ^|�‘.âÓ 
[½Ç}ú(çù|¯÷oOÃ|}ùîš�C?>ìúóýË•§}NpqPPZû1¦¶¼¬U-�¡~w=#„œNÉ_^^WˆŽoRXôùòjó‡þAäÐ}<vÕU,ÀmaŸŽ¨÷õ²v¡‡šˆO=(ÔVx8&»]·—­áñ0Êùë—ºíö‡F m5‘·ïw÷Û—ûmçax“òýrùº¤º“ÊõòuÖ0†TdÚ�¯®}·Óþº¼nöÇ£¬—ëËÚòa8�Äõz]tìb¨
PPZÃ°w=Ïu§�fÓ)ÂêRq<ãëõrËC—Ð‚8(ÖjyzÜ××žÝ.­ \­æ‡L¹=_Kÿ0D"8(h«cÜuë}}¾-{×Ã õz¾—pÈ‰B™v „•KŽoòòôz]b4Õ@‘¶yÙ%¾¼</­?Œ»å~~^ðî1FW ,¥Ú›7!”ëó+0v ‹ƒÂfÞÇ‡z¿ÝS–B€‚¶Á‡}_–óåî©KBŸFP Îµæ}�m¾ÞSìBS²Zmû7Ýay~¾Å}»a‡·ÛUº‡NH¥ÎLïÞ�×õYn‚nÿðúôÝmË§ÝáðîíåééåÜõFW‡L?E¼òÊþÝ÷×—§âŸú®‚âÓAZ+ÕöGéÏ××‹SE¦ˆ¦kÐýÞ¸ÍGL‘Q}úÇ ½ÖhÃq¬çÛ×ûœó.">ý!(n˜‡î]¯çõ¥yØ=FÞnŸ¿6Çwß$ÓÛ×û™1¿‡¶Üž/×^ª  kÎÝpHë­\–‚w‡wèãòz¾Üs·—�§ÛKièO™KY–„ÐG�M¦ßEšÏ`ß§ÍÚ¹m™ûÝ ›]î{Ý3¸øôSPÄÚ¤SÄ²½Ì¦aPˆúô-HÛ2ãýÜ 9¢N?YŠ{x;h{¹½Ì¡ß·Xeú+pß]ŸdkËÝ•îðèó|®Ë‡œ)Ó'Ðk«!†Rï—ó%gõ¨ÓÞZÙ¤lë¼I!· Ó· ·¸I÷k™o—r§`Ÿ>�¾mÆý~®×—û,2H$UL›5û�îež7]—=9 VÆ´¯õ¶`ˆ‘P�¶`ëö±›·ûeÞ�ƒˆº˜šm¦ãñÝR–ç5£â Ìg>)Êrß†G�Ù³h¨<ô§"éº¾à!æ¨B‚mSÉ»C›·ó9Æ.w	PÀÛ&>ûNêu»ºœF…«‚ÅkŸŽÝã¹]_gæÔeR¦ß½šq¿ÛmÝò²œ[öcú�t{}}îbô Dó°›Ûm^‘ŽcWŸnçÛ6tCŒpÀ«Gï
¬s[Væqì¹,ËÓæaÈÃ,‘hbšò±Î6·Ø¥\ƒ5®O)]æû9Ä|ÌXÚíœ=t]¦Á)ƒ H³ž÷YÖõ²%èqØ§z®óuEºDF!§?Y½‰ì÷bË¶”}Fç‘¢¤ÛFÏ±3çR¬ƒä`"Ó·`óuÄNúE¶¦æQ•2ýd5³¸†qk×Ú$§�Œ:ý>Èêe—ƒ–r÷rÚ#ÚºU¸Æ(¢ÓÏ@V©)Ç¤ô²ä$1Èô=8«Gë¤o¬k¡'IÙEè¾æÇNÃÒæmC’gN„{‰©t+wYcÐ^�dÚ�î°Ôg„íÚ®ÉúMU|ÚƒÞÌ$e�Í-EÍdú¢Å%šîÆàukUMc@ôÊÒãÇs»ùâqÈ1XœAÙJé8Ãè÷ù¾óA{Q€Ó°ùV5´ÌsÓ!'QÊô¤ÞJ‰aÜ©Üëù>B´B!YŒèòßl–´Š°YiÒÅ}óunKýQCÅr_7j;f8½áô
xê†TÚ|ßœ]L ›Ux—lí¾‰‡dúp«±¥”Ø–œT3b˜þ=Üªaèá¾ÞWÆ]ÊJZX;¤¾oXçK­q7ìÕ°m7³¼KQ ¯jLq¸,Íút�mõºUÛ1‹„ ™~¤{qÉ]ÞÙZï0ú$�‰L?‡qkC§Ò\a]P•ióbÞí†¨Ë2ÏkçƒF•i­Â5å�»Õâ–ú˜�´Í¢ö{7k÷DHQ§t¶Þ0ähÕ/K•áÐgY}›= dÉqk2ÆÁt]ÖÖ:dv&Ó'˜·Êûl(’G$A�i€iCRbYWh×�¨¾Èýdy�²Ì.§îàºÊ­„<H�R‚¯[sºN¨ÁXIë»P·í¶m6Œì„™þ%H¸[!t‡Æm™Û ‡çkÐnßa®×â±‹*(¥¢iNYÝJi‚±ƒ»oM$z„À­¡ïc­[�Ñú.µA÷fˆ!GJ�‹Dz�¥,›Û€Nlú›poV¡¹�V­\··qì“¯Ëv5b€ªŠLÂÄ­Šô¹Oês{µ“c2[f3Ä”ƒ§*:ý5Ð«@BÎf¶Üœ9ï–RÎVÙ�#òÜÖµ 1hp“­ß’Ž Ê”ƒf‰AœÅ"º.Ãl™-æ˜EÔ§>Eš7×Ô§ÈmåÆ®Û;K»RôèÓ'€·&!t�¯m»—™¢B U³BKa4m›­:ä£êVË¼ ¨DZh:è°Yk÷†îˆXì®«
:¢ hÍ©©B6s	º“PmÕ”‘\ á^A‹i@³v¶uHcd­Ë†ª‘) ½ æö&åÎ9vÝè¾ÎRrÝZ½ÏÕc7&ÝÚ]*rH’H «ƒv‘,7�¹ïÇZ×r«A»Aa:ÀXh1Ç¾zõE=æ‘éÒ›h’ÓV«Þ…±kÚl†Dvc&jmeõÖ!Ä„ ™~¤;E`ÜrÌZËzK2„^ séÞ4†,�êªÖÅœæÂ,)èô C%ƒvÁ½.%§¡K]5,-:%26EU§ß‡S(
b†°%ª@!ê „L8E/)me¹Ï]'‹­ªIB‚p™>€¡*Þj‰èò®¢ÞîÎœF²ù=)bÌ� `
“–(BBS´à."
ÀIj Z¬Qã\­lVIMAÜ)¢ªˆ8Ý›t” ¥µBÕ”]à 	Â$dÄ€Ö<Kˆ£Hi[‘H:àn.9D\s! AtoðˆN”Å¼«)Zh
�Fvæ­ IÕé×Aà­!…^6ƒ%ª°Q¢Šøt 	7VE'=ÉmI 53P”2ý&›"(ªBb1¶ DuÊ »S5„ ÷æîH ºŠST5
[0U„ á]‚
*Œ)$Àm‚Ä*TE¦ïÃFC‰”5�’B„“52dŽÒŒ.1…ˆy‘Ú'(nkK‚’Ñ×	M"ÓO@!èâ^”¡”m[WtºÅªU˜"tLE6 ì™ÑV"HìGËÕ7ƒ¤á„SD»†ŠM%gÂQ“�é.JÑé=èp
TÜjf'!nmi BŒ¢p¸ˆè´I4õÚå>»l+À8æ&À7Tad(N( Ó¿I§h�ØÈÝ$&UaF¥ª‹4¸JÐ on&B§™rŠ:½é4h€éÄL]!Qà"R .¦ô �4_\CÊæs ‹r •û\sÊJÛ–¬CBŒ  
D¦‚p!®€�*Á ºPÄE!@pŠøÿ`€a®BASE      P[  xÁA  ƒ°YãxÔ þµ,¹MrËŒMÔ•Ôt¨¦ª`™Û†­mŽÖœÙTl¸MtcŽœŒ´œ›Î�tT@9(gÌŒA–ÑÆ– 2×F›Ë”Í‘·3›Eh*º§¡S©æÚ67V+RµK]�ª­)€€©Ôp	m[ÃÚ€T×X:#Å©ÔhaS �$J[s4ÂÅhaSXlÀR	¶¤…m“ ŒEŽ ªUªUµ ¬XµhÙjFÑ2Œ²RmbU…TµÊ*€è]Ž‘®Ä mdËl™™)Z–e”–Û´å¶TsÛj[Û²Ž ­A¤6Ì(1bÀB& FY€†Â4#)UD(2…jE+@¡k*”BPÖJÊ*k¶­š#-)ØX£`Ö¶ -(µ¥˜’²å¶�TÈ–: (L1f)›2Ù¶	�*DÒ$Û:¾BPOS      Ma  xÁÉ¡$E ±aý]zY³xÄ·0éßÿþùíÛ·o¿?OÏûëž¯ŸßûõëÇëžûå½Ÿ'~î¸ÈžNÓéø„áÎ}ÎæeÛãiÞÜíÄ}Ïµ3«›ÙÚv[¤¶‘f1gL¶Y
mf÷l†96;³eìÆ0¨€­0Å,†ãh3&M›Æ¶pD0Â Ø04LÀ
Fs“0Z„³,�5Ë�Å†LCˆ!L1€4 hCh@3 ² ƒ�HÌÄ‹¡Ö 8 Z0`šF!0Ñ4DÑ
@Aˆ D	‘””DRJ«u>*ªB_…’œsN‰¶ó×ÊÎC­v¾>vcï×§¼­[r¥µ³s}ô~.ÛÛ8£œîsŠƒýy³§û÷ÞŒ:ÚnW/í>÷y;ß­eÉY½Ï�?Î�Ïõ?Q…4ÍCNF4      Xò  xÁMŽÓ@€ÑÏî®8	‰CPðe1+î0âµæp]Är¤ä2Dùí”»‹÷ªo-è—Š¦T8Nåu	OÎñmv�açå÷ú]¿A4ÒÓÁë^#=›?�6¤Á`g¢CtN‹É@˜ =tú�žN—˜hÄDŸééô+9hGÚ’ƒ~ÇDb¢kL´Ã�a úBÚb ™‚è’Ÿuƒ‰
† &`D§Mâˆm‡N#ÆuÅë^#«÷öë# lÛïþ±51êd½ùz5^d~½nîLÊÅ8>—¡ÌB™§öï
i¬Kä½·É”SµÀšÇ¶&©Œ’™Ž‘ M"åE¶G¬š³ÏC]NŸò=ÁiyöJÜV7šÔÜ¹šŠÝÊ›‹ŒÞs¨|2:E¦÷:3Ëå>KÑ-øº9Ã•Š‹:ê¨£Ž:ê¨£Ž:ê¨£Ž:úÄ‡»TEXT       Ïõ   xÁMjÃ0Ðï(s [ÌŒ,«6x!Ù"þ‰qÔ@W&)Y–tÑrû¾‡%Ì	˜Â’`çãaAè„k_ô�¸Æ‡î­òEî¤rç5ô�Úˆ†�òóN"4__ÄÒ²¶®!eú}P~ÞI„æë‹X[«­­IYÛÇ2@Y…�ˆaau•¤¬ÂNÄ°Zµ5†Ï´bŒ»õ–÷õ´ú=ùÏšïÇsèßâ±\ûRXkÌ§a‚õ–û0aŒæöõƒKÚ•a\Ò¦#‰Qàn5 CLIP       	            Ö<AlignableSequences><Sequence name="85_CMV-F_TSS20210510-027-01701_E02" ID="0" isTrace="1" sortOrder="0"/><Sequence name="85_EF1a-R_TSS20210510-027-01701_A04" ID="1" isTrace="1" sortOrder="1"/></AlignableSequences>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  (<?xml version="1.0"?><Features nextValidID="22"><Feature recentID="21" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2279-2321" color="#ffff99" type="standard"/></Feature><Feature recentID="20" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="4762" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="4379" maxFusedRunOn="4379" visible="0" detectionMode="exactProteinMatch"><Segment range="4763-4774" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="19" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="5595-5611" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="5664-5685" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="5619-5625" color="#ffffff" type="standard"/><Segment range="5626-5643" color="#ffffff" type="standard"/><Segment name="-35" range="5644-5649" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="3688" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="4291" maxFusedRunOn="4291" detectionMode="exactProteinMatch"><Segment range="3638-3691" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7593-7697" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5258-5379" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5398-5533" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2011-2214" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2355-2566" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4953-5186" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2579-2847" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4292-4879" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="5973-6561" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3692-4291" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="CopGFP" directionality="1" translationMW="24523.27" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" maxRunOn="4291" maxFusedRunOn="4291"><Segment range="2906-3568" color="#05fd14" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;green fluorescent protein 2 from Pontellina plumata, also known as ppluGFP2 (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot;&gt;Shagin et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="0" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7523" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="6732-7523" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="7524-7592" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>8984b589-cf3a-4b62-9fd7-cbb814bc6791</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="8:40:26">2021.5.11</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  ÅO     "  þ        þs"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp¥ê•EP h 'HÐE’Ge“]�^TZuWV�U­V©±žI¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4NÊ’ËFÏ�ö÷8ª½‘F¹“±jVÁ¼ÃÌPn1³¼#òÒDÍÛ?t¿ÄR€ °Ö…À�‘ ÌW€T†,‰àï>ªü@€_&e#I,ò+ª³\
�=táN± ìÛ»ës?<þ~óÛÜð¡,ÊãÏ¿> �¾Œ¼òä%*Tíð>¢ðÎþ�>~G´ðî÷:�‡øèí{œºŠ²«Šã<§Fõ8‡Ã>s‘Ï}�DÃãóØ±#Í·Ã…Ã JÄà€Ã@ßýMÍ‡×Q…}PÏáúÓþ~8OrpëŸzÃ~Óqþ¾7=µ×9ß]üÛIÄ0Èãr­9óœCÃÌ†Ãµ 7Ã¯ñL†ë|uo4×=òß�ÿ`1—#‚N³ó~´øÌpÃžtë �ÓÝ�ëQ3ÛßôÛãEÀö+>¼ó A8Ý5ß€Û IôÜúÔöÏ¬ôoÌí,½k� pß<Ã½ðnÌ@Ñ.¹v0‡ Aü?˜|IÔýÂ3ì÷órÿ@òs³Ï2³ÇŸóÜÏwËÁóÝ±0-ñ8Ô^ëíÌË±ÛB ,ÁÇó0¸sÁ,S 0ŠÏ°üÍƒÄ¡0¯ÃƒÌÓ]>ø3ÍðýA?2
ø=òÃ.ÏÇß@Ô€Ó<²;ü0ñ3<?>¾~ó?Í~ÿ®q0ì:ß-óÇ,B?3~Ø5?øV×î�V¢	®—˜£¾©ÎbsŽ¥�¨›cš:ü˜:¶«¾ú&Vø(âî¦J ü¢Ð× È"7ˆ¨áÍ÷‚€6�}ø´ï«Àz³«ÿ¿š=Ãí³Ï�£óŽ@;(áÖ¼‚(°8rú½ƒŽÏˆ£ß�®3ËëŽrþ°þÖôÁúúüÃã�ãºó.óë?´q,¿¨<ûüø'êQõ‡§PÓ‰¤÷ª•EP xZÞýqVQ¸ê£¢x»‚‘ônà»ƒ—�÷Ž”ûYS£èHëRHˆü¸¢!î	y¿´ªKH�VîM$’¶-ºi­&¦^�QXY´D„Az*hÓ¦X)Õ•5“mÕ«ueMª«xÚä¢
‹Õíµ‰ºm‹ƒ¹9¿?åï?Jóö»ÏöZª¦¦4CÄ<û¸NkÑI!:ª>Gª4GÕ¬–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äPtš‚n3¸áOJ~°UD “ºÃWWß8$Â
ªŠ�M4iÌÑUPnÔQ¾¡º®p‡;H{r”¨-„iµT­ùê•¥VªVÖåI™„•è.)õŽ–Òß›´Æâæ¬­½’�‡¿Ë"F^qœŸnôŽ5†|Äs·Ã½›Me}=<4Rã^¦óïoKšZ(ðäII+=)d¨ÍrŠ=£�²·;,¨&¶´ï
ýqµJvÿbˆÕTÂ“¾°¾ñ²‹E%(<Ò)·¶
`ÓxÙkºx¶=¼”cªâIí}Kk„Y"c|J;£ðËYÀeŸ3Ý“EêU#¶Ú\®°UîÔ§Î(Fô¬b_ÞÈß×†ëMº§«}2®Ut5XóUPP1ÜŠ{gºú«Y¦…6¦Ð)¢í„Á�š…‰©Y]Y ¯3v¯ñT�~¹E}¦›aÚ_™U�É·þ¬»3*Âp…_¸wcNüÂÝ:.%0cÀMOË@Ì´ÀŠ°—˜ÃmF‰á7ÙŒ"Ÿ7F2PEYómö³ÚÐã5â€P1°ŒºÎiÏNT b8Ô1¥(	sÐ*¿KqÊ%\pô�S      	
  	  ý  IÕ      IÌ®ZTR

SMP4      D¦ao  xÁÉË·ëšäó¼îæi~Ýû~ÍZkï]IÕ^{oS	•T¥
ƒIQDÑTÊh 		$’Ì"Á�QA0ˆEÉ@ð8ã_!Ž:Ñˆ¨$U©Ú«ùš·ùuOsß÷uzüûÿ0ý¤è!…œB?äã~<îŽûqß¾{÷£÷_<¼ýÁ/}ý£_üÁ/¼ÿúg¿üÇåWåí/ÿìË_þ¥ŸþË_ìO	øøSÂÃôSüMÿÆÔCÓoãÿùÿþñÿûÏþÏßý=ü“ßý½ßüÃÿûŸ¼üÞ7ÿô»ßü³—ñéÛ?üðóoÏß¿|zýþûóë<Ï÷ÛR¶Òš†ßÆÿŽø¿ÿþ' :(!)€r@A
€ ˆà!€¦A‘20Â@eI.ˆt¡u ™²9ärBÔin‚À–)¹à�  )ƒ”‰.§"[‚D2Â2@WU	jNŠƒHQ ‚àÁÖ	ˆ„¤ Né¤ : IpH¤A¨îMNH7@'5��à³à4@9¼A�Š$‚@'H‰tÒ§œt8Íh€)©&¹ ºÜ]S²ÔÊ¶Â\0§¿Á›7YNÀ Òœîµ!…¡ÈW(2�Ó/@î[KCf,Kl!äÆé-¶(Ë%¬�R Áé?‚à­ÕÈÔ[¨µT–`AÓ¯@ðæM!3ÃË¢P;X$¯¡¦”™7ÝÕ-D‚€ÜËæJ]ÚZ«0æŽ¨eÖØ#H´ª§‡Ð®¯—.tâôcˆ@�ò¾bY7ô]@¶¸UÅq,óóµ™ô(Ÿ¾„ùÖBwæÛ<3¤.6ý"¤¥Y<¤Îî—euîÆ4Þ×r­Jyl]ãô3ˆ€×j­ë‡ëVÏ]‡¾p=7	9Fqú
"P@Ë9±¬ë-zêåRoån›õò¥œ9„H›þ8À·Rb|È­ÞžŸi§Mÿ5Ðk)Ûîm¶§×—Çî!´öz^.ˆ}òàœöÐ±•[¿ÿÁnùørNñ!J§ß‚dVê½ôïß¶öñókOƒmAÒô@ZµÖ�·Û¦Üg¦ÊéÏC ·Õe�ÁÖò¼¡O]8ƒÏ÷5ñKßÿáwxüÑc¨r*Ûôc@i…»Üoåò:ç~GjŠh,ä¾³¶\–và^4úô[è[ÛúáÔ•Ûùå†´34båú¡Óz»ÊwÖ‰œþ-HÆ6ß½{÷î°¼~óùòöñ*ä"Pïk9¾;�¯×o¯ñq|t|xº4{8”4ýH¤_×u|ûðo~þÞÞÄRƒ‹Ó¿�î[EwÌiÛnKû}-÷—;ãs4}Ð²–îá„út¾¶zˆ»Q[¹Í‹ï†š8ým`Ã¥ÅÝ›Ü>|¾ÞíÍÐmA)Ôõ¾ÆÃW'¾|úØìá!‡Ü¤un|ÿö ùÓÇó}ì¿ò<ß>TŒ}J-¸8ýC€Ú~xËóù¼ tûa©óëm¶>¾¡éürû!­-Ûô« •KÁÃã»Ûüôé–ÆáxÝm~>W¥ã1ÅÛåóYèÀMï¡)¢”-î÷º�¯K|ØÇ°šþ*°áµ…ÃÛ¸>ŸŸ·Ç¼%Hš~éó½ôoN¹{þæ#ºÓy£‹Óß‚ ¢œïøâ‡?ðá÷^ò»‡ã\¡S9¯ñþè{üþÏ¼ýêáMÆýõÛ-æÜ7„9ýÐÚºïâVŸ?oèãP!C›ÃûŸ—çË6v�¢B+P7în×ùu)Aù°;¼Ü?ÝË8ŒÑ�Òôl¬æûÔß·ó¹ïE£O;H¡¶ûÆÝÃÁ_Ÿž–a’É éoC
�uKáíÎçËÇéa¿k×ë§—Á†}1‡¦ÿ"ØP‚�zmåu‘¥á”ŸçÚÆMFŸþ!º/ã0ÜÖõ\ÉNÃv_Ã›_ü!Î?ÿý+v��yl—çkë£¦ˆ¦¦îMO¿_–¶·A2 j[ñíºÜ�S
0úô3"–y�ï¾—×o¿½ø¸?eÀ·ëÖÇÔÈé7!@,Ë–_�ëüÍ‡+ŽÙ* M"Pçö»=çù¼aLÙš8ý=ˆ,uŽa7l¸•ÙœôéA ë¼Î»·‡þv}þt{8ŒÎhúØ¼,ýá‘Ûíùi;í´�ôé/@êÒb?Œ×õ~®!åH£O_@…»i8Îœ/Wïó¨@úô·á&Õë½ß=>¶ÏŸžýqÜÑ*é€‚æS:DJ)Ð	ND¤@'8�©iúÔƒ‘š O?€HA¤ :@ RSú´ƒHÑ§¯!R è D:)ÐAŸ:ˆÔ”ADJ¤@}úÓA
 súË¡ÐÂìc;/—ËuM»Ã¨u[–‚Ñz}z‘šzÐ§‘DŠ>u O¿ ‘‚H‰„ ôéÏ@±¬·îðå1==ø”w§ÁJ�4½‡@×¬–OÜ®/×Íb~8…íõåvÇhcpÒ§CÅ­„Ó¡kçÛë«ÙnÈñ¾µõ^<¦‡}\Êm™5¦D7úô5DºÖVÓ¡ë¶ûõ|7‘éÓ¯B —Û¥í¿újÀ§�ÿÃ»} c­7ç—_íqùþçkÿåéÔ*$MÂô¯@¤×23�¾z×}xúü™]p'}úEˆ ÊRÑ±;`þðay†âôUæ¹ö_ÄõÃËË§´èaˆ(—™Ãûß|÷ŸŽyìª,øôTq�8æ¬õ:cŠ	�>ý§éµ¹â®G]æ�ìcT Oÿ	Dªø:ïo±]o¯ŸjêPÁ§ÿ
Ri°<t­´ë6Gë–k»®0ËŒÁ§ŸBdÕæ8<˜žo—û<Æ@Ÿ„éïCÚ‹‡Au}i
}ì= ðM›ò.4-¥”ÌÎ,9éµ®[:<¼·ùéå[bŸw�Ó mæ}ÚYkuÛŒv)¡¶Bêb_Ì¦ß‚HÕíºª;0_^.iûhh O^Ûº¦Ã±×:{.Ùzv"§Ÿ@d[UOÛú|»(f&€ü^î<>¾Çýéå[»]t7
š¾†¼,D¿KŽu.	]
2›�o@MÝ`¾ÕY°>#Õé‡Yµ­6>tv[_ž‹âØç!J÷m=¼8Ÿ?~û1ÖS?0púò¥®
Ç‡q]/óó.u §D”yÞòþÝÀ‡§oÓx
Ü²Ãk)K÷uyý|^Á~°Ôb˜þ'¸
ã.*Ìó-®f6´0ý ‚6/b?<nóíu½l)öÜ¨Vëê»Sðù|½ÆúÐ�´éäm­�ùqu¾>¿”>�)oœ~"[[\8…®.ëÍe9fNÈËVbÎÙ½Þ¶£õ§ß€¼ºÅ0ô´²®–Sö0ýÜ­ìSŸ4_–£õ‡–W^µ 9$ƒÙô×àÖ:÷¹-¾?>2~¾}¯ýnc“HpúZ¬kõ´w[¹ßÚ†„‰œ6ý¯\ZZ©ñx¶åååºîs?2(@Õke<�óëëÝã°‹dFjú£\Õ9tÉ°µË!€Ó¯BòÖÖÎrgIõ¾aË¡Bë­Éi„à* Ù˜zmeöf)Zïäô—àª%4ërë…KnHHà4@p©l‹ÒØ�õ²¬·BcŠ
 §rÖÀ¾W×´ÝWù.IµÜ‹”™•DH­)ÅÈæe&ÆÜE´¶úÐÅ`�®ºn
ùØÅ¥œ·Û‚!Ç „Ù!´Ô¬lU]ÞUÛæyÒž!.¸×51Z•êÜZØïvázÿXoÀ.D·@3N=Ü+ŠqŸ:¬e½%³i„CÍ[MÖ‡ÌÖjñj‚…&\ÔóÈ\Û6»bH¦¿Á½••H»`¥Ü—ÕCŒ!�múã˜¢€šGh¾¶¢Í-1:mú3pHj¾°v».…e›å9YFAÒ¦r*{‘‡¸ë:”eáÊ��‚ƒ0â4B€ o¾E¦˜‰º®M�‰Qæ O?€ ‘rÔº©†~Œ¬å¾®2v#@púu�ÃÕ¬Tö}D«]»6„h1@´é/A€WÑJl¸•ùÞ*-´‚ $8 &o6 /”Éé_‡Ò½Uš¥œL>—*!X¨é ‰Õ´ÁÅCË­�×Ñ²YAÓpk]K@³J‹¹§|Ùª#‡d¤ôé× 8œ
„nì»6ûën	
tR.ÁÛ¶)Žã¾âör]ÆÜõ�0s
³Ê¸Œ÷Û|QwÚ§íR®]Ù$zpÚô/A$|úW!´“¼¸‡Þ"›7©ä	múäµâŠ]€0·Æ`É¢"E	uó9†°h]œ1^ã†F‚ÑŒ”W+•]b«mm—û e[¶ž	Imú‹D@.§Â¦û>Ú²^Úª”2-ÐÕB3ÍW¯tÆ`Nrä•Pê9Å•¡O€šWSrKN¥ê%3'R[k²jú�S�{5w)­¨1008œà‡±¢À†>¢.bM]Tji�¾Ëq¹-3cº/uEA€\‚ ‚Z«ÆÜuuÖD&7ƒd€{qÅ�àë&v=´]—bbLA€œ"äÑÊ�Öõc½ÝæóÖ’å`0:Ü$ãôßBr�`A;vMmŽk""@9A›¾€ATØÀ>�lX¶ªÖu)ÔV
,púª)¸àkª9¤n¶¥®M»fÙ¸î§äh™ò¶!…±«VÚ½}ˆ„\FÚôcHp¸haË¡Á›×¢æ1PÜ[í˜-´µÖ6Œýp»×§6–bm­™‚3øôŸC‚à ¬…ªú�Õ¶²5¦dÉ 9	púe-;=À¬¹µœ»�Ò}ÙB`�Ô¼5� Ý\ ¦‚D'©1
ÉRlln-z‘ªVMˆ‚ÀéobŠ¢`$áœH3£{krÒœþ.$Š„{kÎC@s®f±‡±%Š�Š$(sI-Ç�hô5”æ`€EŠ 4š7ÌŒ %M_Â­u-+šAPC° Òš7ÈÝ%#Á)ŠÓ[H(Àá H$‡€Ã"hS†[ËtN	"ˆ`ÁXÃ,Ä¨PU@ÈR6ßTbŒÁP±Òe6%°˜B�W[ƒ*Å@PîT"5l�Bh	p`Ê§¯  „KMD‰– šAÞjl‰´I6or( òRÝ-X¦yõšäPÒÛŸ€—×ôæ0 æ°i€9°º+‚TØanÑ�àtD‡ÁCEtØ”`n. æˆÌÍå¡Z…M<T`hÁ@·jf–�^å­ tDƒA±"B€9€o¡ªVa–Í`îÕ·ÎÝén†¬^9Â[Ù–T«b53BE„ s«ˆuWZ¨VÍenÑ­¦ë N	"RtN	�è C¤“ ƒ t®­ßv-d„|í7©G¹!lZ‡9yëòÖ¡u-ØzÌ»ë®…œ€æUÕºm—??nèA:	§9 N	ª]�÷Û1„Ìe«ë†ýöåïýäÞš˜ƒõV)JM¾�4Ë4N‚ZñÒ…>7àÞš%Ä@5Ô`]è\Û¶1Ö¹¨%%%§‚ûÆ.÷âz½¯UêºNÐZš,…@c+.ëbrÍÜ,©Yeîº`^ïÅ<K4ýˆJ�ä`c·Z�CÝ˜{`k÷êèƒeºµØDÇÎºâóº!y×gØº¬kLÁ‚Mÿ>DÀW´ØÖ´Üî[H;K›~"T·Íó +K©Ì!‘6ý"T‹B©:oÕ02Ð¦_‡ Uo‘{j~š[ßFN"àen!ö(óeÑ:MTÝ-zøu½FîÓ¡¶å¥µ‘9# ¨­ŽüÐ“—r©c<	šNÁÊ•ù�šßÊL¶x|ŒËÓçKÃnìªCØ´–|:ä—åÓÝC7š~›Ï}ÿ8Î÷ËSòqˆ¬¤Oôr÷p<¡Î·ç™c×µäœ~ lÞj<�Pn¯7¤n‚¨lðuc~xè¯÷Ï—{; QV—¥òô¥×ç—O¥õù°{èï¯ß}öaèhúÀgÇðØÛz=ßÍBÞŸ¢>^¿¿/»1¿ÏÝ|ýü|ÓãÞªšöÀ¦µ¤Ã£×óë•qèb‰-rú-@©%ïÆt™_/mÔ EúôS@�‹åc[×k½i—³\T6h)­{sŒ—ûómélçŠê\~Qy<îÂåöáw�
Ð4B¹ms¿Ü‡×ï~îãñd�n”º…qì—Ûå<¯]é¾z�ó·Ÿ7ìÃ°Ø/çOç[7ì­P.óíÌô°^Ïg�c¶lÓ Í[í±<}º½Æ.ç‡ òòz]†ñí8Øóë‡–R<>æîååé<Ú)™ hú’Ñçu9¼Ù÷ÏŸ¿yf|Ãf€¦D ›×¸ïB™ŸÖ6Z¯Ô¤é·¡)b+…‡Ãy~¾Õô.4@Ó¯A ´Vïû¶Þn—¥&;¾éU>÷‚wC/§‹Ó	�Þæ€~è°\Wï»Qé"PçM»7}üt»œÃ0*@Òô×à&ÕÛw�Ã:¿|Ä°S¨€¦ÿš"¶¶Æî½•Oçv»]h”4ý)HÆrk8Ãr½¾–t¢‚¤é+t­^ûa÷ùº))¸  ­,ëøå|ùù'`·?<îçåéyÃnèšLPZa÷�}¹–yƒÇ7§]»}þàãî�\ÁÅéW )¢”Mû7Ÿ®ß\çî´?>†ör>/©?<¼]—ï>�·Ã›1«šþÀïÕ‡ãØ-·×'Ôa8�âýÓËçÙN{V4ýÇ Ÿáã~Ï²\`àFŸþÜä~i¾ÚÛíÓÓ<ÚÄ;!¾VtÇ#Úõv›“ãøîíîúñå’¾Œ{ÁÙ²MPêŠýÃ°®÷×VQš¾€¦ˆÅ—qÿ&òòòéÆãIÓŸ„ ¨\¶±?Ü.—o/ù8�rˆ¾®­{<ùz;ÏKî i€ nØ°ÛwµÜ®‹s7úô! ­x9��ë}~9Ë<=žúøtý®µ±Ïh‘.rãã)Ïíå~N–ððð6¾~¾^N»cJÍ éÇè~÷šÞË.óëmCg- ðrV8œŽËüôëã¾Q”¦z›a»Ã€už›íòØ’|ú5ô¶–Ú=¾^®çÐ�ãš«4�Àf×Žo:Ìç§ŠÝ~p š~ÐªÇôPçí:ß5Ž4±åàZ†/Þ>|ÿóµ{ØEwQ9ÔíZÒc7ÖùÓ©ƒ M#°µ{‰ïjûîÃG½¡:ä&_gôo¿ðéÃ‡‚áÑLpóíF¼}7^ï>—:v»Ó~W^¾}Å›ã!ºšFHf.èÞîÃíûçïÒ¾;YÔuÝÆý›r_ž.—0dé"ü^–Ý›æ×ÏŸ–¡ ‹l\�‡Ým=¿,4å7opþþãwÃîôö8ž/°1F¢};#žÞÚrùô¢@¾èðòùÃùv…r´U·ÓÈ×õùzÙh‡·ïüõúá¬lÃûcß=?ýü¥�JÓ �^æ…»‡];_Ÿ>£YÚ½�íõòrÏi×m±JÓ¯A`ceàüzÛ<âñôe¼=�§ñHNu^«[·Ëh¯ËÍZß¿8^îß¾v½šAÓ ¬÷Ròã›‡Ûw¾ãòî8Úõþü¹åÓÎ@ ª¥Ôá1¯åõósŽû.º@¾�;,Ëý¦šR¿?äu=?•´éÓ_ƒ 6-%¼{“.——�>¾Ù‡\,(ñ8¢ÜŸ–9#iôéK`Ó-âñýŸžg;è”4�À:ou8=z¹¼ÜÖ�ºþËë|¸mïÞ�©Á¨ÍÍ‡Ã›åõr¾”œÒãcæçg÷]XÍD¶òºôoG¼~~~FÚ=»\^ž®C7<¼ßÛýÓË‹íöè2ø]Þöéå~žï-ö‡7#ÎO_v½PIŸþDP®’‡Ün¯÷³0îÞöñþüùœÇýl›"Tn+oŽ¸Þž>�=§1q}}~A8¤ £O_C Úês¿?r]¯×šSaÎinântÍ—×8Xh¤O#D:Öºâø×r{ÙìÞìÀõrÝòq´¼d¬\-íŽ¡,ç{›ãÛ±O¯/6v`�ôi„ 6/KÞ?ÿðòŒÝØ�%TNÿDºoâ~d8ß·-Æ.×há÷²å‡7¸]¯OÛ±“9éÓ×émÝÐ?<¸¿œkÎƒ…Júô5jóµå·Šçù|™úÃÃi­ç×g ïRÎééÕ�}Ÿm)gÕæÝé}?¬—oîØFPàô«ÙêVÛáÑôúúr«!uïìØž/Ÿ_Ðõc1Ñ§=D¶²JýÚz¿SCÈà¡67¥Ç.Î×û½ä¾ï8E°±nÞe,××çëÖŸöï»öúúÝ‡¥ÛÞw¡»Ü¿Y¶¸ß	 §ß„Hok%�Cz]/çë½Þ>,·—Oß…tÚÓk OD¶ZšÅáey½‹ùø˜à/Ÿžñ˜NnpN?�@¯¥Ôîm€¿¼\·]·�B¤ m›ÃñíÑ¯ÏŸÎ:=ìÇf’O#DzmUáâ­~Þæ’l||ìîŸ??Ïq‘>í RµÔˆCìªŸ�ÜuF3‘¾l÷pxónðOOßÀŽ{SM|Ùžö§TÏOß#†ñíízùˆ°÷ŒÍæÚº7'Ãýåìë¡$è@ã¶ZÿÒív=‡|² Ò§Ÿ@¤·¥0Çz^Î×iýãˆxy½}ŽýØ¢O_@¤W/âiçëv~¾^[>¾íÃýüúòâÇÝ›Ü>½~j}„[å´‡ÈVæbÝ®«~»^kGÑ§/!›jH‡£ã|«s¯>¸ 6…ýCÀõéù©�Ã�7„i„lX1c{™o·%ô;ÒHÊ·uæáÍ›ÝíòáyÝƒG‘>émÖƒÅû|¾#]2ç´‡HowÕá¸ãu½¼^ë>Å\Ì¦ß�ÈMåý®›çËùEqÌÝœ@Ÿþ$Dzm†ãqœ·ËË+ûqPhœ~aÃæñ°(óËeÎÃÀèœŽP[Ò>g¬ÛõÞÚ0(ÀèÂ†ã>um[–ºänwê½]ŸÖs¶êôˆô2uÇ}·.·ó­ô!åfÁ§Ÿ¡ÙLÆ]ßÊk)9‡e½¾×Ô‡^äôC¨:Ê¸Ïæ÷ùµ`cj�>ý:TUÌw}¯m¹/wãaDx�Ÿæ…ØY Ùt€ÈR× ¾7ßÖ¹6ã!-6[>¢+õi^·N©Ý__Ï^º]bPði€@¯î-�‡Ní~.5²‡f-–VB:Œõ¼�ëŒÜçÔÒôÇàm†ºÃ!Îëv)ž¬‡!ˆ¨¸“Ý°Û–m~=#ç‡C.·óürõ°³¾%ÀËÚlØÅa«óe©ÈùpÀ\ÖsÝº�2NÿTYCúl[]71¤ÄéUÜÑõÇ¸Ôr�Å!ö §ß€T»=±-×f1§hÍ|:¢…!Æ¡†º,e­Š‡cg×òt½YÎ}£Ùt€Ú…>ŒPÙnÍ¢íÒn[Ëõ¾®¡÷žÛýv¿7äœ=
®º°Ån0n÷[Ýr8„û|©Åú>É9ýu¨•µZ;b»nB—SÓ¯Cò�[Jc&ë2¯Ž˜Ž!]çùÖ°9":Ù|5¦¾�ÐR®°’Yà´‡ûZ¹å}¶vžÏ³lèèm°‹#´ÔËf–Ž=„ûåZ[bH£8í¡V
ó“·­Õ- ‹t°ï,,xE£º~oP™Ï¾Æ0J~­·­‘1jú)ÄgÆ®¼”rs�aœ�WT¥Ôµ¶UÐB°0ýuHp®1vCT-WŒÉ¢:mzÁ½Õ†”ÝË²%O)$§r4+R�I­46X&Áé Wm5w!›ä^=0"pú�Øb“!w1´R÷ÀD™ê¶yÓ€R.[aßí»Nu^nc:¤NÛr•»®sl*KöœÆY¶eÝ‚u1»pú®º•À]Š­Ôë½ªYA´égp5+RN_,äa„õvs´3, ª¨-ä,[]åÆƒhÓ/A‚¼ÚÙu!5¿Ý!…nó¹ÞÃÖ!$d�Ó¹oJ}Š®{)-0æ ³é?ƒ¤ŠZ,�`Õ¶´@vH"¼­¡öcg®y]—ˆ}Þ-¬å¾nf!†\iÓŸF‹EÎ®KD½–3ËDhÑ[Y#‡˜­¶y�™úcê–mY£Â;Ûj»³EKÁ ƒ8=Bèe[¢wQÛºµº}Tê¬�}K€  ‚ÓÀ†Ù1v{Ðï÷+�s@®‚ )B £Ö²)t=¡²^‰Ü�)´:Ïîì÷C¿�BwÊ}[¶ekÌŒIÆ©ƒ¨Ô¬³4ÃºÞgä~ûâ[½[‰b°Èi¹·Re;vTmµ:C°8ýNÅ†æ–»ßÊÅÙïÇÁZ½X¢õ$¨VQÑÇ÷9ÕÈ-M‚¬%ßl‹¡Ï°º¶bÊ!ZH„Fl-t£µæ—Õª…¬¾Š.pJA–Zr6¨”!Y2
š"$ºZ
Ðí{WYî÷Æ.F0  šVn!ö9»¶uñ÷±³µÜ7·cr£T
Zê:¶y¾!Y—IIS„d0÷êÍ¼;b|öë¼‚©OaŠÔ4@­ÂmÈæZj±ªµÕ¢Bôõ>ûq¬—m9KÈ¶óä„É@¨¡@±ïàmž«a—¯m¾«Y>05´V¶´·ê}½ß-¢Cv£CS‚@y•vÉZ™—¥“%‹tN;ˆî37SJó²lÖºÝ|ZA9 Ho^=zêrj~_¯)ÇÁ!qú§MZCÊ#Mër‰eØ¥¶vŸ�.¦“ç¢Ûk5œúž¾ž+r�h‚S‚S‰ÍÊJq_l»µì‡­Ünq³”Ì¢‰N	©Y5¤ÜyÃ½¬°”�A©É<åDmóì){$„†ZSN1”¶n±�cìï~¿¯Ír‡ÎÍÀ)B¤ä­l[MyHòyYˆ”Øµ0í!µÆÆ#RÑ²n°.1ô©ƒH5bq—¨­.Á™@Ÿ�—*,º$eKäô/K`~`*÷õ’·\²l RjÕ£‡Só¹m†c°Ho+ˆ®ë¼¶¹`´qŒ^Öeë•c†Yhyê!okj;î«®l–“%
ªa“ÇÜÇe.Áº±3a½­%[N£©¬eATÉI‡×PSèbj¬U*1  Æ©ƒäl¡nÆ¬uÙœ�ºÆàÓï@rÉÖº™ÁØÊVk¨9EZ˜~Sé^Jˆ]Ì­.ë¢¨,š�6%È9¼æ”Btßä´œœzä^SHÖ5ÕEÐŒtÚô	.ShÍB(Ìî�]` DN	N@Pi²Ü#ÔÚª–H#½Õ¨ÙµâµR–haŠÐô5�\U9tÙËZÖ-‚Ù¢ B.ÐQlKÝÀ€¹Õµ¥`‰SA@½Õû@j)n›1‚tT±5™÷â�YÛZ7"Dt"]^ÍÙ‡H¶V‰�FÈA9a´6SNµm‘b�\tÚô �NJò)ÒÕBcìC�´n¬}ÌÎR‹<z Í ã” Hò¶YoÙ5·1õYáÞ÷l9! ª¡°¡±4®° hú1ä^B0‘Æ�ºÖ´61Y4N=$(À‚cÅÝD:)Nò)Á]s$en
r—Ddr¯hì:£×»‹
"dÆé?€ÜÄ„Ü÷RÑ‚CòÊà!¦³)ÂPŠ\•i‘‚ P%ÂÕ"2½’¡fŠ„ >EZõRÍsîÀz[¶ƒõ°º¶–='o­n@Ÿ³%GÛšËÉ@�Ó�!d2 îr‘‚¹Ãá‚]dˆ¢Ë«•ÖHFãô�(ðæî4‘"à¥nÁE0œEZŽØU–hT³-zBH/wA!&vÍ¼VÀé¤“ Õ(…h½«•­¶F#-ˆ”tÚô ‰¢òšÜƒà54 °Y©0n’Ja@JÉ€â%n™I@±Ò` AH.Õil­¹$ ºà�`f0ª1¸Óh ¢ �‚0E9‘´ Zÿà»ÿ’¦
ºŒD€�è" 4EP€ M” *t DA$ 8ä šD@2 D@)‚œp Œ0r8¦(ˆÊAd)B¢³. $,€Äå’AƒN�èbË”Y i€7Wœe :Ø:Ÿ"è$9 $ÂœÁ!—C.@Ž–@‹)X4x+µ5e€™H8é D
” A.9 F2Š
Õ¼ 2"HM¯?ýf9µüúþ¾ü><~ÿ¾„öÕ?}ÿ¬õô1íf}ùòé'/Ó{hM~Ù‡aÏpÛ.Á®~�¾€ R°F;ZDÝ¶�­³‘òÍšd¢Aî­&Ë)·ÐTÝ‚¦‚ZµÚÙž]ñµº¢rúË¼UEÏ]ŠÞê7¦ä§µ²BÝ0tä|wÅl]jš~Þ*™ûœXZÝ€ˆ„DMÿ.TcÙŒå}ñgûþ4÷<Äëé:!ùÂš‰XÚ[¶§?Ýóë¾¾!oë§—¶ËyûÁ M›sÜqm——yÉ¹7Fçô%D¨Õ¦t8Z¸^_*;�Ñ§ù¦%C²u¾µÒ…Ì N¿mñ†í;>žKÙS=Ü¦ÿ"Ð°z×÷¹µÛFmèa[_ÂØ%9ý"„M-vGG½>/m´   áê8½ûøê¯ü÷è:Ó¸è××—{ÝÜÀiMë:ÇÓcïç×ó�û½bÜœ(‹§qÌëÝÑwL•Ó½¶…ÝÛ¼Ý__^¥RýÝùþíßýÝ3oŽp§‹Ó×�Bc][ÿUßß?}º­‡a'6"´6u�ƒùý23Ú(}ú¤Ðp¯íðfèŸoÏë~ìS3IÓO! ­nÈïòýõóuÝE+vx5~y:îÆ¤j‚›Êù²ìñ—ðÍïÿóo2Þ¿Õ¹BàôÜäu»¦Ý»wÛùéÛ‹å!©�-Ûô‚ÈºÜæîëQÿù÷§w8«ºdŽ[]wo¾jë§ŸŸñpH	§£…×ó­†ÎØßÒ_ÏWÇ.$�-Û4@ Z-ØŸNõåþñÓ!£¥
Úªòi×^o÷kêw15ƒD@ó&{“úùõõcßvB4ýYt¬Åóî”—óe½…<˜ M"d*·y|óÅßý›ßüü[ètÚ/V2ÄéOA |YËxzS—ëÓ+†a A¬ÃYxÿ0ìîOOßƒäøÌé 7©Þn¾ûÑvë÷ß~ùaŒEtqê!@¬å¢Ã�öxýøÝ:çœB¤ßç§3:Ö|<u»~^-šç·‡ÃíãÓ‡šÆ–oÇyþôr^ö
»Çnyyú|Ùu§èpsù¼åñm
×ùS5:ö?|³ûî_üáàÔï»‡wÑ_ž¾Û1÷Ç4àÓÓÓšNG„Ð´ƒ¼Ü[ènç—›ÿÿÁ[«¥kzàûyÞÍ·cÌ9«jV­ÎŽÕ»´ é$D0ÝIh‘l<IGsAB”  ¢ˆ‡9É¹¼x�€�3ñŸˆ“¶ÛµjUÕÜ�1¾Ý»yn¯«³êOwþšÎÕßô±:’éÀä±Ù6î†§åÃÓ†é(’é-Bòžík¯o¯ŸÞuwãèûis×Ëš]/AV¶Ý/ÑØ Òìºòí·ßâ‹¿ú¿ƒŸ»k{Áô@©;‡Ie»>ƒÝr MM(UüxÚ,¯L]çLÅÒ‚‚}›û»ÏNöñáÃÒA‡7¯ï€ŸüÍrûúõ±ÔFêsÍwŸ¿]?üÕ�¿ÂíñüQô2Ÿgvƒ“*€)ÛZtxuÌûå1»þ®))bmÍu¼¿ÃüüéKœ¼‡	m[.×ÖÆ»!ÏÏŸ>­ƒ›†7Ìóõ¡Èí0U(˜¾R¥Í³÷÷7ùáýZoÆ(qc[žö#âplkY_v‰=b¡¤w  u«5¾š†ry|¡ž¼š‚
î3¦7?ÕÏç�ïqº=¹Æ˜Fb¶ÕÚnŸ—kuªêÅÒ„4ÝÌM1Ú~.5Š7˜šÔµno~æî÷þú�Û×îyob”ô9H•²l¾¿U¯_,ìG×õ7ÊõzÇÎKS±ôMP€½å~:	æóÓUâàh”ô/A Å¶p<2çëeÅíè¤ {‹Gë¾m¹ú6ýôÑðøåÇõUcpíúá\ý Í‘TÛ®³¾þÆ;\~üöîþ.ô“`[ž¯´AÆñ(û2o‹¨„ã^×Oçu@ìûi”úòt©ÇÒ  ìÍ‡fÛyã{G‘ôMÔŒU†×ÞêåéQºah&FI¿	BÌ6£ÞvnÛÖ,!v¢ LYk–éöÕ¶¼|Ê~�b”4€!ýaŒyy^¼£3€ib¥µqØ–ÙZÐ¡F“t!V6óÃl×YÐ‡ØDÒÐlwýÛúø¢áÐFEÙj½ysèÖ‡¯>µé.
`º©bëfúî]ÀOž~‚ñÕ©ZÔô‡ ¤a§ô‡,kÎžÎ9ÓôunÛ®Ÿ¿;áG?ùñ�qw‡Þ·—óù*]¼³n{¾^à§NDÅÒ;�®I^íðÙÔòÃW/¸}ÕÁÀ4‚ ZÛk|#X—ÇgÇ _Éô Áé”Û|]Jº®©XúU /ûyxóù=Îó¿ÿç»ýìfc£¤¤kXŠŒoúxý°p8Ä
€i“GÎY_ßßÞ><|Qq¼>ÀôMPêpV¼ë^éöñaN·ûq—ÖÑPj•þæyyÞ7`zs{lO¿Zønz}´——/æ&{p²\?P§C¤62½àÞDOc)Ëã\»n ½Xú/ ÄjÍn¼ë�/üa¨®’ XÉðÇI8/›}ð¦bé Õ"Ýë€íÓãSôÇà0M ÄÊ¶©¾íöËóËº±'T,ý.(âÜžâöéå:óØÒ‰¨ÅtêFÚ¾_¹×z¸?ÝÉ‡/ñöæLÄÒ B¬¶�îîåi=‡nì„^,ý#P Ø[qÇ×ÁÏ�Î†Î»êÅÒB¬¶UÆûƒÙÃóc‹Î…áÖºõå)k#šK#1.ûu:¼õËã§‡OSw`š<š”ÆCËçë¼47õ%TIPÄl‡¸ƒ—Ziê�¨r/rw£îr]¶ã©"&é› @ØêÖŽnY/Ÿj8^LÅÒB¬í¥¯†¸^¯—'ŠŠ¥ïƒ"­]Áã�×íéYc?ÀT,½)õ\»›Ÿió‡O?j77¯ch5y”²¶ÓÛ›0¿|ø£LÝtö¶>_sè‡&PöMççÜ¿ûü¾üÑÿ[æÛWÎ²
™~¹V¼ºëíåÓÓuêÆh”ôbµdö÷'l—/Öí'ŸáËkë§Ñmõygì;Kï@³­”þöüÓ2—.ŒŒYÅÒB¬–býíqŸ®Oê»1˜:KßYwZƒå¼ê:œÞøöôøðÜã)„¤· H«¥`zÓ×ÇËËeë§Ž´ô=PÄÚ¶·xsƒ:??ÃnFu€Xú:(ìVÓ~è÷yß3Ý›¯�‡§§/>M‡7'�L(R¥ÁO�çZæÚù�) ðâÂ«£Ôåù™ºH1Iï@�TÛ8Þñòòéi�Î»Ó+-ûåÓ§%Äã0ÖR–Ë5{�±±ô‹ „eÉ{<}-–Ç�ï·ýxš|�£¥· HÅ\¥»ëÛÓõ|ntñæíñ/O_6jM X¹fL·§íåüüàÂ86 ’~aá³çñ®¶ó§e�Çnƒb-sÖ.&¯€4—›†Sðœ÷k�-xzgéŸÀªÀü‘.·�ÙI§"éW@ÛÕº)ôÈåÊâ5*\º‘›±{5¢Í�s�Äþ0�íq9Ÿá‡1˜ƒXú!h9›ÆÛø²?\úÁÁ™Xú(b,û&Ó©Ï_j<ÁW'–îA@÷‹ßþqyÿñ¹?ö=H±ô]PÐ–=ÇÛ·G>}xÁq8‘*é(�ÖöÜOwÓvùø¸´p;¨5/dúw 3›ï¦ioÛ97�½(œ¥_E¬–�îæUØÎ—¯æ<ÅU˜¾«‚æv›7²‹^½¦ïƒ€˜-»¹›Ûn»<|ºRoúž5Xú6Øò^e8Ž%/ÏÛêú\U­6¸.©e­EB§±¦�»Uú!çy»6tA½¦_‚17§ý0°n3spn(±¦À¬lNÇn+{ŒLÒ	”†¼Åx°�ŸÏ-�½wªfeÉoÅ]×—kÖÎ‡@‘ôˆíu‹îöÆ°^ç³–.ÞP»^Ö•.NPƒJ«fè�±Ïûz�¨Ó¾ºô+`Å,6ê²åê|çœIúi4ÍP7v²c_›R\ K7`Û‘cwR·ïÏuóœÓ–~¤ 5_³Ž§q\×—åŠC8"Z½ÖìtpLÍÏ>Ç.y©®«ÇYa`Å&ì‡rÞ7��ÒU¥‰”|µpêººÏsïºXDØDSŠX+›à$¡•e±ÎùN  ,[Öî0:¾®KÁýÚõUL¤ä½únèÌÖmÏ½(Øƒ¦i/íœ‹C?Þ»µ¾ä2¹¨
K¯@@Ãš-ÜLc¸¾<Ï¶|ïÍ'OI÷ 3ªõSïmYÎµv¾gG‘ôs  d­«)O‡^÷åáœÝÑ�ºN$ÛÖŠª‹¦
À¬ìN† mygsŒ’~lŒ}yo@Ñ(fÅÔz7šÛÖfè\'4–Â¦ƒã|}z®èã ^ ’`Ó0øÑtÍ»ip.VMÿ †‚ê[×÷`¾n[uÂØõ›­wç;¡¤ï�@ó™Rý†–óš«�>ªªHz
ˆR÷ªS¯ýR/;áÆaÌ¶×—\ááDÄ,3×ØûPm[-¨�ðª`Ûö¬ýk�íãü°¶~;ïªÙV«9qª€ÙÅ=ëV6Å44K_wÝõ®Ü[^ËƒÔÃ¸½Þ"Övi2Ðu�}‰:@4M EÌ¶&ÖÑj^·*µ÷£­{ÍÍ#x¯ÞÑöVÐMwÇœ¯ÏOÓ0/›e˜sc§�m_ÀÞ%@AÅŠnÔ­Ûaˆ¡ßëj�F/ V3úA-—=+|ì¢k(¹” à †jºþ(Óžónîöùí*ÉÃ˜¡ìºìy[µŒÃ8æ¼ÍO¹h×O]h,Ûî]u`úC�Ò\u&}„Z]Xµ©„&šz� ÀZiÅÉ$Š|ÙwuÓÍ¨îº>_®õ0LãV°lÕ[�N ’ š–VÔ¨RçZ1j€HzÍ²µ w½Äu[Vºè:	M™þ1¬•ÍÑ\(º­Å·A;¦ˆæÚîá&·¯ÅŠ�*$M U·;êabØ÷½±u~º‹š¨!„b[�9Og¢é·`B_kõ>ôÎår½šsãM7äëþ¼oˆÚyFf¥x×E¯¬Õ6oê‚‰Jú:hhš¹õáÐëe+¾ô�sæ@HúM$Ïj%êœÉ†ÂÔAÒ?�4,ÚüéÖuyœ³ß9TDSÁfe‡Ct­¬«4xïBG²´æBT×JaÓ ê½ˆ¤Ÿ°dC×E©6¯]Uçœ
ÀV6WÇ)v(ë•Dˆâ��
Q 4�l-#†q€æy6´aˆjlµî{±‹êj±5l^¼wHúÐ ¢ùçü$Š|½¢uaÁÚ¾5(4š Õôç YZ3íœ×V–µ®sÁ,ïN½z3kjŽ”ô' �°Ö
\¼!×ì÷à;SAµ nRä¶f±M¶Ü´Y¨Î@$ýX;À�‡r,jgî-x‹ËÓÜ×ÎÔ÷.ìmECçÕ«š´¾¥?E
¶"r;!¬ëË6ƒ=@@T!i„	 ÂÊ*Œ“÷¥í;}4Oš8Húc˜ &€R+Åõ1¢•ki^ãÔ«åªæ½F´ª†Îu¦µlÀ£¶\ŠsÒÁ‘ ÓŸƒ Ä Q4Gß÷Ml)"Î‹* ìŒ’Þ�QC	Å!Ê(ÔÜ 0É}î{»åìÔG£ä©A( ùæjpA; ag3 bâ é’'”àÕ{+æk€ƒ
4µ&¾WoÜk3&×›ßònêàb1!d
 Ùî½ëÑä¼£ŸB´º—ðÎ{ ¹R¾—@î­V‹½¹±EzzlÍLµW(vÐÔ*´\Ý©Wäm-æ�v•¦¦hBWE%ŒAÝ¾Ô]Lz
›ŠŠj:€$L[(Ž.úÐˆ«µ çB«¨ÒÇ`R/¬pÞ;Q:Vk!ª8Û›îžN!„é› °VZcð.T–-À98�„‰¦Ÿa¨Àª–\Ùu1d.;Š3çáT ¤’îA BÐŒ&>ˆÀªE…"k­™è«íÅóÀ¥^l¯^œsQ¡$ÀêÍjGï5h­¥U2ôN­îµyƒƒªŠH£•fœ¹6sâ5Í
AœcÔGg„Y–ßG‡Z¯K3ÇP¡NTÌ(¤ 0QŠfU«Jç;%¶Ñ×\±¦hPïV=�‹pÖv8ƒ#AªAÓß)„@F 5WºÐ‹³’|ª/{FóðNE�¨s"žÚt÷�†ÆÝškêÄ‘¬âÍ¹è“WYd5gªÁ;§Ž4š8Q±ŠÚHG8 i ‰ä	�-:Z++$HU+…N}!³kM)*’þLŒõª€AÅZ)pUÐ¬Äyç„e7S>�-[sTU€  ¨-Jõï£ˆÒµVšÎA` Q@`0š°#àD½µš‰s06Å©4‚„²#%ý}� @mÁ&Ñi€6­Ú`¢& „¢¤¤­3ˆ(„ž5ˆ¨zÌ¬� (© ¤¿‚¦Éƒ†Öµ
¼¨—Æ¢Ö Þ© …æ…t‚fL^ ÖÐ¢ˆ
A� Á@„´Úµžá¯û¿ß+„K!„ S€˜!1�Hˆ‰PLÔD`"aÚ¢ $RL”¢G Ò  ¡	#HˆªTšÐÃ` „¢€ÂÎÒ 1QµäA@€ 1@L1PØ(€¦--2BD4€4«ÎŒŠˆR b 	U1›T�Š€Í5BU½*PÙ‚ªQA1À PU€ÖŒ$¨&1
	±äA@L„Dõ¥‰*¨`ê o€Ë¨z¯ªËhâáÌU­Zµ**<š«æ�ÖÁ˜<¬ ÷¦ÑÅ•vPT»íX$}¤Yiæzéªl,"â¼¨¤‚­em>F%¶bÍ1 R-}†F©±7»V˜×èE ±8S×«²´R4£‹]JÞŒÜ(`É[¦ú8z¶\w@½h¦¯ƒ°VEúƒYnÙ	½ú ¦{¬.+;7©K­-hpê˜~º]¡SÐ²ÏWipqê:–y!CŒð€¨…ˆ‡Qü¼ÏNcPM¿
ÈUÌúb—óuGßyq”ô ÀÚfÆ®­e¹Hî0á.óy_û0ŠkÐô-P€F«qêÆ—}~,ƒžŽN×ËåEBC?ÀÖíJzß<-Ýƒ4¬µëO¹nçZâP%}ÐXªnã¶¼<?‡nÒ®ª2ýPØ×’·pzÚ‡—Ë~8Ž±	ijB)E£b}¾žÇnh"–¾à¶ÒÝÜ»ýüü¼LÃÁÐ ¦Ï@ Ìkó·¯ýöøôü<LG­0ý<±ÜàÆƒXÞ6ô£¦bé—A u+.ÞÖm¾.‹s½#Àô( wC7(ûrŒNœIú äRìî3¿üø¡ÅþèY�QÒ�´V5ÇsY¯Õ!@ÅÒŸ‚ JÍa¸ñ×õ9Ï¾;PÖ—«¹¡s£¤ÿ
À�ì��Ôu.Úû ¦bé×@ª”¹âpÒøáúRà¦7·ùéáâ³Ó6Ñô; €V�Ã8­Û<gßÅh Óg Uj©íxs[žÏ/�~:E£‚é‡  ÜÀ¡›¤îË^CçéÅÒ?`n'K}¹
ƒ1I_°æ§{-×Ëû3ú	¨ Ó? !Mg¶á–:Ï¹DL„K#HÍ×ÒßÞö×õã‚þœ� eÏ~8ººœ—ÍÇ¢bé BÌrqÝM÷öRØgÂÎ„Òà.Ô}Ý�>Š£¥	¤kXJìîâRŸçãÄ�E,}S²•­÷opýôÕKpÓˆêAI¿ `Ýš;¾e¹~¸pÄpûJËöøðÒÇC¸ïýãËW+ú8ÞÜÝçåÃÇ‡ÐºÓ›)žÏ_>a¼™|V€éwAHÃnÝ8ªÍ9» Sq´ôg  Y–a¢•Ë^Gé*i¸nýá¶b~¼xt£@…-­õo0”óå¬ÝA:˜Þ� Z+êOQ¶ýak7½øFIßE¬Ò4NÑÊ:û#B•t ànäMìç2ç]pFI¿B¬åÜmççýRe
A(é—@ˆ•µr»v½^×Ú	îÆãöéù±ÄÓ�ØsöÓ–óóC‰Ö‡7oyýêá‹vàÔ¿¹òW¾¨^†ÃM‡åòþÃÞ‡átû¦<.ïŽý	MAIÿ„X[µ†¤,—]šö¯Ž¸^/ç"ƒ?Œ/ë‡—>:G€é/AªÔ²†ñõ®Ï¦0€é» ]“º·áÍ”—Ç÷íÅõþp§u:?êƒ3€é‡`òØ·†{¿ÎOO‹R©`ú:HÝ¶ÜÝÞù—÷¾Âp<ºf ({Æøö¸==Íûx¼�
”œõæ®çryÜBìš‚i©ûJ¹¹×õéüp®*ãÍ+Ù¿üð^n�'WA2ý%À–Ý›WírþôA†î$æH¦{be]d¼úòtyDC€éO@ˆÙ¶”x{{˜ß|¸êÝA‹’L
Å†vÌµfßN‡a(Ë§çAú�j`z
¤¢Ú4÷}..Œ±y“ô-PÄZ.Þ�ýÕ®Û…ðþæ8–OëÇ¬]ïµ9 äÚš»Ü2?=¶¾?Å$} õºjÿjì×ç�†^…�ô}bmme8¼&ž_ž€8	jò w£Cä¶.¥½§O'P¤"g™‚Ûì²;í:±ô¤.­¸»™ç��ë0ž¨UÄÒ’¹1¾	þúòði=ô·BÒ7@ ­®ê_½~õòþË3ú»ƒ3S±ô±jÍãh[½”zt½y±ôë kièŽ!”œ±®o1˜]‡ñf¯óyË½„N,½Eª4tÃèKÙvzôÎD,½E¬¶ÊØö²^–t¯š;×ëežmè�Ç}Ÿ/Ï‚›®£7Iß!fK6sï——OOÛá0ùj*–¾	Š´¶Ñ†.´6—­ï]G'–þr.6¾î¹ÍOOªîÞ(êåùã"‘¯ÁíççG;ž&_é@‘Šý±óOå¥´¾ï"–~¤´UÜÛ×¯ñåãW6ö“Â’îAZÍŽ¯Ž­=?}\4ø›×ÓM]ÞÙp8A«Š¥ïƒ«¥¶éÎ¡ÌÏ�¾S—!–îA�TÛK|£Çëüx‘xìãL,}±œ3w�›—÷5ÞÍK?‚¼_9Þ6êû?Yµ»U·EÈ,y<¾jÛütyŽc¾¨¦ï�"´r±:¼º®�Om‹ýÝí­¬ËËyÏS¼¡ž/Öõ†€³ô±ZjëßŒîº�/�ÝèÇ*"–¾B¬–Ìþî¶/ŸŸJŒƒ%M ˆqÏ{÷±äùù!S†Û;ßð2?áïªK(Â&»Õãí©ž—÷¨wƒKŸƒ"l8×v|=Ùy~ÿ•ÝM§$E›ß÷Š»c_?Íç3»!º¦*–îA³­(Ž‡Ý_¶-»‚Jò`ÛŠÇ±­û²,,Ótç±=¿Ì[ã›SÀ~ù°Ú'_¨XöŠiŒ¡msÝ8Ó[Ý/óRå0¥äõÓ¼8ß;˜
™FPP±éÁ�b9o™ÚGøçíòR1‡#ò’Ï—µx×Ûüt½x¸¾ÛCh{i~¸ÓvÙžæ­¢7
 +{Õ>vë\šÈ8žL×y½zL£:sDs9›��^·ëœuDMÓ@ÛÕ†nòµå…‹è8Âž÷Ëµ¸Ø‹£K¿¶­Tíïz^Öç¶~ŒM$ý ¬ÜÇ»®ÎO——¾��(“G-�2ôÑ°¬[GJÕôo@d¹"ž†º¬ëK®±ïÅ5I?³ÕÄbWsž¯EÆÞ©BÒ ¹·‚xw’/ç‹táà	—>€,V[7b^×yÞD}„¯é÷ÁRróýx’ú²<_�1(ÔYúEÖÊÊÖÇÎ¸^–ªÖ{‰MÒwÐÜîêÐgm+èÑ›jú5�h&s§!^×ëœ­�=UÒ¿a–¹D?M«_×kC¢s¦ÎÒïÃZ«Šèû&¶¶*�NÒÏƒÖvoˆC¥åµBnòÖj®0u^»&š¾‹ä™ÁmŽ{W×¹ÄEÇ H: Úæ‹ö] \Ú\ÇÊqÔD¤¿ 	’e7ŒqìÜ’—®çL4ý[XÕ¬2vj­íWG­kêÒO@	+;&¬Í™JÑD!égAÂ­bw]ìœÕ¹\Z§ãJÎëL¨×ÎÔÀô�`«dé‡¾ÏÜöÍ™×à „¤[Ð ‰€]7Ar™iÂ N=DS	’-Ka78—KÙ¶à[4¯É‹¦’€µêàºà+òÞèàÄƒ"©	¢ùì›ŒQãÚ.ÆÖ!¨ˆ*Óç ÁXëîÐ÷Î·¼ÕÍ‚:¨&š¾Ff ±nËÛ¥š;Ç‚º–æ}o�Ú2ÔÇ¾æºBšs
(DÓ·`0RPrnnœœÌÛ\ª‹Ó¶V®›QÔ©D%ý’'hmƒ÷‡à˜çÙ„]ˆUBÒ¿hZ)6„Ñ—¼,‡ êEÓ¿I´¾yf1éz¯,e_ã0ìaÍs6• A ŠP… HiB8?j°²]Í›÷AD¡ @Òß�J“ÝË0zÁ–KFPß›¨"–þ¤	Œ»éFÕ­å%8ïœ´@Òƒ˜¤oƒ0�¢îÒtŒž9o90h'¢JP$ý:H1‘êj@pÆÍš3¨ƒ˜$ýW�}SHç=X Ñ9GBL„ ScÝa„«u½:£jUˆ@LŸƒFS:š•
×9WÛn,AÄ $}¢˜R,±ïBk—ën2�XÖœ£óÚÓ»"KGP„ š•†ÝIßÃçúì>¨S13QSRÒÏÂÐ‚Á«WÛ¸û®WßJ.Ye@$Ð‚KÿRÔµ62 ¬„UD¨bÐ �³Òrô]§d-Ê Á©‚TI$R V±;í±VÏ¼�ÇÎ·Ü®Eô^ÄTS!ÓÏ€4B4`U¼ªsB4×H%„ )’¤8†&
I Â(4#Ì¬™Ä®‹¨yµÚ…ãÐlm«‰H/±IòF„ ¦ÿ‚0ÐQçÔÍk�(@6Õ{«d3� Ñ¤é,h×”ÉW	:6°µZœ/NH!!L¿’°‰Qà4h@EH8kU¢.B¤ÈêÍù.4_QDÍ‹Si�F…’bÚ¢¦?ÀÿW~bÆBASE      O[  xÁA  ƒ°Yãx` þµ,¹ª¨ÆH"gÛh�6‰™®S¦˜kÛB§Œ 6GäÈ`3ØÌbš¥s3§µÔ&­’ÈDf*ÒT#h«*ªf	[`µtDP+³j€«€k¶†+§é¶M�jUhcZÒh¦-°Ím›	VÛÒ”@$äfT9“9§›˜©iêÐEiÊÓÚ¢™m.M§¦kµtºÀeÓ´9jÐ6 '5#´ÒmMËœºéÐNÒrN1·¥u¹åç°¹­m¶m®ÍeÚ†Är-´L‡9ÂeEd‘¥KMY3ZšL´D]`ÙŠ6#W«,‹¨DUH*M
B,ˆD�2u¡›¤:t¹H±Å*‡åæPÜ,Ñ¡J–ÃT7]bÊÁ²¢ j2#h…eÙr‰-r“šC(-Í³7¡V«DËM5
ÉsSCˆ1Ulš5HBPOS      8a  xÁÁ‘A ±ãsìt){"À#>¸…éHÿýùñõõužóôÞÏÏÓ=¿úÖØîõYõ½Óíœ÷±á¾OÏæ,ÏÜÜ¸;–‡îôqç&«rÜ˜6º·“r#w»=¹jI¨Q™V¶©rL1ww¶*Z,™©@˜im¦dÆ‰–�b 3–	�#6C[†Ë ¬#˜fpL-Ë `  6´Ã,d Xc±` 0Ú`& AÖÈÂ²À0aD°!  ØÀÄˆih[0	-!&´(M ‚ V€ ‚"DZ2 E4di¤%0ZFˆXÀ`fm ƒNŒ¦9mÃ´ÌÌ�e46óÒvgYf¶ÆÌfkæžÖZã4[�{z63�ín�õü~æã¨ç>®ÔÉó~z×¹·;ý!õ5 CNF4      y   xÁÁnQ€áæÞ3C[Z2ImpaâÚ…õÎ“ø¾ÆÄ4Ý4!2B�™Ã�ã÷e?î@¿gˆgN†<ËÂâ�Þ}³òŸ“·.þ¸:¼:ŽwåZjl[³­ã²£>Mµd=§+×Ô‚I×,ÁD+Ös­XÏµ Hít_þ…¹Ö¤ ·¤ CRÐ‚}%û©~#ýB
º ]a¢Ž~Æò &ú�‚‰
›YsOD#¿>ê) )¤ÃÊ %¢)è˜Á@À˜!†`B"hÄ@LTx„‰ O1{²ëÃ'ìùáTB»…yeˆ‰Ò5usz³Í[n^ê}Å]·¹úvö;ŽÎ#Œsz�Ÿi—M»|&”ä/PÐ÷�×dÒ@‘Ÿ[ ‹ù@GúséBVV'òrávWŠu=×´WÐru‰G&ÿÆpÈˆÉU(zùPùaÜMú|Ô‡ž‡á¬Ž:ê¨£Ž:ê¨£Ž:ê¨£Ž.ø’V½-TEXT       Ëò   xÁËn‚@àÿQÎÀä\d($,f`b	¢IWD—Æ.jß¾ß‡)Œ	Â”ð�Óa?!4%YÛˆgûÆ3gkS±Çi-Ä;6BÖ„õu'¯ob©Yë¢"eú}Òúº“�×7±Ö¦µyRVÁrž:(«p!âXX‹ŠrRVáBÄ±ššG÷•fôq³Òx›�s¹Åný3÷xÞ0†ö!ò¹Í…Õc<v¬4FlÃ€>ºÛ÷.iìã’EIœÿÎw4vCLIP       	           GI     G@®ZTR

SMP4      B!ÿi  xÁK¬¯Yzäßû®ËwûßöÞçÔ9Uít—»Ëm[Ø]� Hn»ã H¬�Rn)²Ã'$$&$ e!KÆ `ˆ„„@BH™b…‹bÓI§»ªÎeïÿý»­µÞÏ#¿ö@úK Tºè¶¾šÍ0|kßíöo÷‡ï|òêÕ§oÞ~û;Ÿþé_üâW¿ú+_üêíËÿöóï}¿”"þ—ßþpÉãï¥âï§Àô+øAzÂ#€ïâþ øgÿøÃòÿþÉýŸô‡_½ÿÉÿóOòÇ?ýÉ¿zyùÙé«Ÿ�Þ_¿y÷ÕW/åt<ßÇÛeÎy-µš(~ÿ+ð .$AŠ	 Õ�Kb" @ €’0yP„€¤�BBH!@Š¥ Jò @€ S€XjA@L„€Xò LÄR€@ 
À*’ AQˆ�"°ä!–Ä@‚"Lb€Ä$m –(T€UÍQEÄ�4«4:*`òK€	¡¨¨
V#i"1% Š˜ˆAL B b€˜ˆ¥T¡Iz ÍŒ&^ÍÍ¾÷¸É±&Ó[ú–šÍ¹¦S'ÚàDÒ ä’¥ó‡‹|œ.£‹Û&ç£»îõ›áã§§ô� •B¢élY§F:¦ßØºÎê?¼~ùPú~ë½˜ˆ¥ÿ°�¥iË·jl„*é3P€"(nÛ„2Ý®µx �ô§A�ÕÙ»0x½­óìµHú>1[×Ìð‰l.—ÓÕvƒóÕ�éP ®ejý«Fqùp^›Ð·:Xú.(”\!í V¦¥bÓ €RÎ»þÓGà§ï>ûX ¦ÿ	Lud	oàýWýÓ@¿ŠXúE,·Ùo¿³Ç¿úÙWÀnïk®¦×  ‹Å¡Ÿ¦ë|O¾¡ær»Õìší&Œóõ˜uhÅeK_€€Ô²d÷°óåùùŠÎÚPëøq\ºØ¢zƒ¤ßp®u»ð|ººmÓ)(dú¤–²;ln—çsØ·Íº‚ ]å�útØùŸ?�úa³y,õòîZö±+¦FI¿	S°NwôŸ>ÊõÝû#ú}_¤LoA œÖysxrþgßŒssè1dú.±µ.¾ßhXÏ÷Ö¹vç]×1gô°×q<ÝQãfÏÛxº/a?xuYBìÛ¼Œ¶>ÆèéÄÒ¿Â\Y§Óúø­oãýWïÞýƒ·¹Á%ýP€:›�–ë¸šj+±ô}˜R¬\>}‹Û»�/^õ2Àô=�¢7ÑíŽ/ó‡‹íàª€é·@ˆåŠúüåt¾Î6"¦„fæf³p:Wt2´Þåå~Ÿ‘;·SÊ|¥†ÖÓ‰¥LAÞköŸpüêë–O_É\Uªjú=�*ežóðºÛçïß¿�CTÌµÚp@¾\Ïw7ô�BPhSvÝ¡ÜÆó|všM#·—ûµh‡¶æu¼ßá70ý¤Ê:×?q}>?g7`úH•:­¥yõ]}>_¥šÂJPªUçwÎ–ù:qb°ôCÔëŠíë�½¼|¸µ�;) QÒ�@@ªÝ½t�˜¦ãM]Û8V©ªé¯‚pÉæ†]ÐÛz´q£×ëZƒ¤Š¥$T¦ùâ¿sÀ»¯~‚í·¾i`ú�º.9ìw»]îkú4Jê@²NKÙ}þ„wÇoÎÿÇ÷Ž7O
,#Û®Öi¼ï]¯¾RÒoÃ´ñ†ðz°å_¾û®Û†·¶äÓ}Ìâû~——ÛMÚ]tf`ú[ El.w÷ôiÀÇùÓ	Ÿú²`ú}PÄ¸º-qÏ·B¸¦·×ÉDû�bœO>ªÅ><N×ñrƒïÅ6;kzï§½ó;¿«Çé4j�°m1^Nw	‡Á±‚éKb˜1»m_Žóù†×nkb`z
„vË¶X¯×;ÚÝàJú(b¥ÐúVê:^ë´ºy¼�·A;S±ô7@ªØ4ß_=îæéëŸØð°�¹VÇë¿ó9¾ùãQðé£ï‹˜~ Rµ.víö�ûöýñ›¥u»ýS˜—ãå¼²õÛÝP.·‘ÚÅ¨UÅÒ_©bsYÞîÞçûûo€ýÎÃL¯AlY$ÚÍr]Æˆû8¯ëižú€~³Í·ãËíC€Ñ(éK@]Šï_+ËûÓÉµ»®.dzB¬.3â¦«Ëý2•!D%ý„TWnl©ãˆvÛ-*–Þ€€T^iûƒwþø.®Û&˜2}ÈkÆîå:~1´±h%Ó— ÄÖº6Ýy¹Þ»­ÇÐ¶s™NÑ`1îCžn75ët?”õ”o3»µªXú(€-‹Ä¾½×Û±íÔWK©6V×lY¯Ë&ô}–´\Á.úãr¾”§Á…êÄÒ  E²Æýv#×Óåü0lj½MG§!6Ð
€u®u÷°ÝÞïï–‡ÖO ™Þ€Éc½Ï~óép-ïß=ÇþÕàV™:�
,ËjoßlóÏ¾ù÷ÍÓ“º›L-H­×ŠÇOžjþðrf?t›Xy»�›µ÷QL Ðf››ÃÎsz>/ûí6ÌZÉô	(bX'ÅîÁ‡——çûàúàM¥ªÂîµt¯^uñë÷GÌ‡m\5›¤× @°¬àCKŒ·†¦¨*–¾E¬ä5ø­.¸Ì±ÁïZŒ·û³ËM«”"i RëˆæÐ8\ÏçûClÍ‰¥ ë|Ëý'‡â_¾zÏvxÜõ¡¹./÷»½ê÷ÛP/ã‡Òî7-P$ý ×<í7O¹¿ž§%øÁÔÄ¨(KÅö	rÿp;×…vãËóz¼âáÑ’¾ŠX]çA:Þ–‹­ÍàE³¤·  %iž¬>Ÿ�7øÇ pbéÇ ÄêŒêŸb~žŽKéB+ð XF¿v‡OÉ×Ë²}3;iÆë„½öÞ™ÃUðêõ>~ü¸Î²Ù"›7Hê@ ¥ŽêŸ¾©ßœÊnØ J!Ó (ß´˜Þ½;¡í`Q±ô	H©‹5¯ŸšòòòõØìvÃ
À2WëöOEnÇcÉ!ì»×Ó­Üô}“Ëñv½ÑI·{Ó¯Ï·Spû&ZU±ô�\îëð8<èñôaÌÍþá­¶§ÛÑè¥PÒo‚"V§ZÝc‹Ûýt+ÛOâfËqœÎ#°�pYÒŠ…‹¯Êî²|6þQýu½Òuƒ�ô› ¹®‹ƒÜ®_Ÿ§f»§AiéG ­Þ]×?Ï÷Ûup~#$ý§`�›ÍFÂý|*›®�Ž&–zP¤”uáðq»]rqû¦™ÄÄÒ¯ƒaYg<üöörùÆd·uRT,u ˆ•yaØ½~˜N¿¹#¼êu%ý— r±ÜGÑ©.“5±zMßëºÖÐïó=_s0¿mp–~r]=›­vy:O£µÍÎëz[.Ë6h'æÄÒÿ«³Ë~4Öqœf?lT«wÔ¢MëTnÓ²5¿Ûj3ß_fvÚx5Ÿ>mÍÚ6]Wê=_oêC4ÈtŸ,ºèÄ$}

r™ÇfxÕV|=}XÛ¶oªU²•2l·ùºœokmº¨Õ9K?®³±Ún®§ÓÏnõÐl¬ ª2—i�»í'Äó×î¾yjuuÅ$ýPÄê²HÓö²ÌcîáC¨ÁÄÒ ÚºfÛãñx¿ ~ëýf]ç•ôA}úælŒ»Óx9N1lvCµÓz½”]lƒÐ9KoAäróq»	åòÍò±¸MÓ.R%�ÀRDÙ¶bµN7 '&éïÃ¬3²nC˜§ëå^\ë[$é¿	æZg×>¶Äñãe„n;QT‘ôû X—•�;ì¤{¾~+6ÝÌe&khÛÁ{[¦u¡ú 
—ZÐä²T›Ý°žïÏ–%¶
ˆ°–Z:ÙUÏ|WéCç
§õÎ¬ÎE5Õô˜H©k.aØˆÕñØ.¡ú@Yæ:J#â(¨D·�•y\7ÂFb’þ&ˆ*E`!tç2]Gä¦oC©o¤6-Û*éAT©k¶Úví6Ç¹–èC¤¹ôDÑUØ£-X1:¸Ð˜“Ô"yš•ÕÊ¦é¤œç©k0©(šƒßD©eZX'f¢ëãjãZ³†0D
l*V‚oƒ[d)b¦.(¼‚)€ ¤èâàÛ¡Çz¯Á‹€¬Yœö¡YÊR$hÓˆVI=ÀêBCœ[ò’k«�R°NÎõ:´àœG3J§ƒ�u­KÞoWWæyÊh$ª8Q¦‚•Å|õÃÆOó|½Á¦u"˜~*–X}ì<9å›«‡ÐÆJ·®êLÚ ÞJ¶\¡>Àkz­f�†¶«2O÷%4ôI4JÈª±	®VË¥×I,¶®"%˜¨¦DUsëª¡Û†užOóÜß8hŠ �¨\‹¹aëú2�§±‘V�VUH
0Y¬Xð�«u^mà%PR£R¹ZÓÅÍšqÂõ�9*E“‡�´ºÖâÚÞ{Ÿ¯ój±Ù¬v_Jõô5«ku¾é\-ÓuFt‘ó�w‚ Lß!Ö²fÈy-™çàV³ËƒàÊZÄª†"€�­³¼¬UèuUÄ’µ :ßd²…ÅÁ;1€u¥¸!´K™¬6ôNÓkÐ+FzFŽs\oRòl3¼º†>0ýYf–­­¡m¼-s¥Q/U%}d‰€§dÌ½÷}a�¦¢Cô‹YYKt�w†%‹â¼JŠHžµZÕÐ	°ÔQúÐúše®K8ïE éÛ ÁJ¥íÔ™�-=bsDeª“úÁ·«­“¬�öÜZÆ<5E¼"($ýy°ÚªÐÆ©šeÍJ#‹˜8QM;˜P¥Úb¦}£K©·2;'­©ˆ@5ma¤�ZÅ­1úe\ÇìBÛyYJ™$;Í	$}’•V]0 ç¶ˆ† ‡â­Š0[X|h­–qÉUü~­³eªxx$ýu°Z1“Ø8›é-8U1PTÒƒT¡Xei´T¢‰ÍXÏ×Ké|„‚jMßITD
‹©ïR²jh‚k+** !S„eŸƒö.².˜
}ÛÉuB†h0	@¢
ˆºÕmG×i† @…ª– *³¯Nzñ9×ÊàƒRfo*Î‹ˆQ)EKã{ï$OMcè(f_Y"!¦¿ ‚FVT… óVG?ÃïMs]šìMU(éO�0°Êì} \Üä!�‹Î¬ÎXc…¯ŽP ’~¤‘¥:õ�iÎ`Ð†^²**éh0q�jfÒ¨™E½S%¦YÅ$8Çš]�É\�I4uaú·A
Í
Mƒ×Šu®Ð>„ÂÙªWª@ U˜@h0DÈj¹Ñ�‰-øÐ_W]¬ÀÄ*ÅDE40ý9�¨*QG¢
� ©âÔA`5‹+£¢bºlÕë f[„¬1y')ÂhÕ¨Ñ#˜-ÙÌ‰Õ²Öä!¦è±š„œÔ¼dgâc­ E5½YÍà½ˆåši\)ëêÅÔ;g0 Åà(²¢HÔ“•VèEU… +ÍÐ1!èÅ)²TTÓ'0«F	ôÊbPBaQ+âTX­@ÔIz€	U …(ÔXÈªª>8AÖjJqbB¤'@3# ‘ô¯ƒ1%ÌT”€èÕ—:çêch\A™×éá�BŒR•ª¢^+ç®úœqA�£ïÄ(„0}
ª€¥Âœø\ïÐ¡AežXiœ·ÊµºZõª^É
u‘Þ³ …*NÄ*Ì­­H%@Q
…4€¨Rºê-˜T«Åª¨¯.Ã¬R 1T…BÓò{øå•4Ä 1Qb ÄDM45˜@ )€ ¤ ” &J
)$  @BHS€  ``¥Áˆˆz§Ra–}…Q¾ŠW@H‚•–< "Ua,Ñ¤Š„�  4 ŽÉ«™c‰R õN}‘*Å×"F!*)B @ BˆAL ª˜	ÕQE½ˆTV«f„xj X­š)Ä;c¥5¨`5;²*DE1bšˆ¥­¢ªwê´qVV3s".}„Y-"Á‹[ëª°i+ŠÜ#;çàƒ2µ �–}uQË”§ ß±Ø<±†nk~²r©5†f[YÆ:¡FZÍ€5Ác±k.ü&HYÆû
lš¶ØœW4¥ä)/½Î¡®+Þy¥dVWÅ9�¤
Q«U¤É:•ê<¼Ó´�j%C†­¬y’�!T°ÖEC­e2í‚6B•ôC´ì
]ô�6%$xç4ýy,ÌA‚�Rê˜MC„óé·A¡¬Uš>êÓXrt�9@rrËf«:/—¼¼FT�€«Siâf/÷ãz:'ÅÁÒ 
Pa}te¬·�¹&n›|Ê—ÅobÍ·i¾õ1´ŽNY²!ìÕÝ—¹Î­�j¾Zú˜-hÓÆ…·1× �0ÀÒ·@)2ÕºßÓqºKpmnW°f®Ã¦o›é¾Ö�qã®·Û­¸&TK¿
Ps­nƒvÊ·k5Bµô æ’u£a^.3œF_ ™³×]°<Ýï[×†@Ó÷@ 6£¯b>]ošK”fp{;2ô]ÍdÚÀ¬ÓèúW/—÷Gnû 4òV¤{B½\Ž¹é©dÚ‚Ë¦M·uíù2ïw÷Íñ|‹»MÈ�b°î!O·Ó¸ ¶UÅÒ  Ké¢�nóe×îúØÞ¾þx·®jj”ô·A@jÉ"‡m+øhcØmÚÕ ¦/A \gë»·�žOýNÛAH]—²;4¸ÌN¥Ù4Jo�ô�×êúÃºžÏ§¨±WS”y^÷O½–ÓÏ¯ºÙl¨+Àô#�
™eŒ��Ÿâãñçþöû8š3JêÁä±Nâ»×=ÆÀ6d˜þ}0yäeòÍ'!¼¾Þb³Y]˜>!†EÙoÅíx-¾ÙH Ó 
€¼ä¦{X×—ùý¦&`ú÷@ˆ•53î�—{Þbè”^,m@P«,o¯Æë7§k³ÙÊ
©"@©³µ¯Ûáåò¡ºCïÝcy¹žfmÚf-Î(é©6Va›_¦›…èœ2½…)XÊÒöÚœ¦÷£6ƒ  Ó[�®ºqvÍƒb>ÞÖv×y)"–¾&�¼ærxpõåø|óŸõâ*©È5cûÆëå:bÛ- Ó÷@:«ëÝmv}ÏçI‡¦½‡J¦·  X—ê†]¹Oã*Ý 0‚T”kqÃÛOp?ýtóÉŸ ¥US&�EÊ°Ý÷ÓõE×ÐFO%ýM0yÌEuóàq|.Èn¿=Ä�ëeÛïèªT€å–ñê±Ï—¯»Ø›öå4fö�;ôî/§Å÷Cq«‚Še)Ûí€é|½®@+¯?i��€¡š	 Ó�*ÙÃ##Îãõ±ï<@€XÔd·Ár=?/Ã&8Ph¢bk6ßlºžî
tºytúr>­®ÙWLH•œúF›>Œ¥m]ß‚/kÛ8SaJ pÖ¸ß•ëe}õþ°mÇoV´MÓ÷Ûu|¾Ìq78]D,}	¨S‰qïóxºzß:ó”´!fëRv];Í÷cdÛGºB¦¿
¤Ö‚0Ä5Ï£©oMT,ý ×eÒÃþA�ÇãÚ·Ûêf€i AábhŸÚr™®KýV´Lÿ L‹dö;9�Žy´Ù¶ý|=úfoËýøò,qÓxšTÕô�@�Ðî±í–f:_:t�]»¾;�ìÓ°�)Àô9L¥Ú¸ôÝÝåzY¤ÔeK¯Áä‘—™ÛƒV¼œGÙÍ(0
P—Õù×ÍnýøJè]³{òy~žV	ì‡O±œOkŸš˜L_‚ lkÿÐát›ÜN�	˜�š—Ùï·˜Î÷£„8xTJú/@ uÎÞ®ÇóhëÐDWLPG�»ÏÚÞ=?Cßtíë(çû»¼†¦Ùwp|>^+£‡€åù|*]×
(dú-@±*þüùvÌêÚ†ZÈô„˜MD³Ý5ÓýèŠtûAêùý¹nº.K€['„}zÉ®Œ±QóbéHgu)~óÆÑN/·ŒÎ÷­æÛåãµkw�'0×,íöíÄé¾°‹íL%(°uÝÌëÇ‹²·ëwr¹¾\·�‹õz™´ï²Š¥ßb˜½Ûï¶÷ùyœ‡~£æ- @L'ó›Ã�óuš-ÐíZ·^®§Nbç!EÒwAˆå²¢ÛÇåz¹Ü‹wØÊûñC¨]P 
ë\eðñ:ÞnKØ…UÓ„X¶¬ñq[ít:×íS«0 ¬ËˆæU\ÇÛÑ‹FWÇ—ç�›N@Hú» @˜W`ÓºãršÇ¦ë´:±ô%(–ì¥?ˆÎ§ëã°(-ý:(®óªÃ°‘é|[¤o›¢EÒß!fã:‡Ã~àõÃs~ØÄf¢£¥‹i;8m�ã2
B×[»žO96[ïŠK„§¼¶»C�—Óibÿ¹_�7ËÜoƒÍ—+‚ï7
PÒï€Áº,ÍpÐõÃuÌþu=«¤€"†÷Ø=Ð_/ÇE|«®¨Xú%P¤Ú6�×iÂÜèàDÔÒ�@³uÊnÛ3œ./‹­‡fI?E,×·�]{½¾<s»ße©"–ˆôß�A™ÖÜ6ùþr5bBÑ"é¿E¬Ì†¸mù<ßnNšÞ±ŠXú±ll›}[¦ùãmÚ·½7/bé¯€"V›Ûýá€ûËåÛ}—¦©ë²´Ýƒ´—ÛÄö}ÕÄÒwAã\àŸ^½6~ü8.›í®JõbéP Ù�Ua×ÜÎïKm‡‡6�çÛ8ì7¾_®u\žúOüC·Þ?íq·-.«XêA�pÍÓ¾ßùë|=Ý$öEUX0‡fÓa½\¯'†6* –¾B¬Ž¹ö;æÓýãÐ÷�Ûízš¬~Ö½nWïnêÂ6n6óí:‹¾î�^ŽGÚ›Ã¦kËíºœJl“ô)XgºfÛúööü|¾K{8ìC3ÝÏ/·¨ý~hÛñþrræ7Û6¬§õtÏ¢ñ!úfº�N9º~ˆëýz¹Ì1Í3}Š”u^šÍNËåþá½ë‚RÓ?ëš�McS¾Œ5û]¿�ÇËiƒ]¡fé—@¬y‘8t³Ýîë„]Ûõ[›îÓËRÂ¾WÐ¥=X×9ú�ïK>^oØ„]VMV×UÛ~pyÍó:ª¶Ã¾]0?_ëcì”PKo@‘º®ÔÇnËóx>¶!ÀUaÍ¹sÝïë¸ÌõÕÐµôK°² 7»e¼Î·›.@L,ý˜Í·óñrŸÊMèDª¤oÁ2&‘}û8žçó×OÀlV»CëÇ—t³@ÄÒk�\g/CÃöå|<‹]t"Õîš›Í“ŽãóI¡ÛM« Ìe=léO·—tÛ©Všr�u}xøl¿:¾Ü¤o{LF�³•¾y°z}9Ê-h¿6Ïã±k›Øx]²[²…ÞÖéºtÝþçÓu‘º&U55 Y—œÝþ°]ïçoÊ›¦™¥’”aJÁ2ÏôOC±¯ïï¯àCë}Q!SŠX�ÖoÃ:�×1çÆG­ž’¾ŠX]òŒ¶íuY¯««ÎÚåî:Ýš\_D,`)\|º]½�Ë}�¾‰L,½kEç£”<#«…m³ìe¹Ï%ôÁ‡â$}
«kn¬íš•ã}¶â]qš¾ KáÚ¸Á»\n6/Œ®‹Žu½�3B¢ä2Ý§åaÛöÍ”O÷ºJ×ŠEJ]œÉ&ÊfÇ’¡Þ‡â$ýo •Å¿Ù*îóy†øàœTÑôÐ².­ô�“µÜgSñ*¢éƒ¤•"Nº5ÛµXlú`Ëz›suí!Š-ušªÔ^U(iãÊB×øvrë:Q¥ëc-õ>Ï^4ˆBEÒkÐlE¡‰~ª£ƒ�ˆŒdY³i?Àò2O9'-(�ô9H®\kï7@™J£—ÆVWŠn=gÌ²:	¾�Jú�AT­ÈÒô¾7æû„âÕ7¦*iƒŠ,ÅÅÆ	óÊfí<‚sé‡ ³ÁºØ‰]ëµ£“ ¢’>a("µñ›¨ë<]goðNàTÒ¿µÖâ�ï-ä|_+ºvÃ0–;W5¥©¢’�0+5ûÐv4æRèû¸¥X™Ö}pÁ{jzÂP-+½�ÍTçõ~¨›m”në}§¢�šÚZ«¸®…\§Ë4½–�º\×[4¢‰
$+µ–fˆ‘˜Æ	µE„�¤G�`-Yªo=×<­¼�
ï%ýßHž0+YÐºŽ—µÖ]3„:å»ÔÄ7tRQWcã[­s«	‚B�AŒµD	AYëH+›¾y\3°nÕ7PjúÇ -ûïƒVÉË¼¶Ò5³ŒÀ:¨@DTÒg0€V3¬mšN—õR²õ~Ç:Ïë\q>P!æ"vVW['À9‰UUÒH¢V[5ºAÌ¦EÌ‚©¢�ô Â@fÍê}ðšó:Q‡užƒ4±GÆmUxxGUI?I˜ÙR]�/u^Š xUª
Ó YHÌÈ¬:DÈ\šM3¡r�‰zïU˜~&°fq24�µÜÌœ´E=(`úf…U]_š\j.„R×jAœº´i‚ºzµtL IŸÂ ’%S|o™y¼¯¬…Ð�ö 	šƒ÷A³,b"Ôà é/‚&t¨(ŽÚzo–³¨±Š€�ô	ˆŠl�>8•œM£ˆ«ÙêÄÅª©FDˆÔ¢kÑêœ: é	Â,Gj¨u]5($Q’þ&”âs”=Èi	@PU¢–bíê›‚Îi®)¢U$y¤atê¤ {mú€:]Öî)½ëí>›ATGG³ì�Þ{�Ë«9SÔlÒ„Î;Y×ek�CžVË.°3¯R@�B+…Ð¶C¶r›$îšVËºB¼ŠŠ¤'˜PÌu"„†(Z2Ë«:ç*”ôc�„Á¬Vß8çÍ×ŒlÑõ
ê$RÄW@@Ò¤	DÅJ­âi�s¨Q#<h„Šh:€ 	QIÞi-!ªËy­&tN¡°B3(š~¤Ð B (ÕÌkCÍ‹˜zÊl®ß”ºæ»¡kZ›kžÛ"â¼S@«…p�SãZ«_Å¡ª€€¤«š:À©–AQ…€ )ÉÓDà+«­âµ%ê29Ï¦‰êevÅ‹S—HÚƒ L  ^„‘
	ŠWÂ*B� &‚äÕQˆj$ „éÏÂ@ÂQ`fôˆ’ui €K¤AgU|g^×
õ®”UjµBªŠ�ˆ¦G�B�„©Š«™	D…fÕŒ"¼ýï�Ok&Í"»ìóšs�i¤*Œb"	�¤$HA(ªN f(( …à†ûðñŸãXh4�€˜@@Hj 
 Š˜@  –ZP„ˆ˜¤ b©PÒB0P¨B€Eá’€Æš<MÍgG%(aòƒX
ƒ˜ˆ	$PÔ’‡ÄK-(B±A� bšS„˜@ „P!*X«@E£9Œ%TLAU Š˜ˆ‰P,P„ Ä * ÂS£9±jÙçh *’þH–â*;m³a\œwtâ�JêATO´p~­«ƒw�ô�bM…1xOÉ›Y�jºXž|�ÚWWkY'zôÑ¹UG¿4@0ç$½Vêú>ú:O¹­O!8ÕªÂš�t]›æëÒ{ïCB”je*ÕùÐ9‡µÞ,kÔ¹VkÃ¦)Ëuœµi£ÓÔƒ©˜ªÄMï—ûóýÚIëO+e-²ku=žžW i=è�…¹t­×ù~»÷®m‚A$}B*gz·é•ï¦ëXûØxP$ý(Ó¼8¿ÆûºÀ÷Îƒš¶  u]Í·{Øm<g¶­C÷”ÇùåâCïšf‹ŒûTá½G,’¾
P$7èwu¹]/3cp]×r™ÏkuMëà	€ÌV£;D\Êí¾éÐ¸ê Â–œ¥ÛøËõ~iC·µ¸:XzÌ,}ÓÔqÎ@ïÔ,õ ˆÕå.zØæûËé¶6í.£ˆXúË €¹Ô®JÉ×¢ƒ6"P …cöûGÌçS-:´‡‡ò<_F†Ø(LHÍÓ¢‡¦¹Ü?ï��Š�‚lÀÐÇûíz½F‹Y»ý×i^sèT«Š¥/@ y­6a¾_NÎBçQ)é?EnvÙlvíåþÕ%Ç_øÉ¯�œ¥?
ª�.ù›OÝ²¥· Eì^ÇîéÛ-~öÓ�·?|»k^�L_‚+sµ~Ó¯Óù2ºMl‹V2ý]�ªÅæÒ~khðî«¯uûº©~×ëòñt¹mö±[‹pQvýº>ß/ÅÁ×ÍëìëãÇí°ku%Àôï€ QOãm÷í_ÄÇÿï�¾>û¬›N*"–ë*ýÁ‡çÓG?tm@QÂÄÙršÊÛÏ^ÇëO_nøå7Ñ—l¹ñj.8%m@�°Ž*ÛNïÇÛÇª¼n<¾ûèÚa#0°¹¢{z›§ãõŠö=Mªjú�*uºÎÃë_ÞÿñO~þæ³7»&FJžoE]#1ŠÖ9»á¡»�§¶ûÝì*˜~	PÒñ~¿-Ñù^éai )À|Ÿõ³o‚þõžðº�áAÝýåÝeìÚÎ± L¤Èºn÷e:Ÿ_Úí+ï	¡)¥r‰~ù¾Ì“l|(–¾ A‘u^,þâƒ]úóÓ†m›%ýS�šÇ†Ç�³çc‰í–X¦_©õ’¹»É^¾>÷Od) Óo�T)óZo^nÇ£;m®"U5ýE¬wºÇÇÿó—c{hºšgX`Ór½Þ.cðEÁôë UÊ²ZûI§—é›�í&¢ß„rO^Üp°1_^V‹ÝcßÞ¯ïoY·-XAŠTÞ
_m:¹^^&�M±¬çu+n }ò Í�mÓ×i�kn‚§§¤Lav‡^my{þêâÞ:J˜>A‘¼Þ¹ÿÖøé7ÇaØu‹fÓï€ 8ëvoœûêÝ¾k%¸Þ—õv¯�v€Ko@ˆ­ÙÙ°�Êù:gçz¡Kß©6ŽÍþàÖëé|‹C'©d@@
'lŸ¶ƒ]ß-uØö`úHÕÂ³õO‡î’þqÜõzîù>Ž\k^«*8-swøV¾ùxÂîÛÛv¡LÿP§¢‡m1]Ðt1B*™ Çu‡}?ŸŸÏu3Ä¸�é×Àä‘grx³ÁíÃ»Líbhúv¹ÝOkyÕ3ôC�óiº—¶4ÛM‹÷çÉÚØTÍ ¤æËŠÃëÿäýìôAÊ}ºf?tð90ëÒuj¹Ï«ßD¥Kß!fË\†Ã.7—ó•mëÔw”©Œ+£sZ5ýu Çœã«ÖåëñŠØGÇ" €Ë}j‡ÏB=¾ûºÊ›�«UIæõ¦¯¾½�/_ÿdíÞîC_LŒ’þ-P ¬ËšGçp¼ÞbÛŒZÉôW@@J×öÕ'¢_½ûžöq]«húH.S·û/—Ké›ÖàÄÒ BŒCØî7¸=Ïµñ}Ìž’¾b3níþmÓ,Ço¼üŠB¦¿
BÌf”þ1–ÓýèÌ5A«K¿
Ä¤¬aß6¥ï‹8ï»ð´ÜÇóÂv«RU,}	ŠX]–ÿ¿ 8ÙÕu»ÎüŽ1‹¯ø«µ×.�±Û‰HQ*·H,Ñ€„&Ž„(š@\ÂÇ­pÐ ‡hÐCBIìã½÷*þê+æœc¼<�Žã0ÏsY«öÉC
l1	§¸a¾Å±;†*ÓÀ;<ìÞÍŸu½§ý)˜)8ý]P ØÖ�ïÞöçó/—¶shN™ö HóÍÃ0�¥z!«ét ØºÉñÝþtÿú«¥äÝŽÎ@Ÿ~‚j¼moß|‡ö—¿|ÞobÃ&âÓA÷Å!=_ÊSp>fB¦=(â¶5Mƒ4«W´Ò1?Ê`Ësåá]J dúŠ¸-hÝ~àm»4t9‹ñéç [()ŽÉC±^û7´½þß?¿þï7ïCkkhäôë  Vï&û�½m_¿ÞÃ7ûÈ9�œ~‚j¸yÿý^ÿâÿ]ía?äv¶ù>ú]�î~9Û»±�MƒO¶ê2Ž"‹•«ôYƒÐ§oA¡¯ÙûN¬ÎzKLŠ|úg ˆ{ÙJßØ¼¾lk¿Ï	ââÓ€AÙîšß%œ___lØ�-ˆO uu=}xkñOŸßàíCgpñéw@@¬ÜK|÷áÍø|~¹¶C¿C(">ýsÐ+¼{Yp[K�ˆÓ7 Äm-ÛËëç{ü^w\…*>½!låfzøØµË/ñÚ†îMCñé(â>×m¿ß�Ê—×ÛÙ÷ŸFP X}	‡GàWO_1Núô·@/µ…ñq8Ì/O¾‡>‹«øô?Aª6\!»�c½~þü9åãÀ*âÓ¯ƒ dgä·§‡òòù|‰ÃÛÎ°‰øDLÿDµæáÑÚm-osèÕeúhesOäe›½ä£˜L?½´-äÝpê–ëu–0f¦:=ÀœOÝ{”ö‹úuä£ÈÃ¢ èU"ºµ•%ybfÓ_}[ê÷z˜×ûêìSTF�þ¾ñ¾K»±ø×¥îØuëû³LŸ@ Y�õð8ñõå©„ÜïzµUhbŠ&Ó·p_ÅSzxlçùrä”Ä§ßYê9uCº­O×j]!Ð‰˜þ5Üjha¹†ŠYRÖCÌë6·`©ïQ–uE¯Q§O ¬ ¶œ——%v¹— R¦=è­)rè¢c©[b€‚m½¢¥®Ï°m^¯Aû¬:ý˜Û&¡ëƒaóMrêw¡w¶{€Cêk.²Zõ¶†\¸ÍÜ:Bði²Z+»î$¨Ïå¼!ÈÐ!ÂlÕ{n]Ê5–Ù4d�M« YÜÊºBãpzÀVîmÕrPiÒVÇñ´èùukiè;�KA±’ìc“¶bmA’g“é°5¶�wÙK¹-tšLÃô 7[Ç> ­7ÛTB@®¢Óo� ÛŠÂñá“e¿ž¡ã~¯êUgmÌm-ìºñÞæËZ¸K’[TÈô�@‡gýNOi½]*{ö ÊÀéÁ¬T"q½¯áË#¢ïo:}²iK’{øÝ`*šB èôk f-zNƒ¡Îº‘!‹™ˆé.03²oÑJ]�ªÉE¦ÿ’h¡&É]Åï±j–‚�é€ÍcîMëj­ŠG$“Àég €Wm5¯¶ÌÆ€Ìà€h 8}]¨Æ-uÝ¾|^%ë… §ÿ16ALûDlK�"]‹NÄô$\Ä½4ùà¡¬ËÝ%+¢@P¦ÿº€æ› ½¹µµtŒ–€ ÒE\ÐÌ<¦Îµ.ëÖvAáÍ,É™>‚p6m‘}ÌÊºl!e	10Ð€Œ¬fV¼e‘)A¦ÂE ÒÍ1¶(óz÷à²ms{*s		�»­)™¨84¥ênØ¶íZkˆšB€@,púmhjÉíÐÆhZx‚Ç’ iƒË´ƒÓ)¢Ê�¦CLZÖëBPÖXh.}—Åe)+É !ˆ«‡éû H73FMpŸÝ‡8Tçêµf†à±‰‚Ó? A‡ˆ",Öb×G[ÊŠ �ƒ.*Ó 	Š"tó†Û—NSiBK„ …„¸U	w*B7§ˆ[É1'ÐKv¦YBã*1-5ßfKQCR€ E¦¿�"!ÄPÍÈØÅàµ,9ŠÆA'"Ó'¤8(U�tÒ	€„©†�RÑHÑs8E§ÿ
ˆ@©TEqº�T§?	�n&ªc]TØZ(bR²y	¦*™z$ p¸»„£‚æÍaâJQ ¤@BCÜZ0"«ÄÖ–ªÚÅ˜ÜËzÑAo-šÁMâ ©¢™" D%Nq‘é )�Á=U·VÇ–³ªW5#BLR¥‘T�pú	¤!š‚Ò[‹.YBToÆ&ª*JÁé_Áò–!.È!ˆ ˆ‹¸@8õ @P@@
)H
„ "„B”¢ @Òà‡O	(D¦!!$ÄEH@@�ˆ‹pÊ œ(Bˆ‹8§8U¡1ˆ(œæ^3DCD€{�ft* �‚j@p%›˜Ãá"hŒDèlÉi@PÄ"„ÐE\ 
D@  ˆâ2u |Š Ä§âˆÀEH'è‘¢‚ÖÞ%uA¬‚‰
™PH³ÚÅQÕk]!}èz¤ÖÖºÈ�¢dW™þ>÷‚Æœú&KÙ´u’U œ~
Ü*(q¯¬k¹U�cß%,­JÞ'•¨$ØÌ=iO´•9ˆ„§?…ôB„1f³µÅ"R¬XÒc,¡Í‹Q�-¶ég ÀlÍzõºÜ»<U DÅ:ê!Ë¼È¨YÕdúÀÊÆ~—Þ•óí¼öcŠÑDA¥µÆþ4¢¬¯kë‡ž�"Ó€·R<õÖ|]—ô=9˜:eúï  V‹…þÁËýuyAŸ²J§Ÿ‚ |^Zzûk˜¿þê¥½=Œ˜	pÚ� lkßÇýåå|ez÷éyýúçËn·Û5§ÿNËºäÇ7å»¯_‘ßŽ08ý€KËÃã0\¾,U�‡CÞ>?]†x‡‡¼}~}¹ÇqH"FNï@ ¶Œb=Ÿo5·>>|ïqö§×ËÃp’ââ”éG  ÖªäÝ>ßÎÏHþ®óã›a{yúî:a­	U§  ÖÊ8~8Ø—ëó»¡9Àé#ªánrüÐÕí—O%>�&¦X¹åôîƒœ//f»CT
8ý`Óî´ËO·¯yHP3ˆÕ5�¸¿žÏÛ€”Ž±|ý®åý!°	HjiûþM]žn_ª�}F¢Çé-j»^—·ý˜( §Ÿ€³Mû}Ò°]g‰§]Áé_€¯Üºa/[y­-Ç^Å§O ÄQ–è‡‡ŒÛåÕ°ß7 äôcâ,w§aK·2#÷ššP·mì·—ë=�púS�ªµÝ=~ˆƒ|y~Õ‡·±»
Hó[û·½^f9îºY@N¿B¼¢aØÑ×Kóæ-<p]ŸžLÆC£€œÞÃl¶Å‡Ç8”ów›ìN]iÁ)ÓŸ‚Tñußÿ nñÝã~Ôæb"@³Êá­Øçë—ÙÇQ©FN; ËÊx8�>_fè˜÷Ç‡rÿz¾¥a×BQØ¶D=íâüòtERjÍ
÷ï£•Ë%àÐw«šS¦ß�+ØÚ"ù}ÂËõ‚îSßµœ2ý1(@C“¾OµÞ¡OAšLàŠ’;¿,¯ë¶ë«88ýÄÚfýÃ#¶¿|ùjvû±ž_¿[ü£ŽÝðüåÙ•.¦:} âa	²…ó­¨ L@|Aywór;÷ØÅÎ“‘Ó?!ÎÖ,îN¾Ý®7‡»C°×Ë\ä˜ûÍƒ© ¾H}Ó�6¯ó]cú/·óòªcŸ( §?€+Ü®­Þ¿K—ç—G¦ñøàéëË–ún8ä¼^nO·ønÔc�°Î/sË}"œ~
BÜjC7ä6_oU=âÓ�AˆùVvû1Ôz©¨-õ§‡d÷gt]? pA V–´?uþõ~ymAe7C¹=­Û©�ÇÝ`õõ¼VÍc÷xª¯¯Ÿïy?öÍN{â¶&9Œ”õ¶:ÇÅ§ÿ`»U¼}»[^¾¾\ßŒ©ÁéG  Ö6§#Î//›~`Ø}êÆ§×¿\åÍ>»Ó)Ó�@°iãÃ�óí†Üiª*>} X™™ã.Û9Œ©ƒ9ýˆëå0¶e¹.ÚC(Ó� lsÛ½ÿÔ^–¯÷§ååz_úc/„�Óï€ |®–>d±Ûíßr°è�é÷@ˆÙÓ8¦yÛfésm2}B¼Xíûã¾–ë}LaP¨øôsâ(ëÖïßk»¼>ßv}(¨¶¥þmöóëçÒngppú'pë6ÇÇÇ!]^¾¬-‡´ïGÞÏŸY‡·�k8�  �kÉ'œ¯Ïgëƒ´@€BÛÇã±½žo®]
0™v „VVÅãæóëKãaŸ” §ÿâµÍáøØùýËùU†!7:eúmâØ°úaß¼~^s¿7º‚ÓT·.Ÿö·ky½kÚ]÷·é B¼š¡?¦zY^æ4ô�Òdú=P (•ûþ¡Ý—û½h$€2}!´6‡q|Ôì·ó]ö]i2í@ˆ·2K:ue¾´‹è(ªU¦O @\È>b�ç—`‡Lñé#q[Zß»×ûÓ}Óa›"(àÊúx_ï«§”ŸFP leÓáÝiûåý—Õ»S¦Gñé§ ˆsKˆ‡ÞÛ}¹zî0TŸþ |ØÅá¾¼ÚCÊQL§ß Âº†ñ°‹z½�W|ÓG•*Óo‚"î[cînm¾…‚ ø4‚"Ž[8¥õúz]öÇØ‹E ×©?Ð×ë*Ø„ŠO;PÄì®Þèö|y½C×E2ý.¡•eóÓé±~Y~±ÈîØ7™v ˆÙRRz“Zz=¯!ƒÅ§¶­¤üNùõöeµþ8uñiŠxE³SŸo^�"
E|[Wß½í–üôº¦´ëÕƒøôˆ{XŽ£Í¯Ëõ°0Ÿ~ Š86¬<œbþrûr/þö¸{D>ÿòâ§~õå¼>“»áðpòùËeEØf L@� ”Êá1Ô§Ëý^Ô»‡ãÇç§ËŸ_×¡Û?žÖûõóµ¡÷§öôzyNÃØm¡@qñ4ƒÕõ^|�‘.âÓ 
[½Ç}ú(çù|¯÷oOÃ|}ùîš�C?>ìúóýË•§}NpqPPZû1¦¶¼¬U-�¡~w=#„œNÉ_^^WˆŽoRXôùòjó‡þAäÐ}<vÕU,ÀmaŸŽ¨÷õ²v¡‡šˆO=(ÔVx8&»]·—­áñ0Êùë—ºíö‡F m5‘·ïw÷Û—ûmçax“òýrùº¤º“ÊõòuÖ0†TdÚ�¯®}·Óþº¼nöÇ£¬—ëËÚòa8�Äõz]tìb¨
PPZÃ°w=Ïu§�fÓ)ÂêRq<ãëõrËC—Ð‚8(ÖjyzÜ××žÝ.­ \­æ‡L¹=_Kÿ0D"8(h«cÜuë}}¾-{×Ã õz¾—pÈ‰B™v „•KŽoòòôz]b4Õ@‘¶yÙ%¾¼</­?Œ»å~~^ðî1FW ,¥Ú›7!”ëó+0v ‹ƒÂfÞÇ‡z¿ÝS–B€‚¶Á‡}_–óåî©KBŸFP Îµæ}�m¾ÞSìBS²Zmû7Ýay~¾Å}»a‡·ÛUº‡NH¥ÎLïÞ�×õYn‚nÿðúôÝmË§ÝáðîíåééåÜõFW‡L?E¼òÊþÝ÷×—§âŸú®‚âÓAZ+ÕöGéÏ××‹SE¦ˆ¦kÐýÞ¸ÍGL‘Q}úÇ ½ÖhÃq¬çÛ×ûœó.">ý!(n˜‡î]¯çõ¥yØ=FÞnŸ¿6Çwß$ÓÛ×û™1¿‡¶Üž/×^ª  kÎÝpHë­\–‚w‡wèãòz¾Üs·—�§ÛKièO™KY–„ÐG�M¦ßEšÏ`ß§ÍÚ¹m™ûÝ ›]î{Ý3¸øôSPÄÚ¤SÄ²½Ì¦aPˆúô-HÛ2ãýÜ 9¢N?YŠ{x;h{¹½Ì¡ß·Xeú+pß]ŸdkËÝ•îðèó|®Ë‡œ)Ó'Ðk«!†Rï—ó%gõ¨ÓÞZÙ¤lë¼I!· Ó· ·¸I÷k™o—r§`Ÿ>�¾mÆý~®×—û,2H$UL›5û�îež7]—=9 VÆ´¯õ¶`ˆ‘P�¶`ëö±›·ûeÞ�ƒˆº˜šm¦ãñÝR–ç5£â Ìg>)Êrß†G�Ù³h¨<ô§"éº¾à!æ¨B‚mSÉ»C›·ó9Æ.w	PÀÛ&>ûNêu»ºœF…«‚ÅkŸŽÝã¹]_gæÔeR¦ß½šq¿ÛmÝò²œ[öcú�t{}}îbô Dó°›Ûm^‘ŽcWŸnçÛ6tCŒpÀ«Gï
¬s[Væqì¹,ËÓæaÈÃ,‘hbšò±Î6·Ø¥\ƒ5®O)]æû9Ä|ÌXÚíœ=t]¦Á)ƒ H³ž÷YÖõ²%èqØ§z®óuEºDF!§?Y½‰ì÷bË¶”}Fç‘¢¤ÛFÏ±3çR¬ƒä`"Ó·`óuÄNúE¶¦æQ•2ýd5³¸†qk×Ú$§�Œ:ý>Èêe—ƒ–r÷rÚ#ÚºU¸Æ(¢ÓÏ@V©)Ç¤ô²ä$1Èô=8«Gë¤o¬k¡'IÙEè¾æÇNÃÒæmC’gN„{‰©t+wYcÐ^�dÚ�î°Ôg„íÚ®ÉúMU|ÚƒÞÌ$e�Í-EÍdú¢Å%šîÆàukUMc@ôÊÒãÇs»ùâqÈ1XœAÙJé8Ãè÷ù¾óA{Q€Ó°ùV5´ÌsÓ!'QÊô¤ÞJ‰aÜ©Üëù>B´B!YŒèòßl–´Š°YiÒÅ}óunKýQCÅr_7j;f8½áô
xê†TÚ|ßœ]L ›Ux—lí¾‰‡dúp«±¥”Ø–œT3b˜þ=Üªaèá¾ÞWÆ]ÊJZX;¤¾oXçK­q7ìÕ°m7³¼KQ ¯jLq¸,Íút�mõºUÛ1‹„ ™~¤{qÉ]ÞÙZï0ú$�‰L?‡qkC§Ò\a]P•ióbÞí†¨Ë2ÏkçƒF•i­Â5å�»Õâ–ú˜�´Í¢ö{7k÷DHQ§t¶Þ0ähÕ/K•áÐgY}›= dÉqk2ÆÁt]ÖÖ:dv&Ó'˜·Êûl(’G$A�i€iCRbYWh×�¨¾Èýdy�²Ì.§îàºÊ­„<H�R‚¯[sºN¨ÁXIë»P·í¶m6Œì„™þ%H¸[!t‡Æm™Û ‡çkÐnßa®×â±‹*(¥¢iNYÝJi‚±ƒ»oM$z„À­¡ïc­[�Ñú.µA÷fˆ!GJ�‹Dz�¥,›Û€Nlú›poV¡¹�V­\··qì“¯Ëv5b€ªŠLÂÄ­Šô¹Oês{µ“c2[f3Ä”ƒ§*:ý5Ð«@BÎf¶Üœ9ï–RÎVÙ�#òÜÖµ 1hp“­ß’Ž Ê”ƒf‰AœÅ"º.Ãl™-æ˜EÔ§>Eš7×Ô§ÈmåÆ®Û;K»RôèÓ'€·&!t�¯m»—™¢B U³BKa4m›­:ä£êVË¼ ¨DZh:è°Yk÷†îˆXì®«
:¢ hÍ©©B6s	º“PmÕ”‘\ á^A‹i@³v¶uHcd­Ë†ª‘) ½ æö&åÎ9vÝè¾ÎRrÝZ½ÏÕc7&ÝÚ]*rH’H «ƒv‘,7�¹ïÇZ×r«A»Aa:ÀXh1Ç¾zõE=æ‘éÒ›h’ÓV«Þ…±kÚl†Dvc&jmeõÖ!Ä„ ™~¤;E`ÜrÌZËzK2„^ séÞ4†,�êªÖÅœæÂ,)èô C%ƒvÁ½.%§¡K]5,-:%26EU§ß‡S(
b†°%ª@!ê „L8E/)me¹Ï]'‹­ªIB‚p™>€¡*Þj‰èò®¢ÞîÎœF²ù=)bÌ� `
“–(BBS´à."
ÀIj Z¬Qã\­lVIMAÜ)¢ªˆ8Ý›t” ¥µBÕ”]à 	Â$dÄ€Ö<Kˆ£Hi[‘H:àn.9D\s! AtoðˆN”Å¼«)Zh
�Fvæ­ IÕé×Aà­!…^6ƒ%ª°Q¢Šøt 	7VE'=ÉmI 53P”2ý&›"(ªBb1¶ DuÊ »S5„ ÷æîH ºŠST5
[0U„ á]‚
*Œ)$Àm‚Ä*TE¦ïÃFC‰”5�’B„“52dŽÒŒ.1…ˆy‘Ú'(nkK‚’Ñ×	M"ÓO@!èâ^”¡”m[WtºÅªU˜"tLE6 ì™ÑV"HìGËÕ7ƒ¤á„SD»†ŠM%gÂQ“�é.JÑé=èp
TÜjf'!nmi BŒ¢p¸ˆè´I4õÚå>»l+À8æ&À7Tad(N( Ó¿I§h�ØÈÝ$&UaF¥ª‹4¸JÐ on&B§™rŠ:½é4h€éÄL]!Qà"R .¦ô �4_\CÊæs ‹r •û\sÊJÛ–¬CBŒ  
D¦‚p!®€�*Á ºPÄE!@pŠøÿ`€a®BASE      P[  xÁA  ƒ°YãxÔ þµ,¹MrËŒMÔ•Ôt¨¦ª`™Û†­mŽÖœÙTl¸MtcŽœŒ´œ›Î�tT@9(gÌŒA–ÑÆ– 2×F›Ë”Í‘·3›Eh*º§¡S©æÚ67V+RµK]�ª­)€€©Ôp	m[ÃÚ€T×X:#Å©ÔhaS �$J[s4ÂÅhaSXlÀR	¶¤…m“ ŒEŽ ªUªUµ ¬XµhÙjFÑ2Œ²RmbU…TµÊ*€è]Ž‘®Ä mdËl™™)Z–e”–Û´å¶TsÛj[Û²Ž ­A¤6Ì(1bÀB& FY€†Â4#)UD(2…jE+@¡k*”BPÖJÊ*k¶­š#-)ØX£`Ö¶ -(µ¥˜’²å¶�TÈ–: (L1f)›2Ù¶	�*DÒ$Û:¾BPOS      Ma  xÁÉ¡$E ±aý]zY³xÄ·0éßÿþùíÛ·o¿?OÏûëž¯ŸßûõëÇëžûå½Ÿ'~î¸ÈžNÓéø„áÎ}ÎæeÛãiÞÜíÄ}Ïµ3«›ÙÚv[¤¶‘f1gL¶Y
mf÷l†96;³eìÆ0¨€­0Å,†ãh3&M›Æ¶pD0Â Ø04LÀ
Fs“0Z„³,�5Ë�Å†LCˆ!L1€4 hCh@3 ² ƒ�HÌÄ‹¡Ö 8 Z0`šF!0Ñ4DÑ
@Aˆ D	‘””DRJ«u>*ªB_…’œsN‰¶ó×ÊÎC­v¾>vcï×§¼­[r¥µ³s}ô~.ÛÛ8£œîsŠƒýy³§û÷ÞŒ:ÚnW/í>÷y;ß­eÉY½Ï�?Î�Ïõ?Q…4ÍCNF4      Xò  xÁMŽÓ@€ÑÏî®8	‰CPðe1+î0âµæp]Är¤ä2Dùí”»‹÷ªo-è—Š¦T8Nåu	OÎñmv�açå÷ú]¿A4ÒÓÁë^#=›?�6¤Á`g¢CtN‹É@˜ =tú�žN—˜hÄDŸééô+9hGÚ’ƒ~ÇDb¢kL´Ã�a úBÚb ™‚è’Ÿuƒ‰
† &`D§Mâˆm‡N#ÆuÅë^#«÷öë# lÛïþ±51êd½ùz5^d~½nîLÊÅ8>—¡ÌB™§öï
i¬Kä½·É”SµÀšÇ¶&©Œ’™Ž‘ M"åE¶G¬š³ÏC]NŸò=ÁiyöJÜV7šÔÜ¹šŠÝÊ›‹ŒÞs¨|2:E¦÷:3Ëå>KÑ-øº9Ã•Š‹:ê¨£Ž:ê¨£Ž:ê¨£Ž:úÄ‡»TEXT       Ïõ   xÁMjÃ0Ðï(s [ÌŒ,«6x!Ù"þ‰qÔ@W&)Y–tÑrû¾‡%Ì	˜Â’`çãaAè„k_ô�¸Æ‡î­òEî¤rç5ô�Úˆ†�òóN"4__ÄÒ²¶®!eú}P~ÞI„æë‹X[«­­IYÛÇ2@Y…�ˆaau•¤¬ÂNÄ°Zµ5†Ï´bŒ»õ–÷õ´ú=ùÏšïÇsèßâ±\ûRXkÌ§a‚õ–û0aŒæöõƒKÚ•a\Ò¦#‰Qàn5 CLIP       	            Ö<AlignableSequences><Sequence name="85_CMV-F_TSS20210510-027-01701_E02" ID="0" isTrace="1" sortOrder="0"/><Sequence name="85_EF1a-R_TSS20210510-027-01701_A04" ID="1" isTrace="1" sortOrder="1"/></AlignableSequences>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  (<?xml version="1.0"?><Features nextValidID="22"><Feature recentID="21" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2273-2315" color="#ffff99" type="standard"/></Feature><Feature recentID="20" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="4756" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="4373" maxFusedRunOn="4373" visible="0" detectionMode="exactProteinMatch"><Segment range="4757-4768" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="19" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="5589-5605" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="5658-5679" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="5613-5619" color="#ffffff" type="standard"/><Segment range="5620-5637" color="#ffffff" type="standard"/><Segment name="-35" range="5638-5643" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="3682" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="4285" maxFusedRunOn="4285" detectionMode="exactProteinMatch"><Segment range="3632-3685" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7587-7691" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1798-1915" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5252-5373" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5392-5527" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2005-2208" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2349-2560" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4947-5180" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2573-2841" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4286-4873" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="5967-6555" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3686-4285" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="CopGFP" directionality="1" translationMW="24523.27" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" maxRunOn="4285" maxFusedRunOn="4285"><Segment range="2900-3562" color="#05fd14" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;green fluorescent protein 2 from Pontellina plumata, also known as ppluGFP2 (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot;&gt;Shagin et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="0" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7517" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="6726-7517" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="7518-7586" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>8984b589-cf3a-4b62-9fd7-cbb814bc6791</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="8:40:14">2021.5.11</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  ÅG        ý        ýs"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp¥ê•EP h 'HÐE’Ge“]�^TZuWV�U­V©±žI¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4NÊ’ËFÏ�ö÷8ª½‘F¹“±jVÁ¼ÃÍA¸ÆÎð�ËH7lýÒÿJ ÃZ>DPƒ0	^R²'ƒ¼ú«ñ |™”�$³È\®ªÍp*<ô]Ó…:Ä³nï­ÌüóùøCÏosÂ„³+�>üø‚>ø^2óË�”©S´,GÀú‹Ã;úùùÓÃ»Üê>ã£µîrê*Ê®+Œò�ÔâùÎG=öLq�Ï`FÄ�6ßþ�+‚õ46]FMõC?‡ëOùøá=È`9Ã®}ëùÿL9Ä_úøÜö×\0ç}wólE'pÃ#�ÈN´çÎq2zÔ €ß¿Ä2­ñÔm¼Ó\÷È~7ý€Æ\Ž:ÏÍúÓã1ÃyÓ¬‚Ov7­DÏoÓo� ?Ø¬úóÌ�ãt×|Nl�'ÓsëQÿÛ>³Ñ¿3´²õ®<�Ã|ð÷Á»1DºåØÂ�[ðþañ'S÷Ï³ßÌqËýÉÍþÏ<ÊÏÏs=ß,oÏvÄÀ·ÄãQ{¯·3,Çl5€³3Ì Âà}ÏL±L Â+<FÃó6„Â¿3Mt`PûàÏ7ÃõüÈ+à÷Ë»?}P.LòÈïðHÃÄÌðüúøûÌÿ5ûþ¹ÄÃ°ë|·Ï±üP|Íø#aüÔü#á[_¸uZˆThx&º^bŽú§9ˆÎ:–>¢mŽhëò`êÚ®ûè™[à£‹º˜A(ƒò‹C\ƒ ˆÞ"£‡5ÿÞ
 Ú=÷âÓ¾¯êÎ¯þþh÷¶Ï>>�Î8 ì8 7‡Zò¢ÀáËêö;>"�~¸Ì/®9ËúÃû[ÓëëóŽ<;Œ>ëÌ»Ï¬þÑÄ°nþ óïóàŸ©GÖ�CN$n“ÞªU@àP9k{õÅYFãªŽ‰à.î
GÑ¸O€Nî^@_Þ:SíeN�¡#­I"#òâˆ‡¸%äFþÑþ©-"[¹4’JØ¶é¦´š™z5EafÑè©£N™`§VTÖM·V­Õ•6ª­ãk’ˆ*/W¶Ö&é¶.äæüÿ—¼ý+ÏÚï?Ø8yjªš˜Ñóì>á9¯E$„ê¨ù¨Ñ?V²[`¶N*øˆVŠo;u¯w]œO6T‰Sàùa!9{v–Œ£;xüêô°ø²=8ÚX[\ÌÂ£&€ÎëÎ¾ÎÞÎ3°²°ãL&Ó·µC	g
ot[@sAQv!5PôÕCÐ_%T<Ê82ªöC¼ÿøq6ÝU±ÎÔ´BWñÐy•ô2¯þ;û#;¾+Çøó§ÁŸ‹Ï«¿¬2êí“·8�›´¬"BÊÎõ8"7ÿÊÓñóŒúo	y²èK×ð”w›=àÓOx%Ði4LBbCçD®… ƒåçw‘AÒj	¸Îã…=)úÁU‚Nèo]_|à“*ª*54Ñ§3EUA»QFú†ê¹À.í \UíÊP ¶¦ÕPn·äoªV•XR©[[•&fW ¸t§Ö:[HC~nÓ‹š²¶öJ>ÿ,‰yÆp:}¸?Ò8ÖóýÎßôjm5•ôôðP<LÑH/�z›Ï½½.ih£ÀS‘%$¬ô¥’£5Ê(öŽt6È"Üì² ˜:ÚÓ¼+õÆÔ1)ØoýŠ#US
NúÂûÆÊ-” óH¦ÞØ)ƒMãe®éâØöòQŽ«ˆx!'µõ-®d‰Œ1ñ(î�Ã-g–|ÏvM©TŽÛhrºÀ1W»PnŸ8¡Ò±‰{#^­6êž­ôÊ¸MUÐPÕcÍU@Y@ÇpV(Yížëê­fšÚ›@¦‹¶vj&¤Ueud¼ÍÚ¿ÅR=øråöšm‡i~eVC&ÜCú²ìÌ«aÂ~áÝ�;ðGtè¸”Á�4u?-2Ó(0"À8:^c´M'„Hßf0ˆV|ÝÉAgÍ´3ÚÏkCŒ×Š@ÆÂ0>ë9§=81PˆãPÆ” %Ï@ªý-Ç(•qÃÒ=N       ü  IÕ      IÌ®ZTR

SMP4      D¦ao  xÁÉË·ëšäó¼îæi~Ýû~ÍZkï]IÕ^{oS	•T¥
ƒIQDÑTÊh 		$’Ì"Á�QA0ˆEÉ@ð8ã_!Ž:Ñˆ¨$U©Ú«ùš·ùuOsß÷uzüûÿ0ý¤è!…œB?äã~<îŽûqß¾{÷£÷_<¼ýÁ/}ý£_üÁ/¼ÿúg¿üÇåWåí/ÿìË_þ¥ŸþË_ìO	øøSÂÃôSüMÿÆÔCÓoãÿùÿþñÿûÏþÏßý=ü“ßý½ßüÃÿûŸ¼üÞ7ÿô»ßü³—ñéÛ?üðóoÏß¿|zýþûóë<Ï÷ÛR¶Òš†ßÆÿŽø¿ÿþ' :(!)€r@A
€ ˆà!€¦A‘20Â@eI.ˆt¡u ™²9ärBÔin‚À–)¹à�  )ƒ”‰.§"[‚D2Â2@WU	jNŠƒHQ ‚àÁÖ	ˆ„¤ Né¤ : IpH¤A¨îMNH7@'5��à³à4@9¼A�Š$‚@'H‰tÒ§œt8Íh€)©&¹ ºÜ]S²ÔÊ¶Â\0§¿Á›7YNÀ Òœîµ!…¡ÈW(2�Ó/@î[KCf,Kl!äÆé-¶(Ë%¬�R Áé?‚à­ÕÈÔ[¨µT–`AÓ¯@ðæM!3ÃË¢P;X$¯¡¦”™7ÝÕ-D‚€ÜËæJ]ÚZ«0æŽ¨eÖØ#H´ª§‡Ð®¯—.tâôcˆ@�ò¾bY7ô]@¶¸UÅq,óóµ™ô(Ÿ¾„ùÖBwæÛ<3¤.6ý"¤¥Y<¤Îî—euîÆ4Þ×r­Jyl]ãô3ˆ€×j­ë‡ëVÏ]‡¾p=7	9Fqú
"P@Ë9±¬ë-zêåRoån›õò¥œ9„H›þ8À·Rb|È­ÞžŸi§Mÿ5Ðk)Ûîm¶§×—Çî!´öz^.ˆ}òàœöÐ±•[¿ÿÁnùørNñ!J§ß‚dVê½ôïß¶öñókOƒmAÒô@ZµÖ�·Û¦Üg¦ÊéÏC ·Õe�ÁÖò¼¡O]8ƒÏ÷5ñKßÿáwxüÑc¨r*Ûôc@i…»Üoåò:ç~GjŠh,ä¾³¶\–và^4úô[è[ÛúáÔ•Ûùå†´34båú¡Óz»ÊwÖ‰œþ-HÆ6ß½{÷î°¼~óùòöñ*ä"Pïk9¾;�¯×o¯ñq|t|xº4{8”4ýH¤_×u|ûðo~þÞÞÄRƒ‹Ó¿�î[EwÌiÛnKû}-÷—;ãs4}Ð²–îá„út¾¶zˆ»Q[¹Í‹ï†š8ým`Ã¥ÅÝ›Ü>|¾ÞíÍÐmA)Ôõ¾ÆÃW'¾|úØìá!‡Ü¤un|ÿö ùÓÇó}ì¿ò<ß>TŒ}J-¸8ýC€Ú~xËóù¼ tûa©óëm¶>¾¡éürû!­-Ûô« •KÁÃã»Ûüôé–ÆáxÝm~>W¥ã1ÅÛåóYèÀMï¡)¢”-î÷º�¯K|ØÇ°šþ*°áµ…ÃÛ¸>ŸŸ·Ç¼%Hš~éó½ôoN¹{þæ#ºÓy£‹Óß‚ ¢œïøâ‡?ðá÷^ò»‡ã\¡S9¯ñþè{üþÏ¼ýêáMÆýõÛ-æÜ7„9ýÐÚºïâVŸ?oèãP!C›ÃûŸ—çË6v�¢B+P7în×ùu)Aù°;¼Ü?ÝË8ŒÑ�Òôl¬æûÔß·ó¹ïE£O;H¡¶ûÆÝÃÁ_Ÿž–a’É éoC
�uKáíÎçËÇéa¿k×ë§—Á†}1‡¦ÿ"ØP‚�zmåu‘¥á”ŸçÚÆMFŸþ!º/ã0ÜÖõ\ÉNÃv_Ã›_ü!Î?ÿý+v��yl—çkë£¦ˆ¦¦îMO¿_–¶·A2 j[ñíºÜ�S
0úô3"–y�ï¾—×o¿½ø¸?eÀ·ëÖÇÔÈé7!@,Ë–_�ëüÍ‡+ŽÙ* M"Pçö»=çù¼aLÙš8ý=ˆ,uŽa7l¸•ÙœôéA ë¼Î»·‡þv}þt{8ŒÎhúØ¼,ýá‘Ûíùi;í´�ôé/@êÒb?Œ×õ~®!åH£O_@…»i8Îœ/Wïó¨@úô·á&Õë½ß=>¶ÏŸžýqÜÑ*é€‚æS:DJ)Ð	ND¤@'8�©iúÔƒ‘š O?€HA¤ :@ RSú´ƒHÑ§¯!R è D:)ÐAŸ:ˆÔ”ADJ¤@}úÓA
 súË¡ÐÂìc;/—ËuM»Ã¨u[–‚Ñz}z‘šzÐ§‘DŠ>u O¿ ‘‚H‰„ ôéÏ@±¬·îðå1==ø”w§ÁJ�4½‡@×¬–OÜ®/×Íb~8…íõåvÇhcpÒ§CÅ­„Ó¡kçÛë«ÙnÈñ¾µõ^<¦‡}\Êm™5¦D7úô5DºÖVÓ¡ë¶ûõ|7‘éÓ¯B —Û¥í¿újÀ§�ÿÃ»} c­7ç—_íqùþçkÿåéÔ*$MÂô¯@¤×23�¾z×}xúü™]p'}úEˆ ÊRÑ±;`þðay†âôUæ¹ö_ÄõÃËË§´èaˆ(—™Ãûß|÷ŸŽyìª,øôTq�8æ¬õ:cŠ	�>ý§éµ¹â®G]æ�ìcT Oÿ	Dªø:ïo±]o¯ŸjêPÁ§ÿ
Ri°<t­´ë6Gë–k»®0ËŒÁ§ŸBdÕæ8<˜žo—û<Æ@Ÿ„éïCÚ‹‡Au}i
}ì= ðM›ò.4-¥”ÌÎ,9éµ®[:<¼·ùéå[bŸw�Ó mæ}ÚYkuÛŒv)¡¶Bêb_Ì¦ß‚HÕíºª;0_^.iûhh O^Ûº¦Ã±×:{.Ùzv"§Ÿ@d[UOÛú|»(f&€ü^î<>¾Çýéå[»]t7
š¾†¼,D¿KŽu.	]
2›�o@MÝ`¾ÕY°>#Õé‡Yµ­6>tv[_ž‹âØç!J÷m=¼8Ÿ?~û1ÖS?0púò¥®
Ç‡q]/óó.u §D”yÞòþÝÀ‡§oÓx
Ü²Ãk)K÷uyý|^Á~°Ôb˜þ'¸
ã.*Ìó-®f6´0ý ‚6/b?<nóíu½l)öÜ¨Vëê»Sðù|½ÆúÐ�´éäm­�ùqu¾>¿”>�)oœ~"[[\8…®.ëÍe9fNÈËVbÎÙ½Þ¶£õ§ß€¼ºÅ0ô´²®–Sö0ýÜ­ìSŸ4_–£õ‡–W^µ 9$ƒÙô×àÖ:÷¹-¾?>2~¾}¯ýnc“HpúZ¬kõ´w[¹ßÚ†„‰œ6ý¯\ZZ©ñx¶åååºîs?2(@Õke<�óëëÝã°‹dFjú£\Õ9tÉ°µË!€Ó¯BòÖÖÎrgIõ¾aË¡Bë­Éi„à* Ù˜zmeöf)Zïäô—àª%4ërë…KnHHà4@p©l‹ÒØ�õ²¬·BcŠ
 §rÖÀ¾W×´ÝWù.IµÜ‹”™•DH­)ÅÈæe&ÆÜE´¶úÐÅ`�®ºn
ùØÅ¥œ·Û‚!Ç „Ù!´Ô¬lU]ÞUÛæyÒž!.¸×51Z•êÜZØïvázÿXoÀ.D·@3N=Ü+ŠqŸ:¬e½%³i„CÍ[MÖ‡ÌÖjñj‚…&\ÔóÈ\Û6»bH¦¿Á½••H»`¥Ü—ÕCŒ!�múã˜¢€šGh¾¶¢Í-1:mú3pHj¾°v».…e›å9YFAÒ¦r*{‘‡¸ë:”eáÊ��‚ƒ0â4B€ o¾E¦˜‰º®M�‰Qæ O?€ ‘rÔº©†~Œ¬å¾®2v#@púu�ÃÕ¬Tö}D«]»6„h1@´é/A€WÑJl¸•ùÞ*-´‚ $8 &o6 /”Éé_‡Ò½Uš¥œL>—*!X¨é ‰Õ´ÁÅCË­�×Ñ²YAÓpk]K@³J‹¹§|Ùª#‡d¤ôé× 8œ
„nì»6ûën	
tR.ÁÛ¶)Žã¾âör]ÆÜõ�0s
³Ê¸Œ÷Û|QwÚ§íR®]Ù$zpÚô/A$|úW!´“¼¸‡Þ"›7©ä	múäµâŠ]€0·Æ`É¢"E	uó9†°h]œ1^ã†F‚ÑŒ”W+•]b«mm—û e[¶ž	Imú‹D@.§Â¦û>Ú²^Úª”2-ÐÕB3ÍW¯tÆ`Nrä•Pê9Å•¡O€šWSrKN¥ê%3'R[k²jú�S�{5w)­¨1008œà‡±¢À†>¢.bM]Tji�¾Ëq¹-3cº/uEA€\‚ ‚Z«ÆÜuuÖD&7ƒd€{qÅ�àë&v=´]—bbLA€œ"äÑÊ�Öõc½ÝæóÖ’å`0:Ü$ãôßBr�`A;vMmŽk""@9A›¾€ATØÀ>�lX¶ªÖu)ÔV
,púª)¸àkª9¤n¶¥®M»fÙ¸î§äh™ò¶!…±«VÚ½}ˆ„\FÚôcHp¸haË¡Á›×¢æ1PÜ[í˜-´µÖ6Œýp»×§6–bm­™‚3øôŸC‚à ¬…ªú�Õ¶²5¦dÉ 9	púe-;=À¬¹µœ»�Ò}ÙB`�Ô¼5� Ý\ ¦‚D'©1
ÉRlln-z‘ªVMˆ‚ÀéobŠ¢`$áœH3£{krÒœþ.$Š„{kÎC@s®f±‡±%Š�Š$(sI-Ç�hô5”æ`€EŠ 4š7ÌŒ %M_Â­u-+šAPC° Òš7ÈÝ%#Á)ŠÓ[H(Àá H$‡€Ã"hS†[ËtN	"ˆ`ÁXÃ,Ä¨PU@ÈR6ßTbŒÁP±Òe6%°˜B�W[ƒ*Å@PîT"5l�Bh	p`Ê§¯  „KMD‰– šAÞjl‰´I6or( òRÝ-X¦yõšäPÒÛŸ€—×ôæ0 æ°i€9°º+‚TØanÑ�àtD‡ÁCEtØ”`n. æˆÌÍå¡Z…M<T`hÁ@·jf–�^å­ tDƒA±"B€9€o¡ªVa–Í`îÕ·ÎÝén†¬^9Â[Ù–T«b53BE„ s«ˆuWZ¨VÍenÑ­¦ë N	"RtN	�è C¤“ ƒ t®­ßv-d„|í7©G¹!lZ‡9yëòÖ¡u-ØzÌ»ë®…œ€æUÕºm—??nèA:	§9 N	ª]�÷Û1„Ìe«ë†ýöåïýäÞš˜ƒõV)JM¾�4Ë4N‚ZñÒ…>7àÞš%Ä@5Ô`]è\Û¶1Ö¹¨%%%§‚ûÆ.÷âz½¯UêºNÐZš,…@c+.ëbrÍÜ,©Yeîº`^ïÅ<K4ýˆJ�ä`c·Z�CÝ˜{`k÷êèƒeºµØDÇÎºâóº!y×gØº¬kLÁ‚Mÿ>DÀW´ØÖ´Üî[H;K›~"T·Íó +K©Ì!‘6ý"T‹B©:oÕ02Ð¦_‡ Uo‘{j~š[ßFN"àen!ö(óeÑ:MTÝ-zøu½FîÓ¡¶å¥µ‘9# ¨­ŽüÐ“—r©c<	šNÁÊ•ù�šßÊL¶x|ŒËÓçKÃnìªCØ´–|:ä—åÓÝC7š~›Ï}ÿ8Î÷ËSòqˆ¬¤Oôr÷p<¡Î·ç™c×µäœ~ lÞj<�Pn¯7¤n‚¨lðuc~xè¯÷Ï—{; QV—¥òô¥×ç—O¥õù°{èï¯ß}öaèhúÀgÇðØÛz=ßÍBÞŸ¢>^¿¿/»1¿ÏÝ|ýü|ÓãÞªšöÀ¦µ¤Ã£×óë•qèb‰-rú-@©%ïÆt™_/mÔ EúôS@�‹åc[×k½i—³\T6h)­{sŒ—ûómélçŠê\~Qy<îÂåöáw�
Ð4B¹ms¿Ü‡×ï~îãñd�n”º…qì—Ûå<¯]é¾z�ó·Ÿ7ìÃ°Ø/çOç[7ì­P.óíÌô°^Ïg�c¶lÓ Í[í±<}º½Æ.ç‡ òòz]†ñí8Øóë‡–R<>æîååé<Ú)™ hú’Ñçu9¼Ù÷ÏŸ¿yf|Ãf€¦D ›×¸ïB™ŸÖ6Z¯Ô¤é·¡)b+…‡Ãy~¾Õô.4@Ó¯A ´Vïû¶Þn—¥&;¾éU>÷‚wC/§‹Ó	�Þæ€~è°\Wï»Qé"PçM»7}üt»œÃ0*@Òô×à&ÕÛw�Ã:¿|Ä°S¨€¦ÿš"¶¶Æî½•Oçv»]h”4ý)HÆrk8Ãr½¾–t¢‚¤é+t­^ûa÷ùº))¸  ­,ëøå|ùù'`·?<îçåéyÃnèšLPZa÷�}¹–yƒÇ7§]»}þàãî�\ÁÅéW )¢”Mû7Ÿ®ß\çî´?>†ör>/©?<¼]—ï>�·Ã›1«šþÀïÕ‡ãØ-·×'Ôa8�âýÓËçÙN{V4ýÇ Ÿáã~Ï²\`àFŸþÜä~i¾ÚÛíÓÓ<ÚÄ;!¾VtÇ#Úõv›“ãøîíîúñå’¾Œ{ÁÙ²MPêŠýÃ°®÷×VQš¾€¦ˆÅ—qÿ&òòòéÆãIÓŸ„ ¨\¶±?Ü.—o/ù8�rˆ¾®­{<ùz;ÏKî i€ nØ°ÛwµÜ®‹s7úô! ­x9��ë}~9Ë<=žúøtý®µ±Ïh‘.rãã)Ïíå~N–ððð6¾~¾^N»cJÍ éÇè~÷šÞË.óëmCg- ðrV8œŽËüôëã¾Q”¦z›a»Ã€už›íòØ’|ú5ô¶–Ú=¾^®çÐ�ãš«4�Àf×Žo:Ìç§ŠÝ~p š~ÐªÇôPçí:ß5Ž4±åàZ†/Þ>|ÿóµ{ØEwQ9ÔíZÒc7ÖùÓ©ƒ M#°µ{‰ïjûîÃG½¡:ä&_gôo¿ðéÃ‡‚áÑLpóíF¼}7^ï>—:v»Ó~W^¾}Å›ã!ºšFHf.èÞîÃíûçïÒ¾;YÔuÝÆý›r_ž.—0dé"ü^–Ý›æ×ÏŸ–¡ ‹l\�‡Ým=¿,4å7opþþãwÃîôö8ž/°1F¢};#žÞÚrùô¢@¾èðòùÃùv…r´U·ÓÈ×õùzÙh‡·ïüõúá¬lÃûcß=?ýü¥�JÓ �^æ…»‡];_Ÿ>£YÚ½�íõòrÏi×m±JÓ¯A`ceàüzÛ<âñôe¼=�§ñHNu^«[·Ëh¯ËÍZß¿8^îß¾v½šAÓ ¬÷Ròã›‡Ûw¾ãòî8Úõþü¹åÓÎ@ ª¥Ôá1¯åõósŽû.º@¾�;,Ëý¦šR¿?äu=?•´éÓ_ƒ 6-%¼{“.——�>¾Ù‡\,(ñ8¢ÜŸ–9#iôéK`Ó-âñýŸžg;è”4�À:ou8=z¹¼ÜÖ�ºþËë|¸mïÞ�©Á¨ÍÍ‡Ã›åõr¾”œÒãcæçg÷]XÍD¶òºôoG¼~~~FÚ=»\^ž®C7<¼ßÛýÓË‹íöè2ø]Þöéå~žï-ö‡7#ÎO_v½PIŸþDP®’‡Ün¯÷³0îÞöñþüùœÇýl›"Tn+oŽ¸Þž>�=§1q}}~A8¤ £O_C Úês¿?r]¯×šSaÎinântÍ—×8Xh¤O#D:Öºâø×r{ÙìÞìÀõrÝòq´¼d¬\-íŽ¡,ç{›ãÛ±O¯/6v`�ôi„ 6/KÞ?ÿðòŒÝØ�%TNÿDºoâ~d8ß·-Æ.×há÷²å‡7¸]¯OÛ±“9éÓ×émÝÐ?<¸¿œkÎƒ…Júô5jóµå·Šçù|™úÃÃi­ç×g ïRÎééÕ�}Ÿm)gÕæÝé}?¬—oîØFPàô«ÙêVÛáÑôúúr«!uïìØž/Ÿ_Ðõc1Ñ§=D¶²JýÚz¿SCÈà¡67¥Ç.Î×û½ä¾ï8E°±nÞe,××çëÖŸöï»öúúÝ‡¥ÛÞw¡»Ü¿Y¶¸ß	 §ß„Hok%�Cz]/çë½Þ>,·—Oß…tÚÓk OD¶ZšÅáey½‹ùø˜à/Ÿžñ˜NnpN?�@¯¥Ôîm€¿¼\·]·�B¤ m›ÃñíÑ¯ÏŸÎ:=ìÇf’O#DzmUáâ­~Þæ’l||ìîŸ??Ïq‘>í RµÔˆCìªŸ�ÜuF3‘¾l÷pxónðOOßÀŽ{SM|Ùžö§TÏOß#†ñíízùˆ°÷ŒÍæÚº7'Ãýåìë¡$è@ã¶ZÿÒív=‡|² Ò§Ÿ@¤·¥0Çz^Î×iýãˆxy½}ŽýØ¢O_@¤W/âiçëv~¾^[>¾íÃýüúòâÇÝ›Ü>½~j}„[å´‡ÈVæbÝ®«~»^kGÑ§/!›jH‡£ã|«s¯>¸ 6…ýCÀõéù©�Ã�7„i„lX1c{™o·%ô;ÒHÊ·uæáÍ›ÝíòáyÝƒG‘>émÖƒÅû|¾#]2ç´‡HowÕá¸ãu½¼^ë>Å\Ì¦ß�ÈMåý®›çËùEqÌÝœ@Ÿþ$Dzm†ãqœ·ËË+ûqPhœ~aÃæñ°(óËeÎÃÀèœŽP[Ò>g¬ÛõÞÚ0(ÀèÂ†ã>um[–ºänwê½]ŸÖs¶êôˆô2uÇ}·.·ó­ô!åfÁ§Ÿ¡ÙLÆ]ßÊk)9‡e½¾×Ô‡^äôC¨:Ê¸Ïæ÷ùµ`cj�>ý:TUÌw}¯m¹/wãaDx�Ÿæ…ØY Ùt€ÈR× ¾7ßÖ¹6ã!-6[>¢+õi^·N©Ý__Ï^º]bPði€@¯î-�‡Ní~.5²‡f-–VB:Œõ¼�ëŒÜçÔÒôÇàm†ºÃ!Îëv)ž¬‡!ˆ¨¸“Ý°Û–m~=#ç‡C.·óürõ°³¾%ÀËÚlØÅa«óe©ÈùpÀ\ÖsÝº�2NÿTYCúl[]71¤ÄéUÜÑõÇ¸Ôr�Å!ö §ß€T»=±-×f1§hÍ|:¢…!Æ¡†º,e­Š‡cg×òt½YÎ}£Ùt€Ú…>ŒPÙnÍ¢íÒn[Ëõ¾®¡÷žÛýv¿7äœ=
®º°Ån0n÷[Ýr8„û|©Åú>É9ýu¨•µZ;b»nB—SÓ¯Cò�[Jc&ë2¯Ž˜Ž!]çùÖ°9":Ù|5¦¾�ÐR®°’Yà´‡ûZ¹å}¶vžÏ³lèèm°‹#´ÔËf–Ž=„ûåZ[bH£8í¡V
ó“·­Õ- ‹t°ï,,xE£º~oP™Ï¾Æ0J~­·­‘1jú)ÄgÆ®¼”rs�aœ�WT¥Ôµ¶UÐB°0ýuHp®1vCT-WŒÉ¢:mzÁ½Õ†”ÝË²%O)$§r4+R�I­46X&Áé Wm5w!›ä^=0"pú�Øb“!w1´R÷ÀD™ê¶yÓ€R.[aßí»Nu^nc:¤NÛr•»®sl*KöœÆY¶eÝ‚u1»pú®º•À]Š­Ôë½ªYA´égp5+RN_,äa„õvs´3, ª¨-ä,[]åÆƒhÓ/A‚¼ÚÙu!5¿Ý!…nó¹ÞÃÖ!$d�Ó¹oJ}Š®{)-0æ ³é?ƒ¤ŠZ,�`Õ¶´@vH"¼­¡öcg®y]—ˆ}Þ-¬å¾nf!†\iÓŸF‹EÎ®KD½–3ËDhÑ[Y#‡˜­¶y�™úcê–mY£Â;Ûj»³EKÁ ƒ8=Bèe[¢wQÛºµº}Tê¬�}K€  ‚ÓÀ†Ù1v{Ðï÷+�s@®‚ )B £Ö²)t=¡²^‰Ü�)´:Ïîì÷C¿�BwÊ}[¶ekÌŒIÆ©ƒ¨Ô¬³4ÃºÞgä~ûâ[½[‰b°Èi¹·Re;vTmµ:C°8ýNÅ†æ–»ßÊÅÙïÇÁZ½X¢õ$¨VQÑÇ÷9ÕÈ-M‚¬%ßl‹¡Ï°º¶bÊ!ZH„Fl-t£µæ—Õª…¬¾Š.pJA–Zr6¨”!Y2
š"$ºZ
Ðí{WYî÷Æ.F0  šVn!ö9»¶uñ÷±³µÜ7·cr£T
Zê:¶y¾!Y—IIS„d0÷êÍ¼;b|öë¼‚©OaŠÔ4@­ÂmÈæZj±ªµÕ¢Bôõ>ûq¬—m9KÈ¶óä„É@¨¡@±ïàmž«a—¯m¾«Y>05´V¶´·ê}½ß-¢Cv£CS‚@y•vÉZ™—¥“%‹tN;ˆî37SJó²lÖºÝ|ZA9 Ho^=zêrj~_¯)ÇÁ!qú§MZCÊ#Mër‰eØ¥¶vŸ�.¦“ç¢Ûk5œúž¾ž+r�h‚S‚S‰ÍÊJq_l»µì‡­Ünq³”Ì¢‰N	©Y5¤ÜyÃ½¬°”�A©É<åDmóì){$„†ZSN1”¶n±�cìï~¿¯Ír‡ÎÍÀ)B¤ä­l[MyHòyYˆ”Øµ0í!µÆÆ#RÑ²n°.1ô©ƒH5bq—¨­.Á™@Ÿ�—*,º$eKäô/K`~`*÷õ’·\²l RjÕ£‡Só¹m†c°Ho+ˆ®ë¼¶¹`´qŒ^Öeë•c†Yhyê!okj;î«®l–“%
ªa“ÇÜÇe.Áº±3a½­%[N£©¬eATÉI‡×PSèbj¬U*1  Æ©ƒäl¡nÆ¬uÙœ�ºÆàÓï@rÉÖº™ÁØÊVk¨9EZ˜~Sé^Jˆ]Ì­.ë¢¨,š�6%È9¼æ”Btßä´œœzä^SHÖ5ÕEÐŒtÚô	.ShÍB(Ìî�]` DN	N@Pi²Ü#ÔÚª–H#½Õ¨ÙµâµR–haŠÐô5�\U9tÙËZÖ-‚Ù¢ B.ÐQlKÝÀ€¹Õµ¥`‰SA@½Õû@j)n›1‚tT±5™÷â�YÛZ7"Dt"]^ÍÙ‡H¶V‰�FÈA9a´6SNµm‘b�\tÚô �NJò)ÒÕBcìC�´n¬}ÌÎR‹<z Í ã” Hò¶YoÙ5·1õYáÞ÷l9! ª¡°¡±4®° hú1ä^B0‘Æ�ºÖ´61Y4N=$(À‚cÅÝD:)Nò)Á]s$en
r—Ddr¯hì:£×»‹
"dÆé?€ÜÄ„Ü÷RÑ‚CòÊà!¦³)ÂPŠ\•i‘‚ P%ÂÕ"2½’¡fŠ„ >EZõRÍsîÀz[¶ƒõ°º¶–='o­n@Ÿ³%GÛšËÉ@�Ó�!d2 îr‘‚¹Ãá‚]dˆ¢Ë«•ÖHFãô�(ðæî4‘"à¥nÁE0œEZŽØU–hT³-zBH/wA!&vÍ¼VÀé¤“ Õ(…h½«•­¶F#-ˆ”tÚô ‰¢òšÜƒà54 °Y©0n’Ja@JÉ€â%n™I@±Ò` AH.Õil­¹$ ºà�`f0ª1¸Óh ¢ �‚0E9‘´ Zÿà»ÿ’¦
ºŒD€�è" 4EP€ M” *t DA$ 8ä šD@2 D@)‚œp Œ0r8¦(ˆÊAd)B¢³. $,€Äå’AƒN�èbË”Y i€7Wœe :Ø:Ÿ"è$9 $ÂœÁ!—C.@Ž–@‹)X4x+µ5e€™H8é D
” A.9 F2Š
Õ¼ 2"HM¯?ýf9µüúþ¾ü><~ÿ¾„öÕ?}ÿ¬õô1íf}ùòé'/Ó{hM~Ù‡aÏpÛ.Á®~�¾€ R°F;ZDÝ¶�­³‘òÍšd¢Aî­&Ë)·ÐTÝ‚¦‚ZµÚÙž]ñµº¢rúË¼UEÏ]ŠÞê7¦ä§µ²BÝ0tä|wÅl]jš~Þ*™ûœXZÝ€ˆ„DMÿ.TcÙŒå}ñgûþ4÷<Äëé:!ùÂš‰XÚ[¶§?Ýóë¾¾!oë§—¶ËyûÁ M›sÜqm——yÉ¹7Fçô%D¨Õ¦t8Z¸^_*;�Ñ§ù¦%C²u¾µÒ…Ì N¿mñ†í;>žKÙS=Ü¦ÿ"Ð°z×÷¹µÛFmèa[_ÂØ%9ý"„M-vGG½>/m´   áê8½ûøê¯ü÷è:Ó¸è××—{ÝÜÀiMë:ÇÓcïç×ó�û½bÜœ(‹§qÌëÝÑwL•Ó½¶…ÝÛ¼Ý__^¥RýÝùþíßýÝ3oŽp§‹Ó×�Bc][ÿUßß?}º­‡a'6"´6u�ƒùý23Ú(}ú¤Ðp¯íðfèŸoÏë~ìS3IÓO! ­nÈïòýõóuÝE+vx5~y:îÆ¤j‚›Êù²ìñ—ðÍïÿóo2Þ¿Õ¹BàôÜäu»¦Ý»wÛùéÛ‹å!©�-Ûô‚ÈºÜæîëQÿù÷§w8«ºdŽ[]wo¾jë§ŸŸñpH	§£…×ó­†ÎØßÒ_ÏWÇ.$�-Û4@ Z-ØŸNõåþñÓ!£¥
Úªòi×^o÷kêw15ƒD@ó&{“úùõõcßvB4ýYt¬Åóî”—óe½…<˜ M"d*·y|óÅßý›ßüü[ètÚ/V2ÄéOA |YËxzS—ëÓ+†a A¬ÃYxÿ0ìîOOßƒäøÌé 7©Þn¾ûÑvë÷ß~ùaŒEtqê!@¬å¢Ã�öxýøÝ:çœB¤ßç§3:Ö|<u»~^-šç·‡ÃíãÓ‡šÆ–oÇyþôr^ö
»Çnyyú|Ùu§èpsù¼åñm
×ùS5:ö?|³ûî_üáàÔï»‡wÑ_ž¾Û1÷Ç4àÓÓÓšNG„Ð´ƒ¼Ü[ènç—›ÿÿÁ[«¥kzàûyÞÍ·cÌ9«jV­ÎŽÕ»´ é$D0ÝIh‘l<IGsAB”  ¢ˆ‡9É¹¼x�€�3ñŸˆ“¶ÛµjUÕÜ�1¾Ý»yn¯«³êOwþšÎÕßô±:’éÀä±Ù6î†§åÃÓ†é(’é-Bòžík¯o¯ŸÞuwãèûis×Ëš]/AV¶Ý/ÑØ Òìºòí·ßâ‹¿ú¿ƒŸ»k{Áô@©;‡Ie»>ƒÝr MM(UüxÚ,¯L]çLÅÒ‚‚}›û»ÏNöñáÃÒA‡7¯ï€ŸüÍrûúõ±ÔFêsÍwŸ¿]?üÕ�¿ÂíñüQô2Ÿgvƒ“*€)ÛZtxuÌûå1»þ®))bmÍu¼¿ÃüüéKœ¼‡	m[.×ÖÆ»!ÏÏŸ>­ƒ›†7Ìóõ¡Èí0U(˜¾R¥Í³÷÷7ùáýZoÆ(qc[žö#âplkY_v‰=b¡¤w  u«5¾š†ry|¡ž¼š‚
î3¦7?ÕÏç�ïqº=¹Æ˜Fb¶ÕÚnŸ—kuªêÅÒ„4ÝÌM1Ú~.5Š7˜šÔµno~æî÷þú�Û×îyob”ô9H•²l¾¿U¯_,ìG×õ7ÊõzÇÎKS±ôMP€½å~:	æóÓUâàh”ô/A Å¶p<2çëeÅíè¤ {‹Gë¾m¹ú6ýôÑðøåÇõUcpíúá\ý Í‘TÛ®³¾þÆ;\~üöîþ.ô“`[ž¯´AÆñ(û2o‹¨„ã^×Oçu@ìûi”úòt©ÇÒ  ìÍ‡fÛyã{G‘ôMÔŒU†×ÞêåéQºah&FI¿	BÌ6£ÞvnÛÖ,!v¢ LYk–éöÕ¶¼|Ê~�b”4€!ýaŒyy^¼£3€ib¥µqØ–ÙZÐ¡F“t!V6óÃl×YÐ‡ØDÒÐlwýÛúø¢áÐFEÙj½ysèÖ‡¯>µé.
`º©bëfúî]ÀOž~‚ñÕ©ZÔô‡ ¤a§ô‡,kÎžÎ9ÓôunÛ®Ÿ¿;áG?ùñ�qw‡Þ·—óù*]¼³n{¾^à§NDÅÒ;�®I^íðÙÔòÃW/¸}ÕÁÀ4‚ ZÛk|#X—ÇgÇ _Éô Áé”Û|]Jº®©XúU /ûyxóù=Îó¿ÿç»ýìfc£¤¤kXŠŒoúxý°p8Ä
€i“GÎY_ßßÞ><|Qq¼>ÀôMPêpV¼ë^éöñaN·ûq—ÖÑPj•þæyyÞ7`zs{lO¿Zønz}´——/æ&{p²\?P§C¤62½àÞDOc)Ëã\»n ½Xú/ ÄjÍn¼ë�/üa¨®’ XÉðÇI8/›}ð¦bé Õ"Ýë€íÓãSôÇà0M ÄÊ¶©¾íöËóËº±'T,ý.(âÜžâöéå:óØÒ‰¨ÅtêFÚ¾_¹×z¸?ÝÉ‡/ñöæLÄÒ B¬¶�îîåi=‡nì„^,ý#P Ø[qÇ×ÁÏ�Î†Î»êÅÒB¬¶UÆûƒÙÃóc‹Î…áÖºõå)k#šK#1.ûu:¼õËã§‡OSw`š<š”ÆCËçë¼47õ%TIPÄl‡¸ƒ—Ziê�¨r/rw£îr]¶ã©"&é› @ØêÖŽnY/Ÿj8^LÅÒB¬í¥¯†¸^¯—'ŠŠ¥ïƒ"­]Áã�×íéYc?ÀT,½)õ\»›Ÿió‡O?j77¯ch5y”²¶ÓÛ›0¿|ø£LÝtö¶>_sè‡&PöMççÜ¿ûü¾üÑÿ[æÛWÎ²
™~¹V¼ºëíåÓÓuêÆh”ôbµdö÷'l—/Öí'ŸáËkë§Ñmõygì;Kï@³­”þöüÓ2—.ŒŒYÅÒB¬–býíqŸ®Oê»1˜:KßYwZƒå¼ê:œÞøöôøðÜã)„¤· H«¥`zÓ×ÇËËeë§Ž´ô=PÄÚ¶·xsƒ:??ÃnFu€Xú:(ìVÓ~è÷yß3Ý›¯�‡§§/>M‡7'�L(R¥ÁO�çZæÚù�) ðâÂ«£Ôåù™ºH1Iï@�TÛ8Þñòòéi�Î»Ó+-ûåÓ§%Äã0ÖR–Ë5{�±±ô‹ „eÉ{<}-–Ç�ï·ýxš|�£¥· HÅ\¥»ëÛÓõ|ntñæíñ/O_6jM X¹fL·§íåüüàÂ86 ’~aá³çñ®¶ó§e�Çnƒb-sÖ.&¯€4—›†Sðœ÷k�-xzgéŸÀªÀü‘.·�ÙI§"éW@ÛÕº)ôÈåÊâ5*\º‘›±{5¢Í�s�Äþ0�íq9Ÿá‡1˜ƒXú!h9›ÆÛø²?\úÁÁ™Xú(b,û&Ó©Ï_j<ÁW'–îA@÷‹ßþqyÿñ¹?ö=H±ô]PÐ–=ÇÛ·G>}xÁq8‘*é(�ÖöÜOwÓvùø¸´p;¨5/dúw 3›ï¦ioÛ97�½(œ¥_E¬–�îæUØÎ—¯æ<ÅU˜¾«‚æv›7²‹^½¦ïƒ€˜-»¹›Ûn»<|ºRoúž5Xú6Øò^e8Ž%/ÏÛêú\U­6¸.©e­EB§±¦�»Uú!çy»6tA½¦_‚17§ý0°n3spn(±¦À¬lNÇn+{ŒLÒ	”†¼Åx°�ŸÏ-�½wªfeÉoÅ]×—kÖÎ‡@‘ôˆíu‹îöÆ°^ç³–.ÞP»^Ö•.NPƒJ«fè�±Ïûz�¨Ó¾ºô+`Å,6ê²åê|çœIúi4ÍP7v²c_›R\ K7`Û‘cwR·ïÏuóœÓ–~¤ 5_³Ž§q\×—åŠC8"Z½ÖìtpLÍÏ>Ç.y©®«ÇYa`Å&ì‡rÞ7��ÒU¥‰”|µpêººÏsïºXDØDSŠX+›à$¡•e±ÎùN  ,[Öî0:¾®KÁýÚõUL¤ä½únèÌÖmÏ½(Øƒ¦i/íœ‹C?Þ»µ¾ä2¹¨
K¯@@Ãš-ÜLc¸¾<Ï¶|ïÍ'OI÷ 3ªõSïmYÎµv¾gG‘ôs  d­«)O‡^÷åáœÝÑ�ºN$ÛÖŠª‹¦
À¬ìN† mygsŒ’~lŒ}yo@Ñ(fÅÔz7šÛÖfè\'4–Â¦ƒã|}z®èã ^ ’`Ó0øÑtÍ»ip.VMÿ †‚ê[×÷`¾n[uÂØõ›­wç;¡¤ï�@ó™Rý†–óš«�>ªªHz
ˆR÷ªS¯ýR/;áÆaÌ¶×—\ááDÄ,3×ØûPm[-¨�ðª`Ûö¬ýk�íãü°¶~;ïªÙV«9qª€ÙÅ=ëV6Å44K_wÝõ®Ü[^ËƒÔÃ¸½Þ"Övi2Ðu�}‰:@4M EÌ¶&ÖÑj^·*µ÷£­{ÍÍ#x¯ÞÑöVÐMwÇœ¯ÏOÓ0/›e˜sc§�m_ÀÞ%@AÅŠnÔ­Ûaˆ¡ßëj�F/ V3úA-—=+|ì¢k(¹” à †jºþ(Óžónîöùí*ÉÃ˜¡ìºìy[µŒÃ8æ¼ÍO¹h×O]h,Ûî]u`úC�Ò\u&}„Z]Xµ©„&šz� ÀZiÅÉ$Š|ÙwuÓÍ¨îº>_®õ0LãV°lÕ[�N ’ š–VÔ¨RçZ1j€HzÍ²µ w½Äu[Vºè:	M™þ1¬•ÍÑ\(º­Å·A;¦ˆæÚîá&·¯ÅŠ�*$M U·;êabØ÷½±u~º‹š¨!„b[�9Og¢é·`B_kõ>ôÎår½šsãM7äëþ¼oˆÚyFf¥x×E¯¬Õ6oê‚‰Jú:hhš¹õáÐëe+¾ô�sæ@HúM$Ïj%êœÉ†ÂÔAÒ?�4,ÚüéÖuyœ³ß9TDSÁfe‡Ct­¬«4xïBG²´æBT×JaÓ ê½ˆ¤Ÿ°dC×E©6¯]Uçœ
ÀV6WÇ)v(ë•Dˆâ��
Q 4�l-#†q€æy6´aˆjlµî{±‹êj±5l^¼wHúÐ ¢ùçü$Š|½¢uaÁÚ¾5(4š Õôç YZ3íœ×V–µ®sÁ,ïN½z3kjŽ”ô' �°Ö
\¼!×ì÷à;SAµ nRä¶f±M¶Ü´Y¨Î@$ýX;À�‡r,jgî-x‹ËÓÜ×ÎÔ÷.ìmECçÕ«š´¾¥?E
¶"r;!¬ëË6ƒ=@@T!i„	 ÂÊ*Œ“÷¥í;}4Oš8Húc˜ &€R+Åõ1¢•ki^ãÔ«åªæ½F´ª†Îu¦µlÀ£¶\ŠsÒÁ‘ ÓŸƒ Ä Q4Gß÷Ml)"Î‹* ìŒ’Þ�QC	Å!Ê(ÔÜ 0É}î{»åìÔG£ä©A( ùæjpA; ag3 bâ é’'”àÕ{+æk€ƒ
4µ&¾WoÜk3&×›ßònêàb1!d
 Ùî½ëÑä¼£ŸB´º—ðÎ{ ¹R¾—@î­V‹½¹±EzzlÍLµW(vÐÔ*´\Ý©Wäm-æ�v•¦¦hBWE%ŒAÝ¾Ô]Lz
›ŠŠj:€$L[(Ž.úÐˆ«µ çB«¨ÒÇ`R/¬pÞ;Q:Vk!ª8Û›îžN!„é› °VZcð.T–-À98�„‰¦Ÿa¨Àª–\Ùu1d.;Š3çáT ¤’îA BÐŒ&>ˆÀªE…"k­™è«íÅóÀ¥^l¯^œsQ¡$ÀêÍjGï5h­¥U2ôN­îµyƒƒªŠH£•fœ¹6sâ5Í
AœcÔGg„Y–ßG‡Z¯K3ÇP¡NTÌ(¤ 0QŠfU«Jç;%¶Ñ×\±¦hPïV=�‹pÖv8ƒ#AªAÓß)„@F 5WºÐ‹³’|ª/{FóðNE�¨s"žÚt÷�†ÆÝškêÄ‘¬âÍ¹è“WYd5gªÁ;§Ž4š8Q±ŠÚHG8 i ‰ä	�-:Z++$HU+…N}!³kM)*’þLŒõª€AÅZ)pUÐ¬Äyç„e7S>�-[sTU€  ¨-Jõï£ˆÒµVšÎA` Q@`0š°#àD½µš‰s06Å©4‚„²#%ý}� @mÁ&Ñi€6­Ú`¢& „¢¤¤­3ˆ(„ž5ˆ¨zÌ¬� (© ¤¿‚¦Éƒ†Öµ
¼¨—Æ¢Ö Þ© …æ…t‚fL^ ÖÐ¢ˆ
A� Á@„´Úµžá¯û¿ß+„K!„ S€˜!1�Hˆ‰PLÔD`"aÚ¢ $RL”¢G Ò  ¡	#HˆªTšÐÃ` „¢€ÂÎÒ 1QµäA@€ 1@L1PØ(€¦--2BD4€4«ÎŒŠˆR b 	U1›T�Š€Í5BU½*PÙ‚ªQA1À PU€ÖŒ$¨&1
	±äA@L„Dõ¥‰*¨`ê o€Ë¨z¯ªËhâáÌU­Zµ**<š«æ�ÖÁ˜<¬ ÷¦ÑÅ•vPT»íX$}¤Yiæzéªl,"â¼¨¤‚­em>F%¶bÍ1 R-}†F©±7»V˜×èE ±8S×«²´R4£‹]JÞŒÜ(`É[¦ú8z¶\w@½h¦¯ƒ°VEúƒYnÙ	½ú ¦{¬.+;7©K­-hpê˜~º]¡SÐ²ÏWipqê:–y!CŒð€¨…ˆ‡Qü¼ÏNcPM¿
ÈUÌúb—óuGßyq”ô ÀÚfÆ®­e¹Hî0á.óy_û0ŠkÐô-P€F«qêÆ—}~,ƒžŽN×ËåEBC?ÀÖíJzß<-Ýƒ4¬µëO¹nçZâP%}ÐXªnã¶¼<?‡nÒ®ª2ýPØ×’·pzÚ‡—Ë~8Ž±	ijB)E£b}¾žÇnh"–¾à¶ÒÝÜ»ýüü¼LÃÁÐ ¦Ï@ Ìkó·¯ýöøôü<LG­0ý<±ÜàÆƒXÞ6ô£¦bé—A u+.ÞÖm¾.‹s½#Àô( wC7(ûrŒNœIú äRìî3¿üø¡ÅþèY�QÒ�´V5ÇsY¯Õ!@ÅÒŸ‚ JÍa¸ñ×õ9Ï¾;PÖ—«¹¡s£¤ÿ
À�ì��Ôu.Úû ¦bé×@ª”¹âpÒøáúRà¦7·ùéáâ³Ó6Ñô; €V�Ã8­Û<gßÅh Óg Uj©íxs[žÏ/�~:E£‚é‡  ÜÀ¡›¤îË^CçéÅÒ?`n'K}¹
ƒ1I_°æ§{-×Ëû3ú	¨ Ó? !Mg¶á–:Ï¹DL„K#HÍ×ÒßÞö×õã‚þœ� eÏ~8ººœ—ÍÇ¢bé BÌrqÝM÷öRØgÂÎ„Òà.Ô}Ý�>Š£¥	¤kXJìîâRŸçãÄ�E,}S²•­÷opýôÕKpÓˆêAI¿ `Ýš;¾e¹~¸pÄpûJËöøðÒÇC¸ïýãËW+ú8ÞÜÝçåÃÇ‡ÐºÓ›)žÏ_>a¼™|V€éwAHÃnÝ8ªÍ9» Sq´ôg  Y–a¢•Ë^Gé*i¸nýá¶b~¼xt£@…-­õo0”óå¬ÝA:˜Þ� Z+êOQ¶ýak7½øFIßE¬Ò4NÑÊ:û#B•t ànäMìç2ç]pFI¿B¬åÜmççýRe
A(é—@ˆ•µr»v½^×Ú	îÆãöéù±ÄÓ�ØsöÓ–óóC‰Ö‡7oyýêá‹vàÔ¿¹òW¾¨^†ÃM‡åòþÃÞ‡átû¦<.ïŽý	MAIÿ„X[µ†¤,—]šö¯Ž¸^/ç"ƒ?Œ/ë‡—>:G€é/AªÔ²†ñõ®Ï¦0€é» ]“º·áÍ”—Ç÷íÅõþp§u:?êƒ3€é‡`òØ·†{¿ÎOO‹R©`ú:HÝ¶ÜÝÞù—÷¾Âp<ºf ({Æøö¸==Íûx¼�
”œõæ®çryÜBìš‚i©ûJ¹¹×õéüp®*ãÍ+Ù¿üð^n�'WA2ý%À–Ý›WírþôA†î$æH¦{be]d¼úòtyDC€éO@ˆÙ¶”x{{˜ß|¸êÝA‹’L
Å†vÌµfßN‡a(Ë§çAú�j`z
¤¢Ú4÷}..Œ±y“ô-PÄZ.Þ�ýÕ®Û…ðþæ8–OëÇ¬]ïµ9 äÚš»Ü2?=¶¾?Å$} õºjÿjì×ç�†^…�ô}bmme8¼&ž_ž€8	jò w£Cä¶.¥½§O'P¤"g™‚Ûì²;í:±ô¤.­¸»™ç��ë0ž¨UÄÒ’¹1¾	þúòði=ô·BÒ7@ ­®ê_½~õòþË3ú»ƒ3S±ô±jÍãh[½”zt½y±ôë kièŽ!”œ±®o1˜]‡ñf¯óyË½„N,½Eª4tÃèKÙvzôÎD,½E¬¶ÊØö²^–t¯š;×ëežmè�Ç}Ÿ/Ï‚›®£7Iß!fK6sï——OOÛá0ùj*–¾	Š´¶Ñ†.´6—­ï]G'–þr.6¾î¹ÍOOªîÞ(êåùã"‘¯ÁíççG;ž&_é@‘Šý±óOå¥´¾ï"–~¤´UÜÛ×¯ñåãW6ö“Â’îAZÍŽ¯Ž­=?}\4ø›×ÓM]ÞÙp8A«Š¥ïƒ«¥¶éÎ¡ÌÏ�¾S—!–îA�TÛK|£Çëüx‘xìãL,}±œ3w�›—÷5ÞÍK?‚¼_9Þ6êû?Yµ»U·EÈ,y<¾jÛütyŽc¾¨¦ï�"´r±:¼º®�Om‹ýÝí­¬ËËyÏS¼¡ž/Öõ†€³ô±ZjëßŒîº�/�ÝèÇ*"–¾B¬–Ìþî¶/ŸŸJŒƒ%M ˆqÏ{÷±äùù!S†Û;ßð2?áïªK(Â&»Õãí©ž—÷¨wƒKŸƒ"l8×v|=Ùy~ÿ•ÝM§$E›ß÷Š»c_?Íç3»!º¦*–îA³­(Ž‡Ý_¶-»‚Jò`ÛŠÇ±­û²,,Ótç±=¿Ì[ã›SÀ~ù°Ú'_¨XöŠiŒ¡msÝ8Ó[Ý/óRå0¥äõÓ¼8ß;˜
™FPP±éÁ�b9o™ÚGøçíòR1‡#ò’Ï—µx×Ûüt½x¸¾ÛCh{i~¸ÓvÙžæ­¢7
 +{Õ>vë\šÈ8žL×y½zL£:sDs9›��^·ëœuDMÓ@ÛÕ†nòµå…‹è8Âž÷Ëµ¸Ø‹£K¿¶­Tíïz^Öç¶~ŒM$ý ¬ÜÇ»®ÎO——¾��(“G-�2ôÑ°¬[GJÕôo@d¹"ž†º¬ëK®±ïÅ5I?³ÕÄbWsž¯EÆÞ©BÒ ¹·‚xw’/ç‹táà	—>€,V[7b^×yÞD}„¯é÷ÁRróýx’ú²<_�1(ÔYúEÖÊÊÖÇÎ¸^–ªÖ{‰MÒwÐÜîêÐgm+èÑ›jú5�h&s§!^×ëœ­�=UÒ¿a–¹D?M«_×kC¢s¦ÎÒïÃZ«Šèû&¶¶*�NÒÏƒÖvoˆC¥åµBnòÖj®0u^»&š¾‹ä™ÁmŽ{W×¹ÄEÇ H: Úæ‹ö] \Ú\ÇÊqÔD¤¿ 	’e7ŒqìÜ’—®çL4ý[XÕ¬2vj­íWG­kêÒO@	+;&¬Í™JÑD!égAÂ­bw]ìœÕ¹\Z§ãJÎëL¨×ÎÔÀô�`«dé‡¾ÏÜöÍ™×à „¤[Ð ‰€]7Ar™iÂ N=DS	’-Ka78—KÙ¶à[4¯É‹¦’€µêàºà+òÞèàÄƒ"©	¢ùì›ŒQãÚ.ÆÖ!¨ˆ*Óç ÁXëîÐ÷Î·¼ÕÍ‚:¨&š¾Ff ±nËÛ¥š;Ç‚º–æ}o�Ú2ÔÇ¾æºBšs
(DÓ·`0RPrnnœœÌÛ\ª‹Ó¶V®›QÔ©D%ý’'hmƒ÷‡à˜çÙ„]ˆUBÒ¿hZ)6„Ñ—¼,‡ êEÓ¿I´¾yf1éz¯,e_ã0ìaÍs6• A ŠP… HiB8?j°²]Í›÷AD¡ @Òß�J“ÝË0zÁ–KFPß›¨"–þ¤	Œ»éFÕ­å%8ïœ´@Òƒ˜¤oƒ0�¢îÒtŒž9o90h'¢JP$ý:H1‘êj@pÆÍš3¨ƒ˜$ýW�}SHç=X Ñ9GBL„ ScÝa„«u½:£jUˆ@LŸƒFS:š•
×9WÛn,AÄ $}¢˜R,±ïBk—ën2�XÖœ£óÚÓ»"KGP„ š•†ÝIßÃçúì>¨S13QSRÒÏÂÐ‚Á«WÛ¸û®WßJ.Ye@$Ð‚KÿRÔµ62 ¬„UD¨bÐ �³Òrô]§d-Ê Á©‚TI$R V±;í±VÏ¼�ÇÎ·Ü®Eô^ÄTS!ÓÏ€4B4`U¼ªsB4×H%„ )’¤8†&
I Â(4#Ì¬™Ä®‹¨yµÚ…ãÐlm«‰H/±IòF„ ¦ÿ‚0ÐQçÔÍk�(@6Õ{«d3� Ñ¤é,h×”ÉW	:6°µZœ/NH!!L¿’°‰Qà4h@EH8kU¢.B¤ÈêÍù.4_QDÍ‹Si�F…’bÚ¢¦?ÀÿW~bÆBASE      O[  xÁA  ƒ°Yãx` þµ,¹ª¨ÆH"gÛh�6‰™®S¦˜kÛB§Œ 6GäÈ`3ØÌbš¥s3§µÔ&­’ÈDf*ÒT#h«*ªf	[`µtDP+³j€«€k¶†+§é¶M�jUhcZÒh¦-°Ím›	VÛÒ”@$äfT9“9§›˜©iêÐEiÊÓÚ¢™m.M§¦kµtºÀeÓ´9jÐ6 '5#´ÒmMËœºéÐNÒrN1·¥u¹åç°¹­m¶m®ÍeÚ†Är-´L‡9ÂeEd‘¥KMY3ZšL´D]`ÙŠ6#W«,‹¨DUH*M
B,ˆD�2u¡›¤:t¹H±Å*‡åæPÜ,Ñ¡J–ÃT7]bÊÁ²¢ j2#h…eÙr‰-r“šC(-Í³7¡V«DËM5
ÉsSCˆ1Ulš5HBPOS      8a  xÁÁ‘A ±ãsìt){"À#>¸…éHÿýùñõõužóôÞÏÏÓ=¿úÖØîõYõ½Óíœ÷±á¾OÏæ,ÏÜÜ¸;–‡îôqç&«rÜ˜6º·“r#w»=¹jI¨Q™V¶©rL1ww¶*Z,™©@˜im¦dÆ‰–�b 3–	�#6C[†Ë ¬#˜fpL-Ë `  6´Ã,d Xc±` 0Ú`& AÖÈÂ²À0aD°!  ØÀÄˆih[0	-!&´(M ‚ V€ ‚"DZ2 E4di¤%0ZFˆXÀ`fm ƒNŒ¦9mÃ´ÌÌ�e46óÒvgYf¶ÆÌfkæžÖZã4[�{z63�ín�õü~æã¨ç>®ÔÉó~z×¹·;ý!õ5 CNF4      y   xÁÁnQ€áæÞ3C[Z2ImpaâÚ…õÎ“ø¾ÆÄ4Ý4!2B�™Ã�ã÷e?î@¿gˆgN†<ËÂâ�Þ}³òŸ“·.þ¸:¼:ŽwåZjl[³­ã²£>Mµd=§+×Ô‚I×,ÁD+Ös­XÏµ Hít_þ…¹Ö¤ ·¤ CRÐ‚}%û©~#ýB
º ]a¢Ž~Æò &ú�‚‰
›YsOD#¿>ê) )¤ÃÊ %¢)è˜Á@À˜!†`B"hÄ@LTx„‰ O1{²ëÃ'ìùáTB»…yeˆ‰Ò5usz³Í[n^ê}Å]·¹úvö;ŽÎ#Œsz�Ÿi—M»|&”ä/PÐ÷�×dÒ@‘Ÿ[ ‹ù@GúséBVV'òrávWŠu=×´WÐru‰G&ÿÆpÈˆÉU(zùPùaÜMú|Ô‡ž‡á¬Ž:ê¨£Ž:ê¨£Ž:ê¨£Ž.ø’V½-TEXT       Ëò   xÁËn‚@àÿQÎÀä\d($,f`b	¢IWD—Æ.jß¾ß‡)Œ	Â”ð�Óa?!4%YÛˆgûÆ3gkS±Çi-Ä;6BÖ„õu'¯ob©Yë¢"eú}Òúº“�×7±Ö¦µyRVÁrž:(«p!âXX‹ŠrRVáBÄ±ššG÷•fôq³Òx›�s¹Åný3÷xÞ0†ö!ò¹Í…Õc<v¬4FlÃ€>ºÛ÷.iìã’EIœÿÎw4vCLIP       	           GI     G@®ZTR

SMP4      B!ÿi  xÁK¬¯Yzäßû®ËwûßöÞçÔ9Uít—»Ëm[Ø]� Hn»ã H¬�Rn)²Ã'$$&$ e!KÆ `ˆ„„@BH™b…‹bÓI§»ªÎeïÿý»­µÞÏ#¿ö@úK Tºè¶¾šÍ0|kßíöo÷‡ï|òêÕ§oÞ~û;Ÿþé_üâW¿ú+_üêíËÿöóï}¿”"þ—ßþpÉãï¥âï§Àô+øAzÂ#€ïâþ øgÿøÃòÿþÉýŸô‡_½ÿÉÿóOòÇ?ýÉ¿zyùÙé«Ÿ�Þ_¿y÷ÕW/åt<ßÇÛeÎy-µš(~ÿ+ð .$AŠ	 Õ�Kb" @ €’0yP„€¤�BBH!@Š¥ Jò @€ S€XjA@L„€Xò LÄR€@ 
À*’ AQˆ�"°ä!–Ä@‚"Lb€Ä$m –(T€UÍQEÄ�4«4:*`òK€	¡¨¨
V#i"1% Š˜ˆAL B b€˜ˆ¥T¡Iz ÍŒ&^ÍÍ¾÷¸É±&Ó[ú–šÍ¹¦S'ÚàDÒ ä’¥ó‡‹|œ.£‹Û&ç£»îõ›áã§§ô� •B¢élY§F:¦ßØºÎê?¼~ùPú~ë½˜ˆ¥ÿ°�¥iË·jl„*é3P€"(nÛ„2Ý®µx �ô§A�ÕÙ»0x½­óìµHú>1[×Ìð‰l.—ÓÕvƒóÕ�éP ®ejý«Fqùp^›Ð·:Xú.(”\!í V¦¥bÓ €RÎ»þÓGà§ï>ûX ¦ÿ	Lud	oàýWýÓ@¿ŠXúE,·Ùo¿³Ç¿úÙWÀnïk®¦×  ‹Å¡Ÿ¦ë|O¾¡ær»Õìší&Œóõ˜uhÅeK_€€Ô²d÷°óåùùŠÎÚPëøq\ºØ¢zƒ¤ßp®u»ð|ººmÓ)(dú¤–²;ln—çsØ·Íº‚ ]å�útØùŸ?�úa³y,õòîZö±+¦FI¿	S°NwôŸ>ÊõÝû#ú}_¤LoA œÖysxrþgßŒssè1dú.±µ.¾ßhXÏ÷Ö¹vç]×1gô°×q<ÝQãfÏÛxº/a?xuYBìÛ¼Œ¶>ÆèéÄÒ¿Â\Y§Óúø­oãýWïÞýƒ·¹Á%ýP€:›�–ë¸šj+±ô}˜R¬\>}‹Û»�/^õ2Àô=�¢7ÑíŽ/ó‡‹íàª€é·@ˆåŠúüåt¾Î6"¦„fæf³p:Wt2´Þåå~Ÿ‘;·SÊ|¥†ÖÓ‰¥LAÞköŸpüêë–O_É\Uªjú=�*ežóðºÛçïß¿�CTÌµÚp@¾\Ïw7ô�BPhSvÝ¡ÜÆó|všM#·—ûµh‡¶æu¼ßá70ý¤Ê:×?q}>?g7`úH•:­¥yõ]}>_¥šÂJPªUçwÎ–ù:qb°ôCÔëŠíë�½¼|¸µ�;) QÒ�@@ªÝ½t�˜¦ãM]Û8V©ªé¯‚pÉæ†]ÐÛz´q£×ëZƒ¤Š¥$T¦ùâ¿sÀ»¯~‚í·¾i`ú�º.9ìw»]îkú4Jê@²NKÙ}þ„wÇoÎÿÇ÷Ž7O
,#Û®Öi¼ï]¯¾RÒoÃ´ñ†ðz°å_¾û®Û†·¶äÓ}Ìâû~——ÛMÚ]tf`ú[ El.w÷ôiÀÇùÓ	Ÿú²`ú}PÄ¸º-qÏ·B¸¦·×ÉDû�bœO>ªÅ><N×ñrƒïÅ6;kzï§½ó;¿«Çé4j�°m1^Nw	‡Á±‚éKb˜1»m_Žóù†×nkb`z
„vË¶X¯×;ÚÝàJú(b¥ÐúVê:^ë´ºy¼�·A;S±ô7@ªØ4ß_=îæéëŸØð°�¹VÇë¿ó9¾ùãQðé£ï‹˜~ Rµ.víö�ûöýñ›¥u»ýS˜—ãå¼²õÛÝP.·‘ÚÅ¨UÅÒ_©bsYÞîÞçûûo€ýÎÃL¯AlY$ÚÍr]Æˆû8¯ëižú€~³Í·ãËíC€Ñ(éK@]Šï_+ËûÓÉµ»®.dzB¬.3â¦«Ëý2•!D%ý„TWnl©ãˆvÛ-*–Þ€€T^iûƒwþø.®Û&˜2}ÈkÆîå:~1´±h%Ó— ÄÖº6Ýy¹Þ»­ÇÐ¶s™NÑ`1îCžn75ët?”õ”o3»µªXú(€-‹Ä¾½×Û±íÔWK©6V×lY¯Ë&ô}–´\Á.úãr¾”§Á…êÄÒ  E²Æýv#×Óåü0lj½MG§!6Ð
€u®u÷°ÝÞïï–‡ÖO ™Þ€Éc½Ï~óép-ïß=ÇþÕàV™:�
,ËjoßlóÏ¾ù÷ÍÓ“º›L-H­×ŠÇOžjþðrf?t›Xy»�›µ÷QL Ðf››ÃÎsz>/ûí6ÌZÉô	(bX'ÅîÁ‡——çûàúàM¥ªÂîµt¯^uñë÷GÌ‡m\5›¤× @°¬àCKŒ·†¦¨*–¾E¬ä5ø­.¸Ì±ÁïZŒ·û³ËM«”"i RëˆæÐ8\ÏçûClÍ‰¥ ë|Ëý'‡â_¾zÏvxÜõ¡¹./÷»½ê÷ÛP/ã‡Òî7-P$ý ×<í7O¹¿ž§%øÁÔÄ¨(KÅö	rÿp;×…vãËóz¼âáÑ’¾ŠX]çA:Þ–‹­ÍàE³¤·  %iž¬>Ÿ�7øÇ pbéÇ ÄêŒêŸb~žŽKéB+ð XF¿v‡OÉ×Ë²}3;iÆë„½öÞ™ÃUðêõ>~ü¸Î²Ù"›7Hê@ ¥ŽêŸ¾©ßœÊnØ J!Ó (ß´˜Þ½;¡í`Q±ô	H©‹5¯ŸšòòòõØìvÃ
À2WëöOEnÇcÉ!ì»×Ó­Üô}“Ëñv½ÑI·{Ó¯Ï·Spû&ZU±ô�\îëð8<èñôaÌÍþá­¶§ÛÑè¥PÒo‚"V§ZÝc‹Ûýt+ÛOâfËqœÎ#°�pYÒŠ…‹¯Êî²|6þQýu½Òuƒ�ô› ¹®‹ƒÜ®_Ÿ§f»§AiéG ­Þ]×?Ï÷Ûup~#$ý§`�›ÍFÂý|*›®�Ž&–zP¤”uáðq»]rqû¦™ÄÄÒ¯ƒaYg<üöörùÆd·uRT,u ˆ•yaØ½~˜N¿¹#¼êu%ý— r±ÜGÑ©.“5±zMßëºÖÐïó=_s0¿mp–~r]=›­vy:O£µÍÎëz[.Ë6h'æÄÒÿ«³Ë~4Öqœf?lT«wÔ¢MëTnÓ²5¿Ûj3ß_fvÚx5Ÿ>mÍÚ6]Wê=_oêC4ÈtŸ,ºèÄ$}

r™ÇfxÕV|=}XÛ¶oªU²•2l·ùºœokmº¨Õ9K?®³±Ún®§ÓÏnõÐl¬ ª2—i�»í'Äó×î¾yjuuÅ$ýPÄê²HÓö²ÌcîáC¨ÁÄÒ ÚºfÛãñx¿ ~ëýf]ç•ôA}úælŒ»Óx9N1lvCµÓz½”]lƒÐ9KoAäróq»	åòÍò±¸MÓ.R%�ÀRDÙ¶bµN7 '&éïÃ¬3²nC˜§ëå^\ë[$é¿	æZg×>¶Äñãe„n;QT‘ôû X—•�;ì¤{¾~+6ÝÌe&khÛÁ{[¦u¡ú 
—ZÐä²T›Ý°žïÏ–%¶
ˆ°–Z:ÙUÏ|WéCç
§õÎ¬ÎE5Õô˜H©k.aØˆÕñØ.¡ú@Yæ:J#â(¨D·�•y\7ÂFb’þ&ˆ*E`!tç2]Gä¦oC©o¤6-Û*éAT©k¶Úví6Ç¹–èC¤¹ôDÑUØ£-X1:¸Ð˜“Ô"yš•ÕÊ¦é¤œç©k0©(šƒßD©eZX'f¢ëãjãZ³†0D
l*V‚oƒ[d)b¦.(¼‚)€ ¤èâàÛ¡Çz¯Á‹€¬Yœö¡YÊR$hÓˆVI=ÀêBCœ[ò’k«�R°NÎõ:´àœG3J§ƒ�u­KÞoWWæyÊh$ª8Q¦‚•Å|õÃÆOó|½Á¦u"˜~*–X}ì<9å›«‡ÐÆJ·®êLÚ ÞJ¶\¡>Àkz­f�†¶«2O÷%4ôI4JÈª±	®VË¥×I,¶®"%˜¨¦DUsëª¡Û†užOóÜß8hŠ �¨\‹¹aëú2�§±‘V�VUH
0Y¬Xð�«u^mà%PR£R¹ZÓÅÍšqÂõ�9*E“‡�´ºÖâÚÞ{Ÿ¯ój±Ù¬v_Jõô5«ku¾é\-ÓuFt‘ó�w‚ Lß!Ö²fÈy-™çàV³ËƒàÊZÄª†"€�­³¼¬UèuUÄ’µ :ßd²…ÅÁ;1€u¥¸!´K™¬6ôNÓkÐ+FzFŽs\oRòl3¼º†>0ýYf–­­¡m¼-s¥Q/U%}d‰€§dÌ½÷}a�¦¢Cô‹YYKt�w†%‹â¼JŠHžµZÕÐ	°ÔQúÐúše®K8ïE éÛ ÁJ¥íÔ™�-=bsDeª“úÁ·«­“¬�öÜZÆ<5E¼"($ýy°ÚªÐÆ©šeÍJ#‹˜8QM;˜P¥Úb¦}£K©·2;'­©ˆ@5ma¤�ZÅ­1úe\ÇìBÛyYJ™$;Í	$}’•V]0 ç¶ˆ† ‡â­Š0[X|h­–qÉUü~­³eªxx$ýu°Z1“Ø8›é-8U1PTÒƒT¡Xei´T¢‰ÍXÏ×Ké|„‚jMßITD
‹©ïR²jh‚k+** !S„eŸƒö.².˜
}ÛÉuB†h0	@¢
ˆºÕmG×i† @…ª– *³¯Nzñ9×ÊàƒRfo*Î‹ˆQ)EKã{ï$OMcè(f_Y"!¦¿ ‚FVT… óVG?ÃïMs]šìMU(éO�0°Êì} \Üä!�‹Î¬ÎXc…¯ŽP ’~¤‘¥:õ�iÎ`Ð†^²**éh0q�jfÒ¨™E½S%¦YÅ$8Çš]�É\�I4uaú·A
Í
Mƒ×Šu®Ð>„ÂÙªWª@ U˜@h0DÈj¹Ñ�‰-øÐ_W]¬ÀÄ*ÅDE40ý9�¨*QG¢
� ©âÔA`5‹+£¢bºlÕë f[„¬1y')ÂhÕ¨Ñ#˜-ÙÌ‰Õ²Öä!¦è±š„œÔ¼dgâc­ E5½YÍà½ˆåši\)ëêÅÔ;g0 Åà(²¢HÔ“•VèEU… +ÍÐ1!èÅ)²TTÓ'0«F	ôÊbPBaQ+âTX­@ÔIz€	U …(ÔXÈªª>8AÖjJqbB¤'@3# ‘ô¯ƒ1%ÌT”€èÕ—:çêch\A™×éá�BŒR•ª¢^+ç®úœqA�£ïÄ(„0}
ª€¥Âœø\ïÐ¡AežXiœ·ÊµºZõª^É
u‘Þ³ …*NÄ*Ì­­H%@Q
…4€¨Rºê-˜T«Åª¨¯.Ã¬R 1T…BÓò{øå•4Ä 1Qb ÄDM45˜@ )€ ¤ ” &J
)$  @BHS€  ``¥Áˆˆz§Ra–}…Q¾ŠW@H‚•–< "Ua,Ñ¤Š„�  4 ŽÉ«™c‰R õN}‘*Å×"F!*)B @ BˆAL ª˜	ÕQE½ˆTV«f„xj X­š)Ä;c¥5¨`5;²*DE1bšˆ¥­¢ªwê´qVV3s".}„Y-"Á‹[ëª°i+ŠÜ#;çàƒ2µ �–}uQË”§ ß±Ø<±†nk~²r©5†f[YÆ:¡FZÍ€5Ác±k.ü&HYÆû
lš¶ØœW4¥ä)/½Î¡®+Þy¥dVWÅ9�¤
Q«U¤É:•ê<¼Ó´�j%C†­¬y’�!T°ÖEC­e2í‚6B•ôC´ì
]ô�6%$xç4ýy,ÌA‚�Rê˜MC„óé·A¡¬Uš>êÓXrt�9@rrËf«:/—¼¼FT�€«Siâf/÷ãz:'ÅÁÒ 
Pa}te¬·�¹&n›|Ê—ÅobÍ·i¾õ1´ŽNY²!ìÕÝ—¹Î­�j¾Zú˜-hÓÆ…·1× �0ÀÒ·@)2ÕºßÓqºKpmnW°f®Ã¦o›é¾Ö�qã®·Û­¸&TK¿
Ps­nƒvÊ·k5Bµô æ’u£a^.3œF_ ™³×]°<Ýï[×†@Ó÷@ 6£¯b>]ošK”fp{;2ô]ÍdÚÀ¬ÓèúW/—÷Gnû 4òV¤{B½\Ž¹é©dÚ‚Ë¦M·uíù2ïw÷Íñ|‹»MÈ�b°î!O·Ó¸ ¶UÅÒ  Ké¢�nóe×îúØÞ¾þx·®jj”ô·A@jÉ"‡m+øhcØmÚÕ ¦/A \gë»·�žOýNÛAH]—²;4¸ÌN¥Ù4Jo�ô�×êúÃºžÏ§¨±WS”y^÷O½–ÓÏ¯ºÙl¨+Àô#�
™eŒ��Ÿâãñçþöû8š3JêÁä±Nâ»×=ÆÀ6d˜þ}0yäeòÍ'!¼¾Þb³Y]˜>!†EÙoÅíx-¾ÙH Ó 
€¼ä¦{X×—ùý¦&`ú÷@ˆ•53î�—{Þbè”^,m@P«,o¯Æë7§k³ÙÊ
©"@©³µ¯Ûáåò¡ºCïÝcy¹žfmÚf-Î(é©6Va›_¦›…èœ2½…)XÊÒöÚœ¦÷£6ƒ  Ó[�®ºqvÍƒb>ÞÖv×y)"–¾&�¼ærxpõåø|óŸõâ*©È5cûÆëå:bÛ- Ó÷@:«ëÝmv}ÏçI‡¦½‡J¦·  X—ê†]¹Oã*Ý 0‚T”kqÃÛOp?ýtóÉŸ ¥US&�EÊ°Ý÷ÓõE×ÐFO%ýM0yÌEuóàq|.Èn¿=Ä�ëeÛïèªT€å–ñê±Ï—¯»Ø›öå4fö�;ôî/§Å÷Cq«‚Še)Ûí€é|½®@+¯?i��€¡š	 Ó�*ÙÃ##Îãõ±ï<@€XÔd·Ár=?/Ã&8Ph¢bk6ßlºžî
tºytúr>­®ÙWLH•œúF›>Œ¥m]ß‚/kÛ8SaJ pÖ¸ß•ëe}õþ°mÇoV´MÓ÷Ûu|¾Ìq78]D,}	¨S‰qïóxºzß:ó”´!fëRv];Í÷cdÛGºB¦¿
¤Ö‚0Ä5Ï£©oMT,ý ×eÒÃþA�ÇãÚ·Ûêf€i AábhŸÚr™®KýV´Lÿ L‹dö;9�Žy´Ù¶ý|=úfoËýøò,qÓxšTÕô�@�Ðî±í–f:_:t�]»¾;�ìÓ°�)Àô9L¥Ú¸ôÝÝåzY¤ÔeK¯Áä‘—™ÛƒV¼œGÙÍ(0
P—Õù×ÍnýøJè]³{òy~žV	ì‡O±œOkŸš˜L_‚ lkÿÐát›ÜN�	˜�š—Ùï·˜Î÷£„8xTJú/@ uÎÞ®ÇóhëÐDWLPG�»ÏÚÞ=?Cßtíë(çû»¼†¦Ùwp|>^+£‡€åù|*]×
(dú-@±*þüùvÌêÚ†ZÈô„˜MD³Ý5ÓýèŠtûAêùý¹nº.K€['„}zÉ®Œ±QóbéHgu)~óÆÑN/·ŒÎ÷­æÛåãµkw�'0×,íöíÄé¾°‹íL%(°uÝÌëÇ‹²·ëwr¹¾\·�‹õz™´ï²Š¥ßb˜½Ûï¶÷ùyœ‡~£æ- @L'ó›Ã�óuš-ÐíZ·^®§Nbç!EÒwAˆå²¢ÛÇåz¹Ü‹wØÊûñC¨]P 
ë\eðñ:ÞnKØ…UÓ„X¶¬ñq[ít:×íS«0 ¬ËˆæU\ÇÛÑ‹FWÇ—ç�›N@Hú» @˜W`ÓºãršÇ¦ë´:±ô%(–ì¥?ˆÎ§ëã°(-ý:(®óªÃ°‘é|[¤o›¢EÒß!fã:‡Ã~àõÃs~ØÄf¢£¥‹i;8m�ã2
B×[»žO96[ïŠK„§¼¶»C�—Óibÿ¹_�7ËÜoƒÍ—+‚ï7
PÒï€Áº,ÍpÐõÃuÌþu=«¤€"†÷Ø=Ð_/ÇE|«®¨Xú%P¤Ú6�×iÂÜèàDÔÒ�@³uÊnÛ3œ./‹­‡fI?E,×·�]{½¾<s»ße©"–ˆôß�A™ÖÜ6ùþr5bBÑ"é¿E¬Ì†¸mù<ßnNšÞ±ŠXú±ll›}[¦ùãmÚ·½7/bé¯€"V›Ûýá€ûËåÛ}—¦©ë²´Ýƒ´—ÛÄö}ÕÄÒwAã\àŸ^½6~ü8.›í®JõbéP Ù�Ua×ÜÎïKm‡‡6�çÛ8ì7¾_®u\žúOüC·Þ?íq·-.«XêA�pÍÓ¾ßùë|=Ý$öEUX0‡fÓa½\¯'†6* –¾B¬Ž¹ö;æÓýãÐ÷�Ûízš¬~Ö½nWïnêÂ6n6óí:‹¾î�^ŽGÚ›Ã¦kËíºœJl“ô)XgºfÛúööü|¾K{8ìC3ÝÏ/·¨ý~hÛñþrræ7Û6¬§õtÏ¢ñ!úfº�N9º~ˆëýz¹Ì1Í3}Š”u^šÍNËåþá½ë‚RÓ?ëš�McS¾Œ5û]¿�ÇËiƒ]¡fé—@¬y‘8t³Ýîë„]Ûõ[›îÓËRÂ¾WÐ¥=X×9ú�ïK>^oØ„]VMV×UÛ~pyÍó:ª¶Ã¾]0?_ëcì”PKo@‘º®ÔÇnËóx>¶!ÀUaÍ¹sÝïë¸ÌõÕÐµôK°² 7»e¼Î·›.@L,ý˜Í·óñrŸÊMèDª¤oÁ2&‘}û8žçó×OÀlV»CëÇ—t³@ÄÒk�\g/CÃöå|<‹]t"Õîš›Í“ŽãóI¡ÛM« Ìe=léO·—tÛ©Všr�u}xøl¿:¾Ü¤o{LF�³•¾y°z}9Ê-h¿6Ïã±k›Øx]²[²…ÞÖéºtÝþçÓu‘º&U55 Y—œÝþ°]ïçoÊ›¦™¥’”aJÁ2ÏôOC±¯ïï¯àCë}Q!SŠX�ÖoÃ:�×1çÆG­ž’¾ŠX]òŒ¶íuY¯««ÎÚåî:Ýš\_D,`)\|º]½�Ë}�¾‰L,½kEç£”<#«…m³ìe¹Ï%ôÁ‡â$}
«kn¬íš•ã}¶â]qš¾ KáÚ¸Á»\n6/Œ®‹Žu½�3B¢ä2Ý§åaÛöÍ”O÷ºJ×ŠEJ]œÉ&ÊfÇ’¡Þ‡â$ýo •Å¿Ù*îóy†øàœTÑôÐ².­ô�“µÜgSñ*¢éƒ¤•"Nº5ÛµXlú`Ëz›suí!Š-ušªÔ^U(iãÊB×øvrë:Q¥ëc-õ>Ï^4ˆBEÒkÐlE¡‰~ª£ƒ�ˆŒdY³i?Àò2O9'-(�ô9H®\kï7@™J£—ÆVWŠn=gÌ²:	¾�Jú�AT­ÈÒô¾7æû„âÕ7¦*iƒŠ,ÅÅÆ	óÊfí<‚sé‡ ³ÁºØ‰]ëµ£“ ¢’>a("µñ›¨ë<]goðNàTÒ¿µÖâ�ï-ä|_+ºvÃ0–;W5¥©¢’�0+5ûÐv4æRèû¸¥X™Ö}pÁ{jzÂP-+½�ÍTçõ~¨›m”në}§¢�šÚZ«¸®…\§Ë4½–�º\×[4¢‰
$+µ–fˆ‘˜Æ	µE„�¤G�`-Yªo=×<­¼�
ï%ýßHž0+YÐºŽ—µÖ]3„:å»ÔÄ7tRQWcã[­s«	‚B�AŒµD	AYëH+›¾y\3°nÕ7PjúÇ -ûïƒVÉË¼¶Ò5³ŒÀ:¨@DTÒg0€V3¬mšN—õR²õ~Ç:Ïë\q>P!æ"vVW['À9‰UUÒH¢V[5ºAÌ¦EÌ‚©¢�ô Â@fÍê}ðšó:Q‡užƒ4±GÆmUxxGUI?I˜ÙR]�/u^Š xUª
Ó YHÌÈ¬:DÈ\šM3¡r�‰zïU˜~&°fq24�µÜÌœ´E=(`úf…U]_š\j.„R×jAœº´i‚ºzµtL IŸÂ ’%S|o™y¼¯¬…Ð�ö 	šƒ÷A³,b"Ôà é/‚&t¨(ŽÚzo–³¨±Š€�ô	ˆŠl�>8•œM£ˆ«ÙêÄÅª©FDˆÔ¢kÑêœ: é	Â,Gj¨u]5($Q’þ&”âs”=Èi	@PU¢–bíê›‚Îi®)¢U$y¤atê¤ {mú€:]Öî)½ëí>›ATGG³ì�Þ{�Ë«9SÔlÒ„Î;Y×ek�CžVË.°3¯R@�B+…Ð¶C¶r›$îšVËºB¼ŠŠ¤'˜PÌu"„†(Z2Ë«:ç*”ôc�„Á¬Vß8çÍ×ŒlÑõ
ê$RÄW@@Ò¤	DÅJ­âi�s¨Q#<h„Šh:€ 	QIÞi-!ªËy­&tN¡°B3(š~¤Ð B (ÕÌkCÍ‹˜zÊl®ß”ºæ»¡kZ›kžÛ"â¼S@«…p�SãZ«_Å¡ª€€¤«š:À©–AQ…€ )ÉÓDà+«­âµ%ê29Ï¦‰êevÅ‹S—HÚƒ L  ^„‘
	ŠWÂ*B� &‚äÕQˆj$ „éÏÂ@ÂQ`fôˆ’ui €K¤AgU|g^×
õ®”UjµBªŠ�ˆ¦G�B�„©Š«™	D…fÕŒ"¼ýï�Ok&Í"»ìóšs�i¤*Œb"	�¤$HA(ªN f(( …à†ûðñŸãXh4�€˜@@Hj 
 Š˜@  –ZP„ˆ˜¤ b©PÒB0P¨B€Eá’€Æš<MÍgG%(aòƒX
ƒ˜ˆ	$PÔ’‡ÄK-(B±A� bšS„˜@ „P!*X«@E£9Œ%TLAU Š˜ˆ‰P,P„ Ä * ÂS£9±jÙçh *’þH–â*;m³a\œwtâ�JêATO´p~­«ƒw�ô�bM…1xOÉ›Y�jºXž|�ÚWWkY'zôÑ¹UG¿4@0ç$½Vêú>ú:O¹­O!8ÕªÂš�t]›æëÒ{ïCB”je*ÕùÐ9‡µÞ,kÔ¹VkÃ¦)Ëuœµi£ÓÔƒ©˜ªÄMï—ûóýÚIëO+e-²ku=žžW i=è�…¹t­×ù~»÷®m‚A$}B*gz·é•ï¦ëXûØxP$ý(Ó¼8¿ÆûºÀ÷Îƒš¶  u]Í·{Øm<g¶­C÷”ÇùåâCïšf‹ŒûTá½G,’¾
P$7èwu¹]/3cp]×r™ÏkuMëà	€ÌV£;D\Êí¾éÐ¸ê Â–œ¥ÛøËõ~iC·µ¸:XzÌ,}ÓÔqÎ@ïÔ,õ ˆÕå.zØæûËé¶6í.£ˆXúË €¹Ô®JÉ×¢ƒ6"P …cöûGÌçS-:´‡‡ò<_F†Ø(LHÍÓ¢‡¦¹Ü?ï��Š�‚lÀÐÇûíz½F‹Y»ý×i^sèT«Š¥/@ y­6a¾_NÎBçQ)é?EnvÙlvíåþÕ%Ç_øÉ¯�œ¥?
ª�.ù›OÝ²¥· Eì^ÇîéÛ-~öÓ�·?|»k^�L_‚+sµ~Ó¯Óù2ºMl‹V2ý]�ªÅæÒ~khðî«¯uûº©~×ëòñt¹mö±[‹pQvýº>ß/ÅÁ×ÍëìëãÇí°ku%Àôï€ QOãm÷í_ÄÇÿï�¾>û¬›N*"–ë*ýÁ‡çÓG?tm@QÂÄÙršÊÛÏ^ÇëO_nøå7Ñ—l¹ñj.8%m@�°Ž*ÛNïÇÛÇª¼n<¾ûèÚa#0°¹¢{z›§ãõŠö=Mªjú�*uºÎÃë_ÞÿñO~þæ³7»&FJžoE]#1ŠÖ9»á¡»�§¶ûÝì*˜~	PÒñ~¿-Ñù^éai )À|Ÿõ³o‚þõžðº�áAÝýåÝeìÚÎ± L¤Èºn÷e:Ÿ_Úí+ï	¡)¥r‰~ù¾Ì“l|(–¾ A‘u^,þâƒ]úóÓ†m›%ýS�šÇ†Ç�³çc‰í–X¦_©õ’¹»É^¾>÷Od) Óo�T)óZo^nÇ£;m®"U5ýE¬wºÇÇÿó—c{hºšgX`Ór½Þ.cðEÁôë UÊ²ZûI§—é›�í&¢ß„rO^Üp°1_^V‹ÝcßÞ¯ïoY·-XAŠTÞ
_m:¹^^&�M±¬çu+n }ò Í�mÓ×i�kn‚§§¤Lav‡^my{þêâÞ:J˜>A‘¼Þ¹ÿÖøé7ÇaØu‹fÓï€ 8ëvoœûêÝ¾k%¸Þ—õv¯�v€Ko@ˆ­ÙÙ°�Êù:gçz¡Kß©6ŽÍþàÖëé|‹C'©d@@
'lŸ¶ƒ]ß-uØö`úHÕÂ³õO‡î’þqÜõzîù>Ž\k^«*8-swøV¾ùxÂîÛÛv¡LÿP§¢‡m1]Ðt1B*™ Çu‡}?ŸŸÏu3Ä¸�é×Àä‘grx³ÁíÃ»Líbhúv¹ÝOkyÕ3ôC�óiº—¶4ÛM‹÷çÉÚØTÍ ¤æËŠÃëÿäýìôAÊ}ºf?tð90ëÒuj¹Ï«ßD¥Kß!fË\†Ã.7—ó•mëÔw”©Œ+£sZ5ýu Çœã«ÖåëñŠØGÇ" €Ë}j‡ÏB=¾ûºÊ›�«UIæõ¦¯¾½�/_ÿdíÞîC_LŒ’þ-P ¬ËšGçp¼ÞbÛŒZÉôW@@J×öÕ'¢_½ûžöq]«húH.S·û/—Ké›ÖàÄÒ BŒCØî7¸=Ïµñ}Ìž’¾b3níþmÓ,Ço¼üŠB¦¿
BÌf”þ1–ÓýèÌ5A«K¿
Ä¤¬aß6¥ï‹8ï»ð´ÜÇóÂv«RU,}	ŠX]–ÿ¿ 8ÙÕu»ÎüŽ1‹¯ø«µ×.�±Û‰HQ*·H,Ñ€„&Ž„(š@\ÂÇ­pÐ ‡hÐCBIìã½÷*þê+æœc¼<�Žã0ÏsY«öÉC
l1	§¸a¾Å±;†*ÓÀ;<ìÞÍŸu½§ý)˜)8ý]P ØÖ�ïÞöçó/—¶shN™ö HóÍÃ0�¥z!«ét ØºÉñÝþtÿú«¥äÝŽÎ@Ÿ~‚j¼moß|‡ö—¿|ÞobÃ&âÓA÷Å!=_ÊSp>fB¦=(â¶5Mƒ4«W´Ò1?Ê`Ësåá]J dúŠ¸-hÝ~àm»4t9‹ñéç [()ŽÉC±^û7´½þß?¿þï7ïCkkhäôë  Vï&û�½m_¿ÞÃ7ûÈ9�œ~‚j¸yÿý^ÿâÿ]ía?äv¶ù>ú]�î~9Û»±�MƒO¶ê2Ž"‹•«ôYƒÐ§oA¡¯ÙûN¬ÎzKLŠ|úg ˆ{ÙJßØ¼¾lk¿Ï	ââÓ€AÙîšß%œ___lØ�-ˆO uu=}xkñOŸßàíCgpñéw@@¬ÜK|÷áÍø|~¹¶C¿C(">ýsÐ+¼{Yp[K�ˆÓ7 Äm-ÛËëç{ü^w\…*>½!låfzøØµË/ñÚ†îMCñé(â>×m¿ß�Ê—×ÛÙ÷ŸFP X}	‡GàWO_1Núô·@/µ…ñq8Ì/O¾‡>‹«øô?Aª6\!»�c½~þü9åãÀ*âÓ¯ƒ dgä·§‡òòù|‰ÃÛÎ°‰øDLÿDµæáÑÚm-osèÕeúhesOäe›½ä£˜L?½´-äÝpê–ëu–0f¦:=ÀœOÝ{”ö‹úuä£ÈÃ¢ èU"ºµ•%ybfÓ_}[ê÷z˜×ûêìSTF�þ¾ñ¾K»±ø×¥îØuëû³LŸ@ Y�õð8ñõå©„ÜïzµUhbŠ&Ó·p_ÅSzxlçùrä”Ä§ßYê9uCº­O×j]!Ð‰˜þ5Üjha¹†ŠYRÖCÌë6·`©ïQ–uE¯Q§O ¬ ¶œ——%v¹— R¦=è­)rè¢c©[b€‚m½¢¥®Ï°m^¯Aû¬:ý˜Û&¡ëƒaóMrêw¡w¶{€Cêk.²Zõ¶†\¸ÍÜ:Bði²Z+»î$¨Ïå¼!ÈÐ!ÂlÕ{n]Ê5–Ù4d�M« YÜÊºBãpzÀVîmÕrPiÒVÇñ´èùukiè;�KA±’ìc“¶bmA’g“é°5¶�wÙK¹-tšLÃô 7[Ç> ­7ÛTB@®¢Óo� ÛŠÂñá“e¿ž¡ã~¯êUgmÌm-ìºñÞæËZ¸K’[TÈô�@‡gýNOi½]*{ö ÊÀéÁ¬T"q½¯áË#¢ïo:}²iK’{øÝ`*šB èôk f-zNƒ¡Îº‘!‹™ˆé.03²oÑJ]�ªÉE¦ÿ’h¡&É]Åï±j–‚�é€ÍcîMëj­ŠG$“Àég €Wm5¯¶ÌÆ€Ìà€h 8}]¨Æ-uÝ¾|^%ë… §ÿ16ALûDlK�"]‹NÄô$\Ä½4ùà¡¬ËÝ%+¢@P¦ÿº€æ› ½¹µµtŒ–€ ÒE\ÐÌ<¦Îµ.ëÖvAáÍ,É™>‚p6m‘}ÌÊºl!e	10Ð€Œ¬fV¼e‘)A¦ÂE ÒÍ1¶(óz÷à²ms{*s		�»­)™¨84¥ênØ¶íZkˆšB€@,púmhjÉíÐÆhZx‚Ç’ iƒË´ƒÓ)¢Ê�¦CLZÖëBPÖXh.}—Åe)+É !ˆ«‡éû H73FMpŸÝ‡8Tçêµf†à±‰‚Ó? A‡ˆ",Öb×G[ÊŠ �ƒ.*Ó 	Š"tó†Û—NSiBK„ …„¸U	w*B7§ˆ[É1'ÐKv¦YBã*1-5ßfKQCR€ E¦¿�"!ÄPÍÈØÅàµ,9ŠÆA'"Ó'¤8(U�tÒ	€„©†�RÑHÑs8E§ÿ
ˆ@©TEqº�T§?	�n&ªc]TØZ(bR²y	¦*™z$ p¸»„£‚æÍaâJQ ¤@BCÜZ0"«ÄÖ–ªÚÅ˜ÜËzÑAo-šÁMâ ©¢™" D%Nq‘é )�Á=U·VÇ–³ªW5#BLR¥‘T�pú	¤!š‚Ò[‹.YBToÆ&ª*JÁé_Áò–!.È!ˆ ˆ‹¸@8õ @P@@
)H
„ "„B”¢ @Òà‡O	(D¦!!$ÄEH@@�ˆ‹pÊ œ(Bˆ‹8§8U¡1ˆ(œæ^3DCD€{�ft* �‚j@p%›˜Ãá"hŒDèlÉi@PÄ"„ÐE\ 
D@  ˆâ2u |Š Ä§âˆÀEH'è‘¢‚ÖÞ%uA¬‚‰
™PH³ÚÅQÕk]!}èz¤ÖÖºÈ�¢dW™þ>÷‚Æœú&KÙ´u’U œ~
Ü*(q¯¬k¹U�cß%,­JÞ'•¨$ØÌ=iO´•9ˆ„§?…ôB„1f³µÅ"R¬XÒc,¡Í‹Q�-¶ég ÀlÍzõºÜ»<U DÅ:ê!Ë¼È¨YÕdúÀÊÆ~—Þ•óí¼öcŠÑDA¥µÆþ4¢¬¯kë‡ž�"Ó€·R<õÖ|]—ô=9˜:eúï  V‹…þÁËýuyAŸ²J§Ÿ‚ |^Zzûk˜¿þê¥½=Œ˜	pÚ� lkßÇýåå|ez÷éyýúçËn·Û5§ÿNËºäÇ7å»¯_‘ßŽ08ý€KËÃã0\¾,U�‡CÞ>?]†x‡‡¼}~}¹ÇqH"FNï@ ¶Œb=Ÿo5·>>|ïqö§×ËÃp’ââ”éG  ÖªäÝ>ßÎÏHþ®óã›a{yúî:a­	U§  ÖÊ8~8Ø—ëó»¡9Àé#ªánrüÐÕí—O%>�&¦X¹åôîƒœ//f»CT
8ý`Óî´ËO·¯yHP3ˆÕ5�¸¿žÏÛ€”Ž±|ý®åý!°	HjiûþM]žn_ª�}F¢Çé-j»^—·ý˜( §Ÿ€³Mû}Ò°]g‰§]Áé_€¯Üºa/[y­-Ç^Å§O ÄQ–è‡‡ŒÛåÕ°ß7 äôcâ,w§aK·2#÷ššP·mì·—ë=�púS�ªµÝ=~ˆƒ|y~Õ‡·±»
Hó[û·½^f9îºY@N¿B¼¢aØÑ×Kóæ-<p]ŸžLÆC£€œÞÃl¶Å‡Ç8”ów›ìN]iÁ)ÓŸ‚Tñußÿ nñÝã~Ôæb"@³Êá­Øçë—ÙÇQ©FN; ËÊx8�>_fè˜÷Ç‡rÿz¾¥a×BQØ¶D=íâüòtERjÍ
÷ï£•Ë%àÐw«šS¦ß�+ØÚ"ù}ÂËõ‚îSßµœ2ý1(@C“¾OµÞ¡OAšLàŠ’;¿,¯ë¶ë«88ýÄÚfýÃ#¶¿|ùjvû±ž_¿[ü£ŽÝðüåÙ•.¦:} âa	²…ó­¨ L@|Aywór;÷ØÅÎ“‘Ó?!ÎÖ,îN¾Ý®7‡»C°×Ë\ä˜ûÍƒ© ¾H}Ó�6¯ó]cú/·óòªcŸ( §?€+Ü®­Þ¿K—ç—G¦ñøàéëË–ún8ä¼^nO·ønÔc�°Î/sË}"œ~
BÜjC7ä6_oU=âÓ�AˆùVvû1Ôz©¨-õ§‡d÷gt]? pA V–´?uþõ~ymAe7C¹=­Û©�ÇÝ`õõ¼VÍc÷xª¯¯Ÿïy?öÍN{â¶&9Œ”õ¶:ÇÅ§ÿ`»U¼}»[^¾¾\ßŒ©ÁéG  Ö6§#Î//›~`Ø}êÆ§×¿\åÍ>»Ó)Ó�@°iãÃ�óí†Üiª*>} X™™ã.Û9Œ©ƒ9ýˆëå0¶e¹.ÚC(Ó� lsÛ½ÿÔ^–¯÷§ååz_úc/„�Óï€ |®–>d±Ûíßr°è�é÷@ˆÙÓ8¦yÛfésm2}B¼Xíûã¾–ë}LaP¨øôsâ(ëÖïßk»¼>ßv}(¨¶¥þmöóëçÒngppú'pë6ÇÇÇ!]^¾¬-‡´ïGÞÏŸY‡·�k8�  �kÉ'œ¯Ïgëƒ´@€BÛÇã±½žo®]
0™v „VVÅãæóëKãaŸ” §ÿâµÍáøØùýËùU†!7:eúmâØ°úaß¼~^s¿7º‚ÓT·.Ÿö·ky½kÚ]÷·é B¼š¡?¦zY^æ4ô�Òdú=P (•ûþ¡Ý—û½h$€2}!´6‡q|Ôì·ó]ö]i2í@ˆ·2K:ue¾´‹è(ªU¦O @\È>b�ç—`‡Lñé#q[Zß»×ûÓ}Óa›"(àÊúx_ï«§”ŸFP leÓáÝiûåý—Õ»S¦Gñé§ ˆsKˆ‡ÞÛ}¹zî0TŸþ |ØÅá¾¼ÚCÊQL§ß Âº†ñ°‹z½�W|ÓG•*Óo‚"î[cînm¾…‚ ø4‚"Ž[8¥õúz]öÇØ‹E ×©?Ð×ë*Ø„ŠO;PÄì®Þèö|y½C×E2ý.¡•eóÓé±~Y~±ÈîØ7™v ˆÙRRz“Zz=¯!ƒÅ§¶­¤üNùõöeµþ8uñiŠxE³SŸo^�"
E|[Wß½í–üôº¦´ëÕƒøôˆ{XŽ£Í¯Ëõ°0Ÿ~ Š86¬<œbþrûr/þö¸{D>ÿòâ§~õå¼>“»áðpòùËeEØf L@� ”Êá1Ô§Ëý^Ô»‡ãÇç§ËŸ_×¡Û?žÖûõóµ¡÷§öôzyNÃØm¡@qñ4ƒÕõ^|�‘.âÓ 
[½Ç}ú(çù|¯÷oOÃ|}ùîš�C?>ìúóýË•§}NpqPPZû1¦¶¼¬U-�¡~w=#„œNÉ_^^WˆŽoRXôùòjó‡þAäÐ}<vÕU,ÀmaŸŽ¨÷õ²v¡‡šˆO=(ÔVx8&»]·—­áñ0Êùë—ºíö‡F m5‘·ïw÷Û—ûmçax“òýrùº¤º“ÊõòuÖ0†TdÚ�¯®}·Óþº¼nöÇ£¬—ëËÚòa8�Äõz]tìb¨
PPZÃ°w=Ïu§�fÓ)ÂêRq<ãëõrËC—Ð‚8(ÖjyzÜ××žÝ.­ \­æ‡L¹=_Kÿ0D"8(h«cÜuë}}¾-{×Ã õz¾—pÈ‰B™v „•KŽoòòôz]b4Õ@‘¶yÙ%¾¼</­?Œ»å~~^ðî1FW ,¥Ú›7!”ëó+0v ‹ƒÂfÞÇ‡z¿ÝS–B€‚¶Á‡}_–óåî©KBŸFP Îµæ}�m¾ÞSìBS²Zmû7Ýay~¾Å}»a‡·ÛUº‡NH¥ÎLïÞ�×õYn‚nÿðúôÝmË§ÝáðîíåééåÜõFW‡L?E¼òÊþÝ÷×—§âŸú®‚âÓAZ+ÕöGéÏ××‹SE¦ˆ¦kÐýÞ¸ÍGL‘Q}úÇ ½ÖhÃq¬çÛ×ûœó.">ý!(n˜‡î]¯çõ¥yØ=FÞnŸ¿6Çwß$ÓÛ×û™1¿‡¶Üž/×^ª  kÎÝpHë­\–‚w‡wèãòz¾Üs·—�§ÛKièO™KY–„ÐG�M¦ßEšÏ`ß§ÍÚ¹m™ûÝ ›]î{Ý3¸øôSPÄÚ¤SÄ²½Ì¦aPˆúô-HÛ2ãýÜ 9¢N?YŠ{x;h{¹½Ì¡ß·Xeú+pß]ŸdkËÝ•îðèó|®Ë‡œ)Ó'Ðk«!†Rï—ó%gõ¨ÓÞZÙ¤lë¼I!· Ó· ·¸I÷k™o—r§`Ÿ>�¾mÆý~®×—û,2H$UL›5û�îež7]—=9 VÆ´¯õ¶`ˆ‘P�¶`ëö±›·ûeÞ�ƒˆº˜šm¦ãñÝR–ç5£â Ìg>)Êrß†G�Ù³h¨<ô§"éº¾à!æ¨B‚mSÉ»C›·ó9Æ.w	PÀÛ&>ûNêu»ºœF…«‚ÅkŸŽÝã¹]_gæÔeR¦ß½šq¿ÛmÝò²œ[öcú�t{}}îbô Dó°›Ûm^‘ŽcWŸnçÛ6tCŒpÀ«Gï
¬s[Væqì¹,ËÓæaÈÃ,‘hbšò±Î6·Ø¥\ƒ5®O)]æû9Ä|ÌXÚíœ=t]¦Á)ƒ H³ž÷YÖõ²%èqØ§z®óuEºDF!§?Y½‰ì÷bË¶”}Fç‘¢¤ÛFÏ±3çR¬ƒä`"Ó·`óuÄNúE¶¦æQ•2ýd5³¸†qk×Ú$§�Œ:ý>Èêe—ƒ–r÷rÚ#ÚºU¸Æ(¢ÓÏ@V©)Ç¤ô²ä$1Èô=8«Gë¤o¬k¡'IÙEè¾æÇNÃÒæmC’gN„{‰©t+wYcÐ^�dÚ�î°Ôg„íÚ®ÉúMU|ÚƒÞÌ$e�Í-EÍdú¢Å%šîÆàukUMc@ôÊÒãÇs»ùâqÈ1XœAÙJé8Ãè÷ù¾óA{Q€Ó°ùV5´ÌsÓ!'QÊô¤ÞJ‰aÜ©Üëù>B´B!YŒèòßl–´Š°YiÒÅ}óunKýQCÅr_7j;f8½áô
xê†TÚ|ßœ]L ›Ux—lí¾‰‡dúp«±¥”Ø–œT3b˜þ=Üªaèá¾ÞWÆ]ÊJZX;¤¾oXçK­q7ìÕ°m7³¼KQ ¯jLq¸,Íút�mõºUÛ1‹„ ™~¤{qÉ]ÞÙZï0ú$�‰L?‡qkC§Ò\a]P•ióbÞí†¨Ë2ÏkçƒF•i­Â5å�»Õâ–ú˜�´Í¢ö{7k÷DHQ§t¶Þ0ähÕ/K•áÐgY}›= dÉqk2ÆÁt]ÖÖ:dv&Ó'˜·Êûl(’G$A�i€iCRbYWh×�¨¾Èýdy�²Ì.§îàºÊ­„<H�R‚¯[sºN¨ÁXIë»P·í¶m6Œì„™þ%H¸[!t‡Æm™Û ‡çkÐnßa®×â±‹*(¥¢iNYÝJi‚±ƒ»oM$z„À­¡ïc­[�Ñú.µA÷fˆ!GJ�‹Dz�¥,›Û€Nlú›poV¡¹�V­\··qì“¯Ëv5b€ªŠLÂÄ­Šô¹Oês{µ“c2[f3Ä”ƒ§*:ý5Ð«@BÎf¶Üœ9ï–RÎVÙ�#òÜÖµ 1hp“­ß’Ž Ê”ƒf‰AœÅ"º.Ãl™-æ˜EÔ§>Eš7×Ô§ÈmåÆ®Û;K»RôèÓ'€·&!t�¯m»—™¢B U³BKa4m›­:ä£êVË¼ ¨DZh:è°Yk÷†îˆXì®«
:¢ hÍ©©B6s	º“PmÕ”‘\ á^A‹i@³v¶uHcd­Ë†ª‘) ½ æö&åÎ9vÝè¾ÎRrÝZ½ÏÕc7&ÝÚ]*rH’H «ƒv‘,7�¹ïÇZ×r«A»Aa:ÀXh1Ç¾zõE=æ‘éÒ›h’ÓV«Þ…±kÚl†Dvc&jmeõÖ!Ä„ ™~¤;E`ÜrÌZËzK2„^ séÞ4†,�êªÖÅœæÂ,)èô C%ƒvÁ½.%§¡K]5,-:%26EU§ß‡S(
b†°%ª@!ê „L8E/)me¹Ï]'‹­ªIB‚p™>€¡*Þj‰èò®¢ÞîÎœF²ù=)bÌ� `
“–(BBS´à."
ÀIj Z¬Qã\­lVIMAÜ)¢ªˆ8Ý›t” ¥µBÕ”]à 	Â$dÄ€Ö<Kˆ£Hi[‘H:àn.9D\s! AtoðˆN”Å¼«)Zh
�Fvæ­ IÕé×Aà­!…^6ƒ%ª°Q¢Šøt 	7VE'=ÉmI 53P”2ý&›"(ªBb1¶ DuÊ »S5„ ÷æîH ºŠST5
[0U„ á]‚
*Œ)$Àm‚Ä*TE¦ïÃFC‰”5�’B„“52dŽÒŒ.1…ˆy‘Ú'(nkK‚’Ñ×	M"ÓO@!èâ^”¡”m[WtºÅªU˜"tLE6 ì™ÑV"HìGËÕ7ƒ¤á„SD»†ŠM%gÂQ“�é.JÑé=èp
TÜjf'!nmi BŒ¢p¸ˆè´I4õÚå>»l+À8æ&À7Tad(N( Ó¿I§h�ØÈÝ$&UaF¥ª‹4¸JÐ on&B§™rŠ:½é4h€éÄL]!Qà"R .¦ô �4_\CÊæs ‹r •û\sÊJÛ–¬CBŒ  
D¦‚p!®€�*Á ºPÄE!@pŠøÿ`€a®BASE      P[  xÁA  ƒ°YãxÔ þµ,¹MrËŒMÔ•Ôt¨¦ª`™Û†­mŽÖœÙTl¸MtcŽœŒ´œ›Î�tT@9(gÌŒA–ÑÆ– 2×F›Ë”Í‘·3›Eh*º§¡S©æÚ67V+RµK]�ª­)€€©Ôp	m[ÃÚ€T×X:#Å©ÔhaS �$J[s4ÂÅhaSXlÀR	¶¤…m“ ŒEŽ ªUªUµ ¬XµhÙjFÑ2Œ²RmbU…TµÊ*€è]Ž‘®Ä mdËl™™)Z–e”–Û´å¶TsÛj[Û²Ž ­A¤6Ì(1bÀB& FY€†Â4#)UD(2…jE+@¡k*”BPÖJÊ*k¶­š#-)ØX£`Ö¶ -(µ¥˜’²å¶�TÈ–: (L1f)›2Ù¶	�*DÒ$Û:¾BPOS      Ma  xÁÉ¡$E ±aý]zY³xÄ·0éßÿþùíÛ·o¿?OÏûëž¯ŸßûõëÇëžûå½Ÿ'~î¸ÈžNÓéø„áÎ}ÎæeÛãiÞÜíÄ}Ïµ3«›ÙÚv[¤¶‘f1gL¶Y
mf÷l†96;³eìÆ0¨€­0Å,†ãh3&M›Æ¶pD0Â Ø04LÀ
Fs“0Z„³,�5Ë�Å†LCˆ!L1€4 hCh@3 ² ƒ�HÌÄ‹¡Ö 8 Z0`šF!0Ñ4DÑ
@Aˆ D	‘””DRJ«u>*ªB_…’œsN‰¶ó×ÊÎC­v¾>vcï×§¼­[r¥µ³s}ô~.ÛÛ8£œîsŠƒýy³§û÷ÞŒ:ÚnW/í>÷y;ß­eÉY½Ï�?Î�Ïõ?Q…4ÍCNF4      Xò  xÁMŽÓ@€ÑÏî®8	‰CPðe1+î0âµæp]Är¤ä2Dùí”»‹÷ªo-è—Š¦T8Nåu	OÎñmv�açå÷ú]¿A4ÒÓÁë^#=›?�6¤Á`g¢CtN‹É@˜ =tú�žN—˜hÄDŸééô+9hGÚ’ƒ~ÇDb¢kL´Ã�a úBÚb ™‚è’Ÿuƒ‰
† &`D§Mâˆm‡N#ÆuÅë^#«÷öë# lÛïþ±51êd½ùz5^d~½nîLÊÅ8>—¡ÌB™§öï
i¬Kä½·É”SµÀšÇ¶&©Œ’™Ž‘ M"åE¶G¬š³ÏC]NŸò=ÁiyöJÜV7šÔÜ¹šŠÝÊ›‹ŒÞs¨|2:E¦÷:3Ëå>KÑ-øº9Ã•Š‹:ê¨£Ž:ê¨£Ž:ê¨£Ž:úÄ‡»TEXT       Ïõ   xÁMjÃ0Ðï(s [ÌŒ,«6x!Ù"þ‰qÔ@W&)Y–tÑrû¾‡%Ì	˜Â’`çãaAè„k_ô�¸Æ‡î­òEî¤rç5ô�Úˆ†�òóN"4__ÄÒ²¶®!eú}P~ÞI„æë‹X[«­­IYÛÇ2@Y…�ˆaau•¤¬ÂNÄ°Zµ5†Ï´bŒ»õ–÷õ´ú=ùÏšïÇsèßâ±\ûRXkÌ§a‚õ–û0aŒæöõƒKÚ•a\Ò¦#‰Qàn5 CLIP       	            Ö<AlignableSequences><Sequence name="85_CMV-F_TSS20210510-027-01701_E02" ID="0" isTrace="1" sortOrder="0"/><Sequence name="85_EF1a-R_TSS20210510-027-01701_A04" ID="1" isTrace="1" sortOrder="1"/></AlignableSequences>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  (<?xml version="1.0"?><Features nextValidID="22"><Feature recentID="21" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7516" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="6725-7516" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="7517-7585" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="CopGFP" directionality="1" translationMW="24523.27" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" maxRunOn="4284" maxFusedRunOn="4284"><Segment range="2899-3561" color="#05fd14" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;green fluorescent protein 2 from Pontellina plumata, also known as ppluGFP2 (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/14963095&quot;&gt;Shagin et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="19" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3685-4284" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="5966-6554" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4285-4872" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2572-2840" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4946-5179" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2348-2559" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2005-2208" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5391-5526" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5251-5372" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1798-1915" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7586-7690" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="3681" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="4284" maxFusedRunOn="4284" detectionMode="exactProteinMatch"><Segment range="3631-3684" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="5612-5618" color="#ffffff" type="standard"/><Segment range="5619-5636" color="#ffffff" type="standard"/><Segment name="-35" range="5637-5642" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="5657-5678" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="5588-5604" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="4755" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="4372" maxFusedRunOn="4372" visible="0" detectionMode="exactProteinMatch"><Segment range="4756-4767" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="0" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2273-2315" color="#ffff99" type="standard"/></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>eb8e5964-188b-4566-b1df-d32dbcd0114f</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="8:29:40">2021.5.11</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  (ý7zXZ  æÖ´F !   t/å£â› å] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*iÚ	´NY]Qó“�úF7î&ƒÕ!Ò÷ÀnãýJ„<Ú§_¨‹›duÅ3Ig¾Ô”¦ŒåPGOìXûÈ%õuhy4^Öœ©€Û4üzÎ¤ªM/´Ý!£‹ï&ÚÃú6ófZ6ã§{%å#iÊ(¿×$ TÇÂê÷s{TÕ¤B›•ŸÍñþÀ¦vMªºÑv°^®ÝîrÙd½É/*�­´ò{léúÇ³ÞìE80Íêu’F+%¬	yÕÆ¾DÄüGí€Í`ÎÒ@$�0îA–-o«u‘é¤\0 ŸŒÜò�Õ(îÛ¸J­E5Š�¡“{r<dwnr½?P:HqÀË€p‡˜�-uÔ÷lRûo ˜;íåÈHx–ùM‰V rà“E“„ª-~§”ÚÌ’ %§b´Ozk=sðnî…9÷Õ3V»/©�ò›òz¥Ä×¥5Œ‚÷Æ€vE÷OŸs<þ·â9”:�%=ÂU½*ETb`¶ß  }zî.¨ejs›—häQà5ßèþmŽVh^D¾‹cÀªRâh7Òc&~Jàq!NQÀËFÛ¡ôu÷è=µ–Íe)R�¶ºõ ¥ãÊÒaQ¢û{ò±�åÈk*�OðñXRÄ¹~¿[ÄIùeê-5¬mM×)µ¤Ïï ãßÝÒ)·D³Rõ“¬òÞ&îÔß5fêjýÆ�Ì.¤…Í;ÖNào=\Ý(›ªïã§Å‹×§W'Aîà²©$,‹d¼AUmÁ•¶ºÏËw»€fv³ÕòÅ»ýV‹{9l	ú\&Öö¦`|Ëï%5äì¡W¶RzÉ²yã¼OC) eE…[ØhsXnê¥ï+“è&¹üÖ x²6;¡ÛhÏç²ÊmR'-v¼”D„«qÍ yLd–�5Þ@Ë«î…»Ühþ{�=î!
jG…ô.™ý_v^#9›bÖØc¸Î…ÀöÇ/Ûo«ï}‰'`ÿ§á£ñœ¡[`øÒÒÜÛ$×kq",¦2û§�:“ðˆJºŽ�¸ÏÖR[›I¢=ÛÝµŠÒã�œnéâgžRÊ,&Su÷rÙH9ªà(Âíà¤7Ä˜�yó]Áô¥ré¨tÉtq†�÷†^Ãú´å£¡gò°Îƒ›ooW\ýw\Égm¢6åêÈ
!ñƒðþJ‡‚kS»0·	DNˆ¢6Æõ LáWÜ—Å:æ44þÆþiÍ7î»gœê(XµöÇàÈb-àP6äHÝŒîïò¹“Ž%#Þ‘áE®¿¿ÕL|»}@Ì<jäWÁ/¢xä¸ßèA�uxGüÕ›°Y	²úÀOfý0¯w­ñ½7}Hã
cyD¼aýÃÇV‘Ù² �$é%r½øKÌÜÆb'¨÷æ¤;â�¿§¬…ä—ªV×yÏ•‰ûg�‹ý3ÿÔÕMÇ¹«BqÆ¬Ùå#üºØó’ÿ5EãõœÞkyuù°!˜V-#ô2Ê;ÆÍ§å®j¿'&fÕ\€hß›5�=BwµTä±Ä¹»Ö‘úrÊú‡ß,‡[bõLŽjr®6Ó ?&s¬3´,	?Â’wE„c´<¶Kx¸vùON;0!¹©Eâø<ŒØ�¹\†d“â©Ìb.ëD®Á%Tàq9KÉÏél!u¾H¡½˜/|iÓMV`2Ó½âqJ¢ö7x¢e9ªœ�|ãDÎÄz¦¤m®CËf·]ƒ)oë¹Àó ZJ,)$Ý›q°«¼
kNÙñ¤ø×z>�'ýbßþæš£XÙ%®'ó8”QEuAHC� -¹gôˆ�j.\-BúÇêÅÖyn	ÛÇžèaž©Z}ð­ÏQ1à}ãÜ£�¯ŽÄe†ŽH(©C<—•'áÍB´~ˆ±éf!y8•b–¶ì2©Ö7˜ŸS¦åZ¥ÖÎp£8®#.³Ü¬Oùû˜"BüQér$Z«J >$;b£R%ÓÝ ˆ@álqE#xä£KƒGRÙßüw/�kIU§ÅZ·b"4ðHL(ûÇ®oííñæIû;ª‡;À!æ
ì4�*dWôK©‹Ú]‰Ãã|ƒ;`ìØB.Q)EÕÉ-]cò�¾Ÿ!Õ„ùÝG%R:çŽV„I—+q;Ã\rë¥*±é?]œz·ñåúÆìræåAêkõ\8TAuó
wJ0s·­Þì¿,R« ´7N»f&¼/DÂ…Ú>Ž�–v¬X½+zWØ¾1Ç&ª)‘½¤9¶ôz=lŸ“iH—�ÇjdIF‡æîQT©ÚßÏQ¦,;pŸ™aîc³[øãA-*ðö^5’ŸM€½.i¿¡>žªJwÚêò@ge÷zKb U°â}ó`ÊÑT¬¼Ú¼1sãZ³1ö>}Ö¼ªX™Àq¹¢6‹‚ÚÆIxæ%{£òU¿‡€¥Ê¼Ô9Àn”“øËm¨É’ÛïßX„@zi#¨ýîáIfÛ¥Ìœ}pµó1«9©§ã–ðnÒwñ*ä/³¥¶¡Á«K¢½?ëþÙÚ®’¦¶ ¥ˆÜ_£ïóÃwü jÅ�:K:ùÚÙª}HB5›�ØÌÆ”§îºkA¬š1¨ïT›»Ì{ip�Ö«t¡wp•LÃ»�æ"ºŠ�ZîOjWv·×mß¦žZGFç¸—ÆqU –«Q^ŒXÎÖ~‚a]Em€­î	(eaÞû6ß­ÐB:øç„çã_ðÜvÇm[œ?‰tƒÈ“°:6î–”Ñ^uÖ›¨P÷ç©Us[`SjªÐ 8[YX¼cÓfæõQÞ‘"iÉ+ø9Õ°¹yïnûzgvøqð/¿ }ŒšªÐ—W¤þ<WÙOö,À£9K˜!é!Úl‘«’É¾‹û”2n�;ÝÓwÝõ…}´‹ªWe;†{°\lË™ë{œ¦Ûë1´x¡5Ìþ>ºH˜5ç×ŸþŠé@5ø…9ñ#ªûT;�f�Ð¾Oõ.™§L€ÌÎu§ž;žÔ´0ÉÙ3þ–ÔšƒCÄð±›ùÃÅÍøÙm°†Qq{eù!0v‘��èèä\ð/4]jÐçŽðFÇ»QàÌ{‘xvX¢\Ô•¼À1WPž›±eu¥4/’®h·•EîAPúoÄÎØ†×¯Kî£á!>ÏÝ£¥Ä|ßáf*Ž½HªXúµÕë]û*·\,$~0f¾ë8T×?s÷×(i¼ž+ÍŽ€Â.ôC²:S¦C¥h¤"®°«”Gü3~&êqy¸ñUL´D×#…f<Üƒ"ÿÕ	îÙbæ$~ÒÊ_ÙhöixÇžPÃÞ¸Èûù#dJ�®ÆnéÞm÷ÿV9êaé*ºZÚ€É15—ÑØ_“‘P“O’oW|„Ys‚?‰[ÿ—˜–Õ¥ÇÐc8: Òº–]¯mé8¤¢C)F’{öYM“õ¤îoËva#ë–s#þSþ‚y˜$$l!-%“~
a:¶ìÊbü�¬J¥f…vH:Rm“ä9�%Ý\ý$¥Uäë|±½H”+Qg84c_Sþ\l–;²Ï3_éøjã#ú¬F>Ê—•xžvðæ/÷´|¤~kç[Ub¹D­ý@“yËþvÛ ¦iD€’ûoMèœ¹"CŸmÜF·êZèw½;i hŽDÂž8uª§ß $›‚0aå·ºkŸ†Ü:x‚,@ÓˆË“ÑðÌþÍ=Ùîß–wu)TáÐÉ¼B2`2•õ€™äÃ §sÈq€p¢Y¿Ú²@`üùø&ê£Ð¾#c-I.Íd".”™Õ*\EÌùªiòæãä]\pi³Í(STxÂkË^ÙªåÎ—;�ígš¦ÈÎ7Ó*fz�ÕÅúB0%\ÐÂÌAüÍ×é‹�a8wÂ'Êif+ö³kÄ¤~ÁºŠR ¾EÏ•‰ë´ÏuãFÜ'Q<:ˆ` ´‰vÆm3ÝŽ¶­J<‘rz¿Ð�vžì>\@¡¹V"‹lV:À N«i[¹ÉG{ÖÔÚ(Ï°�»—Q	^ñïÎ£§sŽÏÎ§ÆPÄgF¤–l+ËxÉÂ¹v@hÿí²á±X	[O•�BHES«©`ŒcT©iÿ¨¹d-“ˆ¡Ï„¢“ælW½ïõKáhMiéŒ€i”>\ã`¡÷ù~Ðˆú¥Ìòíž@åó»ç72¦¿tÅ¸s'ûùÐŒU
Ê\# >†›K¯ã’Ù6;OÉ éÖ¶>Iµ°ú²ïå>­W—^%§Î›ŸƒÁ’2<\¯ì×Ê6Í¿˜òYðg.z ¬ú
€DR¥¨] /FÝÁ`ÑJ{g>9ž³°	ðµXÏ®1ã»Úk‡$@Ÿªéö¥ið�ä Ý9Z×ž‘n‘Ý))Ê‚5„Dp$ò=°D—¦õð8¤·Ë{�M¿ž�‡@¶¬¨‡m¸“6d{;�êF}BËöàºêOE�57ð�AK¶zœ4Ì)]3;*[ãÚzåyÀhs1©‹e°'<XðÒÚ*¡Œ++ÒÔs›³´äÇ�srgêä•kºæ3ù�÷RÌš'x8Kóì»yƒò3Í b¶[]8“N›0%×QÝŽ;ÒTìÞÌƒBË1YB±ÒÏ6é¤_c_ÍŸo.o!t~e@…]O›J�/#ºwÝÇ<»™õÐë¸%Ý‘Ä‹ÏU’M³´wžà²ÓëÒ\ª«ƒ„ÇïÙä¸u~&¨Š~vÊTÄ >8÷^çÓ|i�ëþ2Ì]•;½«Úç{ë¹Ö1ˆ­Ñ±–©×ãZ^yëí)lþïz¶O‰¶*ß@¬ƒp:6Ó'‘²Öñ¡Ú½§8ä°p}ÙKï/ë†6ç¨+……(ä:¥vÄ ÈA@Ë©¼jà”ž ú•ˆEÌ®QŒ–éô¨ãÞÏhúMž;™„Íó�‚’’j„©P~4.º9ïŠ
A�÷¨÷•>U@Ô}
ºEe"ÚíeŸcÂÉ¾ÖmE’`÷”mX›pP½Oƒ :ã7Z7^4‚ÛzŠ{lØÿ÷ArÒª`îÕœ^Mœ‘Ç�Ó¸9?7Ë"ÈPº	j"ÛÆ±Àèx|éR@Yf2�Y™Ó¼ já¦‹3ÊE9Î³Ÿ¤ËB¼`)¢àr³=÷ýŽª+�dÞŽ~Z™ ŒkFÂ,Ó,î|ùþÇ‹P½êÂ�§¸ö†˜Ð¡—B®fmÜFh)ÔHÄi†æ=S ÿc€ŒáÛØÀ
$?@ž2`HÞïÓø�É Pxbî±.¹E©[ŒFo´ê%®¥˜‰„�,û]ˆ´]¿*ôÀ”ðcíÞb²°˜½“ ·ì¢8£¦ö�œ6wê
¾10\Ò-ÝÆDßÑ,fðšGV:h$í¸ÝæLŠÙ&@¸ãAèƒã¦vã"!p÷“ô èÈhü’Ék¾UU/J±dMSJËÖ÷¦SÍ­ØLkR)\zÓ¾X<º“¾4ï®a3ìée=n¼ìª§T‘\Ó0€0:y†ï(ŒÒ`ÿH7¼ª>34"Ë>«Â¾Ýx
9/0!)‡
µÉ UÏÆ#MV×�âp@¶u”
Ù4mÍÄËþK/8Íë¾ âžx?áƒÍFçbc3åHÝ³s‚›FÍß�ÞZ]ìÖå‘Ÿº @yfñú`2±¬!o@'!¡n�o¡¾%¨ìŸ"ªrã²VŠ‹A0\Å ¼z i‡WB8ÚgµŽùsÀí#¿
Pd3F=ûß[ëñnÆëähyÁæé‡«ˆTß³ö‡’À§éÌ±¯¢jVÐìÌ:#û®-Û4ïÚþˆš£Òd–÷S«óâ«I6ØCðÏÌÍ»5É˜fpçÄäy�q—:ô®{á*å�Á‡XœkÏù*â!‘‹*©’Çð\—š—‰ÖQ($në1÷A¹»¡-×
bG-&�‰õá)î¦¸¿;çÀ·õáÊ"ÔÆø+=…è1jÇ3;Q*u
®³ù ¯jFEéâ£\‡C�yzRi&X_ä®ènÙcwÔ^¾1©ô
p?žºR½Ö0ó¡_%†xÊP4´ômÉRÑæ?î]òÌMÿÒ;a„­@eöytqªî-(®B’|Â§ÉQÍp„Mq®Êæ SÏ£¢”:„<‹AÕ´ü•
¨°ºü3†¦ŒdÝ-f•¼dè-Ä¸&"×>™„\­ÌÍøkŽ²Ç™&¤ñÈ×ÜÍzvøKLX.˜æ±u|ñ¶Î“àÈi£³.f‹úàÖËþBýdSnË†a¡ZÙ´(¥½ëÿ†L4[É�ü{–#p°¹øvêÐ/7>(î•ÉŽ@A~ »¸>hG|P úOÔÑ¾|t(ÑöÃs”vÓÔï—øÐåˆïQYîPß©é‚)ëiŒ ˜nù‡“k%1C2YÕëMs¤Í¡Yç9ê}É¨Ã4èÇNÄ€¯ÍÝy‹Ž/¤ÝQôêiÄ®†9¯¶k�›Å“Ó¹<'5™/ÞM-nšŽCv€¸‚Â6±\¨Êó¸¾àñ¤Ý[å9iË&yvø5ÎcµÇ9j¹û+2´�Æ¡m�¯Ñ=éîÇÒ#†8"ü2îB¡ìôÃZŸ”ŠÔ°¬ããš.^]ògA¨ï)‹â d12òï©üœêTó6„Äª�Žg(	N½âüKBJÓ°™zâG8ˆQZÚ	å‘–ÏK¥è2¯À»¥–h*à® mî‹Öû„Y/5”èÅbãmr‰´¬&Ê7û·¶RÛÂÅo"ž·Uƒ©µaIffŒlY¤Ïv¾25–‹ó°_g±«„ükü(Z„QLúšõš øþœ§sÛÔb"xa¥<t(à$snÌTl¨µ/†ˆ¤Ð¯s+ÉÓ¥°
&�$ÇûÖ(¨Ö»©3á*ÉJnPq@ÆªÞæ½qÔ÷¾|¼í7€ƒš†“Çæ¨
³´•ÞˆÁ(O·][¯EÝwZŒ‡çªøêúÿO!ó�7í—Su&*Ü'Iæ¹5Uÿ'CÒ{¤G¸!Ø�‚_àÇE]mË5útõ"•OaùOä&U êF#E”.ÅÜÖÒÈTØƒÚ�·MÓ°\-(7ŠtÀR,†º'ã;MË(¥ª[ÜS¬ï—Ù,Bc¸¥7v€R±ìƒ· ½0³^E$²„Áß§KZvdD°ì?¼½ÄÚìòƒ¯xnPm‰Š?
9¼<°EbÂ>‡b´ý¹LƒcÔbÁq5åÁ)NcYÍÑÕA¬Bœ¤LYÄ0õ¹µ"p#[9	¦ã¿)ë­Ò&(`)>Ÿµ‰€(~!x¤%â/Pö˜Hü^6K*è!ÝmÀk6ám&~œ"c,O‚Dã�±	Ñi:«·˜Í€�Þ{¤ªLb_üj�^ÛŠÓ‘´‚‰ÌgKõÌ«Á:5vmü�\¬ôi +rx È�Ê™ó0§2P&î1¨£Ë²v©ÎÎµÐké—l)Â9A™¿˜ó:ü9¶ÜjV=½+­IS™ÿµ#^úˆV¬¾Œä1É‡“õ8Û—ŒdW+èèèÂ8ßµÖËVCéµˆq­Š4ò¨§°±"ü7í�Ç¢˜¦bŸÒ8z)ªv²QQ¹•@‹NÏV·xI³ÃÍ¼*À�‹ÝÆb?òè4ÖiMØê½£-6¸ÿOžÝ*í†Ãê¤?¿ïˆ]ÄÕë)Tà-TÃ«ÔFþ3òwÓ¿]f†½ÿ)ÒÅC<áI	ÃCDÃ«Éq	¯³„Ûö³P,`: 0«dtøÆÖ«n¬™%mj©±öà ½mZ‹4³ 2Š ÞÝ0#ûÜ¤4�1ñ(×L˜<E6à+@y”XDÏ_ò—GØ9d!:ð&ëI7åëd\QB Ÿâ[@T)°™L¥þÅí£z�žY’‡éc±`©RÑ¸'“Ö�9ÂÚáoñIé)$ƒéô4…aÚhtr=Cß®{b@\xƒ|%ÔÍºä°~oOî1r"7€âsæÇ¶1ªÜúõ†gïÝgéíDmM=ýjZ| .D(ÀÅP(U}bÏ²Íê˜=¢ðÅcR+ú3ð+Ò—¢@{EÜÁœ•,T‡TµØ6_“ˆkYBŽ)ñ¹+éÿÒwÊVÞä°ó�»Åf³áS      œãññŠ9Y÷ �0¡¶
 n¿sy±Ägû    YZ   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ;±<?xml version="1.0"?><Features nextValidID="28"><Feature recentID="0" name="CLDN6" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3977-4639" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MASAGMQILGVVLTLLGWVNGLVSCALPMWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVIALLVALFGLLVYLAGAKCTTCVEEKDSKARLVLTSGIVFVISGVLTLIPVCWTAHAIIRDFYNPLVAEAQKRELGASLYLGWAASGLLLLGGGLLCCTCPSGGSQGPSHYMARYSTSAPAISRGPSEYPTKNYV*"/></Q></Feature><Feature recentID="1" name="2Ã—linker" directionality="1" translationMW="648.58" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="4639" maxFusedRunOn="4639"><Segment range="3947-3976" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="GGGGSGGGGS"/></Q></Feature><Feature recentID="2" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2285-2294" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="3" name="luciferase" directionality="1" translationMW="60746.74" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="4639" maxFusedRunOn="4639"><Segment range="2291-3940" color="#ffcc00" type="standard" translated="1"/><Q name="EC_number"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="experiment"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;luc&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;firefly luciferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MEDAKNIKKGPAPFYPLEDGTAGEQLHKAMKRYALVPGTIAFTDAHIEVNITYAEYFEMSVRLAEAMKRYGLNTNHRIVVCSENSLQFFMPVLGALFIGVAVAPANDIYNERELLNSMNISQPTVVFVSKKGLQKILNVQKKLPIIQKIIIMDSKTDYQGFQSMYTFVTSHLPPGFNEYDFVPESFDRDKTIALIMNSSGSTGLPKGVALPHRTACVRFSHARDPIFGNQIIPDTAILSVVPFHHGFGMFTTLGYLICGFRVVLMYRFEEELFLRSLQDYKIQSALLVPTLFSFFAKSTLIDKYDLSNLHEIASGGAPLSKEVGEAVAKRFHLPGIRQGYGLTETTSAILITPEGDDKPGAVGKVVPFFEAKVVDLDTGKTLGVNQRGELCVRGPMIMSGYVNNPEATNALIDKDGWLHSGDIAYWDEDEHFFIVDRLKSLIKYKGYQVAPAELESILLQHPNIFDAGVAGLPDDDAGELPAAVVVLEHGKTMTEKEIVDYVASQVTTAKKLRGGVVFVDEVPKGLTGKLDARKIREILIKAKKGGKSKL"/></Q></Feature><Feature recentID="4" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5202-5211" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="5" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="10458-10474" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7858-7874" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="mCherry" directionality="1" translationMW="26722.72" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="6578" maxFusedRunOn="6578"><Segment range="5208-5915" color="#ff0000" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric derivative of DsRed fluorescent protein (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot;&gt;Shaner et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MVSKGEEDNMAIIKEFMRFKVHMEGSVNGHEFEIEGEGEGRPYEGTQTAKLKVTKGGPLPFAWDILSPQFMYGSKAYVKHPADIPDYLKLSFPEGFKWERVMNFEDGGVVTVTQDSSLQDGEFIYKVKLRGTNFPSDGPVMQKKTMGWEASSERMYPEDGALKGEIKQRLKLKDGGHYDAEVKTTYKAKKPVQLPGAYNVNIKLDITSHNEDYTIVEQYERAEGRHSTGGMDELYK"/></Q></Feature><Feature recentID="8" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="9810" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="9019-9810" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="9811-9879" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="9" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5979-6578" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MTEYKPTVRLATRDDVPRAVRTLAAAFADYPATRHTVDPDRHIERVTELQELFLTRVGLDIGKVWVADDGAAVAVWTTPESVEAGAVFAEIGPRMAELSGSRLAAQQQMEGLLAPHRPKEPAWFLATVGVSPDHQGKGLGSAVVLPGVEAAERAGVPAFLETSAPRNLPFYERLGFTVTADVEVPEGPRTWCMTRKPGA*"/></Q></Feature><Feature recentID="10" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="8260-8848" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6579-7166" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4905-5173" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7240-7473" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4681-4892" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2011-2214" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7685-7820" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7545-7666" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="21" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="22" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9880-9984" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="23" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="5975" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="6578" maxFusedRunOn="6578" detectionMode="exactProteinMatch"><Segment range="5925-5978" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="EGRGSLLTCGDVEENPGP"/></Q></Feature><Feature recentID="24" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="7906-7912" color="#ffffff" type="standard"/><Segment range="7913-7930" color="#ffffff" type="standard"/><Segment name="-35" range="7931-7936" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="25" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7951-7972" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="26" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="7882-7898" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="27" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7049" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="6666" maxFusedRunOn="6666" visible="0" detectionMode="exactProteinMatch"><Segment range="7050-7061" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="IEGR"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ·<Notes>
<UUID>b4d3fdf4-6151-4e84-9df5-8633b4a70d9e</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pLV3-CMV-Fluc-CLDN6(human)-EF1a-mCherry-Puro</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="16:0:0">2017.6.7</Created>
<LastModified UTC="12:22:28">2026.3.19</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y     K         
?????                                                                                                       ÿ d      DO  d              E              ÿÿÿÿYô? P                                                                                                                                                             g<StrandColors><TopStrand><ColorRange range="3946..3975" colors="blue"/><ColorRange range="4636..4638" colors="blue"/><ColorRange range="5207..5914" colors="black"/></TopStrand><BottomStrand><ColorRange range="3946..3975" colors="blue"/><ColorRange range="4636..4638" colors="blue"/><ColorRange range="5207..5914" colors="black"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
